• Journal of Korea Foundry Society
• /
• v.35 no.4
• /
• pp.88-98
• /
• 2015

The effects of quenching and tempering temperatures on the tensile, impact and corrosion properties of A487 alloy cast with different C contents of 0.16, 0.19 to 0.23 wt.% were examined. The impact tests were conducted at $25^{\circ}C$ and $-60^{\circ}C$ and the immersion test was performed using 3.5% NaCl solution for 14 days. The quenching temperature affected the mechanical properties of A487 alloy cast, while the magnitude of change varied depending on the C content. The increase in tempering temperature showed the typical trend of decreasing tensile strength and increasing impact properties. The change in quenching and tempering temperature in this study did not affect the corrosion properties of A487 alloy significantly. The change in mechanical and corrosion properties of A487 with different C contents was discussed based on the microstructural and fractographic observation.

• Applied Biological Chemistry
• /
• v.40 no.2
• /
• pp.157-162
• /
• 1997

A novel compound, named YH-487, was synthesized by attaching the thiol and aminothiazole residue to $C_3$ and $C_7$ position of 7-aminocephalosporanic acid (7-ACA). The therapeutic efficacy on infected animals, pharmacokinetics in vivo and the effect on intestinal microflora of YH-487 were examined. The pharmacokinetics of YH-487 were similar to that of cefotaxime, a third generation ${\beta}-lactam$ antibiotics, in rat. Upon in vivo administration, YH-487 was predominantly delivered to kidney, and mostly excreted through kidney without making any metabolites. The therapeutic efficacy of YH-487 to animal infected with E. coli was three times and twenty times higher than that of cefotaxime and cefotiam, respectively, In vivo administration of YH-487 to Sprague-Dawley rats significantly decreased the population of intestinal gram negative species such as Enterobacteria and Barteroides. However, no significant changes were obseved in gram positive species such as Lactobacillus, Bifidobacteria and Staphylococcus. In addition, continuous administration of YH-487 did not increase the possibility to induce resistant strains in intestinal microflora.

• Journal of Korea Foundry Society
• /
• v.35 no.3
• /
• pp.45-52
• /
• 2015

The effect of different C and Cr/Mo contents, which were varied within the range allowed in the relevant specification, on the mechanical and corrosion properties of A487 alloy cast steel were examined. The increase in strength level with increasing C content and the decrease in strength along with the increase in tensile elongation with decreasing Cr/Mo contents were observed in A487 alloys with different C and Cr/Mo contents. At room temperature, the decrease in Cr/Mo content was beneficial in improving the impact properties of A487 alloy, with no notable difference in absorbed energy with varying C content. The impact properties of A487 alloy at $-60^{\circ}C$, on the other hand, greatly improved with the increase in C and the decrease in Cr/Mo contents. The corrosion behavior of A487 alloys in 3.5% NaCl solution did not show any meaningful change with different C and Cr/Mo contents.

• Applied Biological Chemistry
• /
• v.40 no.1
• /
• pp.23-29
• /
• 1997

To develop novel cephem antibiotics, We have synthesized a new compound, named YH-487, by attaching the thiol and aminothiazole residue to $C_3$ and $C_7$ position of 7-ACA, respectively. Several characteristics such as structure, antibiotic spectrum, action mechanism, stability against ${\beta}-lactamase$ and synergistic effect were investigated. Anti-bactericidal activity of YH-487 against gram-positive and gram-negative bacteria were superior to that of the other cephem antibiotics. We have examined the action mechanisms of YH-487 using penicillin binding protein (PBP) assay, and found that the bactericidal activity was obtained by inhibiting PBP-1A, PBP-1B and PBP-3. YH-487 showed synergistic effect with gentamicin, tobramycin, and amikacin against Pseudomonas aeruginosa. In addition, YH-487 was effective against Enterobacter cloacae in combination with amikacin. Based on the above observations, YH-487 was classified as a novel third-generation ${\beta}-lactam$ antibiotics.

• Bulletin of the Korean Chemical Society
• /
• v.20 no.4
• /
• pp.487-490
• /
• 1999

• Archives of Plastic Surgery
• /
• v.43 no.6
• /
• pp.487-490
• /
• 2016

• Bulletin of the Korean Chemical Society
• /
• v.7 no.6
• /
• pp.487-488
• /
• 1986

• Bulletin of the Korean Chemical Society
• /
• v.8 no.6
• /
• pp.487-488
• /
• 1987

• Journal of the Korean Mathematical Society
• /
• v.44 no.2
• /
• pp.487-498
• /
• 2007

In this paper, we obtain important combinatorial identities of generalized harmonic numbers using symmetric polynomials. We also obtain the matrix representation for the generalized harmonic numbers whose inverse matrix can be computed recursively.

• Proceedings of the Korea Water Resources Association Conference
• /
• 2005.09a
• /
• pp.487-487
• /
• 2005