Toxicological Research

  • 제41권1호
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  • Pages.36-46
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  • 2025
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  • 1976-8257(pISSN)
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  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
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DOI QR코드

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Genotoxicity evaluation of fucoidan-rich Undaria pinnatifida sporophyll

  • Miran Jang (Department of Food Technology and Nutrition, Inje University) ;
  • Soo-Im Choi (R&D Center, MEDIOGEN, Co., Ltd) ;
  • Gun-Hee Kim (Department of Health Functional New Materials, Duksung Women's University)
  • 투고 : 2024.03.12
  • 심사 : 2024.07.26
  • 발행 : 2025.01.15
⟨ 이전 논문 다음 논문 ⟩

초록

The aim of this study was to investigate genotoxicity of fucoidan-rich Undaria pinnatifida sporophyll (FUPS) using a three-component test battery. Our sulfate analysis method showed that FUPS extract contained 14% fucoidan sulfate. The reverse mutation assay showed that the FUPS extract did not increase the number of revertant colonies in any of the five bacterial strains tested, regardless of metabolic activation by S9 mix. Furthermore, FUPS did not induce chromosomal aberrations in the 6-h short-term test with or without S9, as well as in the 24-h continuous test without S9. Finally, bone marrow micronucleus examination of ICR mice at oral doses up to 5000 mg/kg/day did not show a significantly dose-dependent increase in the frequency of micronucleated polychromatic erythrocytes (MNPCEs) or the ratio of polychromatic erythrocytes (PCEs) to total erythrocytes. In conclusion, it was determined that the FUPS extract does not have a significant genotoxic potential under the expected conditions of use.

키워드

과제정보

This research was part of a project titled "Development of Global Senior-friendly Health Functional Food Materials from Marine Resources (No. 20170297)" funded by the Ministry of Oceans and Fisheries, Korea. A certain part of the research was conducted with the support of the BK-21 FOUR program (grant no. 5199990614110) of the National Research Foundation of Korea (NRF) under the Ministry of Education.

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