• 생물환경조절학회지
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• 제29권2호
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• pp.202-208
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• 2020

본 연구는 Agastache 속 여러 종에서 국내 자생지 환경요건에 적합하면서 생육 및 기능성 물질 함량면에서 가장 최적의 종을 선정하고자 하였다. 첫째, 11종의 배초향(Agastache)속 종자를 구입하여 미국 농무성(USDA) 식물 내한성 지도(plant hardiness zone map) 및 국내 식물 내한성 지도를 참고하여 11종에서 생육 및 기능성 분석을 할 5종을 선정하였다. 둘째, 배초향(Agastache) 속 5개 품종인 A. cana, A. foeniculum, A. rugosa 'Spike Blue', A. rugosa 'Spike Snow', A. rupestris에 대해 초장, 엽장, 엽폭, 엽면적, 엽수, SPAD, 지상부 생체중 및 건물중, 지하부 생체중 및 건물중 등의 생육 분석을 실시하였다. 생육 분석 결과, A. rugosa SB 및 A. rugosa SS 종에서 전체적으로 균형 있게 높은 수치를 나타냄을 알 수 있어, 생육 부문에서는 A. rugosa 계통의 품종이 다른 품종에 비해서 유리하다고 볼 수 있다. 셋째, rosmarinic acid, tilianin, acacetin 성분에 대해 단위 중량당 함량 및 식물체 1중당 함량 등의 기능성물질 함량 분석을 실시하였다. 기능성 물질 분석 결과, A. rugosa 계통 종에서 기능성 물질 및 항산화물질 함량이 유의적으로 높았으며, 이는 생육 결과값과 정비례적인 연계성이 크다고 보여진다. 따라서, 배초향(Agastache)속 종에 대한 생육과 기능성 부분을 종합적으로 고려할 때, A. rugosa SS 및 A. rugosa SB 등 A. rugosa 계통이 가장 최적의 고부가가치 작물로 적합할 것이라고 판단된다.

• Archives of Pharmacal Research
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• 제27권3호
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• pp.295-299
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• 2004

The antifungal activities of the essential oil from Agastache rugosa and its main component, estragole, combined with ketoconazole, one of the azole antibiotics commonly used to treat infections caused by Trichophyton species, were evaluated in this study. The combined effects were measured by the checkerboard microtiter and the disk diffusion tests, against T. erinacei, T. mentagrophytes, T. rubrum, T. schoenleinii and T. soudanense. Susceptibility of the five Trichophyton species to the oil alone, or ketoconazole alone, differed distinctly. The fractional inhibitory concentration indices (FICI) of ketoconazole combined with estragole or A. rugosa essential oil, against the tested Trichophyton species, were between 0.05 and 0.27, indicating synergistic effects. These drug combinations exhibited the most significant synergism against T. mentagrophytes, with FICIs of 0.05 and 0.09 for estragole and the essential oil fraction from A. rugosa, respectively. Isobolograms based on the data from checkerboard titer tests also indicated significant synergism between ketoconazole and the Agastache oil fraction or estragole, against the Trichophyton species evaluated. Trichophyton susceptibility to ketoconazole was significantly improved by combination with the Agastache rugosa oil fraction or its main component, estragole.

• 생약학회지
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• 제19권2호
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• pp.97-98
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• 1988

A triterpene was isolated from the roots of Agastache rugosa(Labiatae) and identified as 3-O-acetyl oleanolic acid.

• 생약학회지
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• 제18권1호
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• pp.50-53
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• 1987

Two triterpenes were isolated from the root of Agastache rugosa (Labiatae). Compound I, mp $238{\sim}240^{\circ}$, was identified as erythrodiol-3-O-acetate and Compound II, mp $223{\sim}225^{\circ}$, as 3-O-acetyl oleanolic aldehyde.

• 한국식생활문화학회지
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• 제36권3호
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• pp.317-324
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• 2021

This study was carried out to investigate the flavoral essential oil components in the stems of Agastache rugosa. These components were analyzed using gas chromatography-mass selective detector (GC-MSD). The stems of Agastache rugosa were contained alcohols, aldehydes, ketones, fatty acid esters, and terpenoids. The peak area (%) of estragole was highest among its oil components and the next were pulegone and menthone. The terpenoid alcohols found were 1-octen-3-ol, chavicol, spatulenol, 3-hexen-1-ol, 2-cyclohexen-1-ol, methyl eugenol, and octaethyllene glycol. The stems also contained ketones such as pulegone, menthone, cis-isopulegone, 2-cyclohexene-1-one, 3-octanone, 1-cyclohexanone, isoindole-1-one, t-ionone, inden-2-one, as well as the aldehydes of 4-methoxycinnam and benzaldehyde. The following esters were also detected 1-isopulegone-3-yl acetate, caryophyllene oxide, acetate and benzendicarboxylic acid ester. The terpenoids in the stems were identified as caryophyllene, limonene, cyclohexasiloxane-D, germacrene-D, anethole, cadinene, muurolene, and bourbonene. Overall Agastache rugosa contained several functional oil components including phenylpropanoids and terpenoids as flavoral essential oil components for natural aromatherapy.

