Applied Chemistry for Engineering (공업화학)

The Korean Society of Industrial and Engineering Chemistry (한국공업화학회)
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Drug Release Properties of Verapamil-Loaded Water Chestnut Starch-Based Microneedles

Verapamil 함유 물밤 전분 기반 마이크로니들의 약물 방출 특성

  • Kyeongjung Kim (Department of Chemical and Biomolecular Engineering, Chonnam National University) ;
  • Eun-Jae Wang (Department of Chemical and Biomolecular Engineering, Chonnam National University) ;
  • Bo-Kyeong Kim (Department of Chemical and Biomolecular Engineering, Chonnam National University) ;
  • Wang-Geun Shim (Department of Chemical Engineering, Suncheon National University) ;
  • Soon-Do Yoon (Department of Chemical and Biomolecular Engineering, Chonnam National University)
  • 김경중 (전남대학교 화공생명공학과) ;
  • 왕은재 (전남대학교 화공생명공학과) ;
  • 김보경 (전남대학교 화공생명공학과) ;
  • 심왕근 (순천대학교 화학공학과) ;
  • 윤순도 (전남대학교 화공생명공학과)
  • Received : 2024.12.24
  • Accepted : 2025.01.12
  • Published : 2025.02.10
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Abstract

Microneedles (MNs) are a promising strategy to solve the fundamental limitations of transdermal drug delivery systems, which could overcome the protective effect of the stratum corneum of the skin and efficiently deliver therapeutic drugs painlessly to the dermal layer. In this study, water chestnut starch-based MNs loaded with the antihypertensive drug verapamil (VPM) were prepared using the centrifugation, the casting method, and the UV irradiation process. The prepared MNs were evaluated for their physicochemical properties, VPM release properties, and drug release simulation. The results of insertion properties confirmed that the prepared MNs could successfully penetrate the stratum corneum of the skin to enable drug delivery into the skin. In addition, the results of VPM release properties using an artificial skin test showed that the VPM-loaded MNs had a 1.57-3.58 times higher release effect than the patch form, and the release was suitably predicted by the Korsmeyer-Peppas model and evaluated to follow the non-Fickian diffusion mechanism. Rhodamine B and VPM-loaded MNs were capable of more efficient VPM delivery than the patch form in pig skin, and the release simulation results indicated that the prepared MNs had a high transdermal penetration effect.

Microneedles (MNs)을 이용한 약물 전달은 경피 약물 전달 시스템의 근본적인 한계를 해결하기에 유망한 전략으로, 피부의 각질층 보호작용을 극복하고 치료 약물을 진피층에 고통 없이 효율적으로 전달할 수 있다. 본 연구에서는 항고혈압제인 베라파밀(verapamil, VPM)이 함유된 물밤 전분 기반의 MNs를 원심분리, casting method, UV 조사 공정을 통해 제조하였다. 제조한 MNs의 물리·화학적 특성, VPM 방출 특성 및 시뮬레이션을 평가하였다. 기계적 특성 및 삽입 특성 결과로 제조한 MNs이 피부의 각질층을 충분히 관통하여 피부 내로의 약물 전달이 가능한 것으로 확인되었다. 또한, 인공피부 테스트를 이용한 VPM 방출 특성 결과는 VPM이 함유된 MNs이 패치 형태보다 높은 방출 효과를 지닌 것을 나타냈으며, Korsmeyer-Peppas model로 적합하게 예측되었고, non-Fickian diffusion 메커니즘을 따르는 것으로 평가되었다. Rhodamine B 및 VPM이 함유된 MNs는 돼지피부에서 패치 형태보다 고효율의 VPM 전달이 가능한 것으로 확인되었고, 방출 시뮬레이션 결과에서 제조한 MNs이 높은 피내 침투 효과를 지니는 것으로 평가되었다.

Keywords

Acknowledgement

이 논문은 전남대학교 연구년교수 연구비(과제번호: 2024-0150-01) 지원에 의하여 연구되었음.

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