• Journal of Positioning, Navigation, and Timing
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• 제3권1호
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• pp.31-36
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• 2014

Precise Point Positioning (PPP) is a stand-alone precise positioning approach. As the quality of satellite orbit and clock products from analysis centers has been improved, PPP can provide more precise positioning accuracy and reliability. A combined use of Global Positioning System (GPS) and Global Orbiting Navigation Satellite System (GLONASS) in PPP is now available. In this paper, we explained about an approach for combined GPS and GLONASS PPP measurement processing, and validated the performance through the comparison with GPS-only PPP results. We also used the measurement obtained from the GRAS reference station for the performance validation. As a result, we found that the combined GPS/GLONASS PPP can yield a more precise positioning than the GPS-only PPP.

• Journal of Positioning, Navigation, and Timing
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• 제12권2호
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• pp.141-148
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• 2023

In this paper, impacts of tropospheric delay gradient correction on PPP positioning performance were analyzed. A correction for tropospheric delay error due to the gradient was created and applied using external data, and reference station data were collected on a sunny day and a rainy day to analyze the GPS only dual-frequency PPP positioning results. As a result, on the sunny day, the convergence time was about 35 minutes and the final 3D position error was 10 cm, regardless of whether the correction for the tropospheric delay error by the gradient was applied. On the other hand, on the rainy day, the 3D position error converges only when the correction was applied, and the convergence time was about 34 minutes. Furthermore, the final 3D position error was improved from 30 cm to 10 cm. In addition, the analysis of the PPP by reference station location on the rainy day showed that the PPP positioning performance was improved when the correction was applied to a user located in an area where the weather changes.

• Journal of Positioning, Navigation, and Timing
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• 제1권1호
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• pp.59-64
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• 2012

Precise Point Positioning (PPP) has been widely used in navigation and orbit determination applications as we can obtain precise Global Positioning System (GPS) satellite orbit and clock products. Kinematic PPP, which is based on the GPS measurements only from the spaceborne GPS receiver, has some advantages for a simple precise orbit determination (POD). In this study, we developed kinematic PPP technique to estimate the orbits of GRACE-A satellite. The comparison of the mean position between the JPL's orbit product and our results showed the orbit differences 0.18 cm, 0.54 cm, and 0.98 cm in the Radial, in Along-track, and Cross-track direction respectively. In addition, we obtained the root mean square (rms) values of 4.06 cm, 3.90 cm, and 3.23 cm in the satellite coordinate components relative to the known coordinates.

• 대한공간정보학회지
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• 제18권4호
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• pp.31-39
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• 2010

이 연구에서는 측지 측량 분야의 GPS 사용자들이 해외 기관에서 제공하는 온라인 자료처리 서비스를 이용해 측점의 정밀좌표를 손쉽게 획득할 수 있도록 여러 기관에서 운영 중인 온라인 자료처리 서비스 간의 성능을 비교하였다. 온라인 GPS 자료처리 서비스 간의 성능비교를 위해 APPS, CSRS-PPP, AUSPOS 그리고 OPUS를 이용해 국내외 상시관측소 7곳의 좌표를 산출하였고, IERS와 국토지리정보원에서 제공하는 고시좌표와 비교하여 정확도를 분석하였다. 국외 상시관측소를 이용한 분석에서는 평균 9.3mm의 수평좌표 정확도에서 APPS, AUSPOS, OPUS, CSRS-PPP의 순서로 정확도가 높은 것으로 나타냈다. 국내 관측소의 경우 국외 분석사례와 유사하게 AUSPOS, APPS, OPUS, CSRS-PPP 순서로 높은 정확도를 보인 반면, 수평좌표 정확도는 평균 37.6mm를 기록하였다. 또한 국내 결과는 국외 결과보다 평균 3cm 큰 3차원 좌표오차를 보였으며, 북쪽 방향으로 약 3cm의 편의가 존재함을 확인하였다.

