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Rarely Observed Jumping Translocation in Spontaneous Abortion (자연 유산에서 드물게 관찰된 Jumping translocation 2례)

  • Lee, Yeon-Woo;Lee, Bom-Yi;Park, Ju-Yeon;Choi, Eun-Young;Oh, Ah-Rum;Lee, Shin-Young;Ryu, Hyun-Mee;Kang, Inn-Soo;Yang, Kwang-Moon;Park, So-Yeon
    • Journal of Genetic Medicine
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    • v.7 no.1
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    • pp.82-86
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    • 2010
  • Jumping translocations (JT) are chromosomal rearrangements involving one donor chromosome and several recipient chromosomes. While JTs are frequently observed as acquired chromosomal abnormalities in hematologic malignancies, constitutional JTs are only rarely reported. We report two cases of constitutional JT in chorionic villi derived from the products of conception. The karyotype of the first case was 46,XY,add(18)(p11.1)[61]/45,XY,der(18;21)(q10;q10)[32]/46,XY,-18,+mar[16]/46,XY,i(18)(q10)[9]/45,XY,der(15;18)(q10;q10)[6]/46,XY,+1,dic(1;18)(p22;p11.1)[2]/45,XY,der(13;18)(q10;q10)[1]/46,XY[32]. The donor was a chromosome 18. The recipient chromosomes were chromosomes 1, 13, 15, 18 and 21. In the second case, the karyotype was 46,XY,der(22)t(9;22)(q12;q13)[22]/46,XY,der(22)t(1;22)(q21;q13)[13]/46,XY,add(22)(q13)[5]/46 XY[23]. The donor was a chromosome 22 and recipients were chromosomes 1 and 9. Both cases were de novo. The breakpoints of chromosomes were mostly in centromeric regions, pericentromeric regions, or telomeric regions. Normal cell lines were observed in both cases. This report supports the prior findings that the unstable nature of JT, resulting in chromosomal imbalance, most likely contributed to these early miscarriages.

Quantum Dot and Iron Oxide Nanoparticle-Loaded Chitosan Nanoparticles for Cancer Imaging (양자점과 산화철 나노입자가 함유된 키토산 나노입자를 이용한 암 영상화 연구)

  • Kim, Min Ah;Jeong, Hwan-Jeong;Lee, Chang-Moon
    • Journal of Chitin and Chitosan
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    • v.23 no.3
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    • pp.158-163
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    • 2018
  • In this study, we report superparamagnetic iron oxide nanoparticles (SPION) and quantum dots (Q-Dots)-loaded glycol chitosan (GC) nanoparticles as a dual imaging probe for tumor imaging. From GC modified with histidine self-assembled GC nanoparticles containing SPION and Q-Dots were prepared as a dual imaging probe. Tumor accumulation of the GC nanoparticles was investigated through optical and magnetic resonance imaging in a MDA-MB231 breast mouse cancer model. The SPION and Q-Dots-loaded GC nanoparticles were successfully accumulated into tumor by prolonged circulation and enhanced permeability and retention effect. As expected, in ex vivo study, the SPION and Q-Dots-loaded GC nanoparticles showed higher uptake in tumor than the other organs. The SPION and Q-Dots-loaded GC nanoparticles are a promising imaging agent for cancer imaging and can be used as a cancer-targeted drug delivery for chemotherapy.

Attitude of Social workers toward Withdrawal 0f Life Sustaining Treatment

  • Lee, Gyeong-Nam;Lee, Hyun-Ju
    • Journal of the Korea Society of Computer and Information
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    • v.23 no.12
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    • pp.171-177
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    • 2018
  • Purpose : This study is conducted to research the attitude of social workers toward withdrawing life sustaining treatment and compare and analyze the different types of their attitudes. Methods : Research design of this study is Q methodology approach. The study population is 23 social workers. Q sample to investigate the attitude of social workers toward withdrawing life sustaining treatment included 30 statements. After listening to the purpose and method of the study, the 23 social workers agreed to fill out a survey asking sociodemographic information and have been forced to be distributed in 9 scale Q-sample. Results : The collected data was processed through QUANL PC program, sorted into 3 types as followings. The first type was 'the pursuit of quality of life' that the quality of life is more important than the length of life, the second 'choosing to withdraw life sustaining treatment' that they want to write or encourage family to write advanced directive, the third 'withholding life sustaining treatment' regardless of the cost. Conclusion : In conclusion, the social workers attitudes toward withdrawing life sustaining treatment were grouped as three different types, the first type was 'the pursuit of quality of life', the second 'choosing to withdraw life sustaining treatment', the third 'withholding life sustaining treatment'.

