대한두개안면성형외과학회지 (Archives of Craniofacial Surgery)

  • 제26권5호
  • /
  • Pages.175-182
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  • 2025
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  • 2287-1152(pISSN)
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  • 2287-5603(eISSN)
대한두개안면성형외과학회 (Korean Association for Cranio Maxillo Facial Surgery)
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The potential use of hydroxyapatite from sea coral as a bone substitute: a systematic review

  • Indra Wahyudi (Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Hasanuddin University) ;
  • Andi Tajrin (Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Hasanuddin University) ;
  • Husni Mubarak (Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Hasanuddin University)
  • 투고 : 2025.02.03
  • 심사 : 2025.09.29
  • 발행 : 2025.10.20
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초록

Background: Bone defects can result from trauma, neoplasms, infections, or congenital anomalies. A common strategy for managing these defects is bone grafting, which must meet three essential biological requirements: osteoconductivity, osteogenicity, and osteoinductivity. Bone graft materials may be sourced from either natural or synthetic origins. Among natural materials, hydroxyapatite derived from marine coral has attracted attention as a bioceramic due to its compositional similarity to the mineral phase of human bone. Methods: Coral-derived hydroxyapatite primarily serves as an osteoconductive scaffold, supporting the attachment, proliferation, and differentiation of stem cells and osteoblasts. This process facilitates bone regeneration and the formation of new bone tissue. Additionally, coral hydroxyapatite may contribute to osteoinduction by stimulating local stem cells and osteoblasts, thus promoting osteogenesis and enhancing bone healing. Results: Owing to these properties, coral hydroxyapatite is considered a promising material for encouraging bone regeneration in defect sites. Conclusion: Hydroxyapatite obtained from marine coral represents a viable and effective bone graft substitute for reconstructing bone defects.

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참고문헌

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