Engineers have developed new instruments that aid in diagnosis and therapy Ultrasonic imaging has provided a nondamaging method of imaging internal organs. A complex transducer emits ultrasonic waves at many angles and reconstructs a map of internal anatomy and also velocities of blood in vessels. Fast computed tomography permits reconstruction of the 3-dimensional anatomy and perfusion of the heart at 20-Hz rates. Positron emission tomography uses certain isotopes that produce positrons that react with electrons to simultaneously emit two gamma rays in opposite directions. It locates the region of origin by using a ring of discrete scintillation detectors, each in electronic coincidence with an opposing detector. In magnetic resonance imaging, the patient is placed in a very strong magnetic field. The precessing of the hydrogen atoms is perturbed by an interrogating field to yield two-dimensional images of soft tissue having exceptional clarity. As an alternative to radiology image processing, film archiving, and retrieval, picture archiving and communication systems (PACS) are being implemented. Images from computed radiography, magnetic resonance imaging (MRI), nuclear medicine, and ultrasound are digitized, transmitted, and stored in computers for retrieval at distributed work stations. In electrical impedance tomography, electrodes are placed around the thorax. 50-kHz current is injected between two electrodes and voltages are measured on all other electrodes. A computer processes the data to yield an image of the resistivity of a 2-dimensional slice of the thorax. During fetal monitoring, a corkscrew electrode is screwed into the fetal scalp to measure the fetal electrocardiogram. Correlations with uterine contractions yield information on the status of the fetus during delivery To measure cardiac output by thermodilution, cold saline is injected into the right atrium. A thermistor in the right pulmonary artery yields temperature measurements, from which we can calculate cardiac output. In impedance cardiography, we measure the changes in electrical impedance as the heart ejects blood into the arteries. Motion artifacts are large, so signal averaging is useful during monitoring. An intraarterial blood gas monitoring system permits monitoring in real time. Light is sent down optical fibers inserted into the radial artery, where it is absorbed by dyes, which reemit the light at a different wavelength. The emitted light travels up optical fibers where an external instrument determines O2, CO2, and pH. Therapeutic devices include the electrosurgical unit. A high-frequency electric arc is drawn between the knife and the tissue. The arc cuts and the heat coagulates, thus preventing blood loss. Hyperthermia has demonstrated antitumor effects in patients in whom all conventional modes of therapy have failed. Methods of raising tumor temperature include focused ultrasound, radio-frequency power through needles, or microwaves. When the heart stops pumping, we use the defibrillator to restore normal pumping. A brief, high-current pulse through the heart synchronizes all cardiac fibers to restore normal rhythm. When the cardiac rhythm is too slow, we implant the cardiac pacemaker. An electrode within the heart stimulates the cardiac muscle to contract at the normal rate. When the cardiac valves are narrowed or leak, we implant an artificial valve. Silicone rubber and Teflon are used for biocompatibility. Artificial hearts powered by pneumatic hoses have been implanted in humans. However, the quality of life gradually degrades, and death ensues. When kidney stones develop, lithotripsy is used. A spark creates a pressure wave, which is focused on the stone and fragments it. The pieces pass out normally. When kidneys fail, the blood is cleansed during hemodialysis. Urea passes through a porous membrane to a dialysate bath to lower its concentration in the blood. The blind are able to read by scanning the Optacon with their fingertips. A camera scans letters and converts them to an array of vibrating pins. The deaf are able to hear using a cochlear implant. A microphone detects sound and divides it into frequency bands. 22 electrodes within the cochlea stimulate the acoustic the acoustic nerve to provide sound patterns. For those who have lost muscle function in the limbs, researchers are implanting electrodes to stimulate the muscle. Sensors in the legs and arms feed back signals to a computer that coordinates the stimulators to provide limb motion. For those with high spinal cord injury, a puff and sip switch can control a computer and permit the disabled person operate the computer and communicate with the outside world.

Recently, the Image compression methods in cooperation with Human Visual System characteristics are being investigated lively. In this study, we propose a new block coding method using i) non-linearity of HVS in the noticeable differences, ii) spatial easting effects, and iii) HVS sensitivity curve according to spatial frequencies. For vector quantization, the third scheme was dole effective than existing ones. We have applied this method on chest images and the results have shown better subjective qualities.

