• Korea journal of population studies
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• v.21 no.1
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• pp.162-183
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• 1998

This study examines the sampling bias that may have resulted from the large number of missing observations. Despite well-designed and reliable sampling procedures, the observed sample values in DSFH(Demographic Survey on Changes in Family and Household Structure, Japan) included many missing observations. The head administerd survey method of DSFH resulted in a large number of missing observations regarding characteristics of elderly non-head parents and their children. In addition, the response probability of a particular item in DSFH significantly differs by characteristics of elderly parents and their children. Furthermore, missing observations of many items occurred simultaneously. This complex pattern of missing observations critically limits the ability to produce an unbiased analysis. First, the large number of missing observations is likely to cause a misleading estimate of the standard error. Even worse, the possible dependency of missing observations on their latent values is likely to produce biased estimates of covariates. Two models are employed to solve the possible inference biases. First, EM algorithm is used to infer the missing values based on the knowledge of the association between the observed values and other covariates. Second, a selection model was employed given the suspicion that the probability of missing observations of proximity depends on its unobserved outcome.

• Journal of Applied Biological Chemistry
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• v.63 no.4
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• pp.327-334
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• 2020

Oxidative stress is common cause of neurodegenerative diseases. The purpose of this study is to investigate the in vitro free radical scavenging activity and protective effect of three Glycyrrhiza species including Glycyrrhiza uralensis, G. glabra, and a new variety of Glycyrrihza (Shinwongam, SW) against hydrogen peroxide-induced oxidative stress in C6 glial cells. In vitro assays, radical scavenging activities of G. uralensis, G. glabra, and SW against 2,2-diphenyl-1-picrylhydrazyl, ·OH, and O2- increased as concentration-dependent manner. In addition, the SW was found to contain the highest polyphenol and flavonoid contents. The treatment of H2O2 to C6 glial cell induced oxidative stress, whereas G. uralensis, G. glabra, and SW significantly increased the cell viability as dose-dependent manner. In particular, SW exerted stronger protective effect on H2O2-induced cytotoxicity, than G. uralensis and G. glabra. Furthermore, reactive oxygen species (ROS) formation was significantly elevated by H2O2 in C6 glial cells. However, treatments of G. uralensis, G. glabra, and SW decreased ROS formation. In addition, SW decreased pro-inflammatory related protein expression levels such as inducible nitric oxide synthase and cyclooxygenase-2, compared to H2O2-treated control group. These results indicated that G. uralensis and G. glavra, especially SW, may be useful for preventing from oxidative stress-induced neuronal damage by regulating inflammatory reaction.

• Journal of the Korea institute for structural maintenance and inspection
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• v.25 no.1
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• pp.59-66
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• 2021

The earthquakes are the natural disasters that can cause the most serious damage to civil structures. Therefore, various studies are being conducted to secure the safety of structures against earthquakes. Most studies on the safety or mechanism of civil structures during earthquakes are being conducted based on lab scale test, because real structure tests are impossible when considering the scale of civil structures. The scaling factor proposed by Iai is mainly cited, but when applying the scaling factor proposed by Iai, there are many difficulties in selecting the structural members necessary for the production of the lab scale model. This is because when applying the scaling factor proposed by Iai, the scaling factor must be applied to the elastic modulus, which is the material property of the structure. Therefore, a new method based on Iai's 's similarity law for determining scale factor is applied in this study where the material property of real structure is same as that of lab-scale model. Through the results of this study, it is considered that the characteristics of the structure calculated through the lab scale model test can more accurately reflect the characteristics of the real structure.

• Journal of the Korean GEO-environmental Society
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• v.24 no.4
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• pp.23-29
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• 2023

Ground subsidence shows a mechanism in which the upper ground collapses due to the formation of a cavity due to the movement of soil particles in the ground due to the formation of a waterway because of damage to the water supply/sewer pipes. As a result, cavity is created in the ground and the upper ground is collapsing. Therefore, ground subsidence frequently occurs mainly in downtown areas where a large amount of underground facilities are buried. Accordingly, research to predict the risk of ground subsidence is continuously being conducted. This study tried to present a ground subsidence risk prediction model for two districts of ○○ city. After constructing a data set and performing preprocessing, using the property data of underground facilities in the target area (year of service, pipe diameter), density of underground facilities, and ground subsidence history data. By applying the dataset to the machine learning model, it is evaluated the reliability of the selected model and the importance of the influencing factors used in predicting the ground subsidence risk derived from the model is presented.

