• Title, Summary, Keyword: Analgesic effect

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Effect of Ginseng Saponin on the Analgesic Effect and Tolerance Development of Clonidine

  • Kim, Hack-Seang;Park, Seung-Ki;Hwang, Seong-Lok;Oh, Ki-Wan;Lee, Myung-Koo
    • Korean Journal of Pharmacognosy
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    • v.21 no.1
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    • pp.103-109
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    • 1990
  • The antagonism against clonidine-induced analgesia by ginseng saponin (GS) and the inhibitory effect of GS on the development of clonidine-induced tolerance were evaluated in mice. GS, when administered systemically, intracerebrally and intrathecally, antagonized significantly the analgesic effect of clonidine. GS, when injected intraperitoneally not only inhibited the development of clonidine-induced analgesic tolerance, but also enhanced the analgesic effect of clonidine on the 2nd and 5th day. Naloxone did not antagonize the analgesic effect of clonidine and had no influence on the deveolpment of tolerance of both acute and delayed types. These results indicate that the antagonism against clonidine-induced analgesia and the inhibition of the deveolpment of clonidine-induced tolerance by GS are not mediated by the opioid mechanism.

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Study on the analgesic Effect of Salicylamide and Combined with some Parasymptholytics and Serveral Antihistaminics (부교감신경차단제(副交感神經遮斷劑) 및 항(抗)Histamine제(劑)의 배합기여(配合技與)가 Salicylamide의 진통작용(鎭痛作用)에 미치는 효과(效果)에 관(關)한 연구(硏究))

  • Kim, Kyl-Hhung;Kim, Jae-Wan;Woo, Chong-Hak;Kim, Shin-Keun
    • Journal of Pharmaceutical Investigation
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    • v.1 no.1
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    • pp.30-33
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    • 1971
  • Comparative studies were made on the analgesic effect of salicylamide, used individually and combined with parasympatholytics (propantheline and atropine) and antihistaminics (tripelennamine, diphenhydramine) as regards the analgesic effect (in thermal contact method) were examined by its oral administration with each combined drug to mouse (three assumption cross-over test), and the following effects were found. 1. The increasing order of the parasympatholytics to the analgesic effect of salicylamide is as follows: propantheline>atropine. 2. The increasing order of the antihistaminics to the analgesic effect of salicylamide is as follows: chlorpheniramine>diphenhdramine>tri pelennamine. In the ratio '1 : 1' salicylamide to parasympatholytics and antihistaminics, the analgesic effect of salicylamide was more increase than the other ratio in this study.

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The Safety and Analgesic Effect of Datura Flos Pharmacopuncture in Sprague-Dawley Rats

  • Jun, Seungah;Lee, Yun Kyu;Lee, Bong Hyo;Kim, Jae Soo;Lee, Hyun-Jong
    • Journal of Acupuncture Research
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    • v.36 no.3
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    • pp.147-153
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    • 2019
  • Background: The aim of this study was to investigate the safety and analgesic effects of Datura Flos pharmacopuncture (DFP). Methods: The analgesic effects of DFP were assessed using mechanical (hot plate), chemical (formalin test), and thermal (von Frey filament test) pain tests. Forty male Sprague Dawley rats were assigned randomly into DFP (75 mg/kg, 150 mg/kg), lidocaine 0.5%, or normal saline group for treatment on Kl3. Gross pathology, histopathology, biochemistry and hematology were performed. Results: In the hot plate test, DFP at a high dose (HDDFP; 150 mg/kg) produced a significant analgesic effect, at 10 and 20-minutes post injection (p < 0.01). Low dose DFP (LDDFP; 75 mg/kg) also showed an analgesic effect at 10 minutes post injection (p < 0.01). In the formalin test, HDDFP produced an analgesic effect, for 0-10 and 10-20 minutes (p < 0.01) post treatment, whereas LDDFP showed analgesic effects between 10-20 minutes (p < 0.05). In the von Frey filament test, DF-H produced an analgesic effect, 10 (p < 0.01) and 20 minutes post treatment (p < 0.05). LDDFP showed analgesic effect at 10 minutes (p < 0.05). In the acupuncture response test, HDDFP produced an analgesic effect at 10 minutes post treatment (p < 0.05). DF-H did not cause any anatomical changes to the liver or kidney and there were no abnormalities in biochemistry or hematology. Conclusion: DF-H was not toxic and provided short term analgesia, suggesting it may be useful in the management of pain.