Image display is the last step of imaging chain in which the diagnostic information is transformed into perceivable intensities and transformed to observer's eye-brain system. In this process, a certain part of information may be efficiently transfered and another part may be inefficiently transfered leading to information loss. In this study, the visual perceptual properties of image display on CRT monitor has been investigated. Psychophysical experiment of target image detection has been performed using CRT monitor for various background grey levels, and the threshold difference grey levels required for visual discrimination have been predicted by computer simulation with visual model.

The discrete cosine transform (DCT)-based progressive coding standard proposed by the International Standardization Orgnnization (ISO) Joint Photographic Experts Groups (JPEG) is investigated for medical image compression and the performance of the JPEG is compared to that of the full-frame bit-allocation (FFBA) technique. From the comparison, the JPEG standard appeals superior to the FFBA technique in the following aspects: 1) JPEG achieves higher compression than the FFBA technique with less mean square error. 2) Less Gibb's artifact is observed in the compressed images by the JPEG. 3) Computational time for the JPEG is about one-fourth or the FFBA technique. Other attractive points of the JPEG include: Implementation of the JPEG with VLSIs is commercially available in relative low price and the JPEG compression format can easily be interchangeable with other applications.

To improve signal-to-noise ratio in sodium image, short echo time (2-3 ms) and long data acquisition (10-20 ms) protocols are used. Sodium in biological specimens demonstrates a bi-exponential decay of transverse magnetization and the fast decaying component of the sodium signal results in the reconstruction of images which are blurred significantly. The spatially-dependent nature of the blurs are due mainly to the presence of short local transverse relaxation values (0.7-3 ms) of sodium in tissue. We present an algorithm that corrects for object-dependent blurs due to fast-decaying T2 and improves the computational behavior of the algorithm by incorporating a relaxation parameter into the iterative process.

This paper describes research about the realization of computerized radial pulse diagnosis system in order to remove the subjectivity of a diagnostician, when diagnostician diagnoses a sickness using tactile percept ion in korean traditional medicine. Using radial pulse wave detection system, we effectively measured pressure radial pulse rave and after analyzing it, we detected the characteristic parameters and also quantified it and then we objectified more or less the judgement standard of radial pulse diagnosis by the aids of a clinical expert. on this base, we confirmed the possibility for realizing of automatic radial pulse diagnosis by radial pulse diagnosis system.

This paper describes research about the realization of a diagnosis system for the surgical operation of the acupuncture. The system consists of the Munjin, Bokjin and Makjin software. The Munjin system diagnoses the pain spots or each Kyoungnats of the hands, root and neck. The Bokjin system diagnoses pressure-pain spots of the twelve Kyoungnak at chest and abdomen by following the displayed positions on the monitor in sequentially. The Maekjin system diagnoses radial pulse or inyoung and chongu according to the Inyoung-Chongu comparison in ethod. Compound diagnosis verifies the results which obtained from each diagnosis routine by the interface rule. This developed system contains the database which for the paitents diagnosis and treatment process recoding.

This paper describes the design of an adaptive closed circuit anesthesia controller based on a multiplexed mass spectrometer system. The controller deals with measurement deterioration caused by measurement delay and rise time through a tong catheter as well as long sampling times due to the multiplexed measurements. Measurement data is extrapolated between sampling periods to increase the estimation convergence rate. A multiple-step-ahead predictive control algorithm is used to calculate intermediatc control inputs between sampling intervals. Simulations are used to validate the designed controller.

In MRI, an image contrast can be developed as a result of the susceptibility effect if an object has paramagnetic substances. This is mainly due to the non-uniform phase distribution or linear gradient developed by the magnetic susceptibility within a voxel, which in turn reduces the signal intensity; e.g., spin phases are dephased and thereby cancel each other resulting in a reduced signal. In this paper, a new concept for manipulating the susceptibility effect through the use of tailored RF pulses is proposed. As potential applications of the method, two different types of tailored RF pulses are introduced: one for susceptibility artifact correction and the other for contrast enhancement. The latter, for example, can be applied to angiography utilizing the paramagnetic property of deoxygenated blood. Both a theoretical study of the method and experimental results are reported.

The pulsatile nature of blood flow makes artefacts in 2D Fourier transform image. Spatial presaturation is known to be effective in eliminating flow artefacts when the spin echo acquisition is employed. However. this method requires additional RF pulse and spoiling gradient for presaturation. In this paper a new flow saturation technique which does not require additional saturation-RF and gradient is proposed. The proposed technique is equivalent to the existing saturation technique but the elimination of the flow component is achieved by a pair of tailored $90^{\circ}-180^{\circ}$ RF pulses in tile spin echo sequence. By use of two tailored RF pulses with opposite phase polarity, a linear phase gradient is generated for those moving materials and consequently all the spins of moving materials become dephased thereby no signal is observable. Computer simulations and experimental results obtained using both a phantom and a human volunteer with a 2.0 T whole body system are also presented.

