The korean journal of orthodontics (대한치과교정학회지)

The Korean Association Of Orthodontists (대한치과교정학회)
권호 표지
DOI QR코드

DOI QR Code

Effectiveness of autologous leukocyte-platelet-rich fibrin on the rate of maxillary canine retraction, rotation, pain, and soft tissue healing: A split-mouth randomized controlled trial

  • Subrat Kumar Satapathy (Department of Orthodontics and Dentofacial Orthopaedics, SCB Dental College and Hospital) ;
  • Surya Kanta Das (Department of Orthodontics and Dentofacial Orthopaedics, SCB Dental College and Hospital) ;
  • Ashish Kumar Barik (Department of Orthodontics and Dentofacial Orthopaedics, SCB Dental College and Hospital) ;
  • Devpartim Mohanty (Department of Periodontics and OralImplantology, SCB Dental College and Hospital) ;
  • Sunil Kumar Rath (Department of Orthodontics and Dentofacial Orthopaedics, SCB Dental College and Hospital) ;
  • Mitali Mishra (Department of Orthodontics and Dentofacial Orthopaedics, SCB Dental College and Hospital)
  • Received : 2023.05.19
  • Accepted : 2024.05.21
  • Published : 2024.09.25
Download PDF
⟨ Previous Next ⟩

Abstract

Objective: To assess the effectiveness of leukocyte-platelet-rich fibrin (L-PRF) compared with conventional treatment on canine retraction, rotation, pain, and soft tissue healing. Methods: Sixteen adult patients aged 18-25 years (10 females, and 6 males; mean age 22.25 ± 2.26 years) with Class I bimaxillary protrusion and Class II div 1 malocclusion participated in this single-center, split-mouth randomized controlled trial at the Orthodontics Department of a single hospital in SCB Dental College and Hospital, Cuttack, India. Randomization was performed using a computer-assisted function with a 1:1 allocation ratio. The intervention included the placement of L-PRF on the experimental side and follow-up for 90 days. The primary outcome measures were canine retraction, rotation, pain, and soft tissue healing. The range of tooth movement was evaluated at 15-day intervals: 0th day (T0), 15th day (T1), 30th day (T2), 45th day (T3), 60th day (T4), 75th day (T5), and 90th day (T6). Canine rotation was assessed at T0 and T6, and pain and soft tissue healing were evaluated on the 3rd, 7th, and 15th days of the treatment. Results: Cumulatively, the L-PRF group demonstrated a significantly greater tooth movement as compared to conventional treatment group (P < 0.001). Overall, canine retraction was 1.5 times greater on the L-PRF side than on the control side. Canine rotation showed no significant relationship, whereas pain and soft tissue healing were significantly better on the L-PRF side than on the control side. Conclusions: Local administration of L-PRF amplifies canine retraction while improving pain and soft tissue repair.

