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Effect of Dietary Coenzyme $Q_{10}$ on Lipid Peroxidation in Adriamycin-treated Rats - II. Effect on Mitochondrial Coenzyme $Q_{10}$ Level and Fatty Acid Composition - (식이 중의 Coenzyme $Q_{10}$첨가가 Adriamycin을 투여한 흰쥐의 체내 지질과산화에 미치는 영향 -II. 미토콘드리아내의 Coenzyme $Q_{10}$ 수준과 지방산 조성에 미치는 영향-)

  • Seo, Jung-Sook;Han, In-Kyu
    • Journal of Nutrition and Health
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    • v.24 no.4
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    • pp.299-307
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    • 1991
  • The present study was designed to evaluate the effects of dietary coenzyme $Q_{10}$ on mitochondrial coenzyme $Q_{10}$ and fatty acid composition in adriamycin (ADR)-treated rats. Two experiments were conducted in rats. Experiment 1 was undertaken under the condition of simultaneous administration of ADR and coenzyme $Q_{10}$ for 4 weeks. Experiment 2 was undertaken under the same condition as experiment 1 after feeding the experimental diets alone without administration of ADR for 4 weeks. Heart mitochondrial coenzyme $Q_{10}$ level of rats was greatly decreased by ADR treatment. but higher level of dietary coenzyme $Q_{10}$ elevated this decrease to control ranges. Pretreatment with dietary supplementation of coenzyme $Q_{10}$ showed a significant increase in myocardial coenzyme $Q_{10}$ level. With ADR treatment. polyunsaturated fatty acids such as arachidonic acid (20 : 4) and docosahexaenoic acid (22 : 6) were decreased. However, dietary supplementation of coenzyme $Q_{10}$ modified this decrement to some extent. In both experiment 1 and 2. the polyunsaturated fatty acids/saturated and polyunsaturated fatty acids (P/S+ M) ratio of ADR-treated rats tended to be lower than that of control rats.

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Vegetational Changes in the Early Stages after Lumbering of Populus albaglandulosa in Urban Forest (도시림에서 은수원사시나무 벌목 후 초기의 식생 변화)

  • 민병미
    • The Korean Journal of Ecology
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    • v.22 no.5
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    • pp.277-285
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    • 1999
  • To develop a better restoration technique for altering urban planted forest to more natural forest, the changes of flora, vegetation structure and woody plant growth in the early stage after lumbering only Populus albaglandulosa of the tree layer were studied in Chungdam Park, Chungdam-dong, Kangnam-gu, Seoul for two years (from 1997 to 1998). The results were as follow. First, in the year after lumbering, the species changes occurred not in woody plants but in herbs, which increased by 44%. Three species including Viola verecunda disappeared, and 15 species including ruderals such as Metaplexis japonica and introduced species such as Erechtites hieracifolia appeared newly. Second, lumbering caused the coverages of Quercus aliena, Q. mongolica, Q. acutissima and Sorbus alnifolia in the subtree, or shrub layer, to be increased abruptly. The coverage of Lespedeza bicolor was affected by neighboring plants. Third, in the herb layer the coverage of Artemisia keiskeana was conspicuously increased but those of the others were not. Fourth, by ridding the upper layer canopy, Quercus' growth rates were increased highly. Rates of DBH growth of Q. aliena, Q. mongolica and Q. dentata were increased to 53.0%, 22.9% and 8% in the experimental area, and 23.1%, 8.3% and 6.1% in the control area, respectively, during two growing seasons (from May 11, 1997 to October 27, 1998). The ratios of twig biomasses of the previous year to the next year were 100:565 in Q. aliena, 100:197 in Q. mongolica and 100:644 in Q. dentata in the experimental area. There were also growth ratios of 100:117 in Q. aliena, 100:100 in Q. mongolica and 100:42 in Q. dentata in the control area, respectively. The growth rate increases of Q. aliena and Q. dentata were thus conspicuous in twig rather than in trunk, but that of Q. mongolica was vice versa.

