• Title/Summary/Keyword: 10q23

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Solving Survival Gridworld Problem Using Hybrid Policy Modified Q-Based Reinforcement

  • Montero, Vince Jebryl;Jung, Woo-Young;Jeong, Yong-Jin
    • Journal of IKEEE
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    • v.23 no.4
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    • pp.1150-1156
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    • 2019
  • This paper explores a model-free value-based approach for solving survival gridworld problem. Survival gridworld problem opens up a challenge involving taking risks to gain better rewards. Classic value-based approach in model-free reinforcement learning assumes minimal risk decisions. The proposed method involves a hybrid on-policy and off-policy updates to experience roll-outs using a modified Q-based update equation that introduces a parametric linear rectifier and motivational discount. The significance of this approach is it allows model-free training of agents that take into account risk factors and motivated exploration to gain better path decisions. Experimentations suggest that the proposed method achieved better exploration and path selection resulting to higher episode scores than classic off-policy and on-policy Q-based updates.

INTEGRAL TRANSFORMS OF FUNCTIONALS ON A FUNCTION SPACE OF TWO VARIABLES

  • Kim, Bong Jin;Kim, Byoung Soo;Yoo, Il
    • Journal of the Chungcheong Mathematical Society
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    • v.23 no.2
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    • pp.349-362
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    • 2010
  • We establish the various relationships among the integral transform ${\mathcal{F}}_{{\alpha},{\beta}}F$, the convolution product $(F*G)_{\alpha}$ and the first variation ${\delta}F$ for a class of functionals defined on K(Q), the space of complex-valued continuous functions on $Q=[0,S]{\times}[0,T]$ which satisfy x(s, 0) = x(0, t) = 0 for all $(s,t){\in}Q$. And also we obtain Parseval's and Plancherel's relations for the integral transform of some functionals defined on K(Q).

Characteristics of Nd:YAG Laser Pumped by cw Ti:sapphire Laser and Its Passive Q-switching with Cr4+:YAG as Saturable Absorber (Cr4+:YAG 포화 흡수체를 이용한 Ti:sapphire 레이저 여기 Nd:YAG 레이저의 수동형 Q-switching 특성)

  • 안범수;추한태;김규욱
    • Korean Journal of Optics and Photonics
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    • v.15 no.3
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    • pp.263-267
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    • 2004
  • We have investigated the characteristics of a Nd:YAG laser pumped by a cw Ti:sapphire laser. When the pumping power of the Ti:sapphire laser was 850 ㎽, the maximum output power of the Nd:YAG laser was 450 ㎽. As a result, the slope efficiency for the output power of the Nd:YAG laser was measured to be 56%. We have also investigated the characteristics of a passively Q-switched Nd:YAG laser by using a Cr$^{4+}$:YAG as saturable absorber with initial transmission of 90%. The maximum average output power of 200 ㎽ was obtained with repetition rate of 23.8 KHz and pulse width of 17.0 ns.

A case of follow-up of a patient with 22q11.2 distal deletion syndrome and a review of the literature

  • Ha, Dong Jun;Park, Ji Sun;Jang, Woori;Jung, Na-young;Kim, Su Jin;Moon, Yeonsook;Lee, Jieun
    • Journal of Genetic Medicine
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    • v.18 no.2
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    • pp.110-116
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    • 2021
  • Microdeletions of chromosome 22q11.2 are one of the most common microdeletions occurring in humans, and is known to be associated with a wide range of highly variable features. These deletions occur within a cluster of low copy repeats (LCRs) in 22q11.2, referred to as LCR22 A-H. DiGeorge (DGS)/velocardiofacial syndrome is the most prevalent form of a 22q11.2 deletions, caused by mainly proximal deletions between LCR22 A and D. As deletions of distal portion to the DGS deleted regions has been extensively studied, the recurrent distal 22q11.2 microdeletions distinct from DGS has been suggested as several clinical entities according to the various in size and position of the deletions on LCRs. We report a case of long-term follow-up of a female diagnosed with a 22q11.2 distal deletion syndrome, identified a deletion of 1.9 Mb at 22q11.21q11.23 (chr22: 21,798,906-23,653,963) using single nucleotide polymorphism array. This region was categorized as distal deletion type of 22q11.2, involving LCR22 D-F. She was born as a preterm, low birth weight to healthy non-consanguineous Korean parents. She showed developmental delay, growth retardation, dysmorphic facial features, and mild skeletal deformities. The patient underwent a growth hormone administration due to growth impairment without catch-up growth. While a height gain was noted, she had become overweight and was subsequently diagnosed with pre-diabetes. Our case could help broaden the genetic and clinical spectrum of 22q11.2 distal deletions.

New Approach to Pell and Pell-Lucas Sequences

  • Yagmur, Tulay
    • Kyungpook Mathematical Journal
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    • v.59 no.1
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    • pp.23-34
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    • 2019
  • In this paper, we first define generalizations of Pell and Pell-Lucas sequences by the recurrence relations $$p_n=2ap_{n-1}+(b-a^2)p_{n-2}\;and\;q_n=2aq_{n-1}+(b-a^2)q_{n-2}$$ with initial conditions $p_0=0$, $p_1=1$, and $p_0=2$, $p_1=2a$, respectively. We give generating functions and Binet's formulas for these sequences. Also, we obtain some identities of these sequences.

