• Journal of Preventive Medicine and Public Health
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• 제52권3호
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• pp.147-153
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• 2019

Objectives: The purpose of this study was to evaluate the association between body mass index (BMI) and severe lower urinary tract symptoms (LUTS) in Korean males. Methods: This study was conducted on males aged ${\geq}50years$ who participated in the 2011 Korean Community Health Survey. LUTS severity was assessed using the Korean version of the International Prostate Symptom Score (IPSS) questionnaire, and was dichotomized as severe (IPSS >19) and non-severe ($IPSS{\leq}19$). BMI was divided into 6 categories: <18.5, 18.5-22.9, 23.0-24.9, 25.0-27.4, 27.5-29.9, and ${\geq}30.0kg/m^2$. To evaluate the relationship between BMI and LUTS, a survey-weighted multivariate Poisson regression analysis was performed to estimate prevalence rate ratios (PRRs). Age, smoking status, alcohol intake, physical activity, educational level, household income, and comorbidities were adjusted for in the multivariate model. Results: A U-shaped relationship was detected between BMI and severe LUTS. Compared with a BMI of $23.0-24.9kg/m^2$, the PRR for a BMI < $18.5kg/m^2$ was 1.65 (95% confidence interval [CI], 1.35 to 2.02), that for a BMI of $18.5-22.9kg/m^2$ was 1.25 (95% CI, 1.09 to 1.44), that for a BMI of $25.0-27.4kg/m^2$ was 1.20 (95% CI, 1.00 to 1.45), that for a BMI of $27.5-29.9kg/m^2$ was 1.11 (95% CI, 0.83 to 1.47), and that for a BMI ${\geq}30.0kg/m^2$ was 1.85 (95% CI, 1.18 to 2.88). Conclusions: This study showed that both high and low BMI were associated with severe LUTS.

• 한국엔터테인먼트산업학회논문지
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• 제14권8호
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• pp.231-236
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• 2020

본 연구의 목적은 40~50대 중년에서 두개척추각(CVA), 나이, BMI와의 상관관계를 알아보는 것이다. 신체 건강한 성인 남녀 40~50대 456명을 대상으로 3D 센서를 활용한 자세측정기를 활용하여 전방머리자세를 측정하였다. 연구결과 전체 중년의 CVA는 나이와는 높은 수준의 음의 상관관계가 있고((r=-.937; p<.01), BMI에 대해서는 매우 낮은 수준의 양의 상관관계(r=.056가 있음을 확인하였다. 성별에 따른 연구에서 중년 남성의 CVA는 나이와는 높은 수준의 음의 상관관계가 있었고(r=-.932; p<.01). BMI에 대해서는 매우 낮은 수준의 양의 상관관계(r=.071)가 있었다. 반면 중년 여성의 경우엔 나이에 대해서만 높은 수준의 음의 상관관계(r=.940, p<.01)가 나타났고 BMI에 대해서는 상관관계가 나타나지 않았다. 본 연구는 CVA가 남성과 여성 모두에서 연령과 유의 한 음의 상관관계를 가지고 있지만, BMI와 낮은 수준의 상관관계를 가지고 있음을 시사한다.

• Journal of Nutrition and Health
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• 제32권4호
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• pp.430-436
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• 1999

This study investigated the correlations among nutrient intakes, and immune status in Korean young women in relation to body mass index(BMI). Subjects were classified as underweight, normal or overweight, with anthropometric measurements of these three groups significatly different in terms of weight, body fat, waist measurement, hip measurement, waist/hip ratio(WHR), and skindfold thickness(p<0.001). Average vitamin A, vitamin B1, vitamin B2, calcium and zinc levles were lower than the Korean RDA. Vitamin A levels were found to be significantly correlated with BMI(p<0.05). There was no significant difference in total T and B lymphocytes or IgG, IgG, and IgM levels with respect to BMI, but Natural Killer(NK) cell levels were found significantly increased with increased BMI(p<0.05). BMI was also positively correlated with iron intake and negatively correlated with vitamin A intake in the normal group. Based upon this study, further research on nutritional, immune and trace-mineral status of overweight and underweight young women is required for better health promotion in this female populaton.

