• Title, Summary, Keyword: 1q22

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A Study of Q$_P^{-1}$ and Q$_S^{-1}$ Based on Data of 9 Stations in the Crust of the Southeastern Korea Using Extended Coda Normalization Method (확장 Coda 규격화 방법에 의한 한국남동부 지각의 Q$_P^{-1}$, Q$_S^{-1}$연구)

  • Chung, Tae-Woong;Sato, Haruo;Lee, Kie-Hwa
    • Journal of the Korean earth science society
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    • v.22 no.6
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    • pp.500-511
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    • 2001
  • For the southeastern Korea aound the Yangsan fault we measured Q$_P^{-1}$ and Q$_S^{-1}$ simultaneously by using the extended coda-normalization method for seismograms registered at 9 stations deployed by KIGAM. We analyzed 707 seismograms of local earthquakes that occurred between December 1994 and February 2000. From seismograms, bandpass filtered traces were made by applying Butterworth filter with frequency-bands of 1${\sim}$2, 2${\sim}$4, 4${\sim}$8, 8${\sim}$16 and 16${\sim}$32 Hz. Estimated Q$_P^{-1}$ and Q$_S^{-1}$ values decrease from (7${\pm}$2)${\times}$10$^{-3}$ and (5${\pm}$4)${\times}$10$^{-4}$ at 1.5 Hz to (5${\pm}$4)${\times}$10$^{-3}$ and (5${\pm}$2)${\times}$10$^{-4}$ at 24 Hz, respectively. By fitting a power-law frequency dependent to estimated values over the whole stations, we obtained 0.009 (${\pm}$0.003)f$^{-1.05({\pm}0.14)$ for Q$_P^{-1}$ and 0.004 (${\pm}$0.001)f$^{-0.75({\pm}0.14)$) for Q$_S^{-1}$, where f is frequency in Hz.

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Sex-related Differences in DNA Copy Number Alterations in Hepatitis B Virus-Associated Hepatocellular Carcinoma

  • Zhu, Zhong-Zheng;Wang, Dong;Cong, Wen-Ming;Jiang, Hongmei;Yu, Yue;Wen, Bing-Ji;Dong, Hui;Zhang, Xiao;Liu, Shu-Fang;Wang, Ai-Zhong;Zhu, Guanshan;Hou, Lifang
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.1
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    • pp.225-229
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    • 2012
  • Background: Males have a higher prevalence of hepatocellular carcinoma (HCC) than females in general, but the reasons for the sex disparity are still obscure. DNA copy number alteration (CNA) is a major feature of solid tumors including HCC, but whether CNA plays a role in sex-related differences in HCC development has never been evaluated. Methods: High-resolution array comparative genomic hybridization (CGH) was used to examine 17 female and 46 male HCC patients with chronic hepatitis B virus (HBV) infection in Shanghai, China. Two-tailed Fisher's exact or ${\chi}^2$ tests was used to compare CNAs between females and males. Results: The overall frequencies and patterns of CNAs in female and male cases were similar. However, female HCC tumors presented more copy number gains compared to those in males on 1q21.3-q22 (76.5% vs. 37.0%, P = 0.009), 11q11 (35.3% vs. 0.0%, P = 0.0002) and 19q13.31-q13.32 (23.5% vs. 0.0%, P = 0.004), and loss on 16p11.2 (35.3% vs. 6.5%, P = 0.009). Relative to females, male cases had greater copy number loss on 11q11 (63.0% vs. 17.6%, P = 0.002). Further analyses showed that 11q11 gain correlated with 19q13.31-q13.32 gain (P = 0.042), 11q11 loss (P = 0.011) and 16p11.2 loss (P = 0.033), while 1q21.3-q22 gain correlated with 19q13.31-q13.32 gain (P = 0.046). Conclusions: These findings suggest that CNAs may play a role in sex-related differences in HBVassociated HCC development.

A Case of 18q-Deletion Syndrome with Hydronephrosis and Anhydrosis (요로계 기형과 무한증을 동반한 18번 염색체 장완 결손 증후군 1례)

  • Kim, Mun Hee;Yoo, Kee Hwan;Hong, Young Sook;Kim, Soon Kyum
    • Clinical and Experimental Pediatrics
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    • v.45 no.5
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    • pp.711-715
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    • 2002
  • The 18q-syndrome is a deletion disorder that occurs in humans. Clinical symptoms are mental retardation, craniofacial anomalies, skeletal deformity, seizure, and hearing loss. 18q- deletion occurs over a broad region, spanning the interval from 18q22.2 to 18qter rather than a single critical region containing 18q. We experienced a case of 18q-syndrome in a male child. It was diagnosed by clinical and chromosomal study. He was a 15month-old infant who was admitted because of prolonged fever and vomiting. And he manifested a depressed midface, esotropia, anhydrosis, and developmental delay. Peripheral blood chromosome studies showed deleted chromosomal material at the distal part of the long arm of chromosome 18. He showed right hydronephroureterosis on IVP. So, he was diagnosed as 18q-syndrome with right hydronephroureterosis and anhydrosis. We report this syndrome with a review and related literature.

