The korean journal of orthodontics (대한치과교정학회지)

The Korean Association Of Orthodontists (대한치과교정학회)
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Effect of bisphosphonate vs. osteoprotegerin during orthodontic tooth movement: A systematic review and meta-analysis

  • Received : 2024.03.25
  • Accepted : 2024.11.26
  • Published : 2025.03.25
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Abstract

Objective: Orthodontic appliances are commonly used to achieve anchorage during orthodontic treatments; however, their use can contribute to oral diseases. Studies have shown that bisphosphonates and osteoprotegerin are highly effective in reducing orthodontic tooth movement. To determine the efficacy of bisphosphonates and osteoprotegerin in reducing orthodontic tooth movement. Methods: A comprehensive search was conducted across five databases-MEDLINE-PubMed, Scopus, Google Scholar, ScienceDirect, and Taylor & Francis-up to August 2, 2023. Clinical trials conducted in healthy animals, where bisphosphonates and osteoprotegerin were administered during tooth movement, were included. The search identified 3,099 articles, which underwent a two-phase screening process, resulting in twelve studies for the systematic review and seven for the meta-analysis. Risk of bias was assessed using the SYRCLE tool, and Egger's regression was used to evaluate publication bias. Results: The administration of bisphosphonates was more effective than osteoprotegerin in reducing mesiodistal orthodontic movement. However, osteoprotegerin did not significantly reduce orthodontic tooth movement. Conclusions: The findings align with previous studies, confirming the superior efficacy of bisphosphonates over osteoprotegerin. Further research is required to determine the optimal dosage and mechanism of action for these drugs in clinical practice, considering the specific objectives of orthodontic treatments.

Keywords

Acknowledgement

This article was paid for by the authors of the article privately but the research was carried out at Catholic University of Cuenca.

