• Korean Journal of Food Science and Technology
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• v.21 no.1
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• pp.13-16
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• 1989

Attempts were made to fix acetaldehyde on base materials, which were selected from carbohydrates, by freeze drying. More acetaldehyde was fixed, in general, on combined base materials than single base materials, and mannitol+lactose were the best among the combined base materials tested. But the combination of mannitol and maltodextrin appeared to be more economical for the mass production. Loss of acetaldehyde during freeze drying was decreased as the concentration of the combined base material was increased, and it reached minimum at 40% of the base material. As dryer chamber pressure was reduced, loss of acetaldehyde during drying was decreased.

• Journal of Food Hygiene and Safety
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• v.8 no.3
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• pp.157-161
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• 1993

In order to get infonnations on the development of alcohol induced cardiovascular disorders, primary cultured vascular smooth muscle cells (PVSMC) were treated with acetaldehyde, one of the most reactive metabolites of ethanol. Acetaldehyde caused the striking release of lactate dehydrogenase (LDH) from PVSMC and it stimulated the prostaglandin synthesis in the same system. But it didn't induce cyclooxygenase activity. lipoxygenase inhibitors-propyl gallate and nordihydroguaiaretic acid could reverse the effect of acetaldehyde, but dexamethasone, a phospholipase $A_2\;(PIA_2)$ inhibitor and cyclooxygenase inhibitors except indomethacin could not protect the cells from acetaldehyde toxicity. These results indicate that enhanced prostaglandin synthesis by acetaldehyde is not a direct cause of cell death, but secondary effect due to the activation of PIAl and also, the roles of the lipoxygenase metabolites and/or $PIA_2$ activity itself might be more important in the cytotoxicity of acetaldehyde.

• KSBB Journal
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• v.10 no.4
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• pp.370-373
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• 1995

The major by-products in ethanol fermentation by Saccharomyces cerevisiae were glycerol, acetaldehyde, acetic acid, lactic acid, and formic acid. The effects of these by-products on the cell growth and ethanol production were studied. By adding acetaldehyde or acetic acid in the fermentation broth, the cell growth decreased while the ethanol production increased. But glycerol and lactic acid had nearly no effects on the cell growth and the ethanol production. Acetic acid and acetaldehyde inhibited the cell growth by diminishing the growth rate as well as by prolonging the lag phase. The ethanol yield increased with the elevation of concentrations of acetic acid and acetaldehyde in the fermentation broth. The maximum ethanol yield was obtained for $3g/\ell$ acetic acid and $2g/\ell$ acetaldehyde, respectively.

• Journal of the Korean Ceramic Society
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• v.45 no.1
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• pp.43-47
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• 2008

The photocatalyst of $TiO_2$ coated on a fly ash composites (TCF) was prepared from precipitant dropping method to remove the acetaldehyde by photocatalytic reaction. The TCF were characterized by crystal aize, crystal structure and specific surface area. The photodegradation of acetaldehyde has been investigated using a UV-illuminated fixed photocatalytic reactor with TCF catalyst and P-25 catalyst in gas phase. The effect of photodegradation reaction conditions, such as initial concentration of acetaldehyde, concentration of oxidant in mixed gas and the light intensity on the photodegradation of acetaldehyde were investigated. P-25 catalyst showed the highest photodegradation of acetaldehyde and anatase $TiO_2$ coated TCF showed higher decomposition rate than rutile coated TCF. The photodegradation rate of acetaldehyde increased with the decrease of flow rate, initial concentration of acetaldehyde ($C_i$) and water vapor, however, it was increased with the increas of UV light intensity. The optimum conditions were weight of TCF=10 g, flow rate=50 ml/min $C_i$=100 ppm, concentration of oxygen=20%, concentration of water vapor=100 ppm.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.5
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• pp.1210-1214
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• 2008

The purpose of this study is to investigate the effect of water extract from Artemisiae Argi Folium (WAAF) on hepatotoxicity caused by acetaminophen (AAP) and acetaldehyde which are regarded as hepatotoxin. Artemisiae Argi Folium was known to have the antibacterial, immune-enhancing, and anticoagulative properties. In Korean Medicine, Artemisiae Argi Folium is supposed to be related with 'liver meridian' according to traditional medical theory. AAP and acetaldehyde reduce the intracellular production of hydrogen peroxide ($H_2O_2$) and nitric oxide (NO) production of human hepatocyte HepG2. The intracellular production of hydrogen peroxide ($H_2O_2$) was measured by dihydrorhodamine 123 (DHR) assay. NO production was measured with Griess test. WAAF increased the production of $H_2O_2$ and NO reduced by AAP and acetaldehyde in HepG2 cells. Therefore, It could be suggested that WAAF has the hepatoprotective activity against AAP and acetaldehyde.

