• 한국비블리아학회지
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• 제35권1호
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• pp.5-26
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• 2024

학교도서관업무지원시스템이 2024년 독서로 DLS로 새로 개발되었으나 DLS를 위한 목록규칙은 초창기 개발된 이후 크게 변경되지 않았으며, 현재 개발된 지침도 2020년에 작성된 것으로 새로운 개정이 필요한 상황이다. 이에 본 연구에서는 DLS의 목록입력규칙 적용을 위한 지침 개발 시 고려사항을 KCR4에 준하여 제안하고자 기존 DLS(Ver. 2.0) 목록입력규칙 및 2024 DLS 목록입력규칙, 2020년 서지등록가이드(Ver. 2.2)를 상호비교하였다. 이를 바탕으로 데이터요소 변경 및 확대, 내용규칙의 수정, 접근점 기록 방안, 통제어휘집 개발의 측면에서 고려사항을 제안하였다. 본 연구를 통해 앞으로 DLS 목록입력규칙의 개정, 지침의 개발, 시스템 개선 등에 활용할 수 있을 것이다.

• 대한약침학회지
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• 제27권1호
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• pp.1-13
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• 2024

Background: Diabetic nephropathy (DN) is one of the major complications of chronic hyperglycaemia affecting normal kidney functioning. The ayurvedic medicine curcumin (CUR) is pharmaceutically accepted for its vast biological effects. Objectives: The Curcuma-derived diferuloylmethane compound CUR, loaded on Poly (lactide-co-glycolic) acid (PLGA) nanoparticles was utilized to combat DN-induced renal apoptosis by selectively targeting and modulating Bcl2. Methods: Upon in silico molecular docking and screening study CUR was selected as the core phytocompound for nanoparticle formulation. PLGA-nano-encapsulated-curcumin (NCUR) were synthesized following standard solvent displacement method. The NCUR were characterized for shape, size and other physico-chemical properties by Atomic Force Microscopy (AFM), Dynamic Light Scattering (DLS) and Fourier-Transform Infrared (FTIR) Spectroscopy studies. For in vivo validation of nephro-protective effects, Mus musculus were pre-treated with CUR at a dose of 50 mg/kg b.w. and NCUR at a dose of 25 mg/kg b.w. (dose 1), 12.5 mg/kg b.w (dose 2) followed by alloxan administration (100 mg/kg b.w) and serum glucose levels, histopathology and immunofluorescence study were conducted. Results: The in silico study revealed a strong affinity of CUR towards Bcl2 (dock score -10.94 Kcal/mol). The synthesized NCUR were of even shape, devoid of cracks and holes with mean size of ~80 nm having -7.53 mV zeta potential. Dose 1 efficiently improved serum glucose levels, tissue-specific expression of Bcl2 and reduced glomerular space and glomerular sclerosis in comparison to hyperglycaemic group. Conclusion: This study essentially validates the potential of NCUR to inhibit DN by reducing blood glucose level and mitigating glomerular apoptosis by selectively promoting Bcl2 protein expression in kidney tissue.