• Title/Summary/Keyword: ADT

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Multimodal therapy for locally advanced prostate cancer: the roles of radiotherapy, androgen deprivation therapy, and their combination

  • Lee, Sung Uk;Cho, Kwan Ho
    • Radiation Oncology Journal
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    • v.35 no.3
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    • pp.189-197
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    • 2017
  • Locally advanced prostate cancer (LAPC) is defined as histologically proven T3-4 prostatic adenocarcinoma. In this review, we define the individual roles of radiotherapy (RT), short-term (ST-) and long-term (LT-) androgen deprivation therapy (ADT), and their combination in multimodal therapy for LAPC. Despite limitations in comparing the clinical outcomes among published papers, in the present study, a trend of 10-year clinical outcomes was roughly estimated by calculating the average rates weighted by the cohort number. With RT alone, the following rates were estimated: 87% biochemical failure, 34% local failure (LF), 48% distant metastasis (DM), 38% overall survival (OS), and 27% disease-specific mortality (DSM). Those associated with ADT alone were 74% BCF, 54% OS, and 25% DSM, which appeared to be better than those of RT alone. The addition of ADT to RT produced a notable local and systemic effect, regardless of ST- or LT-ADT. The LF rate decreased from 34% with RT alone to 21% with ST-ADT and further to 15% with LT-ADT. The DM and DSM rates also showed a similar trend among RT alone, RT+ST-ADT, and RT+LT-ADT. The combination of RT+LT-ADT resulted in the best long-term clinical outcomes, indicating that both RT and ADT are important parts of multimodal therapy.

Control of the Gold Electrode Work Function for High Performance Organic Thin Film Transistors (표면개질된 금 전극의 일함수 조절을 통한 고성능 유기박막 트랜지스터 개발)

  • Park, Yeong Don
    • Applied Chemistry for Engineering
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    • v.23 no.3
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    • pp.289-292
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    • 2012
  • Au electrodes modified with self-assembled monolayers (SAMs) were used to control the work function of source/drain electrodes in triethylsilylethynyl anthradithiophene (TES ADT)-based organic thin film transistors (OTFTs). By using benzothiol (BT) and pentafluorobenzothiol (PFBT) SAMs, the hole injection barrier between Au and the highest occupied molecular orbital (HOMO) of TES ADT was controlled. After a solvent annealing, TES ADT OTFTs with PFBT SAM-treated Au electrodes were found to exhibit high field-effect mobilities of $0.05\;cm^2/Vs$ and on/off current ratios of $10^6$.

Power Conversion Unit for Hybrid Electric Vehicles (하이브리드 전기자동차 구동용 전력변환장치)

  • Lee, Ji-Myoung;Lee, Jae-Yong;Park, Rae-Kwan;Chang, Seo-Geon;Choi, Kyung-Soo
    • Proceedings of the KIPE Conference
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    • 2008.06a
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    • pp.7-11
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    • 2008
  • This paper describes design procedure and control strategy of HDC(High side DC/DC Converter) and MCU(Motor Control Unit) for diesel hybrid electric vehicle. In designing HDC and MCU for HEV high power density and reliability is strongly needed to meet the demand of automotive industry. In order to achieve the high performance of a controller, MPC5554 based control board is developed. An optimized film capacitor and inductor are also developed for high efficiency driving. Skim 63 IGBT module of SEMIKRON for automotive is used for power switching device. The most efficient cooling model for optimal size and reliability were verified by simulation. These procedures are verified by bench or driving test and the results are present in this paper.

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Water Cooled Heatsink Design for Traction Inverter of HEV (하이브리드 차량 구동용 인버터의 수냉 히트싱크 설계)

  • Lee, Ji-Myoung;Park, Rae-Kwan;Choo, Sang-Hyun;Yang, Yi-Woo;Chang, Seo-Geon;Lim, Yong-Soo;Kim, Ki-Eun
    • Proceedings of the KIPE Conference
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    • 2010.07a
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    • pp.556-557
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    • 2010
  • 본 논문은 하이브리드 자동차의 구동모터용 인버터에 적용되는 수랭 히트싱크의 설계 타당을 수치해석을 통해 검증하는 방법을 제시한다. 전력변환장치의 손실 계산, 발열체 모델링, 히트싱크 형상 모델링, 수랭 조건 입력, 히트싱크상의 열적 분포 해석, 유체 거동 시뮬레이션의 과정을 거치며, 본 논문에서는 650Vdc, 150kW급의 시리즈 하이브리드 차량의 구동 모터용 인버터를 예로 그 과정을 설명하고자한다.

