• Title/Summary/Keyword: %EA%B5%B4

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Effect of reaction temperature on synthesis of heptafluoropropane over activated carbon (활성탄상의 heptafluoropropane 합성에서 반응온도의 효과)

  • 김재덕;이윤우;임종성;이경환;이윤용
    • Fire Science and Engineering
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    • v.12 no.1
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    • pp.9-14
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    • 1998
  • The hepatfluoropropane(HFC-227ea) synthesis by fluorinatino of hepafluoroproylene(HFP) over activated carbon has been studied. The reaction temperature was varied from 5$0^{\circ}C$ to 40$0^{\circ}C$ at a constant feed mole ration and a residence time. The optimized reaction temperature was found to be about 20$0^{\circ}C$ at 2.5HF/HFP mole ratio and 238 sec. residence time. From these reaction conditions, the yield of HFC-227ea was obtained above 99% and the deactivation of activated carbon was not appeared. Accordingly, the activated carbon showed good performance to obtain heptafluoropropane by fluorinatin of hexafluoropropylene.

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Enhancement of Testosterone in TM3 Leydig Cells by an Eritadenine-containing Agaricus blazei Mycelial Liquid Culture Extract (TM-3 cell에서 eritadenine 함유 신령버섯균사체 액체배양물의 testosterone 생성 촉진효과)

  • Kim, Young Suk;Jung, Jae Eun;Moon, Yeon Kyu;Jeong, Hui Jeong;Kim, Jeong Ok;Ha, Yeong Lae
    • Journal of Life Science
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    • v.28 no.6
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    • pp.648-655
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    • 2018
  • Enhancement mechanistic actions of testosterone (TS) productions in mouse Leydig TM3 cells by the eritadenine (EA) and/or the Agaricus blazei mycelial liquid culture extract (ABMLCE). Productions of TS in TM3 cells were investigated in normal and oxidative-stressed culture conditions. In the normal culture condition, TM3 cells grown in a Dulbecco's Modified Eagle's Medium (DMEM) were treated with EA (0~100 ppm) and ABMLCE (10 ppm) + EA (0~50 ppm) for 24 hr, and in the oxidative-stressed culture condition, the cells grown in DMEM containing $50{\mu}M$ $H_2O_2$ to induce oxidative stress for 4 h were treated with the same as those in the normal culture condition. TS content, $3{\beta}$-hydroxysteroid dehydrogenase 2 (HSD3B2) enzyme activity, $5{\alpha}$-reductase 2 ($5{\alpha}-R2$) enzyme activity, and free-radical nitric oxide (NO) content in the culture media were measured using their corresponding assay kits. EA, ABMLCE, and ABMLCE + EA significantly, p<0.05, enhanced TS productions in both cultural conditions, relative to control treatment. The activity of the HSD3B2 enzyme, which is involved in the production of precursors for TS production, was elevated by EA, ABMLCE, and ABMLCE + EA treatments in both culture conditions. The activity of the $5{\alpha}-R2$ enzyme, which converts TS to dihydroxytestosterone (DHT), was not significantly affected in either culture condition by EA, ABMLCE, or ABMLCE + EA treatments. The treatments included reduced NO content. These results indicate that EA, ABMLCE, and EA + ABMLCE treatments elevated TS in TM3 cells via the enhancements of HSD3B2 activity and the reduction of NO production, and also imply that EA and ABMLCE or EA + ABMLCE could be useful materials for the production of TS in humans.

Effect of Intracellular Calcium Chelator on Phosphorylation of Spinal N-Methyl-D-Aspartate Receptor following Electroacupuncture Stimulation in Rats (칼슘 저해제가 전침자극에 의한 척수 N-Methyl-D-Aspartate 수용체 인산화에 미치는 영향)