Anti-inflammatory and Analgesic Activities, and Plasma Concentration of Loxoprofen Sodium Plasters (Loxoprofen sodium 플라스타의 소염, 진통 작용 및 혈중 약물 농도에 대한 연구)

  • 채주병;전홍렬;이승목;정남주;김수균;조길도;김동연
    • Biomolecules & Therapeutics
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    • v.7 no.2
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    • pp.198-203
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    • 1999
  • Loxoprofen-Na (sodium 2-〔4-(2-oxocyclopentylmethyl)pheny)propionate dihydrate) is a potent analgesic drug. We developed loxoprofen-Na plasters to extend duration time of analgesic activity and to reduce side effect on gastrointestinal tract. Analgesic effect of Loxoprofen-Na plasters was investigated. Loxoprofen-Na plaster had good analgesic effect in rat paw pressure test, Tail-flick latency test and acetic acid-induced writhing test. Also, it had anti-inflammatory effect on carrageenan-induced rat hind paw edema. In pharmacokinetic study of Loxoprofen-Na, plasters dosage form showed that plasma drug concentration was prolonged up to 14 hours. So, we can conclude that loxoprofen-Na plasters, when applied on skin, will be a new type of drug for controlling the various local pain or inflammation.

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Synthesis and Analgesic and Anti-inflammatory Activities of 1,2-Benzothiazine Derivatives

  • Lee, Eun-Bang;Kwon, Soon-Kyoung;Kim, Sang-Geon
    • Archives of Pharmacal Research
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    • v.22 no.1
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    • pp.44-47
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    • 1999
  • Three 1,2-benzothiazine derivatives were synthesized, and their analgesic / anti-inflammatory efficacy and their effect s of gastric irritation were evaluated. Among the three compounds, 39 exhibited the most potent anlagesic action, but the effect was weaker than that of piroxicam. Nonetheless, the compound showed 4 times more potent analgesic action with less gastric damage than did ibuprofen. These compounds did not show anti-inflammatory effect at an oral dose of 5 mg/kg.

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The study on the analgesic effect and its mechanism of electroacupuncture in the rat model of adjuvant-induced arthritis (Adjuvant 유발(誘發) 관절염(關節炎)에 대(對)한 전침자극(電針刺戟)의 진통효과(鎭痛效果) 및 그 기전(機轉)에 관(關)한 연구(硏究))

  • Baek, Yong-hyeon;Choi, Do-young;Park, Dong-seok
    • Journal of Acupuncture Research
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    • v.20 no.3
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    • pp.117-130
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    • 2003
  • To study the analgesic and effect and its mechanism of eletroacupunture(EA) on the chronic inflammatory pain 50 rats were induced with arthralgesia by injecting complete freund's adjuvant(CFA). Two weeks after the injection of CFA, EA stimulation(2Hz, 0.07mA, 0.3ms) was delivered to Jogsamni($ST_{36}$) for 20 minutes. Analgesic effect was evaluated by using the tail flick latency(TFL) and the analgesic mechanism was observed by applying TFL with the pretreatment with naloxone and yohimbine. The results were as follows ; 1. TFL level for the model of adjuvant-induced arthritis decreased as time went by and it induced the hyperalgesia. 2. EA stimulation delivered to Jogsamni($ST_{36}$) for 20 minutes in the rat model of adjuvant-induced arthritis brought analgesic effect and its effect had lasted for 40 minutes after the stimulation. 3. The analgesic effect of Jogsamni($ST_{36}$) EA in the rat model of adjuvant-induced arthritis was blocked by pretreatment with naloxone(2mg/kg,i.p). This result suggests that the EA effect on the chronic inflammatory pain can be related to the endogenous opioid mechanism. 4. The analgesic effect of Jogsamni($ST_{36}$) EA in the rat model of adjuvant-induced arthritis was blocked by pretreatment with naloxone(2mg/kg,i.p). This result suggests that the EA effect on the chronic inflammatory pain can be related to the ${\alpha}_2$-adrenergic mechanism.

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Comparison of Pharmacological Effects of Magnoliae officinalis, Magnolia and Machilus Barks (후박(厚朴)의 약효(藥效)에 관한 연구(硏究))

  • Lee, Soung-Ro;Lee, Sagn-In
    • Korean Journal of Pharmacognosy
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    • v.17 no.3
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    • pp.199-205
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    • 1986
  • It has been known that Magnolia officinalis, Magnolia and Machilus Barks are reputed to be effective in 'Hagi', 'Sanman' and to be analgesic but there was differences of efficacy of these crude drugs against the kinds and habitates. For this reason, this study was conducted to compare the acute toxicities, analgesic effects and motilities of isolated intestine. This results obtained in this work were summarized as follow: 1. In the test of acute toxicies, Machilus bark was found to be more toxic than the others. 2. Both these was found to have analgesic effect. 3. In the effects against the motility of isolated intestine, Magnolia officinalis and Magnolia barks were found to be relaxant, Machilus bark was found to be contractive. From these results, Magnolia officinalis and Magnolia barks might have analgesic effect and relaxant effect of intestine.