Keywords

References

  1. Segal GR, Schiffman PH, Tuncay OC. Meta analysis of the treatment-related factors of external apical root resorption. Orthod Craniofac Res 2004;7:71-8. https://doi.org/10.1111/j.1601-6343.2004.00286.x
  2. Teixeira CC, Khoo E, Tran J, Chartres I, Liu Y, Thant LM, et al. Cytokine expression and accelerated tooth movement. J Dent Res 2010;89:1135-41. https://doi.org/10.1177/0022034510373764
  3. Andrade I Jr, Taddei SRA, Souza PEA. Inflammation and tooth movement: the role of cytokines, chemokines, and growth factors. Semin Orthod 2012;18:257-69. https://doi.org/10.1053/j.sodo.2012.06.004
  4. Nishimura M, Chiba M, Ohashi T, Sato M, Shimizu Y, Igarashi K, et al. Periodontal tissue activation by vibration: intermittent stimulation by resonance vibration accelerates experimental tooth movement in rats. Am J Orthod Dentofacial Orthop 2008;133:572-83. https://doi.org/10.1016/j.ajodo.2006.01.046
  5. Wilcko MT, Wilcko WM, Bissada NF. An evidence-based analysis of periodontally accelerated orthodontic and osteogenic techniques: a synthesis of scientific perspectives. Semin Orthod 2008;14:305-16. https://doi.org/10.1053/j.sodo.2008.07.007
  6. Gulec A, Bakkalbasi BC, Cumbul A, Uslu u, Alev B, Yarat A. Effects of local platelet-rich plasma injection on the rate of orthodontic tooth movement in a rat model: a histomorphometric study. Am J Orthod Dentofacial Orthop 2017;151:92-104. https://doi.org/10.1016/j.ajodo.2016.05.016
  7. Rashid A, ElSharaby FA, Nassef EM, Mehanni S, Mostafa YA. Effect of platelet-rich plasma on orthodontic tooth movement in dogs. Orthod Craniofac Res 2017;20:102-10. https://doi.org/10.1111/ocr.12146
  8. Del Corso M, Vervelle A, Simonpieri A, Jimbo R, Inchingolo F, Sammartino G, et al. Current knowledge and perspectives for the use of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in oral and maxillofacial surgery part 1: periodontal and dentoalveolar surgery. Curr Pharm Biotechnol 2012;13:1207-30. https://doi.org/10.2174/138920112800624391
  9. Yuan T, Guo SC, Han P, Zhang CQ, Zeng BF. Applications of leukocyte- and platelet-rich plasma (L-PRP) in trauma surgery. Curr Pharm Biotechnol 2012;13:1173-84. https://doi.org/10.2174/138920112800624445
  10. Schar MO, Diaz-Romero J, Kohl S, Zumstein MA, Nesic D. Platelet-rich concentrates differentially release growth factors and induce cell migration in vitro. Clin Orthop Relat Res 2015;473:1635-43. https://doi.org/10.1007/s11999-015-4192-2
  11. Anitua E, Zalduendo M, Troya M, Padilla S, Orive G. Leukocyte inclusion within a platelet rich plasma-derived fibrin scaffold stimulates a more pro-inflammatory environment and alters fibrin properties. PLoS One 2015;10:e0121713. https://doi.org/10.1371/journal.pone.0121713
  12. Pifer MA, Maerz T, Baker KC, Anderson K. Matrix metalloproteinase content and activity in low-platelet, low-leukocyte and high-platelet, high-leukocyte platelet rich plasma (PRP) and the biologic response to PRP by human ligament fibroblasts. Am J Sports Med 2014;42:1211-8. https://doi.org/10.1177/0363546514524710
  13. Baeyens W, Glineur R, Evrard L. [The use of plate-let concentrates: platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in bone reconstruction prior to dental implant surgery]. Rev Med Brux 2010;31:521-7. French. https://pubmed.ncbi.nlm.nih.gov/21290856/
  14. Dohan Ehrenfest DM, Bielecki T, Jimbo R, Barbe G, Del Corso M, Inchingolo F, et al. Do the fibrin architecture and leukocyte content influence the growth factor release of platelet concentrates? An evidence-based answer comparing a pure platelet-rich plasma (P-PRP) gel and a leukocyte- and platelet-rich fibrin (L-PRF). Curr Pharm Biotechnol 2012;13:1145-52. https://doi.org/10.2174/138920112800624382
  15. Pandis N. Sample calculation for split-mouth designs. Am J Orthod Dentofacial Orthop 2012;141:818-9. https://doi.org/10.1016/j.ajodo.2012.03.015
  16. Schulz KF, Altman DG, Moher D. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. J Pharmacol Pharmacother 2010;1:100-7. https://doi.org/10.4103/0976-500X.72352
  17. Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Trends Biotechnol 2009;27:158-67. https://doi.org/10.1016/j.tibtech.2008.11.009
  18. Ziegler P, Ingervall B. A clinical study of maxillary canine retraction with a retraction spring and with sliding mechanics. Am J Orthod Dentofacial Orthop 1989;95:99-106. https://doi.org/10.1016/0889-5406(89)90388-0