  • Jung, Taek-Guen;Cho, Sung-Woo;Kang, Yeon-Kyeong;Chang, Dong-Ho;Lee, In-Seon
    • Journal of Korean Medicine Rehabilitation
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    • v.20 no.1
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    • pp.27-36
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    • 2010
  • Objectives : We investigated the role of intracellular calcium chelator, bis-(2-aminophenoxy)-ethane-N,N,N',N'-tetraacetic acid(BAPTA), on the modulation of phosphorylation of the spinal N-methyl-D-aspartate receptor(NMDAR) NR1 and NR2B subunits following electroacupuncture(EA). Methods : Bilateral 2 Hz EA stimulation with 1.0 mA was delivered at those acupoints corresponding to Zusanli(ST36) and Sanyinjiao(SP6) in man via needles for 30min. Results : EA analgesia was reduced by intra-peritoneal injection at a higher dose of BAPTA from termination of EA stimulation. At 60 min after EA treatment, the total number of c-fos-immunostained neurons in each regions of the dorsal horn in the $L_{4-5}$ segments was decreased by BAPTA injection, especially in nucleus proprius. The mean integrated optical density (IOD) of NR1 and NR2B subunits were increased only in superficial laminae of EA-treated rats when compared with normal rats. However, the mean IOD of pNR1 was significantly decreased by BAPTA injection in both the superficial laminae and neck region and pNR2B in the superficial laminae. Western blot analyses confirmed the decreased expression of pNR1 and pNR2B. Conclusions : We concluded that intracellular calcium may well play an important role in EA analgesia by modulating the phosphorylation state of spinal NMDAR subunits.

The Analgesic Effect and Its Mechanism of Electroacupuncture in the Type II Collagen-induced Arthritis Rats : Mediation by Serotonergic Receptors (전침자극(電鍼刺戟)의 Collagen 유발 관절염(關節炎) 동물(動物)모델에 대한 진통효과(鎭痛效果) 및 기전(機轉)에 관한 연구(硏究) -Serotonergic Mechanism을 중심으로-)

  • Ryu, Seong-Ryong;Baek, Yong-Hyeon;Park, Dong-Suk
    • Journal of Acupuncture Research
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    • v.23 no.3
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    • pp.77-90
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    • 2006
  • Objectives : To evaluate the analgesic effect of electroacupuncture on Choksamni (ST36) in the collagen-induced arthritis rats and investigate the role played by serotonergic receptor subtypes $(5-HT_{1A},\;5-HT_{1B},\;5-HT_4)$ in the antinociceptive effect of electroacupuncture in the thermal hyperalgesia test. Methods : Immunization of male Sprague-Dawley rats with bovine type II collagen emulsified in incomplete Freund's adjuvant, followed by booster injection 14 days later induced collagen-induced arthritis (CIA). The thermal hyperalgesia was evaluated weekly with tail flick latency (TFL). In the fourth week after first immunization. EA stimulation (2Hz, 0.07mA, 0.3ms) was delivered into Choksamni for 20 minutes. We measured the analgesic effect of EA with TFL afer intraperitoneal injection of normal saline, WAYl00635, SB216641 and GR125487. Results : TFLs were gradually decreased in CIA as time elapsed after the immunization of arthrogenic collagen and the maximum value was reached from third to fifth week. EA stimulation on ST36 inhibited chronic inflammatory pain induced by CIA. The analgesic effect of EA was inhibited by pretreatment of $5-HT_{1A}$. antagonist (WAYl00635), $5-HT_{1B}$ antagonist (SB216641) and $5-HT_4$ antagonist (GR125487). Conclusion : Electroacupuncture has the analgesic effect on chronic inflammatory pain and its mechanism was mediated by $5-HT_{1A}$, $5-HT_{1B}$ and $5-HT_4$.

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Esophageal Reconstruction with Gastric Pull-up in a Premature Infant with Type B Esophageal Atresia

  • Han, Young Mi;Lee, Narae;Byun, Shin Yun;Kim, Soo-Hong;Cho, Yong-Hoon;Kim, Hae-Young
    • Neonatal Medicine
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    • v.25 no.4
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    • pp.186-190
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    • 2018
  • Esophageal atresia (EA) with proximal tracheoesophageal fistula (TEF; gross type B) is a rare defect. Although most patients have long-gap EA, there are still no established surgical guidelines. A premature male infant with symmetric intrauterine growth retardation (birth weight, 1,616 g) was born at 35 weeks and 5 days of gestation. The initial diagnosis was pure EA (gross type A) based on failure to pass an orogastric tube and the absence of stomach gas. A "feed and grow" approach was implemented, with gastrostomy performed on postnatal day 2. A fistula was detected during bronchoscopy for recurrent pneumonia; thus, we confirmed type B EA and performed TEF excision and cervical end esophagostomy. As the infant's stomach volume was insufficient for bolus feeding after reaching a body weight of 2.5 kg, continuous tube feeding was provided through a gastrojejunal tube. On the basis of these findings, esophageal reconstruction with gastric pull-up was performed on postnatal day 141 (infant weight, 4.7 kg), and he was discharged 21 days postoperatively. At 12 months after birth, there was no catch-up growth; however, he is currently receiving a baby food diet without any complications. In patients with EA, bronchoscopy is useful for confirming TEF, whereas for those with long-gap EA with a small stomach volume, esophageal reconstruction with gastric pull-up after continuous feeding through a gastrojejunal tube is worth considering.