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The Effect of Hoichunyanggyuksan on the Anti-allergic Effect, Analgesic Action, Anti-inflammatory Action and Antipyretic Action. (回春凉膈散이 抗알레르기 및 消炎, 鎭痛, 解熱效果에 미치는 影響)

  • Kim Gyung Jun;Kim Joong Ho;Chae Byung Yoon
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.7 no.1
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    • pp.1-13
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    • 1994
  • The Effects of Hoichunyanggyuksan on the Anti-allergic Effect, Analgesic Action, Anti-inflammatory Action and Antipyretic Action. Experimental studies were done to research the clinical effects of Hoichunyanggyuksan on the Anti-allergic effect, Analgesic action, Anti-inflammatory action and Antipyretic action. The results obtained as follows; 1. On vascular permeability responses to intradermal histamine, Hoichnyanggyuksan showed significant effect. 2. In the homologous PCA provoked by the IgE-like antibody against white egg albumin, Hoichunyanggyuksan showed the decreasing tendency, but was none significant effect. 3. In the delayed type hypersensitivity responses to Picryl chloride, Hoichunyanggyuksan was proved significant effect. 4. In the delayed type hypersensitivity resposes to SRBC, Hoichunyanggyuksan revealed significant effect. 5. In Anti-pyretic action by yeast method, Hoichunyanggyuksan showed significant effect. 6. In Anti-inflammatory action by carrageenin method, Hoichunyanggyuksan showed significant effect. 7. In analgesic action by acetic acid method, Hoichunyanggyuksan was recognized significantly.

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Analgesic Effects of Electroacupuncture, Warm Needling and Radio Frequency Warm Needling on Surgical Ankle Sprain Model in Rats (흰쥐의 발목염좌에 대한 전침, 온침 및 고주파온침 자극별 진통 효과의 비교)

  • Yang, Seung-Bum;Kim, Min-Su;Choi, Suck-Jun;Kim, Jae-Hyo
    • Korean Journal of Acupuncture
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    • v.32 no.1
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    • pp.20-29
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    • 2015
  • Objectives : The objectives of this study is to compare the effects of electroacupuncture(EA), warm needling(WN) and Radio Frequency warm needling(RFWN) stimulations on the acupoints at the artificially damaged ankles of Sprague-Dawley rats, which could be classified as the Grade 3. Methods : The foot weight bearing force ratio(FWBFR) of ankle sprain was measured first at 24 hours after without any other stimulations. Pain Recovery Index(PRI) represents the analgesic level, and modified Pain Recovery Index(mPRI) shows the accumulated recovery level. PRI was measured at 2 hours after each stimulus on GB34, GB39 and GB42, and mPRI was during 7 days. Results : EA stimulation of GB34 and GB39 acupoint in grade 3 ankle sprain showed a marked analgesic and recovery effect. RFWN of GB42 exhibited significant analgesic and pain recovery effect. RFWN of GB34 resulted in pain recovery effect but not analgesic effects, and RFWN of GB39 resulted in analgesic effect 2 hours after but not pain recovery. However, WN did not affect the pain recovery among three acupoints at all. Conclusions : In the Grade 3 ankle sprain model, the difference of analgesic effects were explained by the acupoints and the stimulation methods according to the accumulated recovery effects during 7 days. It is insufficient to determine that a certain acupoint has a specific analgesic effect depending on the stimulation method by the results of this study. Therefore, the effects of each stimulation on the acupoints in any other meridians at the sprained ankle should be compared and analyzed.

Experimental Studies on the Analgesic and Antiphlogistic Effects of Violae Herba (자화지정(紫花地丁)의 진통(鎭痛) 및 소염작용(消炎作用)에 관(關)한 실험적(實驗的) 연구(硏究))

  • Ko, Wun-Che;Shin, Min-Kyo
    • Korean Journal of Pharmacognosy
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    • v.18 no.4
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    • pp.210-215
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    • 1987
  • Experimental studies were done to investigate analgesic and antiphlogistic actions of Violae Herba. Its water extract showed a significant dose dependent analgesic effect against writhing syndrome induced by acetic acid as well as in hot plate test in mice. The extract also showed a significant inhibitory effect against paw-edema induced by egg-white in rats.

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