• Journal of Power Electronics
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• v.16 no.6
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• pp.2212-2220
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• 2016

Based on the conventional PID algorithm and the adaptive PID (AD-PID) algorithm, a separate sampling adaptive PID (SSA-PID) algorithm is proposed to improve the transient response of digitally controlled DC-DC converters. The SSA-PID algorithm, which can be divided into an oversampled adaptive P (AD-P) control and an adaptive ID (AD-ID) control, adopts a higher sampling frequency for AD-P control and a conventional sampling frequency for AD-ID control. In addition, it can also adaptively adjust the PID parameters (i.e. $K_p$, $K_i$ and $K_d$) based on the system state. Simulation results show that the proposed algorithm has better line transient and load transient responses than the conventional PID and AD-PID algorithms. Compared with the conventional PID and AD-PID algorithms, the experimental results based on a FPGA indicate that the recovery time of the SSA-PID algorithm is reduced by 80% and 67% separately, and that overshoot is decreased by 33% and 12% for a 700mA load step. Moreover, the SSA-PID algorithm can achieve zero overshoot during startup.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• v.9 no.2
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• pp.1023-1026
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• 2005

본 논문에서는 SDR(Software Defined Radio) 시스템을 위한 Digital IF(Intermediate Frequency) Up/Down 변환기를 설계하고 성능을 평가하였다. 설계한 시스템은 AD 변환부, DA 변환부 및 Up-Down conversion 기능을 수행하는 FPGA로 구성된다. AD 변환부는 Analog Device 사의 AD6645를 사용하였으며, DA 변환부는 Analog Device 사의 AD9775를 사용하였다. Up-Down conversion 기능을 수행하는 FPGA부는 샘플된 IF 입력을 혼합기와 NCO에 의해 기저대역(DC)으로 다운 시키는 역할을 하며, 14bit의 기저대역(DC) 신호를 혼합기와 NCO에 의해 IF 출력으로 올려주는 역할을 한다. 이러한 설계는 기존의 아날로그 헤테로다인 방식에 비하여 높은 유연성 및 우수한 성능 향상을 보여준다.

• Journal of the Institute of Electronics and Information Engineers
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• v.51 no.11
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• pp.211-220
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• 2014

In this paper a full FPGA-based and compact motor-control system is shown that makes it easy to control the motor and analyze the result data in real time with embedding not only a DC motor controller but also a TFT LCD interface in a single FPGA. Both a PID speed control module for a DC motor and a monitoring module for plotting real time graphs on to a TFT LCD are designed in a single FPGA, and the system validity is shown through simulation and experimental results. The FPGA used is xc3s400 and the entire system is designed by using the AD (Altium Designer). A PWM motor drive system is constructed by using MOSFETs for a DC motor 4-quadrant operations.

• Journal of the Korean Society of Food Science and Nutrition
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• v.37 no.12
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• pp.1554-1559
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• 2008

This study was performed to investigate the hypoglycemic effect of single and repeated oral administration of medicinal herbal mixture (AD) in streptozotocin (STZ) induced diabetic rats. Angelica decursiva, Lycium chinense and Adenophora triphylla var. japonica Hara were selected by oral glucose tolerance test (OGTT) and mixed for AD mixture. In an oral glucose tolerance test, the AD inhibited the increase in blood glucose levels at 1 hr and 2 hr and decreased incremental glycemic response area under the curve. In a single administration of AD1 (100 mg/kg) and AD2 (500 mg/kg), significant reductions by 5.3% and 12.3% were observed in fasting blood glucose level for 4 hours. During the 1 month of the experimental period, AD1 and AD2 was given to the STZ induced diabetic rats. At 4th week, the fasting blood glucose levels of AD1 and AD2 caused a fall of 25.5% and 37.9%, respectively. In addition, the body weights were decreased by 7.7% (AD1) and 1.7% (AD2), respectively, compared with diabetic control (DC, decreasing of 10.2%). This study suggests that AD could be potentially useful for fasting and post-prandial hyperglycemia treatment and all these effects concluded to the use of this plant extract to manage diabetes mellitus.

• IMMUNE NETWORK
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• v.3 no.4
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• pp.295-301
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• 2003

Background: Carcinoembryonic antigen (CEA) is well-known soluble tumor marker frequently detectable in peripheral blood of carcinoma patients and considered as good target for antigen-specific immunotherapy. In this study, we used a replication-deficient adenovirus containing CEA to study CTL induction in vitro after adenovirus-mediated gene transfer into DC. Methods: DC were obtained from mouse bone marrow and cultured with IL-4 and GM-CSF. For measuring CTL activity, splenocytes were harvested from the mice, which were immunized with DC that had been infected AdV-CEA or pulsed with CEA peptide. Untreated DC was used as a control. Splenocytes were re-stimulated in vitro with DC pulsed with CEA peptide for 7 days and CTL activity with CEA peptide-pulsed EL-4 cells were assessed in a standard $^{51}Cr$-release assay. The frequencies of antigen-specific cytokine-secreting T cell were determined with $mIFN-{\gamma}$ELISPOT. Results: DC infected with recombinant adenovirus expressing CEA induced CEA-specific CTL responses in vivo. Splenocyte induced from mice immunized with AdV-CEA-infected DC increase in the number of $IFN-{\gamma}$ secreting T cells compared with those from mice immunized with CEA peptide-pulsed DC. Conclusion: These results suggested that DC infected with recombinant adenovirus has advantages over other forms of vaccination and could provide an alternative approach vaccination therapies.