• The Korean Journal of Physiology and Pharmacology
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• 제18권2호
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• pp.155-161
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• 2014

Overexpression of amyloid precursor protein with the Swedish mutation causes abnormal hyperphosphorylation of the microtubule-associated protein tau. Hyperphosphorylated isoforms of tau are major components of neurofibrillary tangles, which are histopathological hallmarks of Alzheimer's disease. Protein phosphatase 2A (PP2A), a major tau protein phosphatase, consists of a structural A subunit, catalytic C subunit, and a variety of regulatory B subunits. The B subunits have been reported to modulate function of the PP2A holoenzyme by regulating substrate binding, enzyme activity, and subcellular localization. In the current study, we characterized regulatory B subunit-specific regulation of tau protein phosphorylation. We showed that the PP2A B subunit PPP2R2A mediated dephosphorylation of tau protein at Ser-199, Ser-202/Thr-205, Thr-231, Ser-262, and Ser-422. Down-regulation of PPP2R5D expression decreased tau phosphorylation at Ser-202/Thr-205, Thr-231, and Ser-422, which indicates activation of the tau kinase glycogen synthase kinase 3 beta ($GSK3{\beta}$) by PP2A with PPP2R5D subunit. The level of activating phosphorylation of the $GSK3{\beta}$ kinase Akt at Thr-308 and Ser-473 were both increased by PPP2R5D knockdown. We also characterized B subunit-specific phosphorylation sites in tau using mass spectrometric analysis. Liquid chromatography-mass spectrometry revealed that the phosphorylation status of the tau protein may be affected by PP2A, depending on the specific B subunits. These studies further our understanding of the function of various B subunits in mediating site-specific regulation of tau protein phosphorylation.

• Archives of Pharmacal Research
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• 제16권3호
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• pp.209-212
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• 1993

The anti-coagulant activity of ilexoside D isolated from the roots of ilex pubescens Hook. et Am. was investigated in in vivo models of blood coagulation in rats. On oral administration, ilexoside D prolonged the bleeding time and the whole blood recalcified clotting time, but not the plasma recalcified clotting time. In vitor, ilexoside D did not affect the recalciffed clotting times of whole blood, platelet-rich plasma(PRP), and platelet-poor plasma(PPP), while in the presence of tissue factor the compound prologed the reduced proth-rombin times of whole blood, PRP and PPP in the dose-dependent manner. These results indicate that ilexoside D has the anit-tissue factor activity as well as the antithromobotic activity.

• 한국기계가공학회지
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• 제15권6호
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• pp.83-88
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• 2016

Over the last five years, 568 people have died while hiking according to 2015 statistics from the public safety ministry. Among those deaths, approximately 33% were due to loss of footing or falling. In this respect, the highly advanced functions of hiking boots should be considered to prevent these unfortunate accidents. For example, by utilizing the Internet of Things (IoT) and Information and Communications Technology (ICT), hiking boots equipped with a Global Positioning System (GPS) or vital signs monitoring systems should be considered. In addition, many challenges remain for the production of 3D printed hiking boots, because the functions of hiking boots are variable, which is important when handling changing terrains and situations. The design of customized hiking boots was introduced in this paper, and 3D printing applications for midsoles using a Porous Polymer Printing (PPP) method was also suggested to verify the possibility of manufacturing hiking boots.