• 한국환경복원기술학회지
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• 제24권5호
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• pp.15-23
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• 2021

This study was carried out to suggest an appropriate plant combination by evaluating the growth of flowering ground-cover plants planted with Festuca glauca 'Eljiah Blue' on the roof-top environment. As for the plant materials, Allium senescens and Chrysanthemum coreanum which are shorter than Festuca glauca 'Eljiah Blue' and Sedum takesimense and Agastache rugosa which are taller than Festuca glauca 'Eljiah Blue' were selected. Festuca glauca 'Eljiah Blue' was planted on Conrol, and Festuca glauca 'Eljiah Blue' with Allium senescens (T1), Festuca glauca 'Eljiah Blue' with Sedum takesimense (T2), Festuca glauca 'Eljiah Blue' with Agastache rugosa(T3), and Festuca glauca 'Eljiah Blue' with Chrysanthemum coreanum (T4) were planted in each experimental plot. Plant height and covering rate were measured to evaluate the growth of Festuca glauca 'Eljiah Blue'. Also, relative growth rate (RGR) of plant height, RGR of plant width, and mortality rate of the flowering ground-cover plants were estimated. Plant height and cover rate of Festuca glauca 'Eljiah Blue' was greatest in T3. RGR of plant height was greater in the order of Agastache rugosa, Allium senescens, Chrysanthemum coreanum, and Sedum takesimense. In particular, RGR of plant width was also greatest for Agastache rugosa. Mortality rates of Agastache rugosa and Allium senescens were lowest at 11%. Therefore, based on good growth of Festuca glauca 'Eljiah Blue' planted with Agastache rugosa, these results were suggested as a desirable combination of plant species for rooftop gardening.

• 한국미생물·생명공학회지
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• 제33권2호
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• pp.142-147
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• 2005

The objective of this study was to develop a new potent antibacterial compound against bovine pneumoniae bacteria from medicinal plants or herbs. Among 65 kinds of medicinal plants and herbs, ethanol extracts of Citrus unishiu showed the highest solid yield of $54\%$. However, ethanal extracts from Agastache rugosa had the highest antibacterial activities against bovine pneumoniae bacteria, Mannheimia haemolytica A and Haemophilus somnus (size of clear zone: 16.0 mm and 10.0 mm, respectively). The antibacterial compound was also maximally extracted when the powder of A. rugosa was treated with $70\%$ ethanol at $45^{\circ}C$ for 12 hours.

• 한국자원식물학회지
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• 제22권6호
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• pp.498-505
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• 2009

The plant Agastache rugosa Kuntze has various physiological and pharmacological activities. Especially, it has been regarded as a valuable source for the treatment of anti-inflammatory and oxidative stress-induced disorders. However, little has been known about the functional role of it on oxidative damage in mammalian cells by ROS. In this study, we investigated the DPPH radical, hydroxyl radical, hydrogen peroxide and intracellular ROS scavenging capacity, and $Fe^{2+}$ chelating activity of the extracts from Agastache rugosa. In addition, we evaluated whether the extract can be capable of reducing $H_2O_2$-induced DNA and cell damage in NIH 3T3 cells. These extracts showed a dose-dependent free radical scavenging capacity and a protective effect on DNA damage and the lipid peroxidation causing the cell damage by $H_2O_2$. Therefore, these results suggest that Agastache rugosa is useful as a herbal medicine for the chemoprevention against oxidative carcinogenesis.

• Archives of Pharmacal Research
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• 제22권1호
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• pp.75-77
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• 1999

Two diterpenoid compounds, agastanol (1) and agastaquinone (2), were isolated from the roots of Agastache rugosa (Labiatae). Compound 1 and 2 showed significant inhibitory effects against human immunodeficiency virus type 1 (HIV-1) protease activity with $IC_{50}$ values of 360 and $87{\mu}M$, respectively.

• 한국식품위생안전성학회지
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• 제10권3호
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• pp.181-187
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• 1995

Water extract, and methanol extract, its chloroform and hexane fractions, and estragole from Agastache rugosa O. Kuntze were tested to find the inhibition effect on the growth of several microorganisms. The organisms used were Escherichia coli ATCC 1129, Staphylococcus aureus IAM 1011, Vibrio parahaemolyticus WP, Bacillus subtilis ATCC6633, Aspergillus oryzae KFCC 890, Aspergillus niger KCCM 11240. Water and methanol extracts at the concentration of 0.5%, and chloroform and hexane fraction at the concentration of 0.05% inhibited the growth of microorganisms from 1/5 to 2/3 of the control group. Estragole identified from the hexane faction as a major component, its authentic compound completely inhibited the growth of Vibrio parahaemolyticus completely at the concentration of 0.03%, and the other bacteria were at 0.05%.