A new algorithm using entropy operater with variable threshold for edge detection from 2D short axis echocardiogram is proposed. This algorithm is based on brightness, mean value of entropy, and variance value of entropy in local window. This algorithm is effective to process complex echocardiographic images due to the speckle noises, echo dropouts and characteristics of 2D echocardiographic constituents. Results of computer simulation of the proposed algorithm show excellent edge detection performance comparing wi th other edge operators which have been applied to 2D echocardiograms.

고주파 자장 유도를 사용하는 공막 탐지 코일(scleral search coil) 법에 의한 안구 운동의 측정은 분해능, DC 안정성의 장점때문에 정밀 측정의 대표적인 기법으로 정착되었다. 본 연구에서는 공막 탐지 코일법의 한 변형으로서 비교적 간단한 자장 구동 및 탐지회로를 채택하였고 보다 논은 착용감을 주도록 고안된 금박 공막테를 사용하여 안구 운동을 측정한 결과에 관한 것이다.

We have developed and been using laboratory order communication system which is a computerized laboratory request and reception system wi th bar code between inpatient or outpatient and the clinical laboratory in Chungbuk National Unversity Hospital. Work flows are as follows: Tests are requested by the physicians through hospital information system without issuing request forms. Bar code stickers containing demographics of patient and other informations such as sample number, slip code and specimen code are printed and attached to smaple tubes. At the department of clinical pathology, smaples are received through the bar code reader. Area numbers are automatically created and laboratory work numbers are determined. Worklists can be issued by each section of laboratory when needed. Our order communication system alleviates the human labor such as specimen labelling and making worklist and reduces clerical errors that occur from sample collection to laboratory analysis.

We present a new EEG waveform detection method, based on the search of distinctive line-segments. The method is based on the assumption that EEG waveform morphology is characterized by a sequence of its distinctive line-segments and their structural features. In this method, the distinctive line segments are first searched for, and the structural feature analysis is performed on the found line-segment sequence. Experiments of detecting epileptic spikes are performed on four different subjects.

In this paper, a numerical simulation of steady laminar and turbulent flow in a two dimensional model for the total artificial heart is presented. A trileaflet polyurethane valve was simulated at the outflow orifice while the inflow orifice had a trileaflet or a flap valve. The numerical solutions of the simulated model show that regions of relative stasis and trapped vortices were smaller wi thin the ventricular chamber wi th the flap valve at the inflow orifice than that with the trileaflet valve. The predicted Reynolds stresses distal to the inflow valve within the ventricular chamber were also found to be smaller with the flap valve than with the trileaflet valve. Analysis of the numerical solutions suggests that geometries similar to the flap valve(or a tilting disc valve) results in a better flow dynamics within the total artificial heart chamber compared to a trileaflet valve.

Cellular kinetics formulate the basis of tumor immune system dynamics which may be synthesized mathematically as cascades of bilinear systems which are connected by nonlinear dynamical terms. In this manner, a foundation for the control of syngeneic tumors is presented. We have analyzed the mechanisms of controlling the infiltration of lymphocytes into tumor tissues. Simulated anneal ins, a general-purpose method of multivariate optimization, is applied to combinatorial optimization, which is to find the minimum of a given function depending on many parameters. We compare the results of the different methods including the global optimization algorithm, known as simutated annealing.

Evoked otoacoustic emission (e-OAE) signals are measured from adult and analyzed by computer. Stimulation and detection are repeated and averaged 1000 times for noise cancellation. e-OAE signals are analyzed on frequency domain and time domain. The frequency domain analysis reveals that frequency of stimulus and emission has lineal relationship in 50 dB input sound amplitude. This result altos the cross correlation method to be applied for latency calculation. As the stimulus frequency grows higher, the latency tine is shorter and the gain or emission signal becomes greater. We introduced two mathmatical functions to identify these latecy and gain. These results can be utilized for cochlear modeling.

