• The Korea Journal of Herbology
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• v.32 no.5
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• pp.27-38
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• 2017

Objective : In the present study, we examined whether Canavalia gladiata D.C. (CG) and Arctium lappa L., Redix (AL) mixture (CGAL), their components, lupeol and chicoric acid, regulate immune system and suppress the tumor in vitro and in vivo. Methods : LPS-induced reactive oxygen species (ROS) and nitric oxide (NO) were measured after treatment with CG extract (CGE), CGAL, lupeol, chicoric acid and lupeol and chicoric acid mixture (lupeol+CA) in Raw264.7 cell. To determine the effect of CGE on immune responses, immune cell population and IgG production were assessed in mice. To investigate the effect of CGAL and their component on anti-tumor activity, tumor volume and weight were measured, cell cycles and immune cell population were analyzed in MC38 injected tumor bearing mice. Also, NK cell activity was determined in splenocyte isolated from tumor bearing mice. Results : CGE, CGAL, lupeol, chicoric acid and lupeol+CA decreased the LPS-induced ROS and NO production without cell toxicity in RAW264.7 cells. CGE increased the immune cell populations of $CD4^+T$, $CD8^+T$ and macrophages in various immune organ of mice. In tumor bearing mice, CGAL, lupeol, chicoric acid and lupeol+CA suppressed tumor volume and weight. In cell cycle analysis, they decreased the percentages of S phase. In addition, CGAL, lupeol, chicoric acid and lupeol+CA immune cell populations of $CD4^+T$, $CD8^+Tcell$, NK cell and macrophage in tumor as well as NK cell activity. Conclusion : CGAL and its compounds may enhance immune responses and suppress tumor growth, and may be capable of developing health functional foods.

• Biomolecules & Therapeutics
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• v.11 no.3
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• pp.196-199
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• 2003

The methanol extracts from 60 plant extracts were prepared and evaluated for their antioxidative activity. Arctium lappa, Diospyros kaki, Eugenia caryophyllata, Melia azedarach and Forsythia suspensa showed the inhibitory activity against lipid peroxidation. Caesalpinia sappan, Crataegus pinnatifida, Eugenia caryophyllata, Gleditsia japonica, Osmunda japonica, Rhus javanica and Sanguisorba officinalis showed the highest inhibitory activity against DPPH radical formation. In particular, Eugenia caryophyllata demonstrated strong inhibitory activity on the lipid peroxidation and free radicals. The results suggested that selected plant extracts have a potential as natural antioxidant.

• Plant Resources
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• v.4 no.2
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• pp.85-91
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• 2001

Many plant species are used in China in tradtional medicine for the prevention and treatment of cancer. This paper presents some of these species with defals on other pharmacologic evaluation and its tradional Chinese meditional uses. The known bioaktivities and some chemical constituents of each of the species given. Information on bioactivities of each species resulting from tests on experimental animals are given. Many of the known chemical constituents of each species are given. Various species of plants elective for various types. In this meeting I will present on some antitumor of the plants which are as follows ; (1) Akebia trifoliata(Thunb.)Koidz. ((2) Panax notoginseng (Burk.) F, H, Chen ., (3)Ziziphus jujuba Mill., (4)coriotus versicolor(Fr.) Quel., (5) Trich osanthes kirilowii Maxim., (6) Ficus carica Linnaeus., (7) Acanthopanax senticosus(Rupr. et Maxim.)Harms.,(5) Hibiscus mutabilis Linnaeus.,(9) Arctium lappa Linnaeus., (11) Agrimonia pilose Ledebour and (12) Hedyotis diffusa Willd.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2008.10a
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• pp.865-869
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• 2008

This study was carried out to research antimicrobial agents from medicinal plants, Pueraria thunbergiana, Sophora flavescens, Lonicera japonica, Pinellia ternata, Dictamnus dasycarpus, Paeonia lactiflora, Angelica dahurica, Spirodela polyrhiza, Cryptotympana pustulata, Pinus densiflora, Cimicifuga heracleifolia, Bupleurum falcatum, Magnolia kobus, Artemisia princeps, Houttuynia cordata, Forsythia koreana, Arctium lappa, Castanea crenata, Aster tataricus, Citrus unshiu, Gardenia jasminoides, Ledebouriella seseloides, Hovenia dulcis, Prunus sargentii. The ethanol extracts of 24 medicinal plants were tested for the antimicrobial activity against Streptococcus mutans. The extracts of Sophora flavescens, Pinus densiflora, Cimicifuga heracleifolia, Gardenia jasminoides and Ledebouriella seseloides showed antimicrobial activity against Streptococcus mutans. The extracts of Pinus densiflora and Sophora flavescens among these medical plants showed significant antimicrobial activity against Streptcoccus mutans. These results suggested that the extracts from Pinus densiflora and Sophora flavescens could be the potential source of antimicrobial agents against S. mutans.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1998.11a
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• pp.104-107
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• 1998