Combined Study of Cytogenetics and Fluorescence in Situ Hybridization (FISH) Analysis in Childhood Acute Lymphoblastic Leukemia (ALL) in a Tertiary Cancer Centre in South India

  • Mazloumi, Seyed Hashem Mir;Madhumathi, D.S.;Appaji, L.;Prasannakumari, Prasannakumari
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.8
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    • pp.3825-3827
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    • 2012
  • FISH is one of the most sensitive molecular methods to detect genetic abnormalities with DNA probes. When cytogenetic studies are normal or insufficient, FISH may detect cryptic rearrangements, rare or slowly proliferative abnormal populations in non-mitotic cells. We cytogenetically evaluated 70 childhood ALL - 67.1% were found to have an abnormal karyotype. The 23 patients (32.9%) with a normal karyotype were analyzed by FISH applying two probes; TEL/AML1 and MYB which detect cryptic rearrangements of t(12;21)(p13;q22) and deletion of (6q) respectively, associated with a good prognosis. Out of 23 patients, one was positive for t(12;21)(p13;q22) (4.3%). None of our patients were positive for MYB del(6q). Two patients showed an extra signal for MYB on chromosomes other than 6 (8.6 %) indicating amplification or duplication. Findings were compared with the available literature. Our study clearly indicated the integrated FISH screening method to increase the abnormality detection rate in a narrow range. FISH is less useful for diagnostic study of patients with suspected del(6q) but it helps in detecting known cryptic rearrangements as well as identification of new abnormalities(translocation , duplication and amplification) at the gene level.

A Study of Children's Anger-Expression Styles: A Q-Methodological Approach (초등학교 저학년 아동의 분노표현방식 유형에 관한 연구: Q 방법론 적용)

  • Jang, Hye-Ju;Lim, Ji-Young
    • Journal of the Korean Home Economics Association
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    • v.49 no.4
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    • pp.11-23
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    • 2011
  • The purpose of this study was to identify children's different styles of anger-expression and the characteristics of each anger-expression style. The Q-methodology with a 32 Q-sample was used to investigate and analyze the subjective expression of childrens's anger experiences. The subjects were 22 children living in D city, and the data were collected by means of interviews. The analysis revealed six styles of anger-expression, a solution which accounted for 65.13% of the total variance. The six styles were labeled "Patience type", "Avoidance-conversion type", "Reaction-seek type", "Control type", "Repression type", and "Conversion-consideration type". It was recommended that intervention strategies for children's appropriate anger-expression mode should be based on these six anger-expression styles.

The impact of two doses of coenzyme Q10 on semen parameters and antioxidant status in men with idiopathic oligoasthenoteratozoospermia

  • Alahmar, Ahmed T
    • Clinical and Experimental Reproductive Medicine
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    • v.46 no.3
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    • pp.112-118
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    • 2019
  • Objective: Oxidative stress contributes to male infertility, and antioxidants have been recommended for treating idiopathic oligoasthenoteratozoospermia (OAT). There is, however, a lack of agreement on the type, dosing, and use of individual antioxidants or combinations thereof. The purpose of this study was to compare the effects of two doses of coenzyme Q10 (CoQ10) on semen parameters and antioxidant status in men with idiopathic OAT. Methods: In this prospective study, patients with idiopathic OAT received 200 mg/day (n = 35) or 400 mg/day (n = 30) of CoQ10 orally for 3 months. All patients underwent semen analysis according to the fifth editions of the World Health Organization criteria. Total antioxidant capacity (TAC), catalase (CAT) activity, and superoxide dismutase (SOD) activity were measured both before and after treatment. Results: Treatment with CoQ10 (200 mg/day or 400 mg/day) resulted in a significant increase in sperm concentration from baseline ($8.22{\pm}6.88$ to $12.53{\pm}8.11million/mL$, p= 0.019; $7.58{\pm}5.41$ to $12.33{\pm}6.1million/mL$, p= 0.002, respectively), progressive motility ($16.54%{\pm}9.26%$ to $22.58%{\pm}10.15%$, p=0.011; $14.22%{\pm}12.85%$ to $26.1%{\pm}14.52%$, p= 0.001, respectively), and total motility ($25.68%{\pm}6.41%$ to $29.96%{\pm}8.09%$, p= 0.016; $23.46%{\pm}12.59%$ to $34.82%{\pm}14.17%$, p= 0.001, respectively). CoQ10 therapy also increased TAC (p= 0.009, p= 0.001, respectively), SOD activity (p= 0.004, p= 0.001, respectively), and CAT activity (p= 0.039, p= 0.024, respectively). Furthermore, antioxidant measures correlated significantly with seminal fluid parameters (r = 0.36-0.76). Conclusion: CoQ10 supplementation improved semen parameters and antioxidant status in men with idiopathic OAT, with a greater improvement shown in men who took 400 mg/day than in those who took 200 mg/day.

