• The Korea Journal of Herbology
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• v.28 no.5
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• pp.13-19
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• 2013

Objectives : The purpose of this study is correct the scientific name of Aquilariae Lignum in Korean Herbal Pharmacoepia. Methods : The production areas of Aquilariae Lignum and its trading status with China in Chinese history, Sanscrit-Chinese Translation Sutra, Naming year and the discovered district in main Aquilaria spp., Several nation's Pharmacoepia, The Plant List(TPL), Convention on International Trade in Endangered Species of Wild fauna and flora(CITES) and The International Union for Conservation of Nature(IUCN) were cross-checked. Results : The records in the Jiaozhouyiwuzhi written in the early 2nd century said that Aquilariae Lignum was produced in Vietnam. NanfangCaomuZhuang written in 304 said that Agarwood in Vietnam had white flowers. Vietnam had led production and trading of Aquilariae Lignum until Qing Dynasty. Aquilariae Lignum from Malaysia and Indonesia was not traded with China. In Sanscrit-Chinese Translation Sutra, India Aquilariae Lignum was translated as Vietnam Aquilariae Lignum. Aquilaria malaccensis was discovered from Malay-Peninsular in 1783, and has green or dirty yellow flowers. A. agallocha from North-Eastern India in 1814, white flowers. A. crasssna from Vietnam in 1914, white flowers. A. crassna is different from A. malaccensis in several ways, such as flower, fruit, seed and disribution. In several Nation's Pharmacoepia, A. crassna was a synonym of A. agallocha. But in TPL, CITES and IUCN, A. malaccensis was an accepted name, and A. agallocha was a synonym of A. malaccensis. Conclusions : These results show that the original species of Aquilariae Lignum in Korea Herbal Pharmacoepia should be reversed from A. agallocha to A. crassna Pierre ex Lacomte.

• Natural Product Sciences
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• v.8 no.1
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• pp.30-33
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• 2002

From the bioassay-directed fractionation and isolation of dichloromethane fraction of Aquilaria agallocha, four compounds having MAO inhibitory effect were isolated by repeated silica gel column chromatography. Their chemical structures were established as psoralen (1), bergapten (2), ${\alpha}-amyrin\;acetate$ (3) and 5-hydroxymethylfurfural (4) on the basis of their physicochemical and spectral data. Among these compounds, psoralen and bergapten showed high inhibitory activities in vitro against mouse brain MAO with $IC_{50}$ values $21.3\;{\mu}M\;and\;13.8\;{\mu}M$, respectively.

• The Korea Journal of Herbology
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• v.20 no.3
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• pp.9-18
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• 2005

Objectives : The purpose of this study is to investigate characteristics of cell morphology of two different agar woods (Aquilaria agallocha Roxburgh (AAR) and imitative agar wood (IAW)) using microscopic techniques. Methods : Both light and scanning electron microscopes were used to observe morphological and histological features of the cell of agar woods collected from commercial products in the market. Results : The cell morphology and tissue arrangements of AAR depending on either the adsorption of resin into vessels or no adsorption of resin were observed to compare these features with those of both IAW and Aquilaria sinensis Gilb (ASG). Conclusions : As a result, the vessels of AAR with the resin adsorption was packed with lots of yellow-brownish materials, which were quite different from those of IAW and ASG. The cell walls were thick, and had well-developed traumatic parenchyma tissues with squared cells of the same height and width, which appeared as a clump of small grains packed.

• The Korea Journal of Herbology
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• v.26 no.1
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• pp.97-101
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• 2011

Objectives : The purpose of this research is to identify the actual origin species imported as Aquilaria malaccensis from Indonesia. Methods : After producing the permanent preparat by cutting off the specimen thinly, we observed its characteristics. Results : The imported ones have not interxylary parenchyma, so none is in the genus aquilaria. Since the aliform parenchyma is mostly observed around the vessel pore, they are in the genus gonystylus, and the rest have no aliform parenchyma, so their specimen is unidentified. Conclusion : The imported as A. malaccensis are not in the genus aquilaria, but most of them are in the genus gonystylus and, for the rest, the specimen is unidentified.

