• Anxiety and mood
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• v.2 no.1
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• pp.45-49
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• 2006

Puropse : Disturbances of dopaminergic system might be related to the possible mechanism of panic disorder. This study was aimed to examine the association of DRD2 Taq 1 polymorphism and panic disorder. Methods : One hundred and fourteen patients with panic disorder (62 male (54.4%), mean age $40.96{\pm}0.11$ years) and 200 comparison subjects (114 male (57.0%), mean age $35.57{\pm}8.81$ years)were tested for DRD2 TaqI A polymorphism. We excluded panic patients with comorbid alcohol related disorders, bipolar disorders, and any kinds of psychotic disorders because there have been some reports about association of these disease and DRD2 TaqI A polymorphism. Results : There was significant difference in the frequency of the genotype in DRD2 polymorphism between patients and controls (${\chi}^2$=6.09, df=2, p=0.048). The A1+ allele (A1A1 and A1A2) frequency analysis also showed significant association (${\chi}^2$=4.08, df=1, p=0.043). In addition, we observed a more strong and specific association between panic disorder and the A1+ allele of the DRD2 TaqI polymorphism for men (${\chi}^2$=4.71, df=1, p=0.03), but not for women (${\chi}^2$=0.45, df=1, p=0.50). Conclusion : These results in our Korean sample suggest that the DRD2 TaqI A polymorphism may be associated with panic disorder. Furthermore, we found sex-specific association of DRD2 A1 allele with panic disorder.

• Anxiety and mood
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• v.4 no.2
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• pp.148-156
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• 2008

Objective : Although cognitive-behavior therapy (CBT) is effective in patients with panic disorder, its the-rapeutic mechanism of action in the brain remains unclear. This study was performed to investigate regional blood flow changes associated with successful completion of CBT in drug-naive patients with panic disorder. Method : The regional blood flow in 4 patients with panic disorder was compared to that in 11 healthy controls before and after a 12-week group CBT using $^{99m}Tc$-ECD SPECT imaging. Psychopathology was assessed using Panic Disorder Severity Scale. Data were analyzed using software for statistical parametric mapping (SPM2). Results : Before CBT, significantly decreased blood flow was found in the parietal and occipital area in panic patients than normal volunteers. In all the patients who showed remission after CBT, increased blood flow was detected in the right cingulate gyrus, left lingual gyrus, and left superior parietal lobule, whereas decreased blood flow was seen in the left inferior temporal gyrus. Conclusion : These results suggested that CBT is effective for panic disorder and change the activity of cingulate gyrus and left temporal gyrus, a part of the brain areas associated with fear in panic disorder.

• Journal of Oriental Neuropsychiatry
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• v.28 no.3
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• pp.249-262
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• 2017

Objectives: The aim of this study was to investigate the clinical studies which focus on acupuncture's effect on anxiety disorder. Methods: We selected clinical studies through six databases. We then examined the characteristics of the selected studies and conducted an assessment for Risk of Bias (ROB). Results: Seventeen randomized-controlled trials were selected to determine the effects of acupuncture on anxiety disorders. We found that the risk of bias in most studies was unclear. The intervention of 7 seventeen randomized-controlled trials (RCT) was basic acupuncture, 8 RCT involved electric acupuncture, 2 RCT consisted of acupuncture and Moxibustion. Four of the 7 basic acupuncture RCTs and 5 of the 8 electric acupuncture RCTs had a significant effect on anxiety factors for anxiety disorders. Conclusions: Acupuncture treatment for anxiety disorders was found to be effective compared to the controls, or there was no difference in effectiveness compared to the controls. However, the quality of the included studies was low, and there only were a small number of studies. Therefore, well-designed studies and a greater number of the studies are needed.

• Journal of the Korean Society of Child Welfare
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• no.56
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• pp.1-32
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• 2016

The present study examined the mediating effects of parent-child stress on the relationship between perceived neighborhood disorder and problem behaviors. The research hypotheses were based on Pearlin's(1999) stress process model and findings from previous literature. The data from the $4^{th}$-wave of the Korea Youth Panel Survey (KYPS; a panel survey of $8^{th}$-grade students) were analyzed to identify the relationships between the study variables. The sample included 2,301 adolescents (16 to 18 years old). Findings showed that parent-child stress partially mediated the relationship between perceived neighborhood disorder and problem behaviors in adolescents. As adolescents perceived more neighborhood disorder, they were more likely to experience anxiety/depression and aggression. In addition, greater neighborhood disorder were found to be associated with the higher levels of the parent-child stress. Furthermore, when controlling for perceived neighborhood disorder, the higher levels of the parent-child stress were found to be associated with the higher levels of anxiety/depression and aggression. The Sobel test and bootstrapping results showed that parent-child stress partially mediates the relationship between perceived neighborhood disorder and anxiety/depression, as well as the relationship between perceived neighborhood disorder and aggression. Based on the results, we discussed social welfare implications of the study findings to prevent adolescent problem behavior as well as the limitations of the study.