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Platybasia in 22q11.2 Deletion Syndrome Is Not Correlated with Speech Resonance

  • Spruijt, Nicole E.;Kon, Moshe;Molen, Aebele B. Mink Van Der
    • Archives of Plastic Surgery
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    • v.41 no.4
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    • pp.344-349
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    • 2014
  • Background An abnormally obtuse cranial base angle, also known as platybasia, is a common finding in patients with 22q11.2 deletion syndrome (22q11DS). Platybasia increases the depth of the velopharynx and is therefore postulated to contribute to velopharyngeal dysfunction. Our objective was to determine the clinical significance of platybasia in 22q11DS by exploring the relationship between cranial base angles and speech resonance. Methods In this retrospective chart review at a tertiary hospital, 24 children (age, 4.0-13.1 years) with 22q11.2DS underwent speech assessments and lateral cephalograms, which allowed for the measurement of the cranial base angles. Results One patient (4%) had hyponasal resonance, 8 (33%) had normal resonance, 10 (42%) had hypernasal resonance on vowels only, and 5 (21%) had hypernasal resonance on both vowels and consonants. The mean cranial base angle was $136.5^{\circ}$ (standard deviation, $5.3^{\circ}$; range, $122.3-144.8^{\circ}$). The Kruskal-Wallis test showed no significant relationship between the resonance ratings and cranial base angles (P=0.242). Cranial base angles and speech ratings were not correlated (Spearman correlation=0.321, P=0.126). The group with hypernasal resonance had a significantly more obtuse mean cranial base angle ($138^{\circ}$ vs. $134^{\circ}$, P=0.049) but did not have a greater prevalence of platybasia (73% vs. 56%, P=0.412). Conclusions In this retrospective chart review of patients with 22q11DS, cranial base angles were not correlated with speech resonance. The clinical significance of platybasia remains unknown.

The impact of two doses of coenzyme Q10 on semen parameters and antioxidant status in men with idiopathic oligoasthenoteratozoospermia

  • Alahmar, Ahmed T
    • Clinical and Experimental Reproductive Medicine
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    • v.46 no.3
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    • pp.112-118
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    • 2019
  • Objective: Oxidative stress contributes to male infertility, and antioxidants have been recommended for treating idiopathic oligoasthenoteratozoospermia (OAT). There is, however, a lack of agreement on the type, dosing, and use of individual antioxidants or combinations thereof. The purpose of this study was to compare the effects of two doses of coenzyme Q10 (CoQ10) on semen parameters and antioxidant status in men with idiopathic OAT. Methods: In this prospective study, patients with idiopathic OAT received 200 mg/day (n = 35) or 400 mg/day (n = 30) of CoQ10 orally for 3 months. All patients underwent semen analysis according to the fifth editions of the World Health Organization criteria. Total antioxidant capacity (TAC), catalase (CAT) activity, and superoxide dismutase (SOD) activity were measured both before and after treatment. Results: Treatment with CoQ10 (200 mg/day or 400 mg/day) resulted in a significant increase in sperm concentration from baseline ($8.22{\pm}6.88$ to $12.53{\pm}8.11million/mL$, p= 0.019; $7.58{\pm}5.41$ to $12.33{\pm}6.1million/mL$, p= 0.002, respectively), progressive motility ($16.54%{\pm}9.26%$ to $22.58%{\pm}10.15%$, p=0.011; $14.22%{\pm}12.85%$ to $26.1%{\pm}14.52%$, p= 0.001, respectively), and total motility ($25.68%{\pm}6.41%$ to $29.96%{\pm}8.09%$, p= 0.016; $23.46%{\pm}12.59%$ to $34.82%{\pm}14.17%$, p= 0.001, respectively). CoQ10 therapy also increased TAC (p= 0.009, p= 0.001, respectively), SOD activity (p= 0.004, p= 0.001, respectively), and CAT activity (p= 0.039, p= 0.024, respectively). Furthermore, antioxidant measures correlated significantly with seminal fluid parameters (r = 0.36-0.76). Conclusion: CoQ10 supplementation improved semen parameters and antioxidant status in men with idiopathic OAT, with a greater improvement shown in men who took 400 mg/day than in those who took 200 mg/day.

