• Title/Summary/Keyword: Acy-Cpa

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Screening of Microorganisms Having ACAT Inhibitor Activity from Soil and Characterization of AI-3, ACAT Inhibitor Produced by Streptomyces sp. A-3 (토양으로부터 ACAT 저해활성을 나타내는 미생물의 탐색과 방선균이 생산하는 ACAT 저해물질, AI-3의 특성)

  • 정태숙;김성욱;이항우;손광희;권용욱;최명언;복성해
    • Microbiology and Biotechnology Letters
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    • v.21 no.6
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    • pp.600-608
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    • 1993

  • About 1, 300 strains isolated from soil were evaluated for acyl-CoA:cholesterol acyltransferase (ACAT) inhibition activity. About 4.0% of actinomycetes and 3.6% of fungi showed greater than 50% inhibition activity, respectively. However, none of the isolated bacteria exhibited inhibition activity more than 50%. Among them, one Streptomyces sp. A-3 showed a higher ACAT inhibition activity in culture broth. Isolation of the ACAT inhibitor (AI-3) was achieved by Amberlite XAD-7 column, silica-gel column, Sephadex LH-20 gel-filtration and reverse phase HPLC.

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