• Title/Summary/Keyword: 혈류개선

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Effect of Pulse Magnetic Field Stimulus on Blood Flow using Digital Infrared Thermal Imaging (체열진단을 통한 펄스자기장 자극기의 혈류개선효과 고찰)

  • Lee, Hyun-Sook
    • Journal of the Korean Magnetics Society
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    • v.21 no.5
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    • pp.180-184
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    • 2011
  • The changes in the blood flow in the peripheral vascular system under strong pulsed magnetic fields (pMF) were studied by digital infrared thermal imaging (DITI). After pMF stimulus temperatures in stimulated area were commonly increased in both groups of age and gender. In order to reduce heat generated from coil in pMF stimulus system plastic moldings were fabricated, so that certain distance was kept between stimulus system and the skin and to prevent direct contact to the skin. It is believed that skin temperature is increased by internal electromagnetic energy stimulated the peripheral vascular system by non-contact method.

Studies on Nutritional Analysis and Antioxidant activity of Oriental Medicines with Bloodstream Improvement (혈류개선 효능을 지닌 한약재의 영양성분 분석 및 항산화 활성에 관한 연구)

  • Park, Sung-Hye;Park, Byung-Ju;Park, Hae-Ryoung
    • Journal of Digital Convergence
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    • v.14 no.10
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    • pp.563-570
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    • 2016
  • This study investigated applicable values and developments of 5 different kinds of oriental medicine materials as functional supplements or medicinal uses, known to improve blood circulation by means of analyzing nutritional compositions and antioxidant activities. Among general nutritional compositions, protein, iron and copper contents in Polygini Multiflori Radix (20.28%, $132.22{\mu}g$/100 g, $26.54{\mu}g$/100 g), Angelica Gigantis Radix (16.54%, $98.20{\mu}g$/100 g, $32.15{\mu}g$/100 g) and Paeoniae Radix(18.67%, $62.10{\mu}g$/100 g, $20.32{\mu}g$/100 g) were significantly higher than other materials. Angelica Gigantis Radix had the highest of total polyphenols and flavonoid contents, Polygini Multiflori Radix (middle), Paeoniae Radix (the lowest). Antioxidant activities by using DPPH radicals removal showed the highest in Polygini Multiflori Radix, Angelica Gigantis Radix (middle), Paeoniae Radix (the lowest). This study tried to use integrated approaches, including Western and Oriental medicine to improve blood circulation and to set up base to develop products originated from natural compositions.

참당귀(Angelica Gigas)의 DPPH Radical 소거활성 및 항산화 효과

  • 강순아;한진아;장기효;조여원
    • Proceedings of the KSCN Conference
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    • pp.435.2-436
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    • 2004
  • Cyclophosphamide (CYP)는 일반적으로 항암제로 사용되는 약제로써 투여 후 백혈구 감소증, 황달, 대장염, 신우내의 출혈 등의 부작용을 유발하며, 빈혈증상을 악화시키며, 자유기와 활성산소의 생성으로 산화적 스트레스를 유도한다. 한국당귀 즉 참당귀(Angelica Gigas)는 냉증, 빈혈과 같은 부인과 질환에 주로 쓰이며 혈행을 수월하게 하며, 조혈 및 혈류개선에 사용하고 있는데 CYP를 투여한 흰쥐에서 빈혈이 유도됨을 확인 후 참당귀 추출물의 투여에 의하여 혈액학적 빈혈지표의 개선을 볼 수 있었다.(중략)

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Efficacy Assessment of Endovascular Stenting in Patients with Unilateral Middle Cerebral Artery Stenosis Using Statistical Probabilistic Anatomical Mapping Analysis of Basal/Acetazolamide Brain Perfusion SPECT (기저/아세타졸아미드 국소뇌혈류 SPECT의 확률 뇌지도 분석을 이용한 일측 중대뇌동맥 협착환자에서 시행한 스텐트 삽입술의 효용성 평가)

  • Kim, Hae-Won;Won, Kyoung-Sook;Zeon, Seok-Kil;Lee, Chang-Young
    • Nuclear Medicine and Molecular Imaging
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    • v.43 no.4
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    • pp.280-286
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    • 2009
  • Purpose: The aim of this study was to evaluate the hemodynamic changes after endovascular stenting in patients with unilateral middle cerebral artery (MCA) stenosis using statistical probabilistic anatomical mapping (SPAM) analysis of basal/acetazolamide (ACZ) Tc-99m ECD brain perfusion SPECT. Materials and Methods: Eight patients (3 men and 5 women, 64.8$\pm$10.5 years) who underwent endovascular stenting for unilateral MCA stenosis were enrolled. Basal/ACZ Tc-99m ECD brain perfusion SPECT studies were performed by one-day protocol before and after stenting. Using SPAM analysis, we compared basal cerebral perfusion (BCP) counts and cerebrovascular reserve (CVR) index of the MCA territory before stenting with those after stenting. Results: After stenting, no patient had any complication nor additional stroke. In SPAM analysis, 7 out of the 8 patients had improved BCP counts of the MCA territory and 7 out of the 8 patients had improved CVR index of the MCA territory after stenting. Before stenting, the mean BCP counts and CVR index in the affected MCA territory were 47.1$\pm$2.2 ml/min/100 g and -2.1$\pm$2.9%, respectively. After stenting, the mean BCP counts and CVR index in the affected MCA territory were improved significantly (48.3$\pm$2.9 ml/min/100 g, p =0.025 and 0.1$\pm$1.3%, p =0.036). Conclusion: This study revealed that SPAM analysis of basal/ACZ brain perfusion SPEG would be helpful to evaluate hemodynamic efficacy of endovascular stenting in unilateral MCA stenosis.