• Anxiety and mood
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• v.7 no.2
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• pp.85-91
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• 2011

Objective : This study aimed to investigate the characteristics of the early maladaptive schemas in patients with panic disorder. Methods : Patients (n=35) included people who had met the DSM-IV-TR criteria for panic disorder. The normal control group (n=35) were those people who had no psychiatric disorder and had never experienced panic attack. The early maladaptive schemas and the severity of depression and anxiety were assessed by the Young Schema Questionnaire Short-form (YSQ-SF), the Beck Depression Inventory (BDI), and the Spielberger State-Trait Anxiety Inventory (STAI). Results : The scores on the STAI-S, STAI-T, and BDI were significantly higher in the patient group. Compared to the control group, the scores of vulnerability to harm and illness, and abandonment/instability schemas were significantly higher in the patient group. In the patient group, defectiveness/shame and subjugation schemas were found to predict BDI, dependent/incompetence, abandonment/instability schemas were found to predict STAI-S, and vulnerability to harm and illness, and abandonment/instability schemas were found to predict STAI-T. In normal controls, failure and insufficient self-control/self-discipline, failure, and emotion inhibition schemas were found to predict BDI, STAI-T, and STAI-S. Conclusions : Vulnerability to harm and illness and abandonment/instability schemas may be characteristic schema in patients with panic disorder.

• 대한상한금궤의학회지
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• v.6 no.1
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• pp.55-62
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• 2014

Objective : This case report show the effect of Yonggyechulgam-tang on Panic disorder. Methods : The patient was diagnosed Panic disorder based on DSM-5. According to Shanghanlun six meridian patterns diagnostic system, the patient treated with Yonggyechulgam-tang for 4 months. The level of panic disorder was evaluated by VAS and BAI. Results : After the treatment, VAS and BAI decreased $10{\rightarrow}2$, $42{\rightarrow}4$ each. Conclusions : Yonggyechulgam-tang improved the symptoms of Panic disorder on this study. Although Yonggyechulgam-tang is not an usual treatment for Panic disorder, we could prescribe the medicine due to Shanghanlun six meridian patterns diagnostic system.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.16 no.3
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• pp.59-68
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• 2012

The purpose of this study is to report the effects of oriental demonstration treatment for Panic Disorder. Panic Disorder is an anxiety disorder, characterized by panic attacks which are recurring episodes of fear accompanied by somatic symptoms such as shortness of breath, palpitations, chest pain, choking, dizziness, trembling and/or faintness. Objectives: We experienced one case of Panic Disorder treated with Asian medical treatment, acupuncture and herbal medication. 20-year-old female patient suffered from Panic Disorder with nausea and insomnia. Methods: Shihosogantang-gami had been applied to the patient. Results: After treatment her Panic Disorder was improved. Conclusions: Shihosogantang -gami of Asian medical treatment could be safe and effective.

• Journal of Oriental Neuropsychiatry
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• v.18 no.3
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• pp.181-191
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• 2007

Jeon-zeong(癲證) is mostly caused by anxiety and melancholy, impairment of heart and the spleen, or stasis of phlegm-Gi and heart confused by phlegm. Its manifestation are characterized by depression, expressionlessness, inclination for quietness, self muttering and hallucinating, caprice in crying and laughing, paraphasia, loss of appetite, unawareness of filth and cleanness, etc. We experienced a 50year-old man who bad brief psycbotic disorder that specified with Marked Stressor and whose condition was improved through oriental medical treatment. We treated the patient with Herbal medications and Giungoroen (至言高論)-wise saying and lofty opinion) and Relaxation therapy. After being treated, the patient showed that symptoms (insomnia, anxiety, depression) was improved considerably. This result suggests that oriental medical treatment has good effect on brief psychotic disorder due to Marked Stressor.

• Anxiety and mood
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• v.3 no.1
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• pp.26-31
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• 2007

Object : This study was designed to assess the change of heart rate variability (HRV) during stimulation test among the patients with major depressive disorder. Methods : 15 patients with major depressive disorder (MDD) and 15 normal controls were enrolled in this study. We sequentially measured HRV at baseline, during cognitive stimuli and emotional stimuli. Results : There are significant differences between the two groups in HRV index, TINN on baseline state and under cognitive stimulus. Conclusion : Stimulation protocol using HRV can be useful in estimating autonomic nervous function.

• Anxiety and mood
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• v.3 no.2
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• pp.69-76
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• 2007

Anorexia nervosa is a physical and psychosocial disorder that occurs most frequently in adolescent girls and young adult women. A decade ago, anorexia nervosa was rare outside of the developed western countries. However, it is now becoming a common clinical problem among young women in Korea. It is not enough to merely focus on relieving patients from the symptoms of "not eating," which is a practice that has been adopted by some forms of hospital care. The evidence base to guide treatment is limited. Nevertheless, there is the hope that a better understanding of the factors that play a role in the initiation and maintenance of disordered eating behaviors may be lead to more sophisticated treatments. This review aims to look beyond the overt "not eating" phenotype of anorexia nervosa and considers eating disorder endophenotypes based on Treasure's model. The first part of the review sets the basis for a framework of potential eating disorder endophenotypes. A description of the evidence of disordered eating behaviors as well as the clinical and psychopathological features associated with the central control of appetite follow. Finally, we describe how endophenotypes can be translated into treatments.