A Study on the Perception of the Parental Role among College Students (대학생의 부모역할에 관한 인식유형)

  • Doo, Hyun Jung;Lee, Yun Jeong
    • Journal of East-West Nursing Research
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    • v.22 no.1
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    • pp.68-77
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    • 2016
  • Purpose: This study was conducted to classify the subjective perception of college students on the role of parents and to identify the characteristics of each classified type. Methods: The Q methodology was used for this study interviewing 150 college student, 70 statements were derived as a result from interviews conducted among college students. Thirty seven final Q-statements were derived by categorizing the statements based on significant similarities. The Q-statements were sorted by 37 college students. The collected data was analyzed through PC QUANL. Results: The analyzed types resulted in 4 categories:"friend-like parents type," "stability-oriented parents type," "discipline and guidance parents type", and "personality nurturing parents type." Conclusion: The result of this study can be utilized for establishing a proper role and values of parenting. It can also contribute to designing an important educational material for parental education.

Self-Reported Speech Problems in Adolescents and Young Adults with 22q11.2 Deletion Syndrome: A Cross-Sectional Cohort Study

  • Spruijt, Nicole E.;Vorstman, Jacob A.S.;Kon, Moshe;Molen, Aebele B. Mink Van Der
    • Archives of Plastic Surgery
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    • v.41 no.5
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    • pp.472-479
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    • 2014
  • Background Speech problems are a common clinical feature of the 22q11.2 deletion syndrome. The objectives of this study were to inventory the speech history and current self-reported speech rating of adolescents and young adults, and examine the possible variables influencing the current speech ratings, including cleft palate, surgery, speech and language therapy, intelligence quotient, and age at assessment. Methods In this cross-sectional cohort study, 50 adolescents and young adults with the 22q11.2 deletion syndrome (ages, 12-26 years, 67% female) filled out questionnaires. A neuropsychologist administered an age-appropriate intelligence quotient test. The demographics, histories, and intelligence of patients with normal speech (speech rating=1) were compared to those of patients with different speech (speech rating>1). Results Of the 50 patients, a minority (26%) had a cleft palate, nearly half (46%) underwent a pharyngoplasty, and all (100%) had speech and language therapy. Poorer speech ratings were correlated with more years of speech and language therapy (Spearman's correlation=0.418, P=0.004; 95% confidence interval, 0.145-0.632). Only 34% had normal speech ratings. The groups with normal and different speech were not significantly different with respect to the demographic variables; a history of cleft palate, surgery, or speech and language therapy; and the intelligence quotient. Conclusions All adolescents and young adults with the 22q11.2 deletion syndrome had undergone speech and language therapy, and nearly half of them underwent pharyngoplasty. Only 34% attained normal speech ratings. Those with poorer speech ratings had speech and language therapy for more years.

Comparative Study on the Attenuation of P and S Waves in the Crust of the Southeastern Korea (한국 남동부 지각의 P파와 5파 감쇠구조 비교연구)

  • Chung, Tae-Woong
    • Journal of the Korean earth science society
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    • v.22 no.2
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    • pp.112-119
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    • 2001
  • The Yangsan fault in the southeastern Korea has been receiving increasing attention in its seismic activity. In this fault region, by using the extended coda-normalization method for 707 seismograms of local earthquakes, were obtained 0.009f$^{-1.05}$ and 0.004f$^{-0.70}$ for fitting values of Q$_p^{-1}$ and Q$_s^{-1}$, respectively. These results indicate that Q$_p^{-1}$ and Q$_s^{-1}$ in the southeastern Korea is the lowest level in the world although the exponent values agree well with those in the other areas. The low Q-1 is not related to the movement of the Yangsan fault but to the tectonically inactive status like a shield area.

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Combined Study of Cytogenetics and Fluorescence in Situ Hybridization (FISH) Analysis in Childhood Acute Lymphoblastic Leukemia (ALL) in a Tertiary Cancer Centre in South India

  • Mazloumi, Seyed Hashem Mir;Madhumathi, D.S.;Appaji, L.;Prasannakumari, Prasannakumari
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.8
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    • pp.3825-3827
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    • 2012
  • FISH is one of the most sensitive molecular methods to detect genetic abnormalities with DNA probes. When cytogenetic studies are normal or insufficient, FISH may detect cryptic rearrangements, rare or slowly proliferative abnormal populations in non-mitotic cells. We cytogenetically evaluated 70 childhood ALL - 67.1% were found to have an abnormal karyotype. The 23 patients (32.9%) with a normal karyotype were analyzed by FISH applying two probes; TEL/AML1 and MYB which detect cryptic rearrangements of t(12;21)(p13;q22) and deletion of (6q) respectively, associated with a good prognosis. Out of 23 patients, one was positive for t(12;21)(p13;q22) (4.3%). None of our patients were positive for MYB del(6q). Two patients showed an extra signal for MYB on chromosomes other than 6 (8.6 %) indicating amplification or duplication. Findings were compared with the available literature. Our study clearly indicated the integrated FISH screening method to increase the abnormality detection rate in a narrow range. FISH is less useful for diagnostic study of patients with suspected del(6q) but it helps in detecting known cryptic rearrangements as well as identification of new abnormalities(translocation , duplication and amplification) at the gene level.