References

  1. Amador Carranza NE, Gutiérrez-Rojo JF. [Aceleración del movimiento dental en ortodoncia]. Revista Latinoamericana de Ortodoncia y Odontopediatría 2022. Venezuelan Spanish. https://www.ortodoncia.ws/publicaciones/2022/art-4/
  2. Ciaffi Terán MK, González Leal MF, Quirós Álvarez ÓJ. [Influencia de los Bifosfonatos en tratamientos ortodóncicos]. Revista Latinoamericana de Ortodoncia y Odontopediatría 2022. Venezuelan Spanish. https://www.ortodoncia.ws/publicaciones/2022/art-28/
  3. Aguilar Vanegas AB, García Cano DL, Quizhpe Quito AA, Siso Pérez SS, Quirós Castillo JJ. [Anclaje con microimplantes en tratamientos ortodonticos: artículo de revisión bibliográfica]. Revista Latinoamericana de Ortodoncia y Odontopediatría 2020. Venezuelan Spanish. https://www.ortodoncia.ws/publicaciones/2020/art-70/
  4. Trehan M, Bhanotia D, UI Hassan MS, Shaikh TA, Sharma S, Kumar AS. Recent advances in orthodontic retention: a review. Neuroquantology 2022;20:20-6. https://doi.org/10.48047/NQ.2022.20.20.NQ109004
  5. Yanes Ruiz Y, Cárdenas MO. [Afectación de la higiene bucal por el uso de aparatos de ortodoncia]. Gac Méd Espirit 2022;24:1-9. Spanish. http://scielo.sld.cu/scielo.php?pid=S1608-89212022000200003&script=sci_arttext
  6. Kaipatur NR, Wu Y, Adeeb S, Stevenson TR, Major PW, Doschak MR. Impact of bisphosphonate drug burden in alveolar bone during orthodontic tooth movement in a rat model: a pilot study. Am J Orthod Dentofacial Orthop 2013;144:557-67. https://doi.org/10.1016/j.ajodo.2013.06.015
  7. Venkataramana V, Chidambaram S, Reddy BV, Goud EV, Arafath M, Krishnan S. Impact of Bisphosphonate on Orthodontic tooth movement and osteoclastic count: an animal study. J Int Oral Health 2014;6:1-8. https://pubmed.ncbi.nlm.nih.gov/24876695/ https://doi.org/10.17303/jdoh.2013.101
  8. Zymperdikas VF, Yavropoulou MP, Kaklamanos EG, Papadopoulos MA. Effects of systematic bisphosphonate use in patients under orthodontic treatment: a systematic review. Eur J Orthod 2020;42:60-71. https://doi.org/10.1093/ejo/cjz021
  9. Harikrishnan S, Ramasamy N. Effect of local administration of bisphosphonate on orthodontic anchorage - a systematic review of animal studies. J Orthod Sci 2022;11:31. https://doi.org/10.4103/jos.jos_189_21
  10. Kaipatur N, Major P, Stevenson T, Pehowich D, Adeeb S, Doschak M. Impact of selective alveolar decortication on bisphosphonate burdened alveolar bone during orthodontic tooth movement. Arch Oral Biol 2015;60:1681-9. https://doi.org/10.1016/j.archoralbio.2015.08.008
  11. Chaudhari SD, Sharma KK, Marchetto JJ, Hydren JR, Burton BM, Moreno AP. Modulating OPG and TGF-β1 mRNA expression via bioelectrical stimulation. Bone Rep 2021;15:101141. https://doi.org/10.1016/j.bonr.2021.101141
  12. Fernández-González FJ, Cañigral A, López-Caballo JL, Brizuela A, Cobo T, de Carlos F, et al. Recombinant osteoprotegerin effects during orthodontic movement in a rat model. Eur J Orthod 2016;38:379-85. https://doi.org/10.1093/ejo/cjv056
  13. Srikanth E, Seena Naik E, Narasimha Lakshmi M, Ashok Babu D, Goud Padala R, Aravind Kumar A. Assessment of microsphere-controlled drug delivery for local control of tooth movement. Int J Oral Care Res 2020;8:71-3. https://doi.org/10.4103/INJO.INJO_39_20
  14. Gao X, Zheng J, Tu S, Cai B, Zeng R, Xiang L. Role of osteoprotegerin in the regulation of dental epithelial-mesenchymal signaling during tooth development. Mol Med Rep 2019;20:3035-42. https://doi.org/10.3892/mmr.2019.10567
  15. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Rev Esp Cardiol (Engl Ed) 2021;74:790-9. https://doi.org/10.1016/j.rec.2021.07.010
  16. Cumpston M, Li T, Page MJ, Chandler J, Welch VA, Higgins JP, et al. Updated guidance for trusted systematic reviews: a new edition of the Cochrane Handbook for Systematic Reviews of Interventions. Cochrane Database Syst Rev 2019;10:ED000142. https://doi.org/10.1002/14651858.Ed000142
  17. Shamseer L, Moher D, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ 2015;350:g7647. https://doi.org/10.1136/bmj.g7647
  18. Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan-a web and mobile app for systematic reviews. Syst Rev 2016;5:210. https://doi.org/10.1186/s13643-016-0384-4
  19. Karras JC, Miller JR, Hodges JS, Beyer JP, Larson BE. Effect of alendronate on orthodontic tooth movement in rats. Am J Orthod Dentofacial Orthop 2009;136:843-7. https://doi.org/10.1016/j.ajodo.2007.11.035
  20. Venkataramana V, Rajasigamani K, Kurunjikumaran N, Chidambaram AM. The effect of bisphosphonate [pamidronate] on orthodontic tooth movement in rabbits. IOSR J Dent Med Sci 2012;1:21-6. http://www.iosrjournals.org/iosr-jdms/papers/Vol1-issue5/F0152126.pdf https://doi.org/10.9790/0853-0152126