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Control System of Traction Motor for a Series Hybrid Electric Truck (직렬형 하이브리드 전기 트럭 구동용 견인전동기 제어 시스템)

  • Lee, Jae-Hyun;Lee, Ji-Myoung;Yang, Yi-Woo;Park, Rae-Kwan;Chang, Seo-Geon;Lee, Jin-Ju;Kim, Sang-Min
    • Proceedings of the KIPE Conference
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    • 2010.07a
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    • pp.432-433
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    • 2010
  • 본 논문에서는 직렬형 디젤 하이브리드 전기 트럭 구동을 위한 견인 전동기 제어 시스템 개발에 대해 소개한다. 높은 출력 밀도를 요구하는 복합형 전기 차량의 특성을 고려하여 매입형 영구자석 동기전동기를 선정하고, 대전류 고효율 시스템 구성을 위해 수랭식 MCU(Motor Control Unit)를 개발 하였다. 또한 빠른 토크 응답 특성과 넓은 영역의 속도 운전을 위한 약자속 제어 기법을 적용하였으며, 전체 시스템 효율을 향상시키기 위해 단위 전류당 최대 토크 제어 기법(MTPA)이 사용 되었다. 개발 된 제어 시스템 및 제어 기법을 실험을 통해 검증 하였다.

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Accelerated Degradation Test of Electrolyte Membrane in PEMFC Stack (고분자 전해질 연료전지 스택에서 전해질막의 열화 가속시험)

  • Jeong, Jaejin;Lee, Sehoon;Lee, Hyeri;Kim, Saehoon;Ahn, Byungki;Ko, Jaijoon;Park, Kwonpil
    • Korean Chemical Engineering Research
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    • v.54 no.1
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    • pp.6-10
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    • 2016
  • Until a recent day, degradation of PEMFC (Proton Exchange Membrane Fuel Cells) has been mainly studied in unit cell. But operation and degradation of real PEMFC going along in stack instead of unit cell. Therefore in this work, ADT (Accelerated Degradation Test) of PEMFC was done in stack and the result from stack's test was compared with that of unit cell. The polymer electrolyte membrane was degraded by repeated electrochemical and mechanical degradation method among several ADT methods. Current densities of MEA at 0.6V decreased in stack and unit cell, 28.4% and 27.8% respectively after ADT for 312 hours. Hydrogen crossover current densities of membrane increased in stack and unit cell, 16.8% and 15.2% respectively after ADT for 312 hours. The result of ADT in stack was similar that of ADT in unit cell, which showed that ADT method of unit cell was available to the stack.

Initial Investigation on Consolidation with Adaptive Dynamic Threshold for ABR Multicast Connections in ATM Networks (비동기 전송모드 망의 점대다중점연결을 위한 적응동적임계치기반 병합알고리즘)

  • Shin, Soung-Wook;Cho, Kwang-Hyun
    • Journal of Institute of Control, Robotics and Systems
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    • v.7 no.11
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    • pp.962-966
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    • 2001
  • The major problem at a branch point for point-to-multipoint available bit rate(ABR) services in asynchronous transfer mode (ATM) networks is how to consolidate backward resource management(BRM) cells from each branch for a multicast connection. In this paper, we propose an efficient feedback consolidation algorithm based on an adaptive dynamic threshold(ADT) to eliminate the consolidation noise and the reduce the consolidation delay. The main idea of the ADT algorithm lies in that each branch point estimates the ABR traffic condition of the network through the virtual queue estimation and the transmission threshold of the queue level in branch points is adaptively controlled according to the estimation. Simulation results show that the proposed ADT algorithm can achieve a faster response in congestion status and a higher link utilization compared with the previous works.