In this paper, we study about reflectance photometer for measuring teflectance changes on reagent strip material after applying of a liguid sample. To obtain more accurate reflectance parameter, the strip loader and cassette is designed. The system is designed to work with IBM personal computer. As the experimental results, reflectance level measured of korean standard color paper and shows a exponentially proportion to brightness of paper. A diagnostic strip for total protein is applied to our system and shows a good correlation in a physically protein concentration range.(up to 500 mg/dl).

There is a definite requirement to continuously monitor the operating characteristics of radiation therapy machines. It is advisable to monitor the symmetry, flatness, and energy stability of x-ray beams. The semiconductor system was developed using commercially available rectifier diode for th assessment of quality assurance In radiation therapy, which is capable of the above measurements. The beam characteristics of 6MV, 10MV and 21MV photon of Microtron electron accelerator were measured using seven-diodes as detectors and the results were compared with that of using a film results dosimetry with a X-Y plotter. The seven-diode detetor is versatile enough to be used for checking beam profile, flatness, symmetry and energy.

We computerized outpatient's prescription using personal computer and local area network(LAN). The information and history of patient which is stored in the HOST computer is transfered to the local file server via emulatort & LAN. Then, the computerized outpatient's prescription which is made in each examination room is transfered to the admission of discharge office and pharmacy via LAN. In the admission of discharge office, drug charge is automatically calculated, and the prescription and envelope is printed out automatically in the pharmacy. Using this system, the patient takes the drug faster than before, eventually we improve medical service. Also, this system manage hospital works and administration effectively.

Liver function test is one of the most common tests for diagnosis and follow-up of patients and for heal th screening. Automatic interpretation and suggestions on the diagnostic possibilities contribute to shorten the interpretation time of the test results and help to provide qualified health care. Fuzzy logic has been recently introduced and being spread for these purposes. The present study aims at model Ins the foray rule-based laboratory diagnosis system. The fuzzy rule-based laboratory diagnosis system was applied to the diagnosis regarding liver function test. The system was evaluated by comparing with the stepwise multivariate discriminant function analysis, which showed similar results, and the overall accuracy of the fuzzy diagnosis system was about 80%.

In this study, the extractions of formant and articulately motion trajectorles from Korean diphthongs are performed by using the RISL adaptive linear prediction filter. This enables us to extract spectrum transition of speech signal accurately. This study showes that the RISL algorithm is superior to the Levinson algorithm, specially in transition part of speech.

본 논문에서는 감각성 난청자들이 정상인들과 유사한 음성 인식을 하도록 청각 보철 기기를 구성하였다. 음성의 포먼트를 추출하기 위해서는 PLP(Perceptual Linear Prediction) 방식을 이용하였으며, pitch 추출을 위해서는 3 단계 클리핑 함수를 이용한 자기 상관법을 이용하였다. 또한 다중 채널 - 다중 전극 방식을 이용하여 내이의 헤어셀에 17 개의 전극을 삽입하여 신호를 가하는 시뮬레이션을 하였다. 실험에 사용한 데이타는 모음 /a/, /e/, /i/, /o/, /u/로 전모음과 후모음의 차이를 구별하였으며 두번째 포먼트의 변화와 포먼트 통합 이론에 대한 검증을 하였다.

Development of a noninvasive intensive care system calls for the use of evoked potentials (EPs), as a means of diagnosing traumatic head-injured patients. The experiment entails surgically plating two subarachnoid bolts and a subdural balloon through the skull to simulate a subdural hematoma. Using various levels of intracranial pressure (ICP) and/or different sizes of balloons, auditory evoked potentials (AEPs) were recorded from a rabbit. Six positive peat latencies ($P_1-P_6$) and five negative peak latencies ($N_1-N_5$) were extracted from an averaged AEP waveform. Multiple regression analyses were performed for determining a relationship between the ICP and AEP peak latencies. The results indicate that a major correlation of changes on AEP peak latencies is due to mechanical forcer of a mass (inflated balloon simulating a hematoma) in the distortion of the brain matter rather than increased ICP.

This paper proposes a method called linear prediction (a high performant technique in digital speech processing) for analyzing digital ECG signals. There are several significant properties indicating that ECG signals have an important feature in the residual error signal obtained after processing by Durbin's linear prediction algorithm. The ECG signal classification puts an emphasis on the residual error signal. For each ECG's QRS complex. the feature for recognition is obtained from a nonlinear transformation which transforms every residual error signal to set of three states pulse-cord train relative to the original ECG signal. The pulse-cord train has the advantage of easy implementation in digital hardware circuits to achive automated ECG diagnosis. The algorithm performs very well feature extraction in arrythmia detection. Using this method, our studies indicate that the PVC (premature ventricular contration) detection has a at least 90 percent sensityvity for arrythmia data.

