• Title/Summary/Keyword: 10q23

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Association of Genetic Polymorphisms at 1q22 but not 10q23 with Gastric Cancer in a Southern Chinese Population

  • Yang, Xue-Xi;Li, Fen-Xia;Zhou, Cui-Ping;Hu, Ni-Ya;Wu, Ying-Shong;Li, Ming
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.6
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    • pp.2519-2522
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    • 2012
  • Objective: Data from a recent genome-wide association studiesy of gastric cancer (GC) and oesophageal squamous cell carcinoma in Chinese living in the Taihang Mountains of north-central China suggest that 1q22 and 10q23 are susceptibility-associated regions for GC. However, this has not been confirmed in southern Chinese populations. The aim of this study was to investigate whether these polymorphisms at 1q22 and 10q23 are associated with the risk of GC in a southern Chinese population. Methods: We selected seven top significant associated single nucleotide polymorphisms (SNPs) at 1q22 and 10q23 and conducted a population-based case-control study in a southern Chinese population. Genotypes were determined using MassARRAYTM system (Sequenome, San Diego, CA). Results: Two SNPs at 1q22, rs4072037 and rs4460629, were significantly associated with a reduced risk of GC, best fitting the dominant genetic model. Logistic regression models adjusted for age and sex showed that rs4072037 AG and GG (OR=0.64, P=0.017, compared with AA) and rs4460629 CT and TT (OR=0.54, P=0.0016, compared with TT) significantly reduced the risk of GC. However, no significant results for the five SNPs at 10q23 were obtained in this study. Conclusion: These outcomes indicate that 1q22 is associated with GC susceptibility in this southern Chinese population, while an association for the locus at 10q23 was not confirmed.

The protective effect of coenzyme Q10 on cytotoxicity of regin monomer of odontoblast caused by TEGDMA (코엔자임 Q10 처리에 따른 TEGDMA에 의해 유발된 치아 세포 사멸 억제 효과)

  • Lee, Ahreum;Park, Soyeong;Lee, Kyung Hee
    • Journal of Korean society of Dental Hygiene
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    • v.14 no.5
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    • pp.775-781
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    • 2014
  • Objectives : The purpose of the study is to investigate the protective effect of coenzyme $Q_{10}$ on cytotoxicity effect of dental monomers in odontoblast(MDPC-23). Methods : MDPC-23 was incubated with the(co)monomers triethylene glycol dimethacrylate (TEGDMA) with and without addition of coenzyme $Q_{10}$. The cell proliferation and survival was determined using WST-1 assay. The level of reactive oxygen species(ROS) was measured by immunofluorescent staining for DCF-DA. Results : TEGDMA treatment decreased the cell proliferation by dose dependently(0.1, 1, 2.5, 5, 10 mM) on the growth of MDPC-23 cells. Coenzyme $Q_{10}$ showed cell proliferation from 5 to $500{\mu}M$ by WST-1 assay. Pre-treatment coenzyme $Q_{10}$ showed the antioxidant effect on proliferation and viability of MDPC-23 after 48h(p<0.05). The positive cells were observed in non-coenyme $Q_{10}$ treatment group(group 2) in comparison with coenyme $Q_{10}$ pre-treatment group(group 1) by DCF-DA. The fluorescence positive cells showed 14.715(group 1) and 19.788(group 2) using image J system. Conclusions : TEGDMA induced cytotoxicity. The MDPC-23 cell death was associated with the increasing ROS. Coenyme $Q_{10}$ showed the antioxidant effects by decreasing ROS. This effects may contribute to the treatment of periodontal disease induced by TEGDMA after operation.

De novo interstitial deletion of 15q22q23 with global developmental delay and hypotonia: the first Korean case

  • Kim, Ha-Su;Han, Jin-Yeong;Kim, Myo-Jing
    • Clinical and Experimental Pediatrics
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    • v.58 no.8
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    • pp.313-316
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    • 2015
  • Interstitial deletions involving the chromosome band 15q22q24 are very rare and only nine cases have been previously reported. Here, we report on a 12-day-old patient with a de novo 15q22q23 interstitial deletion. He was born by elective cesarean section with a birth weight of 3,120 g at 41.3-week gestation. He presented with hypotonia, sensory and neural hearing loss, dysmorphism with frontal bossing, flat nasal bridge, microretrognathia with normal palate and uvula, thin upper lip in an inverted V-shape, a midline sacral dimple, severe calcanovalgus at admission, and severe global developmental delay at 18 months of age. Fluorescence in situ hybridization findings confirmed that the deleted regions contained at least 15q22. The chromosome analysis revealed a karyotype of 46,XY,del(15) (q22q23). Parental chromosome analysis was performed and results were normal. After reviewing the limited literature on interstitial 15q deletions, we believe that the presented case is the first description of mapping of an interstitial deletion involving the chromosome 15q22q23 segment in Korea. This report adds to the knowledge of the clinical phenotype associated with the 15q22q23 deletion.