• 운동영양학회지
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• 제14권2호
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• pp.81-86
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• 2010

The purpose of this study was to identify the factors associated with child's Body Mass Index (BMI) and physical activity. The participants (n = 133) were Korean juveniles (3^rd and 4^th graders) and their parents. They completed a questionnaire packet including the SPARK (Sports, Play, and Active Recreation for Kids) survey and the parent equivalent survey. Correlation, multiple linear regression and binary logistic regression analyses were applied to identify the association between child's BMI and 10 factors of SPARK as predict or variables. 25.6% of the participants were classified as overweight (21.1%) or obesity (4.5%). 3 parental factors including mother's BMI and frequency of mother's and father's physical activity were identified as significant predictors of children's BMI. The 10 variables accounted for 28% of the variance (p<.01) in the linear regression model. These results provide insight into parental factors which are related to a child's BMI and physical activity. Parental role modeling which refers to parents' efforts to model an active lifestyle for children plays an important role.

• 전자공학회논문지
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• 제53권12호
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• pp.147-151
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• 2016

Standing Whole Spine 검사는 많은 병원에서 자동노출제어장치 (automatic exposure control, AEC)를 사용하고 있어 체질량지수 (body mass index, BMI)에 따라 방사선량이 조절되는 특징이 있으며, 이를 통하여 환자 별 측정 DAP (dose area product) 값을 얻을 수 있다. 하지만, 검사 시 장기의 위치에 따른 흡수선량에 관한 연구는 크게 이루어지지 않고 있으며, 이에 본 연구에서는 Standing Whole Spine 검사 시 환자의 두께정보를 대표하는 BMI와 장기의 위치에 따른 흡수선량의 분포를 평가하고자 한다. 연구의 목적을 위하여 측정된 DAP값을 이용하여 PCXMC에서 환자의 5곳의 장기를 선정 (갑상샘, 유방, 심장, 콩팥, 이자)하여 선량을 계산하였다. 결과적으로, 측정된 DAP값은 BMI에 따라 증가하는 경향을 보였지만 전방 장기인 갑상샘, 유방, 그리고 심장에서는 BMI에 따라 장기선량이 감소하는 경향을 보였다. 또한 후방장기인 콩팥과 이자에서는 BMI와 아무런 상관관계를 가지지 않았다. 결론적으로, 본 연구결과를 통하여 Standing Whole Spine 검사 시 BMI와 장기의 위치에 따라 방사선의 영향이 다르게 나타남을 증명하였다.

• 한국산학기술학회논문지
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• 제16권5호
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• pp.3353-3360
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• 2015

본 연구는 현역병을 대상으로 BMI 현황과 같은 연령대의 남성에 비해 BMI가 어떤 차이가 있는지 및 현역병의 BMI 변화에 영향을 미치는 요인이 무엇인지 확인하고자 하였다. 연구방법으로는 4개 부대에서 복무 중인 현역병을 대상으로 2009년 2월 23일부터 3월 31일까지 자기기입식 설문을 실시하였다. 통계분석에는 총 301명을 대상으로 독립표본 T-검정, 교차분석 및 다중선형회귀분석이 사용되었다. 연구결과, 현역병의 과체중 비율은 18.6%로 같은 연령대 남성의 22.1%에 비해 낮아 또래 남성에 비해 현역병의 비만율이 낮은 것으로 확인되었다. 건강행태에서는 정상체중 이하 군(2.39)이 과체중군(2.13)보다 식습관 점수가 높아 정상군이 상대적으로 천천히 먹고, 맵고 단것을 덜 먹는 것으로 확인되었다. 과체중군(2.25)이 정상체중 이하 군(2.98)에 비해 자신의 체형에 대한 만족도가 낮은 반면 체중조절활동은 과체중군(4.01)이 정상체중 이하 군(3.37)보다 점수가 유의하게 더 높게 나타났다. BMI 변화에 대한 영향요인으로는 식습관, 주관적 체형인식, 체중조절활동이 확인되었다. 따라서 현역병의 BMI를 향상시키기 위해서는 개인적 노력보다는 단체 급식과 군 내 매점 운영을 개선하여 조직차원에서 비만에 영향을 주는 요인에 접촉하지 못하도록 하는 중재노력 및 올바른 체형인식에 대한 교육, 체중조절활동에 대한 독려가 필요할 것으로 사료된다.

