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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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Association between Angiotensin I-Converting Enzyme Gene Polymorphism and Hypertension in Selected Individuals of the Bangladeshi Population

  • Morshed, Mahboob (Department of Biochemistry and Molecular Biology, University of Dhaka) ;
  • Khan, Haseena (Department of Biochemistry and Molecular Biology, University of Dhaka) ;
  • Akhteruzzaman, Sharif (Department of Biochemistry and Molecular Biology, University of Dhaka)
  • Published : 2002.05.31
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Abstract

The genetic factors that contribute to the development of coronary artery disease (CAD) are poorly understood. It is likely that multiple genes that act independently or synergistically contribute to the development of CAD and the outcome. Recently, an insertion/deletion (I/D) polymorphism of the human angiotensin I-converting enzyme (ACE) gene, a major component of the renin-angiotensin system (RAS), was identified. The association of the ACE gene D allele with essential hypertension and CAD has been reported in the African-American, Chinese, and Japanese populations. However, other studies have failed to detect such an association. It has been suggested that these inconsistencies may be due to the difference in backgrounds of the population characteristics. In the present study, we investigated the I/D polymorphism of the ACE gene in 103 subjects of both sexes, consisting of 59 normal controls and 44 patients with hypertension. The allele and genotype frequency were significantly different between the hypertensive and control groups (p < 0.01). Among the three ACE I/D variants, the DD genotype was associated with the highest value of the mean systolic blood pressure [SBP] and mean diastolic blood pressure [DBP] (p = < 0.05) in men, but not in women. In the overall population, the mean SBP and DBP was highest in DD subjects, intermediate in I/D subjects, and the least in II subjects.