Purification of Macrophage Phagocytic Activity-Enhancing Component from Ethanol-Acetic Acid Extract of Korean Wheat (우리밀 Ethanol-Acetic Acid 추출물에 함유된 대식세포의 식작용 활성 증강 물질의 분리.정제)

  • Choe, Myeon;Kim, Sun-Lyul;Kim, Jong-Dai;Lee, Sang-Young;Kim, Hyun-Sook
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.29 no.2
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    • pp.312-315
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    • 2000
  • To purify the macrophage phagocytic activity-enhancing component, ethanol-acetic acid (100 : 1, EA) extract of Korean wheat (Gobun wheat) and imported one (Australian Standard White, ASW) were fractionated with ethylacetate : methanol : $H_2O$(65 : 25 : 4, v/v/v), and identified by TLC and column chromatography. At least five fractions were separated from the EA extract of the wheats but amounts of fraction B, C and D were more in Gobun wheat than in ASW. The effects of all fractions on phagocytic activity were tested in macrophage J774 cells. Among the fractions, only fraction b of Gobun wheat showed significant increase of phagocytic activity against yeast.

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Computational Chemistry Study on Gas Hydrate Formation Using HFC & HCFC Refrigerants (R-134a, R-227ea, R-236fa, R-141b) (수소불화탄소 및 수소염화불화탄소 냉매(R-134a, R-227ea, R-236fa, R-141b)를 이용한 가스 하이드레이트 형성에 관한 계산화학적 해석)

  • Kim, Kyung Min;An, Hye Young;Lim, Jun-Heok;Lee, Jea-Keun;Won, Yong Sun
    • Korean Chemical Engineering Research
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    • v.55 no.5
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    • pp.704-710
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    • 2017
  • Although the desalination technique using gas hydrate formation is at a development stage compared to the commercially well-established reverse osmosis (RO), it still draws attention because of its simplicity and moderate operational conditions especially when using refrigerants for guest gases. In this study, DFT (density functional theory)-based molecular modeling was employed to explain the energetics of the gas hydrate formation using HFC (hydrofluorocarbon) and HCFC (hydrochlorofluorocarbon) refrigerants. For guest gases, R-134a, R-227ea, R-236fa, and R-141b were selected and three cavity structures ($5^{12}$, $5^{12}6^2$, and $5^{12}6^4$) composed of water molecules were constructed. The geometries of guest gas, cavity, and cavity encapsulating guest gas were optimized by molecular modeling respectively and their located energies were then used for the calculation of binding energy between the guest gas and cavity. Finally, the comparison of binding energies was used to propose which refrigerant is more favorable for the gas hydrate formation energetically. In conclusion, R-236fa was the best choice in terms of thermodynamic spontaneity, less toxicity, and low solubility in water.

Future Change Using the CMIP5 MME and Best Models: II. The Thermodynamic and Dynamic Analysis on Near and Long-Term Future Climate Change over East Asia (CMIP5 MME와 Best 모델의 비교를 통해 살펴본 미래전망: II. 동아시아 단·장기 미래기후전망에 대한 열역학적 및 역학적 분석)

  • Kim, Byeong-Hee;Moon, Hyejin;Ha, Kyung-Ja
    • Atmosphere
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    • v.25 no.2
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    • pp.249-260
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    • 2015
  • The changes in thermodynamic and dynamic aspects on near (2025~2049) and long-term (2075~2099) future climate changes between the historical run (1979~2005) and the Representative Concentration Pathway (RCP) 4.5 run with 20 coupled models which employed in the phase five of Coupled Model Inter-comparison Project (CMIP5) over East Asia (EA) and the Korean Peninsula are investigated as an extended study for Moon et al. (2014) study noted that the 20 models' multi-model ensemble (MME) and best five models' multi-model ensemble (B5MME) have a different increasing trend of precipitation during the boreal winter and summer, in spite of a similar increasing trend of surface air temperature, especially over the Korean Peninsula. Comparing the MME and B5MME, the dynamic factor (the convergence of mean moisture by anomalous wind) and the thermodynamic factor (the convergence of anomalous moisture by mean wind) in terms of moisture flux convergence are analyzed. As a result, the dynamic factor causes the lower increasing trend of precipitation in B5MME than the MME during the boreal winter and summer over EA. However, over the Korean Peninsula, the dynamic factor causes the lower increasing trend of precipitation in B5MME than the MME during the boreal winter, whereas the thermodynamic factor causes the higher increasing trend of precipitation in B5MME than the MME during the boreal summer. Therefore, it can be noted that the difference between MME and B5MME on the change in precipitation is affected by dynamic (thermodynamic) factor during the boreal winter (summer) over the Korean Peninsula.