  19. Landry RG, Turnbull RS, Howley T. Effectiveness of benzydamyne HCl in the treatment of periodontal post-surgical patients. Res Clin Forums 1988;10:105-18. https://scholar.google.com/scholar_lookup?journal=Res+Clin+Forums&title=Effectiveness+of+benzydamyne+HCl+in+the+treatment+of+periodontal+post-surgical+patients&author=RG+Landry&author=RS+Turnbull&author=T+Howley&volume=10&publication_year=1988&pages=105-118& 10&publication_year=1988&pages=105-118
  20. McCaffery M, Beebe A. Pain: clinical manual for nursing practice. St. Louis: Mosby; 1989. https://books.google.co.kr/books/about/Pain.html?id=GlBwnQAACAAJ&redir_esc=y
  21. Frost HM. The regional acceleratory phenomenon: a review. Henry Ford Hosp Med J 1983;31:3-9. https://pubmed.ncbi.nlm.nih.gov/6345475/
  22. El-Timamy A, El Sharaby F, Eid F, El Dakroury A, Mostafa Y, Shaker O. Effect of platelet-rich plasma on the rate of orthodontic tooth movement. Angle Orthod 2020;90:354-61. https://doi.org/10.2319/072119-483.1
  23. Gkantidis N, Mistakidis I, Kouskoura T, Pandis N. Effectiveness of non-conventional methods for accelerated orthodontic tooth movement: a systematic review and meta-analysis. J Dent 2014;42:1300-19. https://doi.org/10.1016/j.jdent.2014.07.013
  24. Hoffmann S, Papadopoulos N, Visel D, Visel T, Jost-Brinkmann PG, Prager TM. Influence of piezotomy and osteoperforation of the alveolar process on the rate of orthodontic tooth movement: a systematic review. J Orofac Orthop 2017;78:301-11. https://doi.org/10.1007/s00056-017-0085-1
  25. Liou EJ. The development of submucosal injection of platelet rich plasma for accelerating orthodontic tooth movement and preserving pressure side alveolar bone. APOS Trends Orthod 2016;6:5-11. https://doi.org/10.4103/2321-1407.173725
  26. Li Z, Zhou J, Chen S. The effectiveness of locally injected platelet-rich plasma on orthodontic tooth movement acceleration. Angle Orthod 2021;91:391-8. https://doi.org/10.2319/061320-544.1
  27. Tehranchi A, Behnia H, Pourdanesh F, Behnia P, Pinto N, Younessian F. The effect of autologous leukocyte platelet rich fibrin on the rate of orthodontic tooth movement: a prospective randomized clinical trial. Eur J Dent 2018;12:350-7. https://doi.org/10.4103/ejd.ejd_424_17
  28. Nemtoi A, Sirghe A, Nemtoi A, Haba D. The effect of a plasma with platelet-rich fibrin in bone regeneration and on rate of orthodontic tooth movement in adolescents. Rev Chim 2018;69:3727-30. https://doi.org/10.37358/RC.18.12.6829
  29. Erdur EA, Karakasli K, Oncu E, Ozturk B, Hakki S. Effect of injectable platelet-rich fibrin (i-PRF) on the rate of tooth movement. Angle Orthod 2021;91:285-92. https://doi.org/10.2319/060320-508.1
  30. Nakornnoi T, Leethanakul C, Samruajbenjakun B. The influence of leukocyte-platelet-rich plasma on accelerated orthodontic tooth movement in rabbits. Korean J Orthod 2019;49:372-80. https://doi.org/10.4041/kjod.2019.49.6.372
  31. Reyes Pacheco AA, Collins JR, Contreras N, Lantigua A, Pithon MM, Tanaka OM. Distalization rate of maxillary canines in an alveolus filled with leukocyte-platelet-rich fibrin in adults: a randomized controlled clinical split-mouth trial. Am J Orthod Dentofacial Orthop 2020;158:182-91. https://doi.org/10.1016/j.ajodo.2020.03.020
  32. Barhate UH, Duggal I, Mangaraj M, Sharan J, Duggal R, Jena AK. Effects of autologous leukocyte-platelet rich fibrin (L-PRF) on the rate of maxillary canine retraction and various biomarkers in gingival crevicular fluid (GCF): a split mouth randomized controlled trial. Int Orthod 2022;20:100681. https://doi.org/10.1016/j.ortho.2022.100681
  33. Cagli Karci I, Baka ZM. Assessment of the effects of local platelet-rich fibrin injection and piezocision on orthodontic tooth movement during canine distalization. Am J Orthod Dentofacial Orthop 2021;160:29-40. https://doi.org/10.1016/j.ajodo.2020.03.029
  34. Zeitounlouian TS, Zeno KG, Brad BA, Haddad RA. Effect of injectable platelet-rich fibrin (i-PRF) in accelerating orthodontic tooth movement: a randomized split-mouth-controlled trial. J Orofac Orthop 2021;82:268-77. https://doi.org/10.1007/s00056-020-00275-x
  35. Zeitounlouian TS, Zeno KG, Brad BA, Haddad RA. Three-dimensional evaluation of the effects of injectable platelet rich fibrin (i-PRF) on alveolar bone and root length during orthodontic treatment: a randomized split mouth trial. BMC Oral Health 2021;21:92. https://doi.org/10.1186/s12903-021-01456-9
  36. de Almeida Barros Mourao CF, de Mello-Machado RC, Javid K, Moraschini V. The use of leukocyte- and platelet-rich fibrin in the management of soft tissue healing and pain in post-extraction sockets: a randomized clinical trial. J Craniomaxillofac Surg 2020;48:452-7. https://doi.org/10.1016/j.jcms.2020.02.020