Journal of Korean Medicine Rehabilitation (한방재활의학과학회지)

The society of Korean Medicine Rehabilitation (한방재활의학과학회)
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A Study on the Anti-Inflammatory Effect of Gyejigeojakyakgabuja-tang

계지거작약가부자탕(桂枝去芍藥加附子湯)의 항염증 효과에 대한 연구

  • Jae-Min Jeong (Department of Korean Medicine Rehabilitation, College of Korean Medicine, Dongshin University) ;
  • Seung-Kyu Im (Department of Korean Medicine Rehabilitation, College of Korean Medicine, Dongshin University) ;
  • Song Choi (Department of Internal Medicine, College of Korean Medicine, Dongshin University) ;
  • Hyun-Ji Kim (Department of Internal Medicine, College of Korean Medicine, Dongshin University) ;
  • Jin-Bong Choi (Department of Korean Medicine Rehabilitation, College of Korean Medicine, Dongshin University)
  • 정재민 (동신대학교 한의과대학 한방재활의학교실 ) ;
  • 임승규 (동신대학교 한의과대학 한방재활의학교실 ) ;
  • 최송 (동신대학교 한의과대학 한방내과학교실) ;
  • 김현지 (동신대학교 한의과대학 한방내과학교실) ;
  • 최진봉 (동신대학교 한의과대학 한방재활의학교실 )
  • Received : 2024.03.18
  • Accepted : 2024.05.20
  • Published : 2024.07.31
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Abstract

Objectives This study was conducted in in vitro environments to investigate the anti-inflammatory effect and expression mechanism of Gyejigeojakyakgabuja-tang (GJBT). Methods In the experiment, an inflammatory response was induced with lipopolysaccharide in macrophage RAW 264.7 cells treated with GJBT, and the production of nitric oxide (NO), prostaglandin E2 (PGE2), and cytokines were measured, and inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were measured. The intracellular gene and protein expression levels of cytokines were measured. Results In vitro, GJBT significantly reduced intracellular NO, PGE2, and cytokine production in a concentration-dependent manner. The intracellular iNOS, COX-2, and Cytokine gene expression levels were significantly decreased, and the intracellular iNOS, COX-2, and cytokine protein expression levels were significantly decreased in a concentration-dependent manner. Conclusions These results show that GJBT has an anti-inflammatory effect.

Keywords

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