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A Study on Tool for Agent System Develpoment (에이전트 시스템 개발도구에 관한연구)

  • Lee, Gwang-Ro;Park, Sang-Gyu;Jang, Myeong-Uk;Min, Byeong-Ui;Hwang, Seung-Gu
    • The Transactions of the Korea Information Processing Society
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    • v.4 no.2
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    • pp.441-455
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    • 1997
  • An agent system is comsisted of agents that have the following properties: autonomy, scial ability, reactivity, pro-activeness.It provides a good enbironment to an end-user.Therefore, an end-user can feel more natural and comfortable in using a computer system.However, a system develper will have difficulty because he(or she) has to follow the funditons and the speiciffcation which are generally required for an agent system.Moreover, it is hard to ues resoures mutually and share information between agent systems that are solely developed without satisfying the standardization .In this paper, we describe the requirments for and agent development tools(ADT).We also introduce the ADT that is developed to efficiently resolve the problems occurred in develping an agent system.The main properties of the ADT are:ether expert or non-expert can easily intervace an appli-cation to existiong agent systems and effectively manage the resoures that are related to the agent systems.There-fore , one can easily expand agent system and achieve high quality of services with our ADT.

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Characteristics of stormwter runoff from highways with unit traffic volume (고속도로 자동차 통행량에 따른 강우유출수 유출 특성 분석)

  • Choi, Jiyeon;Hong, Jungsun;Kang, Heeman;Kim, Lee-Hyung
    • Journal of Wetlands Research
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    • v.18 no.3
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    • pp.275-281
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    • 2016
  • This study was conducted to analyze the runoff characteristics of the highway depending on the number of vehicles and to provide the installation proposal of an NPS pollution reduction facility. There were a total of 5 monitoring sites used for the study namely, Gyeongbu, Seohaean, Honam and Tongyeoung Dageon highway. Monitoring events started from 2006 until 2015 having a total of 44 storm events. According to monitoring statistics, the average antecedent dry days (ADD) and rainfall was 6.2 days and 19.2 mm, respectively. The Gyeongbu Highway (H-4) was recorded having the highest Average Daily Traffic and Catchment Area (ADT/CA) with $49.4car/day{\cdot}m^2$ while other site were less than $10car/day{\cdot}m^2$. The average concentration of the NPS pollutants generated from monitoring sites were 63.5 mg/L(TSS), 24.9 mg/L(BOD), 3.35 mg/L(TN), 0.63 mg/L(TP) and 298 ug/L(Total Zn). This exhibited lower values in comparison to the remarks of highway related runoff EMC values published in Korea. Moreover, through the results of the correlation analysis between the contaminant concentration and ADT/CA, $R^2$ value of SS showed the highest correlation with 585. Through the correlation equation between ADT/CA and EMC of TSS, when there is 73.7 mg/L of TSS EMC found from a domestic highway, ADT/CA ratio is normally $13car/day{\cdot}m^2$. Therefore, in a case of more than 13 cars passing through a certain area, the area can be considered and present as the point of generation of nonpoint source pollutants. Also, in this study, since it considered a unit area ADT indicated in previous studies, it was determined that it has a high applicability and utilization in generalized units than conventional study which were conventionally done.

An Analysis of Change in Traffic Demand with Coronavirus Disease 2019 (코로나바이러스감염증-19로 인한 교통수요 변화 분석)

  • Lim, Sung Han
    • The Journal of The Korea Institute of Intelligent Transport Systems
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    • v.19 no.5
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    • pp.106-118
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    • 2020
  • This study examined the impact of COVID-19 on traffic demand (Average Daily Traffic : ADT) by analyzing the available data on highway traffic volume and the spread of COVID-19 cases in Korea. This study used the data from 228 permanent traffic counts (PTCs) on highways from January to May of 2019 and 2020 to analyze the change in ADT. The first cases of infection in Korea occurred on January 20, 2020, and the maximum daily number of infections was 909 on February 29. On April 30, 2020, the daily number of infections decreased to four. The ADT decreased by 3.3% due to the impact of COVID-19. Considering that the traffic volume has increased 2.3% annually over the past decade, the actual decrease in ADT due to the COVID-19 is estimated to be 5.6% (3.3% + 2.3%). The ADT for weekends decreased significantly, compared to during the week. An analysis of the changes in ADT according to the road type revealed decreases in the following: urban roads -4.6%, rural roads -3.2%, and recreational roads -0.7%. Urban roads decreased the most, and tourist roads decreased the least.