• Biomolecules & Therapeutics
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• 제24권6호
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• pp.595-603
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• 2016

(E)-3-Phenyl-1-(2-pyrrolyl)-2-propenone (PPP) is a pyrrole derivative of chalcone, in which the B-ring of chalcone linked to ${\beta}$-carbon is replaced by pyrrole group. While pyrrole has been studied for possible Src inhibition activity, chalcone, especially the substituents on the B-ring, has shown pharmaceutical, anti-inflammatory, and anti-oxidant properties via inhibition of NF-${\kappa}B$ activity. Our study is aimed to investigate whether this novel synthetic compound retains or enhances the pharmaceutically beneficial activities from the both structures. For this purpose, inflammatory responses of lipopolysaccharide (LPS)-treated RAW264.7 cells were analyzed. Nitric oxide (NO) production, inducible NO synthase (iNOS) and tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) mRNA expression, and the intracellular inflammatory signaling cascade were measured. Interestingly, PPP strongly inhibited NO release in a dose-dependent manner. To further investigate this anti-inflammatory activity, we identified molecular pathways by immunoblot analyses of nuclear fractions and whole cell lysates prepared from LPS-stimulated RAW264.7 cells with or without PPP pretreatment. The nuclear levels of p50, c-Jun, and c-Fos were significantly inhibited when cells were exposed to PPP. Moreover, according to the luciferase reporter gene assay after cotransfection with either TRIF or MyD88 in HEK293 cells, NF-${\kappa}B$-mediated luciferase activity dose-dependently diminished. Additionally, it was confirmed that PPP dampens the upstream signaling cascade of NF-${\kappa}B$ and AP-1 activation. Thus, PPP inhibited Syk, Src, and TAK1 activities induced by LPS or induced by overexpression of these genes. Therefore, our results suggest that PPP displays anti-inflammatory activity via inhibition of Syk, Src, and TAK1 activity, which may be developed as a novel anti-inflammatory drug.

• 한국정밀공학회지
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• 제33권5호
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• pp.333-339
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• 2016

In this paper, a fundamental experiment regarding the formation of porous 3D structures for personal safety products using 3D PPP (Porous Polymer Printing) was introduced for the first time. The filament was manufactured by mixing PP (Polypropylene) and CBA (Chemical Blowing Agent) with polymer extruder, and the diameter of the filament was approximately 1.75mm. The proposed 3D PPP method, combined with the conventional FDM (Fused Deposition Modeling) procedure, was influenced by process parameters, such as the nozzle temperature, printing speed and CBA density. In order to verify the best processing conditions, the depositing parameters were experimentally investigated for the porous polymer structure. These results provide parameters under which to form a multiple of 3D porous polymer structures, as well as various other 3D structures, and help to improve the mechanical shock absorption for personal safety products.

• 대한화장품학회지
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• 제33권3호
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• pp.159-163
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• 2007

본 연구에서는 O/W 제형 마스카라에서의 레올로지 특성과 함께, 마스카라 내의 수상 폴리머에 따른 발림성과 볼륨과의 상관관계를 살펴보고자 하였다. 마스카라의 레올로지 특성은 최종 마스카라 내용물과 점증 수용액으로 측정하였으며, 수상 점증 폴리머는 hydroxyethylcellulose(HC), carboxymethylcellulose(CMC), hectorite, sodium magnesium silicate(SMS), hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer(HS), polyacrylate 13/polyisobutene/polysorbate 20(PPP)를 사용하였다. 실험결과 2.0 wt%의 수용액 점도에서 아크릴계 점증 폴리머인 HS와 PPP가 가장 높은 부착력을 가졌으며, 이는 마스카라의 품질 특성 중 볼륨과 밀접한 관계를 가졌다. 또한 HC와 SMS, HS를 0.2 wt% 함유한 마스카라를 oscillation stress가 $1.0{\sim}1,000s^{-1}$의 범위에서 저장계수를 측정한 결과 높은 진동힘 구간인 $100{\sim}1,000s^{-1}$ 구간에서 SMS의 저장계수가 가장 낮게 측정되었고, 이는 마스카라 특성 중 발림성 항목과 밀접한 관계를 가진다. 이는 O/W제형의 마스카라에서 수상 점증제의 구조적인 특성이 마스카라 물성에 크게 영향을 주어 최종적으로 볼륨과 발림성 등의 사용감에도 큰 영향을 주고 있음으로 해석할 수 있다.