Antimutagenic Activities of 24 Synthetic Flavones with The Salmonella Microsomal Assay

  • Laget, M.;De Meo, M.;Wallet, J.C.;Gaydou, E.M.;Guiraud, H.;Dumenil, G.
    • Archives of Pharmacal Research
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    • v.18 no.6
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    • pp.415-422
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    • 1995
  • Twenty-four flavones were synthesized with various hydroxyl and/or methoxyl groups on A and B rings. Their antimutagenic properties were evaluated against ben:w(a)pyrene (BaP) and a pool of mutagenic urine concentrate (U) using a modified liquid incubation method of Ames test. The tester strain was Salmonella typhimurium TA98+S9 Mix. The antimutagenic activities were calculated by non linear regression analysis and the doses of flavones (in nmoles) required for a 50% reduction of induced revertants with BaP and U were defined as the inhibition doses (TEX>$ID_{508}{\;}and{\;}ID_{508}$ respectively). Seventeen flavones possessed significant antimutagenic activity against BaP. $ID_{508}$ ranged from 15.1 nmoles (F22) to 1000.6 nmoles (F13). Eighteen f1avones showed significant antimutagenic activity against U. $ID_{50U}$ ranged from 23.5 nmoles (F22) to 354.6 nmoles (F3). The 2',3',4'-trihydroxyflavone (F22, $ID_{508}=15.1$ nmoles, $ID_{50U}=23.5$ nmoles) and the 2',3',4',7-tetrahydroxyflavone (F20, $ID_{508}=37.8$ nmoles; $ID_{50U}=62.3$ nmoles) had antimutagenic activities similar to those of chlorophyllin ($ID_{508}=19.6$ nmoles and $ID_{50U}=44.2$ nmoles) and were evaluated against B(alP 7,8-dihydrodiol-9,10-epoxide. Against this last mutagen, the flavones which included three OH in B ring showed the highest activity and this property seemed independent of the substituent groups on A ring.

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Assessment of Anion Generation on the Isolated Trees at Summer (여름철 단일수목의 음이온 발생에 관한 평가)

  • Kim, Jeong-Ho;Seo, Yu-Hwan;Joo, Chang-Hun;Yoon, Yong-Han
    • Journal of the Korean Institute of Landscape Architecture
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    • v.42 no.4
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    • pp.1-9
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    • 2014
  • This research aims to analyze changes in anion according to locations through changes in the measuring point centering on a single tree. The subject tree was the Zelkova serrata which is most widely used as a landscape tree, and the measurement was conducted for a total of 3 days with summer solstice as the basic date. In consideration of the solar altitude and the location of the Zelkova serrata, a total of 4 measurement points - $T_a$ at the opposite direction of the shadow, $T_b$ in the center of the tree $T_c$ in the center of the shadow, and $T_d$ at the end of the shadow - were established. The mean temperature of the measurement days was the highest at $T_a$ with $28.4^{\circ}C$ and was the lowest at $T_c$, in the center of the shadow with $27.9^{\circ}C$. The relative humidity was the lowest with 42.5% at $T_a$ where the temperature was the highest. The amount of insolation was the highest at $T_a$ with $1,024.6W/m^2$, followed by $T_d(701.48W/m^2$), $T_c$($215.63W/m^2$), and $T_b(227.75W/m^2)$, and the anion was the highest at $T_a$ with $654ea/cm^3$, followed by $T_d$, $T_c$, and $T_b$, with $639.4ea/cm^3$, $615.3ea/cm^3$, $612.3ea/cm^3$, respectively. The results of the correlation analysis proved that anion correlated with the temperature, the amount of insolation, and the relative humidity on the significant level. Of these, the temperature and the amount of insolation had the positive correlation with the correlation coefficients of .687 and .332, respectively, and the significance probability of .000, and .037, respectively. The relative humidity was found to have negative correlation. Its correlation coefficient and the significance probability were -.557, and .000, respectively.