EXISTENCE OF SOLUTION FOR A FRACTIONAL DIFFERENTIAL INCLUSION VIA NONSMOOTH CRITICAL POINT THEORY

  • YANG, BIAN-XIA;SUN, HONG-RUI
    • Korean Journal of Mathematics
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    • v.23 no.4
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    • pp.537-555
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    • 2015
  • This paper is concerned with the existence of solutions to the following fractional differential inclusion $$\{-{\frac{d}{dx}}\(p_0D^{-{\beta}}_x(u^{\prime}(x)))+q_xD^{-{\beta}}_1(u^{\prime}(x))\){\in}{\partial}F_u(x,u),\;x{\in}(0,1),\\u(0)=u(1)=0,$$ where $_0D^{-{\beta}}_x$ and $_xD^{-{\beta}}_1$ are left and right Riemann-Liouville fractional integrals of order ${\beta}{\in}(0,1)$ respectively, 0 < p = 1 - q < 1 and $F:[0,1]{\times}{\mathbb{R}}{\rightarrow}{\mathbb{R}}$ is locally Lipschitz with respect to the second variable. Due to the general assumption on the constants p and q, the problem does not have a variational structure. Despite that, here we study it combining with an iterative technique and nonsmooth critical point theory, we obtain an existence result for the above problem under suitable assumptions. The result extends some corresponding results in the literatures.

Estimation of the Sound Radiation Efficiency of the Hull Considering the Type and Natural Frequency of Plates of It (선체 구성 강판의 종류 및 고유진동수를 고려한 선체의 음향방사효율 추정)

  • Han, HyungSuk;Lee, KyungHyun;Park, SungHo
    • Transactions of the Korean Society for Noise and Vibration Engineering
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    • v.23 no.12
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    • pp.1073-1081
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    • 2013
  • The definition of the radiation efficiency is very important to estimated underwater radiated noise of a ship. Considering the structure of the ship, it can be found that the hull of a ship consists of a lot of plates supporting by longitudinal and transverse stiffener. Therefore, various modes of the hull vibration occur related to the combination of these plates including stiffeners. In this paper, the method to define the radiation efficiency is suggested considering the vibration mode of the hull based on Uchida's experimental equation of the radiation efficiency. The suggested method is verified by the experiments with various kinds of naval vessels.

Comparison of QSAR Methods (CoMFA, CoMSIA, HQSAR) of Anticancer 1-N-Substituted Imidazoquinoline-4,9-dione Derivatives

  • Suh, Myung-Eun;Park, So-Young;Lee, Hyun-Jung
    • Bulletin of the Korean Chemical Society
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    • v.23 no.3
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    • pp.417-422
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    • 2002
  • Comparison studies of the Quantitative Structure Activity Relationship (QSAR) methods with new imidazo-quinolinedione derivatives were conducted using Comparative Molecular Field Analysis (CoMFA), Comparative Molecular Similarity Indices Analysis (CoMSIA), and the Hologram Quantitative Structure Activity Relationship (HQSAR). When the CoMFA crossvalidation value, q2, was 0.625, the Pearson correlation coefficient, r2, was 0.973. In CoMSIA, q2 was 0.52 and r2 was 0.979. In the HQSAR, q2 was 0.501 and r2 was 0.924. The best result was obtained using the CoMSIA method according to a comparison of the calculated values with the real in vitro cytotoxic activities against human ovarian cancer cell lines.