Genetic Change from Colorectal Carcinoma Patients Using Comparative Genomic Hybridization (비교유전자교잡법을 이용한 대장암환자에서의 유전자변화)

  • Lee, Jae Sik
    • Korean Journal of Clinical Laboratory Science
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    • v.47 no.4
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    • pp.209-215
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    • 2015
  • Colorectal carcinoma is one of the four major cancers in Korea, and it shows the tendency of increase every year due to economic development and changes to western styles. Accordingly, various diagnostic methods are needed and so comparative genomic hybridization (CGH) was performed. Deletion was detected on 5q (10%), 10q (17%), 17p (40%), 18p (23%), 18q (47%), 22q (23%), and higher deletion loci were 18q (12/30, 47%), 17p (12/30, 40%), and 22q (7/30, 23%). Amplification was shown on chromosomes 6pq (10%), 7p (17%), 7q (33%), 8q (13%), 9pq (10%), 12q (17%), 13q (37%), 20p (23%), and 20q (57%) respectively. The highest amplification was detected on chromosomes 20q (17/30, 57%), 13q (11/30, 37%), and 7q (10/30, 33%). The genetic change pattern with the locus of colorectal carcinoma was shown mean 3.1 (amplification 1.7, deletion 1.4) on the right colorectal carcinoma, while rectal carcinoma appeared high mean 6.3 (amplification 3.7, deletion 2.6) (p<0.001). The genetic change pattern with lymphatic gland metastasis, mean 3.5 (amplification 2.2, deletion 1.3) from "no metastasis" group, while high mean 6.3 (amplification 3.5, deletion 2.8) from metastasis group (p<0.003). The genetic change pattern with disease stages appeared mean 3.5 (amplification 2.1, deletion 1.4) from I-II stages, while high mean 6.0 (amplification 3.4, deletion 2.6) from III-IV stages (p<0.006). No significance was observed in comparing histological classification and serum CEA increased groups.

ON SOME GROWTH ANALYSIS OF COMPOSITE ENTIRE AND MEROMORPHIC FUNCTIONS FROM THE VIEW POINT OF THEIR RELATIVE (p, q)-TH TYPE AND RELATIVE (p, q)-TH WEAK TYPE

  • Biswas, Tanmay
    • Korean Journal of Mathematics
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    • v.26 no.1
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    • pp.23-41
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    • 2018
  • The main aim of this paper is to prove some results related to the growth rates of composite entire and meromorphic functions on the basis of their relative (p, q)-th order, relative (p, q)-th lower order, relative (p, q)-th type and relative (p, q)-th weak type where p and q are any two positive integers.

ON THE q-EXTENSION OF THE HARDY-LITTLEWOOD-TYPE MAXIMAL OPERATOR RELATED TO q-VOLKENBORN INTEGRAL IN THE p-ADIC INTEGER RING

  • Jang, Lee-Chae
    • Journal of the Chungcheong Mathematical Society
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    • v.23 no.2
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    • pp.207-213
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    • 2010
  • In this paper, we define the q-extension of the Hardy-Littlewood-type maximal operator related to q-Volkenborn integral. By the meaning of the extension of q-Volkenborn integral, we obtain the boundedness of the q-extension of the Hardy-Littlewood-type maximal operator in the p-adic integer ring.

MEAN VALUES OF THE HOMOGENEOUS DEDEKIND SUMS

  • WANG, XIAOYING;YUE, XIAXIA
    • Korean Journal of Mathematics
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    • v.23 no.4
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    • pp.571-590
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    • 2015
  • Let a, b, q be integers with q > 0. The homogeneous Dedekind sum is dened by $$\Large S(a,b,q)={\sum_{r=1}^{q}}\(\({\frac{ar}{q}}\)\)\(\({\frac{br}{q}}\)\)$$, where $$\Large ((x))=\{x-[x]-{\frac{1}{2}},\text{ if x is not an integer},\\0,\hspace{75}\text{ if x is an integer.}$$ In this paper we study the mean value of S(a, b, q) by using mean value theorems of Dirichlet L-functions, and give some asymptotic formula.

COMPLEX FACTORIZATIONS OF THE GENERALIZED FIBONACCI SEQUENCES {qn}

  • JUN, SANG PYO
    • Korean Journal of Mathematics
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    • v.23 no.3
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    • pp.371-377
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    • 2015
  • In this note, we consider a generalized Fibonacci sequence {$q_n$}. Then give a connection between the sequence {$q_n$} and the Chebyshev polynomials of the second kind $U_n(x)$. With the aid of factorization of Chebyshev polynomials of the second kind $U_n(x)$, we derive the complex factorizations of the sequence {$q_n$}.

ON DUALITY OF WEIGHTED BLOCH SPACES IN ℂn

  • Yang, Gye Tak;Choi, Ki Seong
    • Journal of the Chungcheong Mathematical Society
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    • v.23 no.3
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    • pp.523-534
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    • 2010
  • In this paper, we consider the weighted Bloch spaces ${\mathcal{B}}_q$(q > 0) on the open unit ball in ${\mathbb{C}}^n$. We prove a certain integral representation theorem that is used to determine the degree of growth of the functions in the space ${\mathcal{B}}_q$ for q > 0. This means that for each q > 0, the Banach dual of $L_a^1$ is ${\mathcal{B}}_q$ and the Banach dual of ${\mathcal{B}}_{q,0}$ is $L_a^1$ for each $q{\geq}1$.