• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.17 no.3
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• pp.114-119
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• 2004

Background: Atopic dermatitis is chronic exzemaous dermatosis characterized by severe itching, licalized eruption and chronic relapsing progress and has familu history of atopic diseases and hereditary disposition. This Study is attempted in order to estimate of possibility of oriental treatment on atopic dermatitis. Objective: We studied 24 years old women with atopic dermatitis from June 2004 to July 2004 Method: We treated her with herb medication and used three index to assess the severity of atopic dermatitis. Results: Each index show us about 50-60$\%$ of improvement Conclusion: On the basis of this study, It should be considered that treatment of atopic dermatitis should be focused on fever of yang-ming.

• CELLMED
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• v.13 no.11
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• pp.41.1-41.4
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• 2023

Objective: A case report on the improvement of acute atopic dermatiti using Ortho-Cellular Nutrition Therapy (OCNT). Methods: A teenage Korean male was suffering from acute atopic dermatitis. Results: Acute atopic dermatitis improved after performing OCNT. Conclusion: OCNT can be helpful in the treatment of patients with acute atopic dermatitis.

• Biomolecules & Therapeutics
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• v.20 no.6
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• pp.506-512
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• 2012

Although pruritus is the critical symptom of atopic dermatitis that profoundly affect the patients' quality of life, controlling and management of prurirtus still remains as unmet needs mainly due to the distinctive multifactorial pathogenesis of pruritus in atopic dermatitis. Based on the distinct feature of atopic dermatitis that psychological state of patients substantially influence on the intensity of pruritus, various psychotropic drugs have been used in clinic to relieve pruritus of atopic dermatitis patients. Only several psychotropic drugs were reported to show real antipruritic effects in atopic dermatitis patients including naltrexone, doxepin, trimipramine, bupropion, tandospirone, paroxetine and fluvoxamine. However, the precise mechanisms of antipruritic effect of these psychotropic drugs are still unclear. In human skin, serotonin receptors and serotonin transporter protein are expressed on skin cells such as keratinocytes, melanocytes, dermal fibroblasts, mast cells, T cells, natural killer cells, langerhans cells, and sensory nerve endings. It is noteworthy that serotonergic drugs, as well as serotonin itself, showed immune-modulating effect. Fenfluramine, fluoxetine and 2, 5-dimethoxy-4-iodoamphetamine significantly decreased lymphocyte proliferation. It is still questionable whether these serotonergic drugs exert the immunosuppressive effects via serotonin receptor or serotonin transporter. All these clinical and experimental reports suggest the possibility that antipruritic effects of selective serotonin reuptake inhibitors in atopic dermatitis patients might be at least partly due to their suppressive effect on T cells. Further studies should be conducted to elucidate the precise mechanism of neuroimmunological interaction in pruritus of atopic dermatitis.

• Journal of Physiology & Pathology in Korean Medicine
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• v.29 no.1
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• pp.33-38
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• 2015

This study investigated the clinical parameters of atopic dermatitis and evaluated the inhibitory effects of Black currant seed oil for atopic dermatitis by using a Dinitrochlorobenzene(DNCB) induced BALB/c mice model. Five-week-old BALB/c mice were divided into four groups: normal group (N, non-treated), control group (C, atopic dermatitis-induced), positive control group (PC, Tacrolimus ointment-treated against induced atopic dermatitis, PC), experiment group (E, Black currant seed oil-treated against induced atopic dermatitis). After induction of atopic dermatitis by DNCB, the erythema, edema, eschar, and scratching were severely observed. The symptoms of atopic dermatitis were improved after 2 weeks, and almost disappeared after 4 weeks in PC and E group. The increased frequencies of scratching in C group were decreased in PC and E group. Transepidermal water loss, erythema index and serum IgE level were significantly decreased in E and PC compared to that in C after 4 weeks of the treatment. The results indicated that Black currant seed oil can relieve atopic dermatitis symptoms effectively, and may be possibly used as a functional material for suppression of atopic dermatitis.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.21 no.2
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• pp.71-79
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• 2008

Objectives : The relativity of food allergy to infant atopic dermatitis and the effect of dietary treatment were studied. Methods : Many kinds of medical thesis and books about food allergy and infant atopic dermatitis were surveyed. Results and Conclusion : In this study, we found that food allergen is concerned in infant atopic dermatitis. So the proper dietary treatment can not only improve the symptoms of atopic dermatitis but also prevent atopic dermatitis itself, especially to infants, But before taking dietary treatment, patients' balance of growth and development should be considered, Because they are in the growth period.

• 대한상한금궤의학회지
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• v.9 no.1
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• pp.75-83
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• 2017

Objective : This study reports the effect of Kyejiinsam-tang on Atopic Dermatitis. Methods : This is a case report on a patient who has been suffering from Atopic Dermatitis. According to Diagnostic system based on Shanghanlun provisions, Kyejiinsam-tang was provided for 250 days. The severity of Atopic Dermatitis was evaluated by SCORAD index and pictures. Results : When analyzing the patient's history and symptoms, it can be found in article No. 163 in Shanghanlun. The area and intensity of Atopic Dermatitis were reduced when viewed photos findings, and SCORAD index decreased 58.1 to 7.1. So diagnosis and therapies showed valid results in Atopic Dermatitis. Conclusions : Kyejiinsam-tang is efficient to patient of this case report as a treatment.