• The Korea Journal of Herbology
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• v.26 no.4
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• pp.163-168
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• 2011

Objective : The purpose of this study is to determine the origin of Aquilariae Lignum. Method : Firstly identify the production areas of Aquilariae Lignum and its trading status with China in Chinese history through Chinese historical books such as Twenty-Five Histories(二十五史) and the records of the Chosun Dynasty and then, compare the distribution of the genus Aquilaria in the concerned areas. Result : Since the records in the NanfangCaomuZhuang(南方草木狀) written in 304 saying that Aquilariae Lignum was produced in Vietnam and had white flowers, Vietnam had led production and trading of Aquilariae Lignum until Qing Dynasty(淸代). Even though Thailand traded Aquilariae Lignum during Qing Dynasty, however, the volume was at a low level. Aquilariae Lignum from southern Thailand, Malaysia and Indonesia was rated as low quality and low-priced because of its fishy smell and strong flavor. Conclusion : These results show that the origin of Aquilariae Lignum comes from Vietnam and this species is distinguished from the ones of Indodesia or Malaysia.

• Food Science and Preservation
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• v.22 no.3
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• pp.437-442
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• 2015

In a continuing screening of selected medicinal plants native to South Korea, the antioxidant and pancreatic lipase inhibitory activities of an aqueous methanolic extract from the heartwood of Aquilaria agallocha were investigated. Eighty percent of the methanolic extract of A. agallocha was further divided into $CH_2Cl_2$, EtOAc and n-BuOH in order to yield four solvent-soluble portions, namely $CH_2Cl_2$-soluble, EtOAc-soluble, n-BuOH-soluble and $H_2O$ residue. The antioxidant properties were evaluated by employing radical scavenging assays using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) ($ABTS^+$) radicals, while the anti-obesity efficacy of A. agallocha extracts and solvent-soluble portions were tested by porcine pancreatic lipase assay. All tested samples showed dose-dependent radical scavenging and pancreatic lipase inhibitory activities. Among the tested extracts and solvent-soluble portions, the $CH_2Cl_2$-soluble portion showed much higher radical scavenging activity and pancreatic lipase inhibitory properties when compared with other solvent-soluble portions. This result suggested that there was a significant relationship between the total phenolic content and biological efficacies, and A. agallocha extract might be considered as a new potential source of natural antioxidants and as a pancreatic lipase inhibitory source. A more systematic investigation of this biomass will be performed for further investigation of activity against antioxidative and anti-obesity effects.

• The Korea Journal of Herbology
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• v.26 no.1
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• pp.7-12
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• 2011

Objectives : The purpose of this study is to evaluate the quality of four different kinds of agarwood and analysis chemical constituents by GC-MS. Methods : Four source plants were two of Vietnamese agarwood, Indonesian agarwood and Myanmar agarwood. These plant materials were named sample No. 1-4. The chemical constituents of each agarwood were analysed by GC-MS. Results : GC-MS analysis showed that ${\beta}$-selinene was found in all the samples. The Vietnamese agarwood, Sample 1, and 4 has contained 6.861% and 7.497% of ${\beta}$-selinene and reached the highest level at the retention times 46.245 and 46.274 (min). Sample 2, the Myanmar agarwood has contained 1.608%, the lowest level of ${\beta}$-selinene, and it also has contained about 20% of ${\alpha}-,{\beta}-,{\gamma}$-eudesmol and 4.076% of valerianol. Sample 3, the Indonesian agarwood has contained 9.59% of ${\beta}$-selinene, 9.493% of ${\beta}$-selinene and shown its highest level (more than 19%) at the retention time 43.998 (min). Conclusion : It suggested that ${\beta}$-selinene could be a standard marker to evaluate agarwood by GC-MS analysis.