Effects of Crude Saponin and Saponin-free Fraction of Korea Red Ginseng on the Skin and Cerebral Blood Flow in the Rats (백서의 피부 및 뇌혈류에 미치는 고려홍삼 사포닌 및 비사포닌의 영향)

  • Kim, Shin-Hee;Kim, Cuk-Seong;Park, Jin-Bong;Han, Chan-Soo;Kim, Kwang-Jin;Kim, Shin-Hye;Kim, Se-Hoon;Nam, Ki-Yeul;Jeon, Byeong-Hwa
    • Journal of Ginseng Research
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    • v.26 no.3
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    • pp.132-138
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    • 2002
  • To study the effect of Korea red ginseng (KCG) on the skin and cerebral blood flow, we evaluated the change of skin perfusion rate and cerebral perfusion rate after the intravenous, intraperitoneal, and oral administration of crude saponin (CS) and saponin-free fraction (SFF) of KRG in the rats. The change of skin perfusion rate and cerebral perfusion rate was measured laser doppler flowmetry. The intravenous injections of CS or SFF of KRG and intraperitoneal injection of SFF of KRG did not change the relative skin and cerebral blood flow in the rats. When the rats were treated by the intraperitoneal injection of CS of KRG, relative cerebral blood flow was significantly increased with a time-dependent manner, however, relative skin blood flow was not influenced by the them. Oral administration of CS of KRG slightly increased skin blood flow in the rats. Also, the change of cerebral blood flow by transient bilateral carotid arterial clamp in the CS-treated rats was significantly decreased, compared with control groups. From the above results, it was suggested that Korea red ginseng have a increasing property of cerebral blood flow in the rats.

Cerebral blood flow enhancement device using Blood Oxygen Level Sensor (Blood Oxygen Level Sensor를 이용한 대뇌혈류증가 장치)

  • Lim, Jung-hyun;Joh, In-Hee;Kim, Young-kil
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.22 no.8
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    • pp.1083-1089
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    • 2018
  • Surgery to increase cerebral blood flow is one of the treatment methods of cerebral infarction. In order to supplement this invasive method, non-invasive devices have been introduced that use human blood pressure to pressurize the extremities to increase cerebral blood flow. However, the problem of poor speed and accuracy was raised. In this paper, the perfusion index of each arm is measured by applying pressure to both arms using Blood Oxygen Level Sensor to improve the accuracy of measurement and measurement time. The pressure applied to the arm is calculated by using the pressure value obtained from the arm. Like the existing blood pressure measuring cerebral blood flow increasing device, the blood flow can be increased by more than 20% and the measurement time can be shortened, so that it can be selectively used for the patient with cerebral infarction.

Establishment of Featal Heart Surgery with an Improvement of the Placental Blood Flow in Cardiopulmonary Bypass Using Fetal Lamb Model (양태아를 이용한 심폐우회술에서의 태반혈류개선을 통한 태아심장수술의 기반기술 확립)

  • 이정렬;박천수;임홍국;배은정;안규리
    • Journal of Chest Surgery
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    • v.37 no.1
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    • pp.11-18
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    • 2004
  • Background: We tested the effect of indomethacine and total spinal anesthesia on the improvement of placental flow during cardiopulmonary bypass on fetal lamb. Material and Method: Twenty fetuses at 120 to 150 days of gestation were subjected to bypass via trans-sternal approach with a 12 G pulmonary arterial cannula and 14 to 18 F venous cannula for 30 minutes. All ewes received general anesthesia with ketamine. In all the fetuses, no anesthetic agents were used except muscle relaxant. Ten served as a control group in which placenta was worked as an oxygenator during bypass (Control group). The remainder worked as an experimental group in which pretreatment with indomethacine and total spinal anesthesia was performed before bypass with the same extracorporeal circulation technique as control group (Experimental group). Observations were made every 10 minutes during a 30-minute bypass and 30-minute post bypass period. Result: Weights of the fetuses ranged from 2.2 to 5.2 kg. In Control group, means of arterial pressure decreased from 44.7 to 14.4 mmHg and means of Pa$CO_2$ increased from 61.9 to 129.6 mmHg at each time points during bypass. Flow rate was suboptimal (74.3 to 97.0 $m\ell$/kg/min) during bypass. All hearts fibrillated immediately after the discontinuation of bypass. On the contrary, in Experimental group, means of arterial pressure reamined higher (45.8 to 30 mmHg) during bypass (p<0.05). Means of Pa$CO_2$ were less ranging from 59.8 to 79.4 mmHg during bypass (P<0.05). Flow rates were higher (78.8 to 120.2 $m\ell$/kg/min) during bypass (p<0.05). There were slower deterioration of cardiac function after cessation of bypass. Conclusion: In this study, we demonstrated that the placental flow was increased during fetal cardiopulmonary bypass in the group pretreated with indomethacine and total spinal anesthesia. However, further studies with modifications of the bypass including a creation of more concise bypass circuit, and a use of axial pump are mandatory for the clinical application.