• Biomedical Science Letters
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• v.28 no.4
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• pp.276-283
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• 2022

Saccharina japonica (SJ), a brown algae, exerts various pharmacological effects, including anti-oxidant, immunemodulating and anti-cancer properties. This study aimed to determine the pharmacological mechanism of SJ on atopic dermatitis in vivo and in vitro. We investigated the pharmacological effects of SJ on 2, 4-dinitrochlrobenzene (DNCB)- induced atopic dermatitis clinical symptoms in mice. Additionally, we evaluated the effects of SJ on the inflammatory cytokine production and nuclear factor-κB (NF-κB) activation in HaCaT cells. The findings of this study demonstrated that SJ reduced the clinical symptoms of atopic dermatitis, such as skin dryness, erythema and eczematous, and serum histamine and IgE level in DNCB-induced atopic dermatitis model. Additionally, SJ inhibited the NF-κB activation in atopic dermatitis-like skin lesion and HaCaT cells. Collectively, this result suggests that SJ could be used as a therapeutic agent for skin inflammation, including atopic dermatitis.

• Herbal Formula Science
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• v.21 no.1
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• pp.80-90
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• 2013

Objectives : The water extract of Hwangnyeonhaedok-tang (HHT), composed of the Scutellariae Radix, Coptidis Rhizoma, Phellodendri Cortex and Gardeniae Fructus has been traditionally used to treat fever, inflammation, gastritis and hypertension in east asia. However, little is known about the ameliorative effects of HHT on atopic dermatitis. Therefore, the purpose of this study was to investigate the therapeutic effect of HHT on atopic dermatitis Methods : We investigated the inhibitory effects of HHT on the production of proinflammatory cytokines in rat peritoneal mast cells (RPMCs), on the scratching behavior in ICR mice, and on atopic dermatitis symptoms in 2,4-dinitrofluorobenzene (DNFB)-induced atopic dermatitis-like model hairless mice. Results : Levels of TNF-${\alpha}$ and IL-$1{\beta}$ increased by PMA plus A23187 co-treatment were significantly inhibited by HHT in a dose-dependent manner. HHT also inhibited the histamine release from RPMCs stimulated by compound 48/80, which promotes histamine release. The oral administration of HHT reduced the scratching behavior induced by compound 48/80 and histamine in ICR mice. Furthermore, the intradermal treatment of HHT reduced the ear edema, skin lesions, and atopic molecular marker (IgE and IL-4) in DNFB-induced atopic dermatitis model mice. Conclusions : These results suggest that HHT may be used as a potential treatment for AD as a prescription for treatment of atopic dermatitis.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.12 no.1
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• pp.241-253
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• 1999

The results of the study about comparison of Eastern-Western medicine on the Atopic dermatitis were as follows. 1. Atopic dermatitis is chronic eczematous dermatosis which have severe itching, characteristic eruption, easily occur region and pass on chronic relapsing progress and have family history of Atopic disease and hereditary disposition. 2. Atopic dermatitis assume an remarkable clinical aspect and it's diagnosis depends on family history and clinical symptom. 3. In all cases of Western medical treatment is nothing but a symptomatic treatment because can not find out certainly the cause of Atopic dermatitis. 4. Atopic dermatitis is belong to the category of the 'Naesun(내癬)', 'Taeryumchang(胎斂瘡)', 'Samanpoong(四灣風)' etc. in Oriental medicine. 5. The etiology and pathogenesis of Atopic dermatitis in oriental medicine are congenital defect(稟賦不足), internal accumulation of damp and heat(濕熱內鬱), improper diet(飮食不節), exogenous pathogenic factors(外邪侵襲), etc.. 6. The treatments of Atopic dermatitis in oriental medicine are thought effective clear up heat and remove dampness with febrifugal arld diuretic drug(淸熱利濕), invigorate the spleen to resolve dampness(健脾燥濕), nourish Um and blood to relave dryness(滋陰養血潤燥), etc..

• The Journal of Pediatrics of Korean Medicine
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• v.28 no.1
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• pp.1-6
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• 2014

Objectives This study aimed to evaluate the effects of atopic care program through observing atopic patients who have lived in atopic-free village located Geumsan of Chungnam province. Methods Seventeen children (boy 7, and girl 10) with atopic dermatitis had moved into atopic-free village of Geumsan, and they have been cared with atopic care program. Atopic dermatitis symptoms were measured every month using SCORAD (Scoring of Atopic Dermatitis) and EASI (Eczema Area and Severity Index) from March, 2012 to September, 2013. The changes of scores were analyzed using paired t-test. Results The median month of residence period was 19.9 months (range from 6 to 42 months). The atopic symptoms were significantly improved on SCORAD (p<0.01) and EASI (p<0.1) respectively. Conclusion Despite the limitation of the small number of study subjects, this study may provide the possibility of natural environment-based therapy for children with atopic dermatitis.