Rarely Observed Jumping Translocation in Spontaneous Abortion (자연 유산에서 드물게 관찰된 Jumping translocation 2례)

  • Lee, Yeon-Woo;Lee, Bom-Yi;Park, Ju-Yeon;Choi, Eun-Young;Oh, Ah-Rum;Lee, Shin-Young;Ryu, Hyun-Mee;Kang, Inn-Soo;Yang, Kwang-Moon;Park, So-Yeon
    • Journal of Genetic Medicine
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    • v.7 no.1
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    • pp.82-86
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    • 2010
  • Jumping translocations (JT) are chromosomal rearrangements involving one donor chromosome and several recipient chromosomes. While JTs are frequently observed as acquired chromosomal abnormalities in hematologic malignancies, constitutional JTs are only rarely reported. We report two cases of constitutional JT in chorionic villi derived from the products of conception. The karyotype of the first case was 46,XY,add(18)(p11.1)[61]/45,XY,der(18;21)(q10;q10)[32]/46,XY,-18,+mar[16]/46,XY,i(18)(q10)[9]/45,XY,der(15;18)(q10;q10)[6]/46,XY,+1,dic(1;18)(p22;p11.1)[2]/45,XY,der(13;18)(q10;q10)[1]/46,XY[32]. The donor was a chromosome 18. The recipient chromosomes were chromosomes 1, 13, 15, 18 and 21. In the second case, the karyotype was 46,XY,der(22)t(9;22)(q12;q13)[22]/46,XY,der(22)t(1;22)(q21;q13)[13]/46,XY,add(22)(q13)[5]/46 XY[23]. The donor was a chromosome 22 and recipients were chromosomes 1 and 9. Both cases were de novo. The breakpoints of chromosomes were mostly in centromeric regions, pericentromeric regions, or telomeric regions. Normal cell lines were observed in both cases. This report supports the prior findings that the unstable nature of JT, resulting in chromosomal imbalance, most likely contributed to these early miscarriages.

Attitude of Social workers toward Withdrawal 0f Life Sustaining Treatment

  • Lee, Gyeong-Nam;Lee, Hyun-Ju
    • Journal of the Korea Society of Computer and Information
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    • v.23 no.12
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    • pp.171-177
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    • 2018
  • Purpose : This study is conducted to research the attitude of social workers toward withdrawing life sustaining treatment and compare and analyze the different types of their attitudes. Methods : Research design of this study is Q methodology approach. The study population is 23 social workers. Q sample to investigate the attitude of social workers toward withdrawing life sustaining treatment included 30 statements. After listening to the purpose and method of the study, the 23 social workers agreed to fill out a survey asking sociodemographic information and have been forced to be distributed in 9 scale Q-sample. Results : The collected data was processed through QUANL PC program, sorted into 3 types as followings. The first type was 'the pursuit of quality of life' that the quality of life is more important than the length of life, the second 'choosing to withdraw life sustaining treatment' that they want to write or encourage family to write advanced directive, the third 'withholding life sustaining treatment' regardless of the cost. Conclusion : In conclusion, the social workers attitudes toward withdrawing life sustaining treatment were grouped as three different types, the first type was 'the pursuit of quality of life', the second 'choosing to withdraw life sustaining treatment', the third 'withholding life sustaining treatment'.

Combined Study of Cytogenetics and Fluorescence in Situ Hybridization (FISH) Analysis in Childhood Acute Lymphoblastic Leukemia (ALL) in a Tertiary Cancer Centre in South India

  • Mazloumi, Seyed Hashem Mir;Madhumathi, D.S.;Appaji, L.;Prasannakumari, Prasannakumari
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.8
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    • pp.3825-3827
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    • 2012
  • FISH is one of the most sensitive molecular methods to detect genetic abnormalities with DNA probes. When cytogenetic studies are normal or insufficient, FISH may detect cryptic rearrangements, rare or slowly proliferative abnormal populations in non-mitotic cells. We cytogenetically evaluated 70 childhood ALL - 67.1% were found to have an abnormal karyotype. The 23 patients (32.9%) with a normal karyotype were analyzed by FISH applying two probes; TEL/AML1 and MYB which detect cryptic rearrangements of t(12;21)(p13;q22) and deletion of (6q) respectively, associated with a good prognosis. Out of 23 patients, one was positive for t(12;21)(p13;q22) (4.3%). None of our patients were positive for MYB del(6q). Two patients showed an extra signal for MYB on chromosomes other than 6 (8.6 %) indicating amplification or duplication. Findings were compared with the available literature. Our study clearly indicated the integrated FISH screening method to increase the abnormality detection rate in a narrow range. FISH is less useful for diagnostic study of patients with suspected del(6q) but it helps in detecting known cryptic rearrangements as well as identification of new abnormalities(translocation , duplication and amplification) at the gene level.

A Study of Children's Anger-Expression Styles: A Q-Methodological Approach (초등학교 저학년 아동의 분노표현방식 유형에 관한 연구: Q 방법론 적용)

  • Jang, Hye-Ju;Lim, Ji-Young
    • Journal of the Korean Home Economics Association
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    • v.49 no.4
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    • pp.11-23
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    • 2011
  • The purpose of this study was to identify children's different styles of anger-expression and the characteristics of each anger-expression style. The Q-methodology with a 32 Q-sample was used to investigate and analyze the subjective expression of childrens's anger experiences. The subjects were 22 children living in D city, and the data were collected by means of interviews. The analysis revealed six styles of anger-expression, a solution which accounted for 65.13% of the total variance. The six styles were labeled "Patience type", "Avoidance-conversion type", "Reaction-seek type", "Control type", "Repression type", and "Conversion-consideration type". It was recommended that intervention strategies for children's appropriate anger-expression mode should be based on these six anger-expression styles.