Change of Regional Myocardial Blood Flow After Transmyocardial Laser Revascularization in Porcine Model of Chronic Myocardial Ischemia (돼지 만성 심근허혈 모델에서 경심근레이저혈류재건술 후 국소 심근 혈류량의 변화)

  • Park, Kay-Hyun;Ahn, Hyuk
    • Journal of Chest Surgery
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    • v.34 no.9
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    • pp.662-671
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    • 2001
  • Background: This study was aimed to assess improvement in myocardial perfusion after TMR by measuring regional myocardial blood flow(RMBF) in porcine model of chronic myocardial ischemia. Material and Method: Ameroid ring was placed around the proximal left circumflex coronary artery in fourteen pigs. After 4 weeks, the control group(7 pigs) underwent rethoracotomy only, and the TMR group(7 pigs) underwent Ho:YAG laser TMR at the circumflex territory. After another 4 weeks, the animals were sacrificed for the measurement of RMBF using colored microspheres. The ratio of RMBF between the circumflex territory and the interventricular septum was calculated and compared. Result: At 4 weeks after ameroid constriction, RMBF of the circumflex territory decreased to 46∼89% of RMBF of the interventricular septum. In five of six animals in the TMR group, RMBF of the circumflex territory at 8 weeks after ameroid constriction was higher compared with RMBF at 4 weeks after ameroid constriction. However, the improvement was statistically significant only in two animals. In three of the four animals in the control group, RMBF of the circumflex territory also increased at 8 weeks compared with RMBF at 4 weeks. The degree of increase in RMBF was not different between the control and the TMR groups. Conclusion: In porcine model of chronic myocardial ischemia, the degree of increase in RMBF of the ischemic area after Ho:YAG TMR was not different from the increase by development of native collateral circulation. Perfusion of ischemic myocardium after TMR is not thought to improve to the degree that can be demonstrated by currently available method of assessment such as radioisotope myocardial scintigraphy.

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A Study on Cerebral Blood Flow Enhancement Device Using Blood Oxygen Level Sensor (Blood Oxygen Level Sensor를 이용한 대뇌혈류증가 장치에 관한 연구)

  • Lim, Jung-Hyun;Joh, In-Hee;Kim, Young-kil
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • pp.188-192
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    • 2018
  • Surgery to increase cerebral blood flow is one of the treatment methods of cerebral infarction. However, invasive methods, such as surgery, may result in postoperative complications or side effects. In order to supplement this invasive method, non-invasive devices have been introduced that use human blood pressure to pressurize the extremities to increase cerebral blood flow. However, the problem of poor speed and accuracy was raised. In this paper, the perfusion index of each arm was measured by applying pressure to both arms using Blood Oxygen Level Sensor to improve the accuracy of measurement and measurement time. The pressure applied to the arm by 75% of the moment when it falls to the leg and the pressure calculated by using the pressure value obtained from the arm. Like the existing blood pressure measuring cerebral blood flow increasing device, the blood flow can be increased by more than 20% and the measurement time can be shortened, so that it can be selectively used for the patient with cerebral infarction.

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A Study of Medicinal Plants for Applications in Functional Foods 1. Effects of Schizandrae fructus on the Regional Cerebral Blood Flow and Blood Pressure in Rats (기능성 식품으로의 활용을 위한 한약자원에 관한 연구 1. 오미자 열수추출물이 흰쥐의 국소 뇌혈류량과 혈압에 미치는 영향)

  • 박성혜;한종현
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.33 no.1
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    • pp.34-40
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    • 2004
  • The purpose of this study was to measure the changes of regional cerebral blood flow (rCBF) and blood pressure (BP) in rats, following the intravenous injection of Schizandrae fructus water extract. The measurement was continually monitored by laser-doppler flowmeter and pressure tranducer in anesthetized adult Sprague-Dawley rats for 2 hours to 2 hours and a half through the data acquisition system composed of MacLab and Macintosh computer. The result of this experiment was as followed. Schizandrae fructus increased the changes of rCBF in rats significantly. The rCBF of Schizandrae fructus did not change by pretreated propranolol, atropine, L-NNA and indomethacin. But the rCBF of Schizandrae fructus was increased by pretreated methylene blue. Schizandrae fructus decreased the changes of BP, significantly. The BP of Schizandrae fructus did not change by pretreated propranolol, atropine, L-NNA and indomethacin. But the BP of Schizandrae fructus was decreased by pretreated methylene blue. There results indicated that Schizandrae fructus can increase the rCBF and decrease the BP, that is related to guanylyl cyclase activity.