• Reproductive and Developmental Biology
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• 제31권2호
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• pp.71-76
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• 2007

Previous studies have shown that BMI-1026 is a potent inhibitor of the cyclin-dependent kinases (cdk). In cell culture, the compound also arrests G2/M strongly and G1/S and S weakly. Two key kinases, cdk1 (p34cdc2 kinase) and mitogen-activated protein (MAP) kinase (erk1 and 2), perform crucial roles during oocyte maturation and, later, metaphase II (MII) arrest. In mammalian oocytes, both kinases are activated gradually around the time of germinal vesicle breakdown (GVBD) and maintain high activity in eggs arrested at metaphase II. In this study, we examined the effects of BMI-1026 on GVBD and MII arrest in mouse oocytes. BMI-1026 inhibited GVBD of immature oocytes and activated MII-arrested oocytes in a concentration-dependent manner, with more than 90% of oocytes exhibiting GVBD inhibition and MII activation at 100 nM This is approximately 500$\sim$1,000 times more potent than the activity reported for the cdk inhibitors roscovitine (${\sim}50{\mu}M$) and butyrolactone (${\sim}100{\mu}M$). Based on the results of previous in vitro kinase assays, we expected BMI-1026 to inhibit only cdk1 activation in oocytes and eggs, not MAP kinase. However, in our cell-based system, it inhibited the activity of both kinases. We also found that the effect of BMI-1026 is reversible. Our results suggest that BMI-1026 inhibits GVBD and activates MII-arrested oocytes efficiently and reversibly and that it also inhibits both cdk1/histone HI kinase and MAP kinase in mouse oocytes.

• Journal of Nutrition and Health
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• 제21권4호
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• pp.213-222
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• 1988

The purpose of this study was to investigate physical condition, physical fitness, sociodemographic factors, biochemical factors and personality factors of 5th grade students of elementary school. The number of students surveyed was 760 from each school of urban, middle and rural areas. All data analysis was done by BMI group which is based on previous study. 1) The children whose parents were on low education level and mother had a job had lower BMI values than others. Nine percent of male and 21% of female subjects skipped breakfast almost everyday. The 21.7% of all subjects regularly took nutritive pills, which had no difference in various BMI groups. 2) The physical condition of children had a high correlation with that of parents. 3) The physical fitness in BMI 5 groups was weaker than other groups, especially in male. 4) The contents of blood hemoglobin, cholesterol and glucose and hematocrit value were estimated. In female, the values of hemoglobin content and hematocrit had significant difference between BMI groups, but there are no trends. 5) The impulsiveness of male was the highest in BMI 1 group and the lowest in BMI 5 group among 5 groups. Besides, general activity, reflectivity and sociality in BMI 5 group had a low level. In female, personality factors except sociality didn't show any considerable difference.

• BMB Reports
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• 제41권7호
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• pp.523-528
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• 2008

BMI-1026 is a synthetic aminopyrimidine compound that targets cyclin dependent kinases (cdks) and was initially designed as a potential anticancer drug. Even though it has been well documented that BMI-1026 is a potent cdk inhibitor, little is known about the cellular effects of this compound. In this study, we examined the effects of BMI-1026 treatment on inducing premature senescence and then evaluated the biochemical features of BMI-1026-induced premature senescence. From these experiments we determined that BMI-1026 treatment produced several biochemical features of premature senescence and also stimulated expression of mitogen activated protein kinase (MAPK) family proteins. BMI-1026 treatment caused nuclear translocation of activated Erk1/2 and the formation of senescence associated heterochromatin foci in 5 days. The heterochromatin foci formation was perturbed by inhibition of Erk1/2 activation.

• Knee surgery & related research
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• 제30권4호
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• pp.319-325
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• 2018

Purpose: Body mass index (BMI) is often used to predict surgical difficulty in patients receiving total knee arthroplasty (TKA); however, BMI neglects variation in the central versus peripheral distribution of adipose tissue. We sought to examine whether anthropometric factors, rather than BMI alone, may serve as a more effective indication of surgical difficulty in TKA. Materials and Methods: We prospectively enrolled 67 patients undergoing primary TKA. Correlation coefficients were used to evaluate the associations of tourniquet time, a surrogate of surgical difficulty, with BMI, pre- and intraoperative anthropometric measurements, and radiographic knee alignment. Similarly, Knee Injury and Osteoarthritis Outcome Score (KOOS) was compared to BMI. Results: Tourniquet time was significantly associated with preoperative inferior knee circumference (p=0.025) and ankle circumference (p=0.003) as well as the intraoperative depth of incision at the quadriceps (p=0.014). BMI was not significantly associated with tourniquet time or any of the radiographic parameters or KOOS scores. Conclusions: Inferior knee circumference, ankle circumference, and depth of incision at the quadriceps (measures of peripheral obesity) are likely better predictors of surgical difficulty than BMI. Further study of alternative surgical indicators should investigate patients that may be deterred from TKA for high BMI, despite relatively low peripheral obesity.