The studies for antithrombotic substances from medicinal plants in my laboratory were started from the studies on PAF-antagonistic substances from Korean medicinal plants. The screening studies of PAF-receptor binding antagonistic activity were conducted on the extracts of 300 Korean medicinal plants, 37 tropical medicinal plants, 20 mushrooms, and 30 vegetables. From the results of screening studies, it was possible to select two Korean medicinal plants, i.e. 1) the leaf of Biota orientalis and 2) the seed of Arctium lappa, and two tropical medicinal plants, i.e. 3) the rhizome of Alpinia officinarum and 4) the leaf of Ardisia crispa as the candidates for the activity guided isolation of PAF-antagonistic substances.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2000.10a
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• pp.52-63
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• 2000

Many plant species are used in China in traditional medicine for the prevention and treatment of cancer. This paper presents some of these species with details on other pharmacologic evaluation and its traditional Chinese meditional uses. The known bioaktivities and some chemical constituents of each of the species given. Information on bioactivities of each species resulting from tests on experimental animals are given. Many of the known chemical constituents of each species are given. Various species of plants elective for various types. In this meeting I will present on some antitumor of the plants which are as follows; (1) Akebia trifoliata(Thunb.)Koidz. ((2) Panax notoginseng(Burk.) F, H, Chen., (3) Ziziphus jujuba Mill., (4) coriolus versicolor(Fr.)Que l., (5) Trichosanthes kirilowii Maxim., (6) Ficus carica Linnaeus., (7) Acanthopanax senticosus(Rupr.et Maxim.)Harms., (8) Hibiscus mutabilis Linnaeus., (9) Arctium lappa Linnaeus., (11) Agrimonia pilosa Ledebour and (12) Hedyotis diffusa Willd.

• Proceedings of the Zoological Society Korea Conference
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• 2003.08a
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• pp.184.3-184
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• 2003

No Abstract, See Full Text

• Korean Journal of Pharmacognosy
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• v.28 no.4
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• pp.275-279
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• 1997

Fruits of Arctium lappa L. (Compositae), which has been used as the antiinflammatory, detoxifying and diuretic agents in the folk remedies, was examined on the in vitro oxidation of human low density lipoprotein (LDL). Several lines of evidence indicate that oxidized LDL (Ox-LDL) may promote atherogenesis. Hence. The role of antioxidants in the prevention of LDL oxidation needs to be determined. The activity of fractions of Arctii Fructus treated with oxidized LDL which was incubated with $16\;{\mu}M$ of $Cu^{2+}$ for metal catalyzed oxidation was investigated. The BuOH fraction (4\;ppm) inhibited the oxidative modification of LDL as evidenced by a decrease in the lipid peroxide content (thiobarbituric acid reacting substances activity), the negative charge of LDL (electrophoretic mobility) and increase of the vitamine E content.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.126.1-126.1
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• 2003

Compound-A is a phenylpropanoid isolated from Arctium lappa fruit. In this experiments, effect of Compound-A on sheep red bood cells (sRBC) - induced delayed type hypersensitivity (DTH) were studied in ICR male mice and determined the Rosette Forming Cells (RFC). Two weeks after sensitization of i.p. injection of sRBC (4$\times{10}^8$ cells), ICR male mice were challenged by i.p. injection of sRBC (2\times{10}^8$ cells). Five days the challenge of antigen, paw edema induced twenty-four hours after the last challenge by DTH. (omitted)

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.126.2-127
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• 2003

Effect of Compound-A, a phenylpropanoid isolated from Arctium lappa fruit, on the reversed cutaneous anaphylaxis (RCA) and complement-dependent hypersensitivity (CDH) were studied in SD male rats and ICR male mice, respectively. RCA and hemolysin (HY) titer test are related to reaction of Type II Hypersensitivity. Experiments were carried out to determine RCA as the edema of skin two hours after injection of 0.05 ml/site of anti-rat serum rabbit serum in SD rat. Drugs were orally administered one hour before antigen challenge. (omitted)