90일간에 걸쳐 수집된 후천성 맹인의 체온데이타를 분석하였다. 이 데이타는 1일 주기 리듬을 갖고 있음을 잘 보여주었으며, 데이타 분석 방법으로는 시계열분석을 이용, 잡음을 제거하고 푸리에분석방법에 의하여 추정데이타를 만든후, 원 데이타와의 오차 자승항이 최소가 되는 주기를 찾는 방법을 사용하였다. 전체 데이타를 1일, 3일, 5일씩의 길이로 잘라서 분석을 하였으며 90여일에 걸친 분석 결과들을 모아 추정파형의 진폭과 서카디안 페이즈를 그래프로 도시하였다. 고찰결과, 1. 이 맹인의 체온데이타는 24, 25시간의 일정한 주기를 갖고있다. 2. 이 데이타는 24시간의 주기와 24, 25시간의 주기로 분리할 수 있다. 3. 따라서 1일 주기리듬의 체온데이타는 근소한 차이의 두 가지 성분이 존재함을 알 수 있다.라는 결론을 내릴 수 있었다.

This paper investigates the EEG waveform distortions caused by the transient responses of the various types of signal conditioning filters, which are generally introduced for the automated EEG analysis. This study explicitly simulates the filter responses to the typical EEG waveform models, and compares the distortions.

Adaptive fliter for noise cancellation of ECG is proposed. An adaptive noise canceller using the least mean squares algorithm is used to reduce unwanted noise. The adaptive noise canceller minimizes the mean-square error between a primary input, which is the noisy ECG, and a reference input, which is either noise that is correlated in some way with the noise in the primary input or a signal that is correlated only with ECG in the primary input.

In this paper, we have performed an experiment to obtain an optimized electric stimulation condition on the tip or a ringer skin. The desired parameters for stimulation of the finger tip skin are waveforms, frequency, stimulation intensity, duty cycle. As a result, when the finger skin was stimulated with monophasic, biphasic, and differntial phasic, the most appropriate condition was 200 to 250[Hz] in frequency, 10 to 25[%] in duty cycle. Burst type pulse was more sensitive effect than that of continuous pulse methode.

In order to restore the gait function by functional electrical stimulation(FES) in hemiplegic patients, an electrical stimulator and foot sensor were developed on the basis of optimal parameters which resulted from animal experiments. Physical properties of the soleus muscle were quite different from those of themedial gastrocnemius muscle, that is, the former had a characteristic or slow muscle and the letter had a characteristic of fast muscle in rats. Optimal parameters for electrical stimulation were 0.2ms of pulse width and 20Hz of frequency in the soleus muscle and 0.3ms, 40Hz in the medial gastrocnemius muscle. Amplitude modulated electrical stimulator with -15V of maximal output was made and automatic on-off time if the stimulator was 5 seconds. The foot sensor composed of 3 sensors in 3 pressure points of the foot was made in order to control the gai t function by closed loop feedback system. The gait function was improved by using the stimulator and foot sensor in peroneal palsy. These results suggest that the electrical stimulator with closed loop feedback system may restore the gait function in hemiplegic patients.

A major technical problem in encountered in nerve stimulation technique is the control of stimulus artifact and the convenience of nerve stimulator. The artifacts remained must be removed by processing the contaminated signal. This paper discusses about the artifact cancellation algorithms in constant voltage type nerve stimulator(CVS) and constant current type nerve stimulator(CCS).

An inductively coupled magnetical signal (pulse wave, 0.7 to 60Hz, eighteen volts peak to Peak) that was applied non-invasively on the skin surface overlying the approximate site(measure position). In the group with unipolar pulse signal currents produced smaller than in the group with bipolar pulse signal. The signal was transmitted to the active coil, including a time-varying magnetic field: this in turn induced a the-varying electrical field in the field in the bone. It is very important to determine system parameters due to treatment time(healing) and the simplicity. This paper investigation was designed to compare the relative effects of pulsed unipolar currents with the effects of an identical pulsed bipolar currents. Since Inductive coupling is non-invasive and involves portable equipment, it is easy to apply and requires precise localization, it has distinct advantages and field characteristics along the bone for each different signal.