A Study on Sediment Load in the Milyang River (유사량 산정에 관한 연구 (밀양강을 중심으로))

  • 안세영;민벙형
    • Magazine of the Korean Society of Agricultural Engineers
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    • v.22 no.4
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    • pp.96-107
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    • 1980
  • This study is carried out to estimate the rate of sediment transportation both to measure the amount of suspended and bedload sediment that moves on or near the river bed and passes through the cross section of a river in unit time, with suspended and bed load samplers used for the Milyang river and to determine the most satisfactory and convenient formula of some formulas for sediment discharge by comparing the measured rate with the calculated rate. The results of this study are summarized as follows; 1) The interrelationship (1) between the total discharge and the total sediment discharge (2) between discharge and suspended sediment load and (3) between discharge and bed load in the Milyang river are (1) i) 4$\leq$Q$\leq$100 C.M.S. Qr=0. 00272 Q0.70 (kg/sec) ii) 150$\leq$Q$\leq$800 C.M.S. Qr=0. 4807 Q0.46 (kg/sec) (2) Qs~=0. 07576 Q1.02 (kg/sec) (3) QB=0. 00957 Q0.44 (kg/sec) 2) The rate of suspended sediment load to total sediment discharge is found to be about; 99%. The suspended load is shown to be almost wash load which consists of silt and clay. 3) The relation between the total discharge and the suspended sediment load that are measured at three medium and small rivers in Korea is Qs=0. 13831 Q0.97 (kg/sec) 4) Brown's formula is determined to be the most convenient formula for application and comparison with observed data obtained for the Milyang river.

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Distributional Pattern of tetQ and aacC2 genes in Stream Water (하천에서 tetQ와 aacC2 유전자의 분포 양상)

  • 정재성;이영종;김종홍
    • The Korean Journal of Ecology
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    • v.22 no.5
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    • pp.305-309
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    • 1999
  • The occurrence of tetQ and aacC2 genes encoding tetracycline and gentamicin resistance determinant, respectively, was assessed in total bacterial community DNA isolated from Dongchon stream of Sunchon area. To examine the resistance potential of bacteria that were not cultured, total DNA from 1 liter of stream water was extracted by freeze-thaw method. The PCR technique was employed to determine the abundance of the target genes. The highest frequency of tetQ gene was obtained from site 1, located near the animal farms area, whereas the incidence of aacC2 was highest in site 5, the downstream area. These results showed that the occurrence of antibiotic resistance gene may be used as a convenient marker of water quality related to source.

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Replication of the Association of the 6q22.31c Locus near GJA1 with Pulse Rate in the Korean Population

  • Kim, Nam-Hee;Kim, Young-Jin;Oh, Ji-Hee;Cho, Yoon-Shin
    • Genomics & Informatics
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    • v.10 no.2
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    • pp.106-109
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    • 2012
  • Pulse rate is known to be related to diverse phenotypes, such as cardiovascular diseases, lifespan, arrhythmia, hypertension, lipids, diabetes, and menopause. We have reported two genomewide significant genetic loci responsible for the variation in pulse rate as a part of the Korea Association Resource (KARE) project, the genomewide association study (GWAS) that was conducted with 352,228 single nucleoride polymorphisms typed in 8,842 subjects in the Korean population. GJA1 was implied as a functionally causal gene for pulse rate from the KARE study, but lacked evidence of replication. To re-evaluate the association of a locus near GJA1 with pulse rate, we looked up this signal in another GWAS conducted in a Health Examinee-shared cohort of 3,703 samples. Not only we were able to confirm two pulse rate loci (1q32.2a near CD46 and 6q22.13c near LOCL644502) identified in the KARE GWAS, we also replicated a locus (6q22.31c) near GJA1 by the lookup in the Health Examinee GWAS. Considering that the GJA1-encoded protein is a major component of cardiac gap junctions, a functional study might be necessary to validate its genuine molecular biological role in the synchronized contraction of the heart.

Comparison of Mass and Nutrient Dynamics of Coarse Woody Debris between Quercus serrata and Q. variabilis Stands in Yangpyeong