• Advances in Traditional Medicine
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• v.4 no.3
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• pp.125-136
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• 2004

The pharmacological mechanisms of most Oriental medicines have not been clearly defined in spite of their effective use in treating many diseases throughout the world. Many Oriental medicines have been used against various allergic diseases for generations, and still occupy an important place in traditional medicine in far eastern countries including Korea. It is also still unclear how Oriental drugs prevent allergic disease in vivo or in vitro models. Some Korean folk medicine inhibited the mast cell-mediated allergic reaction. This review summarizes the effective folk medicine in experimental effect on systemic or local anaphylaxis reaction. Potential anti-anaphylactic folk medicines include: Poncirus trifoliata; Siegesbeckia glabrescence; Solanum lyratum; Aquilaria agallocha; Ulmi radicis; Polygonum tinctorium; Hwanglyun-Haedok-Tang; Rehmannia glutinosa; Kum-Hwag-San; Syzygium aromaticm; Spirulina platensis; Sosiho-Tang; Sinomenium acutum; Schizonepta tenuifolia; Shini-San; Magnoliae flos; Sochungryong-Tang; Oryza sativa; Cryptotympana atrata; Salviae radix; Rosa davurica; Asiasari radix; Chung-Dae-San; Cichorium intybus; Perilla frutescens; Vitex rotundifolia; Terminalia chebula; Siberian Ginseng; Solanum melongena; Gahmi-Shini-San; Alpinia oxyphylla; Acanthopanax senticosus root; Prunella vulgaris; Allergina; Ixeris dentate; Acanthopanax senticosus stem; Tongkyutang; Salvia plebeia; Rubus coreanus; Sinpo- Tang; Dodutang; Forsythia fructus; Xanthii fructus; and Purple bamboo slat. Ensuring the effects and understanding the mechanisms of action for these Oriental medicines can permit drug development and laying of the ground-work for evaluating potential synergistic effects by addition and subtraction of prescriptions.

• Advances in Traditional Medicine
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• v.1 no.1
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• pp.1-7
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• 2000

Although Oriental medicines have long been used effectively in treating many diseases throughout the world, the pharmacological mechanisms of most Oriental medicines used have not been defined. As part of our continuing search for biologically active antiallergic drugs from natural sources, Oriental medicines were analyzed. Some Oriental medicines have been used against various allergic diseases for generations, and still occupies an important place in traditional medicine in Korea. It is also still unclear how Oriental medicine prevents allergic disease in experimental animal models. Some Korean folk medicines inhibited the mast cell-mediated allergic reaction. This review summarizes the effective folk medicine in experimental effect of allergic reaction. Potential antiallergic folk medicines include: Poncirus trifoliata; Siegesbeckia glabrescence; Solanum lyratum; Aquilaria agallocha; Ulmi radicis; Polygonum tinctorium; Hwanglyun-Haedok-Tang; Rehmannia glutinosa; Kum- Hwag-San; Syzygium aromaticm; Spirulina platensis; Sosiho-Tang; Sinomenium acutum; Schizonepta tenuifolia; Shini-San; Magnoliae flos; Sochungryoung-Tang; Oryza sativa; Cryptotympana atrata; Salviae radix; Rosa davurica; Asiasari radix; Chung-Dae-San; and Cichorium intybus. Understanding the mechanisms of action for these Oriental medicines can permit drug development and laying of the ground-work for evaluating potential synergistic effects by addition and subtraction of prescriptions.

• Journal of Conservation Science
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• v.10 no.1 s.13
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• pp.21-30
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• 2001

The antibacterial and insecticidal properties of ethanol extracts and volatile components extracted from Eugenia caryophyllata, Boswellia carterii, Agastache rugosa, Aristolochia contorta, and Aquilaria agallocha were evaluated. The ethanol extract and volatile component of E. caryophyllata showed strong antimicrobial effect against all strains (Mucor hiemalis, Aspergillus niger, Penicillium funiculosum, Trichoderma viride) and the volatile component of B. carterii showed antimicrobial effect against all strains except T. viride. The ethanol extract of E. caryophyllata and A. contorta showed $100\%\;and\;32\%$ mortality against Reticulitemes spertus kyushuensis Morimoto for 48 hours and 72 hours, respectively. In the case of volatile component, E. aryophyllata showed $100\%\;and\;20\%$ mortality against R. spertus and Lyctus linearis GOZE, respectively. The main constitute, eugenol $(92\%)$ among nine components from volatile component of E. aryophyllata were identified as antibacterial active substance.