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References

  1. Barley, J., Blackwood, A., Cartere, N. D., Crew, D. E., Cruickshank, J. K., Jeffreys, S., Ogunlesi, A. O. and Segnella, G. A. (1994) Angiotensin converting enzyme insertion/deletion polymorphism: Association with ethnic origin. J. Hypertes. 12, 955-957.
  2. Cambien, F. and Evans, A. (1995) Angiotensin I converting enzyme gene polymorphism and coronary heart disease. Eur. Heart J. 16(Suppl K), 13-22.
  3. Chiang, F. T., Chern, T. H., Lai, Z. P., Tseng, C. D., Hsu, K. L., Lo, H. M. and Tseng, Y. Z. (1996) Age- and gender-dependent association of the angiotensin-converting enzyme gene with essential hypertension in a Chinese population. J. Hum. Hypertens. 10, 823-826.
  4. Duru, K., Farrow, S., Wang, J., Lockbetteb, W. and Kurtz, T. (1994) Frequency of a deletion polymorphism in the gene for angiotensin converting enzyme is increased in African- Americans with hypertension. Am. J. Hypertens. 7, 759-762. https://doi.org/10.1093/ajh/7.8.759
  5. Gustincich, S., Manfiolett, G., Del Sal, G., Schneider, C. and Carninci, P. (1991) A fast method for high quality genomic DNA extraction from human whole blood. BioTechniques 11, 298-302.
  6. Harrap, S. B., Davison, H. R., Connor, J. M., Soubrier, F., Fraser, R., Foy, C. J. and Walt, G. C. (1993) The angiotensin-converting enzyme gene and predisposition of high blood pressure. Hypertension 21, 455-460. https://doi.org/10.1161/01.HYP.21.4.455
  7. Higaki, J., Baba, S., Katsuya, T., Sato, N., Ishikawa, K., Mannami, T., Ogata, J. and Ogihara, T. (2000) Deletion allele of Angiotensin-Converting Enzyme Gene increases risk of essential hypertension in Japanese men. Circulation 101, 2060- 2065. https://doi.org/10.1161/01.CIR.101.17.2060
  8. Jeunemaitre, X., Soubrier, F., Kotelevtsev, Y. V., Lifton, R. P., Williams, C. S., Charru, A., Hunt, S. C., Hopkins, P. N., Williams, R. R., Lalouel, J. M. and Corvol, P. (1992) Molecular basis of human hypertension: role of angiotensinogen. Cell 71, 196-180.
  9. Jeunemaitre, X., Lipton, P. R., Hunt, S. C., Williams, R. R. and Lalouel, J. M. (1992) Absence of linkage between the angiotensin-converting enzyme gene and human essential hypertension. Nature Genet. 1, 72-75. https://doi.org/10.1038/ng0492-72
  10. Kamdar, S., Daniel, H., Fogarty, P., Lawson, M., Munroe P. and Caulfield, M. (1994) ACE insertion/deletion (I/D) polymorphism in Vincentian African Caribbean with essential hypertension. J. Hum. Hypertens. 8, 611.
  11. Kirkendal, W. M., Feinleib, M., Freis, E. D. and Mark, A. L. (1980) Recommendations for human blood pressure determination by sphygmomanometers. Subcommittee of the AHA Postgraduate Education Committee. Circulation 62, 1146A-1155A.
  12. Morise, T., Takeguchi, Y. and Takeda, R. (1994) Angiotensin-converting enzyme polymorphism and essential hypertension. Lancet 343, 125.
  13. Nakano, Y., Oshima, T., Hiraga, H., Matsuura, H., Kajiyama, G. and Kambe, M. (1998) DD genotype of the angiotensin I-converting enzyme gene is a risk factor for early onset of essential hypertension in Japanese patients. J. Lab. Clin. Med. 131, 502-506. https://doi.org/10.1016/S0022-2143(98)90058-0
  14. Pfeffer, M. A., Braunwald, E., Maye, L. A., Basta, L., Brown, E. J., Cuddy, T. E., Davis, B. R., Geltman, E. M., Goldman, S., Flaker, G. C., Klein, M., Lamas, G. A., Packer, M., Rouleau, J. L., Rutherford, J., Werthheimer, J. H. and Hawkins, C. M. (1992) Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infraction. N. Eng. J. Med. 327, 669-677. https://doi.org/10.1056/NEJM199209033271001
  15. Raynolds, M. V., Bristow, M. R., Bush, E. W., Abraham, W. T., Lowers, B. D., Zisman, L. S., Taft, C. S. and Perryman, M. B. (1993) Angiotensin-converting enzyme DD genotype in patients with ischemic or idiopathic cardiomyopathy. Lancet 342, 1073- 1075. https://doi.org/10.1016/0140-6736(93)92061-W
  16. Rigat, B., Hubert, C., Corvol, P. and Soubrier, F. (1992) PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase). Nucleic Acid Res. 20, 1433.
  17. Samani, N. J., Thompsom, J. R., OToole, L., Channer, K. and Woods, K. L. (1994) A meta-analysis of the association of the deletion allele of the angiotensin-converting enzyme gene with myocardial infarction. Circulation 94, 708-712.
  18. Stassen, J. A., Wang, J. G., Ginocchio, G., Petrov, V., Saavedra, A. P., Soubrier, F. and Vlietnck, R. (1977) The deletion/ insertion polymorphism of the angiotensin converting enzyme gene and cardiovascular-renal risk. J. Hypertens 15, 1579-1592. https://doi.org/10.1097/00004872-199715120-00059
  19. Tugray, I., Hulya, Y., Bedia, A., Makbule, A. and Selim, A. I. (1999) Association between angiotensin-converting enzyme gene polymorphism and coronary artery disease. IUBMB Life 48, 205-207. https://doi.org/10.1080/713803502
  20. Wenzel, K., Blackburn, A., Ernst, M., Affelt, M., Hanke, R., Baumann, G., Felix, S. B., Kleber, F. X., Rohde, K., Glaser, C. and Speer, A. (1997) Relationship of polymorphism in the renin angiotensin system and in the E-selection of patients with early severe coronary heart disease. J. Mol. Med. 75, 57-61. https://doi.org/10.1007/s001090050087
  21. Yoshida, H., Kuriyama, S., Atsumi, Y., Tomonari, H., Mitarai, T., Hamaguchi, A., Kubo, H., Kawaguchi, Y., Kon, V., Matsuoka, K., Ichikawa, I. and Sakai, O. (1980) Angiotensin I converting enzyme gene polymorphism in non-insulin dependent diabetes mellitus. Kidney Int. 62, 1146A-1155A.
  22. Zee, R. Y. L., Lou, Y. K., Griffiths, L. R. and Morris, B. J. (1992) Association of a polymorphism of angiotensin I converting enzyme gene with essential hypertension. Biochem. Biophys. Res. Commun. 184, 9-15. https://doi.org/10.1016/0006-291X(92)91150-O

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