Journal of Marine Bioscience and Biotechnology (한국해양바이오학회지)

The Korean Society for Marine Biotechnology (한국해양바이오학회)
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The skin-improving effects of ultrasonic extract from viscera of Turbo cornutus, fishery by-products

수산 부산물 소라 (Turbo cornutus) 내장 초음파 추출물의 피부 개선 효과

  • Jun-Ho Heo (Jeju Bio Research Center, Korea Institute of Ocean Science and Technology (KIOST)) ;
  • Nalae Kang (Jeju Bio Research Center, Korea Institute of Ocean Science and Technology (KIOST)) ;
  • Eun-A Kim (Jeju Bio Research Center, Korea Institute of Ocean Science and Technology (KIOST)) ;
  • Seong-Yeong Heo (Jeju Bio Research Center, Korea Institute of Ocean Science and Technology (KIOST)) ;
  • Seung Tae Im (Research Group of Process Engineering, Korea Food Research Institute) ;
  • Seung-Hong Lee (Department of Medical Science, Soonchunhyang University) ;
  • Soo-Jin Heo (Jeju Bio Research Center, Korea Institute of Ocean Science and Technology (KIOST))
  • 허준호 (한국해양과학기술원 제주바이오연구센터) ;
  • 강나래 (한국해양과학기술원 제주바이오연구센터) ;
  • 김은아 (한국해양과학기술원 제주바이오연구센터) ;
  • 허성영 (한국해양과학기술원 제주바이오연구센터) ;
  • 임승태 (한국식품연구원 가공공정연구단) ;
  • 이승홍 (순천향대학교 의료과학과) ;
  • 허수진 (한국해양과학기술원 제주바이오연구센터)
  • Received : 2025.12.15
  • Accepted : 2026.01.14
  • Published : 2026.06.30
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Abstract

Turbo cornutus (sea snail) viscera are generated as seafood-processing byproducts but remain underutilized, despite their potential as sources of marine bioactives. This study evaluated the skin-improving activities of Turbo cornutus viscera ultrasonic extract (TVSE) to assess its suitability as a functional cosmetic ingredient. TVSE was produced via ultrasonic-assisted extraction and assessed for whitening, anti-wrinkle, and antioxidant properties. Whitening activity was examined through tyrosinase inhibition and suppression of melanin production in B16F10 melanoma cells. Anti-wrinkle potential was assessed by inhibiting collagenase and elastase activities and by quantifying matrix metalloproteinase-1 (MMP-1) and procollagen type I C-peptide (PIP) levels in human dermal fibroblast (HDF) cells. Antioxidant activity was assessed by measuring intracellular reactive oxygen species (ROS) levels in HDF cells using a DCFH-DA fluorescence assay under oxidative stress conditions. TVSE significantly inhibited tyrosinase activity and mela- nogenesis, attenuated collagenase and elastase activities, reduced MMP-1 production, promoted PIP production, a marker of collagen synthesis, and mitigated stress-induced ROS accumulation. These findings indicate that TVSE exerts multimodal skin-improving effects and represents a promising marine-derived cosmeceutical material for the valorization of seafood-processing byproducts.

Keywords

Acknowledgement

이 논문은 해양수산부의 재원으로 해양수산과학기술진흥원-해양수산부산물 바이오 소재화 기술개발 사업 (RS-2022-KS221555) 지원을 받아 수행된 연구임

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