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Sarcomatoid squamous cell carcinoma arising in a post-acupuncture keloid scar: a case report and literature review

  • Minwoo Park (Department of Plastic and Reconstructive Surgery, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine) ;
  • Sug Won Kim (Department of Plastic and Reconstructive Surgery, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine) ;
  • Jiye Kim (Department of Plastic and Reconstructive Surgery, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine)
  • 투고 : 2025.04.17
  • 심사 : 2025.07.19
  • 발행 : 2025.08.20

초록

Keloids are benign fibroproliferative skin tumors that typically arise after cutaneous injuries, such as surgical incisions, burns, lacerations, tattoos, or infections. Malignant transformation of keloids is exceedingly rare, with only sporadic reports of squamous cell carcinoma. To date, sarcomatoid squamous cell carcinoma-an uncommon, highly aggressive squamous cell carcinoma variant-has not been described in association with keloidal scars. We present the first known case of sarcomatoid squamous cell carcinoma developing within a post-acupuncture keloid scar, detailing its clinical presentation, histopathology, and surgical management. This report underscores the importance of malignancy screening in keloids displaying atypical features, particularly in trauma-exposed regions.

키워드

참고문헌

  1. Majumder A, Srivastava S, Ranjan P. Squamous cell carcinoma arising in a keloid scar. Med J Armed Forces India 2019;75:222-4. https://doi.org/10.1016/j.mjafi.2018.07.018
  2. Lee Y, Lee D, Yeo H, Park H, Park H. Extraordinarily aggressive cutaneous sarcomatoid squamous cell carcinoma of the face: a case report. Arch Craniofac Surg 2022;23:77-82. https://doi.org/10.7181/acfs.2022.00059
  3. Choi HR, Sturgis EM, Rosenthal DI, Luna MA, Batsakis JG, El-Naggar AK. Sarcomatoid carcinoma of the head and neck: molecular evidence for evolution and progression from conventional squamous cell carcinomas. Am J Surg Pathol 2003;27:1216-20. https://doi.org/10.1097/00000478-200309000-00004
  4. Ba W, Guo Q, Chen H, Yang H. Cutaneous sarcomatoid squamous cell carcinoma with smooth muscle actin expression: two case reports and review of the literature. Am J Dermatopathol 2022;44:616-8. https://doi.org/10.1097/DAD.0000000000002194
  5. Read C, Borba A, Lantz D, Berg D. Polysemous terms need context: a case of poorly differentiated spindle cell cutaneous squamous cell carcinoma. JAAD Case Rep 2024;49:117-20. https://doi.org/10.1016/j.jdcr.2024.04.046
  6. Rewis K, Yuhan BT, Borys D, Mehrotra S, Bier-Laning C. Sarcomatoid squamous cell carcinoma of the scalp: case report and review of the literature. Int J Head Neck Surg 2024;15:17-20. https://doi.org/10.5005/jp-journals-10001-1563
  7. Gandhe S, Patil R, Nagarkar R. Sarcomatoid carcinoma of the penis: an uncommon penile neoplasm. Iran J Pathol 2020;15:151-3. https://doi.org/10.30699/ijp.2020.117401.2275
  8. Thompson LD, Wieneke JA, Miettinen M, Heffner DK. Spindle cell (sarcomatoid) carcinomas of the larynx: a clinicopathologic study of 187 cases. Am J Surg Pathol 2002;26:153-70. https://doi.org/10.1097/00000478-200202000-00002
  9. Mingo KM, Derakhshan A, Abdullah N, Chute DJ, Koyfman SA, Lamarre ED, et al. Characteristics and outcomes in head and neck sarcomatoid squamous cell carcinoma: the cleveland clinic experience. Ann Otol Rhinol Laryngol 2021;130:818-24. https://doi.org/10.1177/0003489420977778
  10. Lee ET. A spindle cell squamous cell carcinoma on the cheek presenting with in-transit metastases and a satellite lesion. Arch Craniofac Surg 2020;21:58-63. https://doi.org/10.7181/acfs.2019.00654
  11. Goder M, Kornhaber R, Bordoni D, Winkler E, Haik J, Tessone A. Cutaneous basal cell carcinoma arising within a keloid scar: a case report. Onco Targets Ther 2016;9:4793-6. https://doi.org/10.2147/OTT.S113724
  12. Lu YY, Tu HP, Wu CH, Hong CH, Yang KC, Yang HJ, et al. Risk of cancer development in patients with keloids. Sci Rep 2021;11:9390. https://doi.org/10.1038/s41598-021-88789-1
  13. He Y, Merin MR, Sharon VR, Maverakis E. Eruptive keloids associated with breast cancer: a paraneoplastic phenomenon? Acta Derm Venereol 2011;91:480-1. https://doi.org/10.2340/00015555-1089
  14. Ernst E, Cassileth BR. The prevalence of complementary/alternative medicine in cancer: a systematic review. Cancer 1998;83:777-82. https://doi.org/10.1002/(SICI)1097-0142(19980815)83:4<777::AID-CNCR22>3.0.CO;2-O
  15. Lee YS, Lim Y, Yeo J. Acupuncture needles and the risk of lymphedema after breast cancer surgery: a retrospective national cohort study. Perspect Integr Med 2024;3:29-36. https://doi.org/10.56986/pim.2024.02.004
  16. Tseng HS, Chan SE, Kuo SJ, Chen DR. Acupuncture-related rapid dermal spread of breast cancer: a rare case. J Breast Cancer 2011;14:340-4. https://doi.org/10.4048/jbc.2011.14.4.340
  17. Gulamhuseinwala N, Mackey S, Meagher P, Powell B. Should excised keloid scars be sent for routine histologic analysis? Ann Plast Surg 2008;60:186-7. https://doi.org/10.1097/SAP.0b013e318056d6cc
  18. Monarca C, Maruccia M, Palumbo F, Parisi P, Scuderi N. A rare case of postauricular spontaneous keloid in an elderly patient. In Vivo 2012;26:173-5.
  19. Boisen J, Malone CH, Kelly B, Wagner RF Jr. Cutaneous squamous cell carcinoma with invasion through ear cartilage. Case Rep Dermatol Med 2016;2016:9067428. https://doi.org/10.1155/2016/9067428