• Journal of Ginseng Research
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• v.13 no.1
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• pp.5-7
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• 1989

The objective of this study was to investigate the preventive effect of ginseng on acetaldehyde-induced acute toxicity in mice . Compared to the control group, treatment with acetaldehyde inhibited the hepatic cytosolic xanthine oxidise activity with increase in dose. The inhibition of enzyme activity was not changed after dialysis. Pretreatment with ginseng butanol fraction prevented the inhibition of enzyme activity by acetaldehyde. In conjunction with the our previous results (Yakhak Hoeji, 29, 18 (1985)), these results suggest that the most likely mechanism for the observed preventive effects of ginseng against the acetaldehyde-induced acute toxicity may be the decrease hepatic acetaldehyde level.

• Journal of the Korean Society of Food Science and Nutrition
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• v.23 no.2
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• pp.187-191
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• 1994

The present stduy was undertaken to investigate the possible effect of Puffer fish skin extract (Pf) on the heptic acetaldehyde metabolism . It was obsrved that PF markedly decreased the acetaldehyde levels in blood and liver. The activity of mitochondrial aldehyde dehydrogenase (Ald DH) increased by induction of acute intoxicatiion of alcohol (5 g/kg) was further increased through pretreatment with PF for 2 weeks. When PF was given to rat fed with 25% alcohol solution instead of water for 6 weeks. the activity of Ald DH in mitochondrial fraction decreased to about 28% compared with sucrose-treated group. But after pretreatemnt of PF, the activity was restored to the normal level. By the treatment with disulfiram (300 mg/kg, once a day for 3days) was restored to the control after the pretreatment with PF. And also mitochondrial Ald DH activity in vitro was not changed. All these observations suggest that reduction of acetaldehyde levels are partly due to increase activity of mitochondrial Ald DH. Therefore, the recovery from intoxication of acetaldehyde may be enhanced by treatment with PF.

• YAKHAK HOEJI
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• v.31 no.6
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• pp.399-401
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• 1987

A gas chromatographic utilizing procedure headspace gas analysis is performed to study effect of malotilate on levels of ethanol and its metabolite acetaldehyde in a blood sample from the rat. The concentrations of ethanol and acetaldehyde were determined simultaneously at 1, 3, and 6h after ethanol administration. Our results would suggest the malotilate could promote clearances of ethanol and acetaldehyde in blood, and could accelerate it, especially, in $CCl_4$ pretreated rats.

• Preventive Nutrition and Food Science
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• v.4 no.3
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• pp.209-214
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• 1999

In this study, the effectof ethanol and acetaldehyde on DNA binding activities of NF-$textsc{k}$B and AP-1 were evaluated in C6 rat glial cells. Both NF-$textsc{k}$B and AP-1 are important transcription factors for the expression of various cytokines in glial cells. Our data showed that neither ethanol nor acetaldehyde induced conspicuous cell death of C6 cells at clinically realistic concentrations. When the DNA binding activities of nuclear NF-$textsc{k}$B and AP-1 were estimated using electrophoretic mobility shift assay (EMSA), ethanol(0.3%) or acetaldehyde(1mM) induced transient activation of these transcription factors, which attained peak levels at 4~8 hours and declined to basal levels at 12 hours after treatement . The supershift analysis showed that the increased activities of NF-$textsc{k}$B in ethanol/acetaldehyde-treated C6 cells were due to the preferential induction of p65/p50 heterodimer complex. The DNA binding activities of these transcriptional factors decreased below basal levels when cells were cultured with either ethanol or acetaldehyde for 24 hours, and showed the inhibitory effect of chronic ehtanol /acetaldehyde treatment on the activities of these transsriptional factors. Our data indicate that either ethanol or acetaldehyde can induce functional changes of glial cells throught bi-directional modulation of NF-$textsc{k}$B and AP-1 DNA binding activities.

• Journal of Korean Society for Atmospheric Environment
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• v.16 no.4
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• pp.409-414
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• 2000

Catalytic combustion of acetaldehyde has been investigated as a representative of unpleasant odor by its reaction with metal-phthalocyanines(PC). The experiment was conducted at the reaction temperature of 200~41$0^{\circ}C$ and the concentratio of acetaldehyde in air at the range of 0.07~0.94 mole% The pretreated metal-PC has been characterized by UV-VIS and XRD analysis. According to this study catalytic activity of metal -PC was improved by air pretreatment at 45$0^{\circ}C$ for 1hr. Under this pretreatment condition Co-PC and Cu($\alpha$)-PC were destroyed and new metal oxides were formed such as Co3O4 and CuO respectively. However Zn-PC retained its basic structure even afte air pretreatment. The order of catalytic activity on acetaldehyde combustion was summarized as follows : Zn-PC$\alpha$)-PC. It was found that the complete combustin of acetaldehyde with Cu($\alpha$)-PC was accomplished at its concentrations below 0.2mole% (32$0^{\circ}C$) and 0.6 mole%(35$0^{\circ}C$) in air.