Applied Chemistry for Engineering (공업화학)

The Korean Society of Industrial and Engineering Chemistry (한국공업화학회)
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Emulsion Stability of PEG-free Oil-in-water Emulsion Using Mixed Polyglyceryl Esters with Tailored Hydrophilic-lipophilic Balance (HLB) Value

맞춤형 hydrophilic-lipophilic balance (HLB) 값을 갖는 혼합 polyglyceryl esters를 이용한 PEG-free oil-in-water 유화액의 유화안정성

  • Se Mi Park (Department of Chemical Engineering, Dankook University) ;
  • Jin Mo Kim (Convergence Technology Laboratory, Kolmar Korea) ;
  • Seung Bum Lee (Department of Chemical Engineering, Dankook University)
  • 박세미 (단국대학교 화학공학과) ;
  • 김진모 ((주)한국콜마 융합기술연구소) ;
  • 이승범 (단국대학교 화학공학과)
  • Received : 2025.08.06
  • Accepted : 2025.08.19
  • Published : 2025.10.10
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Abstract

The effects of mixed polyglyceryl esters on the emulsification behavior and droplet characteristics of medium-chain triglyceride (MCT) oil-based oil-in-water (O/W) emulsions were investigated in this paper. The hydrophilic-lipophilic balance (HLB) value of the mixed polyglyceryl esters and the surfactant concentration were selected as formulation variables, and their effects were evaluated by measuring the emulsification stability index (ESI), mean droplet size (MDS), and droplet size distribution (using SPAN). Under the optimized conditions, the emulsion exhibited excellent stability, with an ESI of 96.4%, an MDS of 2.96 ㎛, and a SPAN of 0.878. The average deviation from predicted values was ± 1.28%, demonstrating high model reliability. Optical microscopy confirmed that the droplet structure remained stable, showing no discernible changes between immediately after preparation and after 3 days of storage.

본 연구는 polyethylene glycol (PEG)-free 계면활성제인 polyglyceryl ester 기반 혼합 계면활성제를 활용하여 medium-chain triglyceride (MCT) 오일 기반 oil-in-water (O/W) 유화 시스템의 유화 특성과 액적(droplet) 물성에 미치는 영향을 평가하고자 하였다. 실험에서는 혼합 계면활성제의 hydrophilic-lipophilic balance (HLB) 값 및 계면활성제의 양을 조절하여 유화 안정도 지수(emulsification stability index, ESI), 평균 액적 크기(mean droplet size, MDS), 액적 크기 분포 지수 (droplet size distribution, SPAN식 이용) 등을 측정하였다. 다중반응 최적화를 통한 최적 조건에서 제조된 유화액은 ESI 96.4%. MDS 2.96 ㎛, SPAN 0.878을 나타냈으며 예측값과의 평균 오차율은 ± 1.28%로 모델의 신뢰성을 입증하였다. 광학현미경 관찰 결과 제조 직후와 3일 경과 후 모두에서 액적 구조의 뚜렷한 변화 없이 안정적인 물성을 유지하였다.

Keywords

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