• BMB Reports
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• v.39 no.6
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• pp.730-736
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• 2006

To evaluated the effect of recombinant adenovirus Ad-ODC-AdoMetDCas which can simultaneously express both antisense ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AdoMetDC) on cell cycle distribution in colorectal cancer cell and investigated underlying regulatory responses, human colorectal cancer cells HT-29 were cultured in RPMI 1640 medium and infected with Ad-ODC-AdoMetDCas. Cell cycle progression was detected by flow cytometry analysis. The expression levels of cell cycle regulated proteins were measured by Western blot analysis. The mRNA level of cyclin D1 was measured by RT-PCR. And a luciferase reporter plasmid of cyclin D1 promoter was constructed to observe the effect of Ad-ODC-AdoMetDCas on cyclin D1 promoter activity. The results showed that recombinant adenovirus Ad-ODC-AdoMetDCas significantly induced $G_1$ arrest, decreased levels of cyclin D1 protein and mRNA and suppressed the promoter activity. Ad-ODC-AdoMetDCas also inhibited nuclear translocation of $\beta$-catenin. In conclusion, downregulation of ODC and AdoMetDC mediated by Ad-ODC-AdoMetDCas transfection induces $G_1$ arrest in HT-29 cells and the arrest was associated with suppression of cyclin D1 expression and inhibition of $\beta$-catenin nuclear translocation. As a new anticancer reagent, the recombinant adenovirus Ad-ODC-AdoMetDCas holds promising hope for the therapy of colorectal cancers.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.41 no.6
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• pp.67-74
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• 2004

Differently from an existing analog control, because the digital control includes microprocessor basically, the digital control is enable to monitor internal parameters of DC-DC converter and to control output voltage remotely by communicating with a Windows based PC. These things are impossible in an analog control and there are more advantages in a digital control than an analog control. In this paper, with the advantages mentioned above, the feasibility of digital controlled DC-DC converter in low price is proposed. In order to implement these functions, it is used the inexpensive H8/3672 made by Renesas that has built in AD converters and PWM logic generators. The proposed digital controller is applied to a flyback converter that is designed to output DC 5[V] from DC 20∼30[V] and is remotely controlled to make variable outputs from DC 0[V] to 5[V] above in PC. The PWM controller adopts the PD controller in PID. In the last, the response characteristics of a step reference voltage and in a steady state are experimented to verify the feasibility and the usefulness of the proposed flyback converter that is implemented inexpensively.

• Proceedings of the KIPE Conference
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• 2002.07a
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• pp.378-381
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• 2002

This paper describes a novel multilevel ad/dc power converter suitable for the protection of frequent output short-circuit. The output dc power of the proposed converter can be disconnected from the load within several hundred microseconds at the instant of short-circuit fault. The rising time of the dc load voltage is as small as several hundred microseconds, and there is no overshoot of the do voltage because the dc output capacitors keep undischarged state. Analysis and simulations are carried out to investigate the operation and usefulness of the proposed scheme.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.6
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• pp.2447-2451
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• 2014

Human papillomavirus (HPV) is the primary etiologic agent of cervical cancer. Consideration of safety and non human leukocyte antigen restriction, protein vaccine has become the most likely form of HPV therapeutic vaccine, although none have so far been reported as effective. Since tumor cells consistently express the two proteins E6 and E7, most therapeutic vaccines target one or both of them. In this study, we fabricated DC vaccines by transducing replication-defective recombinant adenoviruses expressing E6/E7 fusion gene of HPV-16, to investigate the lethal effects of specific cytotoxic T lymphocytes (CTL) against CaSki cells in vitro. Mouse immature dendritic cells (DC) were generated from bone marrow, and transfected with pAd-E6/E7 to prepare a DC vaccine and to induce specific CTL. The surface expression of CD40, CD68, MHC II and CD11c was assessed by flow cytometry (FCM), and the lethal effects of CTL against CaSki cells were determined by DAPI, FCM and CCK-8 methods. Immature mouse DC was successfully transfected by pAd-E6/E7 in vitro, and the transfecting efficiency was 40%-50%. A DC vaccine was successfully prepared and was used to induce specific CTL. Experimental results showed that the percentage of apoptosis and killing rate of CaSki cells were significantly increased by coculturing with the specific CTL (p <0.05). These results illustrated that a DC vaccine modified by HPV-16 E6/E7 gene can induce apoptosis of CaSki cells by inducing CTL, which may be used as a new strategy for biological treatment of cervical cancer.

• Proceedings of the KIPE Conference
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• 2008.06a
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• pp.49-51
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• 2008

본 논문은 중용량급 전원회로의 구성을 간략화 할 수 있는 절연형 AC-DC 컨버터의 구조와 그 제어 방법을 제안한다. 제안하는 회로의 구조는 병렬 전력 처리를 기반으로 한다. 병렬 모듈의 기능을 각각 AC 입력 전류의 위상을 제어하는 역률개선(PFC) 기능과, 콘덴서에 저장된 에너지를 이용하여 DC 전압을 생성하는 DC-DC 컨버터의 기능으로 분리한다. 병렬 모듈의 최종 출력단을 서로 직렬 연결하여, PFC 모듈이 생성한 전압과 DC-DC 컨버터 모듈이 생성한 전압을 서로 더해서 출력하는 구조이다. 이러한 구조를 통해서 기존의 병렬형 AC-DC 컨버터에 대비하여 반도체 소자의 내압을 감소시킬 수 있고, 최종 DC 전압의 동작응답특성 향상이 가능하다. 회로의 동작모드 분석이 실시되었고, 제어기 구현 방법이 제시되었다. 제안된 구조는 PDP 전원회로에의 응용을 위해서 400W(출력전압-200V, 출력전류-2A)급 실험용 회로를 구현하여 동작검증을 실시하였다.