Toxicological Research

  • 제41권2호
  • /
  • Pages.123-129
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  • 2025
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  • 1976-8257(pISSN)
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  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
권호 표지
DOI QR코드

DOI QR Code

Maternal smoking and its short- or long-term impact on offspring liver pathologies: a review of experimental and clinical studies

  • Daram Yang (Biosafety Research Institute and College of Veterinary Medicine, Jeonbuk National University) ;
  • Yu Ji Kim (Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical School, Jeonbuk National University, Research Institute of Clinical Medicine of Jeonbuk National University - Biomedical Research Institute of Jeonbuk National University Hospital) ;
  • Jong‑Won Kim (Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh)
  • 투고 : 2024.07.24
  • 심사 : 2024.12.02
  • 발행 : 2025.03.15
⟨ 이전 논문 다음 논문 ⟩

초록

This review investigates the correlation between prenatal tobacco exposure and the risk of liver diseases in offspring. By synthesizing data from clinical trials and animal studies, it provides a comprehensive overview of the potential mechanisms underlying this association. This review begins by analyzing the prevalence of maternal smoking and its impact on fetal development. It then discusses specific liver diseases observed in offspring exposed prenatally to tobacco, such as acute liver injuries and metabolic dysfunction-associated fatty liver disease, and discusses the underlying pathophysiological pathways. Current evidence indicates that altered fetal liver development, oxidative stress, and genetic modifications may predispose offspring to liver diseases. Furthermore, this review highlights the gaps in current research and the need for longitudinal studies to better understand the long-term effects of prenatal tobacco exposure on the liver. The review concludes with recommendations for public health policies aimed at enhancing our understanding of maternal smoking and mitigating its adverse effects on offspring, emphasizing the importance of smoking cessation during pregnancy.

키워드

과제정보

This paper was supported by the Fund of the Biomedical Research Institute, Jeonbuk National University Hospital, and the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) (HI20C0209) (to J-W.K.) funded by the Ministry of Health & Welfare, Republic of Korea. This paper was also supported by a grant (RS-2023-00275922) (to D.Y.) from the Basic Science Research Program through the National Research Foundation (NRF) funded by the Ministry of Education, Republic of Korea.

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