The Impact of Esophageal Reflux-Induced Symptoms on Quality of Life after Gastrectomy in Patients with Gastric Cancer

  • Im, Min Hye;Kim, Jong Won;Kim, Whan Sik;Kim, Jie-Hyun;Youn, Young Hoon;Park, Hyojin;Choi, Seung Ho
    • Journal of Gastric Cancer
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    • v.14 no.1
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    • pp.15-22
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    • 2014
  • Purpose: To evaluate the prevalence of esophageal reflux-induced symptoms after gastrectomy owing to gastric cancer and assess the relationship between esophageal reflux-induced symptoms and quality of life. Materials and Methods: From January 2012 to May 2012, 332 patients were enrolled in this cross-sectional study. The patients had a history of curative resection for gastric cancer at least 6 months previously without recurrence, other malignancy, or ongoing chemotherapy. Esophageal reflux-induced symptoms were evaluated with the GerdQ questionnaire. The quality of life was evaluated with the European Organization for Research and Treatment QLQ-C30 and STO22 questionnaires. Results: Of the 332 patients, 275 had undergone subtotal gastrectomy and 57 had undergone total gastrectomy. The number of GerdQ(+) patients was 58 (21.1%) after subtotal gastrectomy, and 7 (12.3%) after total gastrectomy (P=0.127). GerdQ(+) patients showed significantly worse scores compared to those for GerdQ(-) patients in nearly all functional and symptom QLQ-C30 scales, with the difference in the mean score of global health status/quality of life and diarrhea symptoms being higher than in the minimal important difference. Additionally, in the QLQ STO22, GerdQ(+) patients had significantly worse scores in every symptom scale. The GerdQ score was negatively correlated with the global quality of life score (r=-0.170, P=0.002). Conclusions: Esophageal reflux-induced symptoms may develop at a similar rate or more frequently after subtotal gastrectomy compared to that after total gastrectomy, and decrease quality of life in gastric cancer patients. To improve quality of life after gastrectomy, new strategies are required to prevent or reduce esophageal reflux.

Morphological Characteristics of Leaves, Trichomes and acorns in artificial hybrids of Quercus aliena ${\times}$ Q. mongolica var. crispula and Q. serrata ${\times}$ Q. mongolica var. crispula hybrids

  • Lee, Jeong-Ho;Kang, Kyu-Suk
    • Korean Journal of Plant Resources
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    • v.22 no.3
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    • pp.266-272
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    • 2009
  • Morphological characteristics of leaves, trichomes and acorns were investigated in 6-year-old artificial hybrids of Q. aliena ${\times}$ Q. mongolica var. crispula and Q. serrata ${\times}$ Q. mongolica var. crispula. Leaf shapes of Q. aliena ${\times}$ Q. mongolica var. crispula $F_{1}$ were obovate and resembled to that of Q. aliena. But several characters including the size of leaf and petiole and the shape of leaf base resembled to those of Q. mongolica var. crispula. In F1 hybrids, small stellate hairs distributed sparsely on the abaxial surface and their lay length was intermediate between both parents. There were no big differences on characters of nuts and cupules between both parents and $F_{1}$ hybrids. Leaf shapes of Q. serrata ${\times}$ Q. mongolica var. crispula $F_{1}$ were obovate-elliptic, and the leaf shape and leaf base and the length of petiole resembled to those of Q. mongolica var. crispula, but leaf size and serration resembled to those of Q. serrata. The number of serration in a leaf was intermediate between both parents. Small stellate hairs distributed sparsely and large single hairs were mixed on the reverse side of leaves. there were no big differences on the number and size of stellate hairs between $F_{1}$ hybrid and Q. serrata. It is able to distinguish $F_{1}$ hybrids from both parents by the size leaf size and shapes, leaf base and serration, petiole length and trichome type in the leaf.