  • Kim, RaeHyun;Son, Yowhan;Hwang, Jaehong
    • The Korean Journal of Ecology
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    • v.27 no.2
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    • pp.115-120
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    • 2004
  • Coarse woody debris (CWD, $\ge$ 5 cm in maximum diameter) is an important functional component, especially to nutrient cycling in forest ecosystems. To compare mass and nutrient dynamics of CWD in natural oak forests, a two-year study was conducted at Quercus serrata and Q. variabilis stands in Yangpyeong, Kyonggi Province. Total CWD (snag, stump, log and large branch) and annual decomposition mass (Mg/ha) were 1.9 and 0.4 for the Q. serrata stand and 7.5 and 0.5 for the Q. variabilis stand, respectively. Snags covered 72% of total CWD mass for the Q. variabilis stand and 42% for the Q. serrata stand. Most of CWD was classified into decay class 1 for both stands. CWD N and P concentrations for the Q. variabilis stand significantly increased along decay class and sampling time, except for P concentration in 2002. There were no differences in CWD N concentration for the Q. serrata stand along decay class and sampling time. However, CWD P concentration decreased along sampling time. CWD N and P contents (kg/ha) ranged from 3.5∼4.7 and 0.8∼1.3 for the Q. serrata stand to 22.8∼23.6 and 3.7∼4.7 for the Q. variabilis stand. Nitrogen and P inputs (kg/ha/yr) into mineral soil through the CWD decomposition were 0.7 and 0.3 for the Q. serrata stand and 1.6 and 0.3 for the Q. variabilis stand, respectively. The number of CWD and decay rate were main factors influencing the difference in CWD mass and nutrient dynamics between both stands.

Application of array comparative genomic hybridization in Korean children under 6 years old with global developmental delay

  • Lee, Kyung Yeon;Shin, Eunsim
    • Clinical and Experimental Pediatrics
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    • v.60 no.9
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    • pp.282-289
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    • 2017
  • Purpose: Recent advancements in molecular techniques have greatly contributed to the discovery of genetic causes of unexplained developmental delay. Here, we describe the results of array comparative genomic hybridization (CGH) and the clinical features of 27 patients with global developmental delay. Methods: We included 27 children who fulfilled the following criteria: Korean children under 6 years with global developmental delay; children who had at least one or more physical or neurological problem other than global developmental delay; and patients in whom both array CGH and G-banded karyotyping tests were performed. Results: Fifteen male and 12 female patients with a mean age of $29.3{\pm}17.6months$ were included. The most common physical and neurological abnormalities were facial dysmorphism (n=16), epilepsy (n=7), and hypotonia (n=7). Pathogenic copy number variation results were observed in 4 patients (14.8%): 18.73 Mb dup(2)(p24.2p25.3) and 1.62 Mb del(20p13) (patient 1); 22.31 Mb dup(2) (p22.3p25.1) and 4.01 Mb dup(2)(p21p22.1) (patient 2); 12.08 Mb del(4)(q22.1q24) (patient 3); and 1.19 Mb del(1)(q21.1) (patient 4). One patient (3.7%) displayed a variant of uncertain significance. Four patients (14.8%) displayed discordance between G-banded karyotyping and array CGH results. Among patients with normal array CGH results, 4 (16%) revealed brain anomalies such as schizencephaly and hydranencephaly. One patient was diagnosed with Rett syndrome and one with $M{\ddot{o}}bius$ syndrome. Conclusion: As chromosomal microarray can elucidate the cause of previously unexplained developmental delay, it should be considered as a first-tier cytogenetic diagnostic test for children with unexplained developmental delay.

A Prenatal Case of Paracentric Inversion of Chromosome 18, inv(18)(q21.1q22)

  • An, Gye-Hyeong;Kim, Moon Young;Kim, Min Hyoung;Kim, Yun Young;Choi, Kyu Hong;Kwak, Dong Wook;Park, So Yeon;Lee, Bom Yi;Park, Ju Yeon;Ryu, Hyun Mee
    • Journal of Genetic Medicine
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    • v.9 no.2
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    • pp.101-103
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    • 2012
  • Paracentric inversion of chromosome 18 is a rare cytogenetic abnormality. The vast majority of paracentric inversions are harmless and the offspring of paracentric inversion carriers have only slightly elevated risks for unbalanced karyotypes. However, various clinical phenotypes are seen due to breakpoint variation or recombination. We report a prenatally detected case of familial paracentric inversion of chromosome 18, inv(18)(q21.1q22), with normal clinical features.

Effect of Step Width and TOA on Q-Angle and CTA in Walking (보행에 있어서 보격과 발목각도가 종경골각 및 대퇴사두근각에 미치는 영향)

  • Hwangbo Gak;Lee Jin-Hee;Chung Hyung-Kuk;Bae Sung-Soo
    • The Journal of Korean Physical Therapy
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    • v.8 no.1
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    • pp.33-47
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    • 1996
  • This study was performed to examine the correlation between calcaneus to tibia angle and Q-angle, and the effects of step width and toe out angle on the calcaneus to tibia angle and Q-angle. The age of participated subjects was from 19 to 29 years(Mean=22.95, SD=2.23) who have no significant orthopedic and neurological dysfunction. The marking tapes for measurement of Q-angle and calcaneus to tibia angle were placed on seven location of each subject. Video data were collected while the subject walked on a walking grid. The result as follows : 1. There were significant differences in the step width, toe out angle, and Q-angle but not calcaneus to tibia angle between male and female. 2. There were significant differences in toe calcaneus to tibia angle and Q-angle n step width increased, respectively. 3. There were significant differences between tee out angle and calcaneus to tibia angle but not toe out angle and q-angle. 4. There was statistically significant correlation between calcaneus to tibia angle and Q-angle.

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