  21. Ortega AJ, Campbell PM, Hinton R, Naidu A, Buschang PH. Local application of zoledronate for maximum anchorage during space closure. Am J Orthod Dentofacial Orthop 2012;142:780-91. https://doi.org/10.1016/j.ajodo.2012.07.010
  22. Kirschneck C, Wolf M, Reicheneder C, Wahlmann U, Proff P, Roemer P. Strontium ranelate improved tooth anchorage and reduced root resorption in orthodontic treatment of rats. Eur J Pharmacol 2014;744:67-75. https://doi.org/10.1016/j.ejphar.2014.09.039
  23. Kanzaki H, Chiba M, Takahashi I, Haruyama N, Nishimura M, Mitani H. Local OPG gene transfer to periodontal tissue inhibits orthodontic tooth movement. J Dent Res 2004;83:920-5. https://doi.org/10.1177/154405910408301206
  24. Zhao N, Lin J, Kanzaki H, Ni J, Chen Z, Liang W, et al. Local osteoprotegerin gene transfer inhibits relapse of orthodontic tooth movement. Am J Orthod Dentofacial Orthop 2012;141:30-40. https://doi.org/10.1016/j.ajodo.2011.06.035
  25. Igarashi K, Mitani H, Adachi H, Shinoda H. Anchorage and retentive effects of a bisphosphonate (AHBuBP) on tooth movements in rats. Am J Orthod Dentofacial Orthop 1994;106:279-89. https://doi.org/10.1016/s0889-5406(94)70048-6
  26. Dunn MD, Park CH, Kostenuik PJ, Kapila S, Giannobile WV. Local delivery of osteoprotegerin inhibits mechanically mediated bone modeling in orthodontic tooth movement. Bone 2007;41:446-55. https://doi.org/10.1016/j.bone.2007.04.194
  27. Schneider DA, Smith SM, Campbell C, Hayami T, Kapila S, Hatch NE. Locally limited inhibition of bone resorption and orthodontic relapse by recombinant osteoprotegerin protein. Orthod Craniofac Res 2015;18 Suppl 1:187-95. https://doi.org/10.1111/ocr.12086
  28. Sydorak I, Dang M, Baxter SJ, Halcomb M, Ma P, Kapila S, et al. Microsphere controlled drug delivery for local control of tooth movement. Eur J Orthod 2019;41:1-8. https://doi.org/10.1093/ejo/cjy017
  29. Hooijmans CR, Rovers MM, de Vries RB, Leenaars M, Ritskes-Hoitinga M, Langendam MW. SYRCLE's risk of bias tool for animal studies. BMC Med Res Methodol 2014;14:43. https://doi.org/10.1186/1471-2288-14-43
  30. Balduzzi S, Rücker G, Schwarzer G. How to perform a meta-analysis with R: a practical tutorial. Evid Based Ment Health 2019;22:153-60. https://doi.org/10.1136/ebmental-2019-300117
  31. Al Shayea EI. Effects of common medications on orthodontic tooth movement: a systematic literature review. J Res Med Dent Sci 2021;9:149-61. https://www.jrmds.in/articles/effects-of-common-medications-on-orthodontic-tooth-movement-a-systematic-literature-review-82323.html
  32. Rivas BC, Cedillo FVM. [Clinical protocol for patients with history of use of bisphosphonates]. Rev ADM 2017;74:252-60. Spanish. https://www.medigraphic.com/cgi-bin/new/resumenI.cgi?IDARTICULO=75486
  33. Blanco Rodriguez K, Lilia Dobles Jiménez A. [Orthodontic management of patient in bisphosphonates treatment: literature review]. iDental 2019;11:39-47. Spanish. https://app.periodikos.com.br/journal/idental/article/5f9061ab0e8825c3411ddb38
  34. Krishnan S, Pandian S, Kumar SA. Effect of bisphosphonates on orthodontic tooth movement-an update. J Clin Diagn Res 2015;9:ZE01-5. https://doi.org/10.7860/jcdr/2015/11162.5769
  35. Arbelaez ML, Viafara Garcia SM, Lopez JP, Avila D, Munevar JC, Pauwels A. Effect of bisphosphonates on orthodontic tooth movement in osteoporotic patients: a review. J World Fed Orthod 2018;7:49-55. https://doi.org/10.1016/j.ejwf.2018.03.001
  36. Lotwala RB, Greenlee GM, Ott SM, Hall SH, Huang GJ. Bisphosphonates as a risk factor for adverse orthodontic outcomes: a retrospective cohort study. Am J Orthod Dentofacial Orthop 2012;142:625-34.e3. https://doi.org/10.1016/j.ajodo.2012.05.019
  37. Fernández-González FJ, Cañigral A, Balbontín-Ayala F, Gonzalo-Orden JM, Carlos F, Cobo T, et al. Experimental evidence of pharmacological management of anchorage in Orthodontics: a systematic review. Dental Press J Orthod 2015;20:58-65. https://doi.org/10.1590/2177-6709.20.5.058-065.oar
  38. Fernández-González FJ, López-Caballo JL, Cañigral A, Menéndez-Díaz I, Brizuela A, de Cos FJ, et al. Osteoprotegerin and zoledronate bone effects during orthodontic tooth movement. Orthod Craniofac Res 2016;19:54-64. https://doi.org/10.1111/ocr.12115
  39. Ajwa N. The role of bisphosphonates in orthodontic tooth movement-a review. J Family Med Prim Care 2019;8:3783-8. https://doi.org/10.4103/jfmpc.jfmpc_825_19
  40. de Sousa FRN, de Sousa Ferreira VC, da Silva Martins C, Dantas HV, de Sousa FB, Girão-Carmona VCC, et al. The effect of high concentration of zoledronic acid on tooth induced movement and its repercussion on root, periodontal ligament and alveolar bone tissues in rats. Sci Rep 2021;11:7672. https://doi.org/10.1038/s41598-021-87375-9