Animal Bioscience

Asian Australasian Association of Animal Production Societies (아세아태평양축산학회)
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Effects of dietary 25-hydroxycholecalciferol supplementation on growth performance, blood vitamin D and antioxidant status in nursery pigs

  • Chan Ho Kwon (Department of Animal and Dairy Science, University of Georgia) ;
  • Eva S. Safaie (Department of Animal and Dairy Science, University of Georgia) ;
  • Savannah L. Locke (Department of Animal and Dairy Science, University of Georgia) ;
  • Jannell A. Torres (Department of Animal and Dairy Science, University of Georgia) ;
  • Zhaohui Yang (Nutribins LLC) ;
  • Xi Chen (Nutribins LLC) ;
  • Young Dal Jang (Department of Animal and Dairy Science, University of Georgia)
  • Received : 2025.01.14
  • Accepted : 2025.04.24
  • Published : 2025.09.01
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Abstract

Objective: This study was conducted to evaluate the effect of dietary 25-hydroxycholecalciferol (25-OHD3) supplementation on growth performance, blood 25-OHD3 level, and antioxidant parameters in nursery pigs. Methods: A total of 48 newly weaned piglets (5.27±1.42 kg initial body weight) were allotted to 3 treatments in 4 replicates with 4 pigs per pen for a 28-d feeding trial in two phases for d 0-14 (Phase 1) and d 14-28 (Phase 2) postweaning with basal diets without supplemental vitamin D3 (VD3). Treatments were: 1) basal diet+2,000 IU/kg VD3 supplementation, 2) basal diet+1,000 IU/kg 25-OHD3 supplementation, and 3) basal diet+2,000 IU/kg 25-OHD3 supplementation. Growth performance, plasma 25-OHD3 and malondialdehyde (MDA) levels, total antioxidant capacity, and superoxide dismutase activity were measured. Results: There was no significant difference in growth performance among dietary treatments until d 21 postweaning. Dietary 25-OHD3 supplementation increased feed intake (p<0.07) and growth rate (p<0.05) greater than the VD3 treatment in d 21-28 and d 14-28 postweaning, resulting in a greater growth rate in the overall period (p = 0.10). Increasing levels of 25-OHD3 supplementation resulted in greater plasma 25-OHD3 concentrations at d 14 and 28 postweaning (p<0.05), while decreasing plasma MDA levels at d 28 postweaning (p<0.05) with no differences in plasma superoxide dismutase activity and total antioxidant capacity. In the broken-line analysis, the estimated plasma 25-OHD3 concentration for plasma MDA concentration to reach the minimum level was 23.7 ng/mL (p<0.05). Conclusion: Supplementing 25-OHD3 in nursery diets increased blood vitamin D status and had potential to enhance feed intake and growth rate in the late nursery period, while reducing oxidative stress compared with VD3 supplementation.

Keywords

Acknowledgement

Appreciation is also expressed to Setareh Khani, Sarah Han, Savannah Cheek, Mariah Yori, and Russell Utley for care of pigs.

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