• Journal of Life Science
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• v.34 no.4
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• pp.227-235
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• 2024

Hepatocyte damage caused by medications or herbal products is one of the important problem when these compounds are chronically administrated. Thus, improving hepatocyte survival during treatment offers a wide range of opportunities. Valproic acid (VPA), a branched short-chain fatty acid derived from naturally occurring valeric acid, is commonly used to treat epilepsy and seizures. Although VPA exerts numerous effects in cancer, HIV therapy, and neurodegenerative disease, its effects on the liver and its mechanism of action have not been fully elucidated. Here, we demonstrated that VPA caused moderate liver cell toxicity and apoptosis. Interestingly, VPA treatment increased transcription levels of PPAR alpha (PPAR-α) and fibroblast growth factor 21 (FGF21) in murine (Hepa1c1c7) hepatoma cells in a time and concentration dependent manner. VPA-induced FGF21 expression was significantly weaker under PPAR-α silencing condition than in cells transfected with non-targeting control siRNA. Subsequent experiments showed that cell viability was significantly lowered when the FGF21 signaling pathway was blocked by FGF receptor antagonist. Finally, we further determined that AMPK phosphorylation was not responsible for VPA-induced FGF21 expression and PPAR-a increments. These results indicate that increases of FGF21 expression alleviate VPA-induced hepatic toxicity, thereby making FGF21 a potential biomarker for predicting liver damage during VPA treatments.

• Journal of Applied Biological Chemistry
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• v.67
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• pp.153-158
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• 2024

This study aims to investigate the protective effects and mechanisms of pectolinarin against hydrogen peroxide (H₂O₂) induced oxidative stress in C6 glial cells. Neurodegenerative diseases are potentially associated with oxidative stress, which causes excessive production of reactive oxygen species (ROS) that damage DNA and proteins in glial cells. The results of this study demonstrate that pectolinarin significantly increased cell viability, reduced ROS production, and Lactate dehydrogenase release in the H₂O₂-induced C6 glial cells. Additionally, pectolinarin decreased the level of pro-inflammatory cytokines interleukin1beta, interleukin-6, and tumor necrosis factor-alpha from H₂O₂-altered levels back close to normal C6 cell levels. These findings suggest that pectolinarin has the potential to be used as a natural material to be applied in the treatment of neurodegenerative diseases by mitigating oxidative stress-induced damage to C6 cells.

• Journal of rehabilitation welfare engineering & assistive technology
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• v.6 no.2
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• pp.15-22
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• 2012

The mechanical system of wearable walking assist robot needs to be optimized for adapting with human body structure and the planned control algorithm should have a secure procedure when a incongruity situation which can cause musculoskeletal injury occurs because a wearable robot is attached to a body. The understanding of walking or musculoskeletal motions characteristics must be preceeded and analyzed for developing novel wearable walking assist robot. In this study we tried to find out the capacities of powers and torques of joint actuators to design optimized performances of system and to obtain the analysis data to figure out the characteristics of joint movements during some types of walk. The major types of walk and motion are stair climbing and descending, sit-to-stand motion, and slope walking. In this study all these motions were analyzed experimentally except slope walking.

• Journal of the Korea Society of Computer and Information
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• v.18 no.9
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• pp.111-120
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• 2013

Uncertainty in Context-aware computing is mainly a consequence of the complexity of context acquisition mechanisms and context processing. The presence of uncertainty may harm the users' confidence in the application, rendering it useless. This paper describes a three-phase strategy to manage uncertainty by identifying its possible sources, representing uncertain information, and determining how to proceed, once uncertain context is detected. The level of effort that is necessary to eliminate the uncertainty of context information affects the reliability of the system, because Sensor network system have no intervention of humans. In this paper, We applied proposed method to the development for the sensor network system, Uncertainty management can be applied a part of the system development life-cycle. It confirmed that result of testing show that detection performance is stable.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.24 no.1
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• pp.75-86
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• 2014

Demand for the femtocell is largely credited to the surge in a more always best connected communication conscious public. 3GPP defines new architecture and security requirement for Release 9 to deal with femtocell, Home eNode B referred as HeNB. In this paper, we analyze the HeNB security with respect to mutual authentication, access control, and secure key agreement. Our analysis pointed out that a number of security vulnerabilities have still not been addressed and solved by 3GPP technical specification. These include eavesdropping, man-in-the-middle attack, compromising subscriber access list, and masquerading as valid HeNB. To the best of our knowledge, any related research studying HeNB security was not published before. Towards this end, this paper proposes an improved authentication and key agreement mechanism for HeNB which adopts proxy-signature and proxy-signed proxy-signature. Through our elaborate analysis, we conclude that the proposed not only prevents the various security threats but also accomplishes minimum distance from use-tolerable authentication delay.

• Journal of the Korea Concrete Institute
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• v.24 no.6
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• pp.737-744
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• 2012

Hysteretic steel damper has been applied mainly to steel buildings. However, the usage in RC buildings is rapidly increasing recently. In order to apply the steel hysteretic damper in RC buildings, supporting elements of the damper should have sufficient strength and stiffness suitable for transferring damper forces to beams and walls. But due to the inevitable damage in reinforced concrete elements due to cracking, identification of the load transfer mechanism from damper to supporting element and hysteretic characteristics of the supporting element are extremely important in evaluating the damper behavior. Experiments were carried out on connection details between RC walls and supporting elements of the steel plate typed damper such as EaSy damper. The test results showed that fracture patterns of all specimens were almost identical except in the crack number and pattern associated with shear loading condition. Among the specimens, HD-3 shoed a well distributed cracks patterns along with good performance with respect to energy dissipation capacity, stiffness deterioration, and strength degradation.