• Journal of Korean Society of Industrial and Systems Engineering
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• v.42 no.1
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• pp.55-63
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• 2019

This paper develops an algorithm to determine the batch size of the batch process in real time for improving production and efficient control of production system with multiple processes and batch processes. It is so important to find the batch size of the batch process, because the variability arising from the batch process in the production system affects the capacity of the production. Specifically, batch size could change system efficiency such as throughput, WIP (Work In Process) in production system, batch formation time and so on. In order to improve the system variability and productivity, real time batch size determined by considering the preparation time and batch formation time according to the number of operation of the batch process. The purpose of the study is to control the WIP by applying CONWIP production system method in the production line and implements an algorithm for a real time batch size decision in a batch process that requires long work preparation time and affects system efficiency. In order to verify the efficiency of the developed algorithm that determine the batch size in a real time, an existed production system with fixed the batch size will be implemented first and determines that batch size in real time considering WIP in queue and average lead time in the current system. To comparing the efficiency of a system with a fixed batch size and a system that determines a batch size in real time, the results are analyzed using three evaluation indexes of lead time, throughput, and average WIP of the queue.

• Journal of Institute of Control, Robotics and Systems
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• v.12 no.12
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• pp.1163-1168
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• 2006

Manufacturing technology for the production of high value-added fine chemical products is emphasized and getting more attention as the diversified interests of customers and the demand of high quality products are getting bigger and bigger everyday. Thus, the development of advanced batch processes, which is the preferred and most appropriate way of producing these types of products, and the related technologies are becoming more important. Therefore, high-precision batch distillation is one of the important elements in the successful manufacturing of fine chemicals, and the importance of the process operation strategy with quality assurance cannot be overemphasized. Accordingly, proposing a process structure explanation and operation strategy of such processes including batch processes and batch distillation would be of great value. We investigate optimal operation strategy and production planning of multi-purpose plants consisting of batch processes and batch distillation for the manufacturing of fine chemical products. For the short-term scheduling of a sequential multi-purpose batch plant consisting of batch distillation under MPC and UIS policy, we proposed a MILP model based on a priori time slot allocation. Also, we consider that the waste product of being produced on batch distillation is recycled to the batch distillation unit for the saving of raw materials. The developed methodology will be especially useful for the design and optimal operations of multi-purpose and multiproduct plants that is suitable for fine chemical production.

• KSBB Journal
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• v.24 no.1
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• pp.70-74
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• 2009

For continuous culture of cellulolytic enzymes production to saccharify food wastes, refill concentration of Mandel's medium for continuous culture was 0.5%, and refill intervals were determined to 12 hours by analysis of COD and total nitrogen concentration after 4-days batch culture in flask level. As a result, amylase and FPase productivities were 3.5 and 1.0 U/L.hr, respectively. In 10 L bioreactor, the batch culture mode was compared with fed-batch, fill-and-draw for continuous production of cellulolytic enzyme. Enzyme productivities were most high at batch culture and followed by fed-batch culture. Amylase and FPase activities were 42.3 and 5.6 U/L.hr at batch culture, and 23.0, 2.8 U/L.hr at fed-batch culture, respectively. As a result, in continuous cultivation of cellulolytic enzymes by T. inhamatum KSJ1, the mode of fed-batch was most effective in 10 L bioreactor.

• Journal of the Korea Society for Simulation
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• v.5 no.2
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• pp.59-72
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• 1996

The purpose of this study is to make an improvement to the batch-means method, which is a procedure to construct a confidence interval(c.i.) for the steady-state process mean of a stationary simulation output process. In the batch-means method, the data in the output process are grouped into batches. The sequence of means of the data included in individual batches is called a batch-menas process and can be treated as an independently and identically distributed set of variables if each batch includes sufficiently large number of observations. The traditional batch-means method, therefore, uses a batch size as large as possible in order to. destroy the autocovariance remaining in the batch-means process. The c.i. prodedure developed and empirically tested in this study uses a small batch size which can be well fitted by a simple ARMA model, and then utilizes the dependence structure in the fitted model to correct for bias in the variance estimator of the sample mean.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.36 no.3
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• pp.118-125
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• 2013

This paper deals with the picking batch size which a bi-directional carousel system can be feasible. The items that customers order are retrieved from the bins of carousel with batch size. The mathematical equations representing rotary travel distance and retrieval lead time to pick a given batch size are derived. Rotary travel distance represents the distance which carousel system rotates to retrieve items in a batch. The bi-directional carousel system rotates to minimize the travel distance in retrieving the items in a batch. Rotary travel distance and retrieval lead time are analyzed for the batch size through the simulation approach. From the simulation, the retrieval batch size that carousel system can be feasible is obtained. A numerical example is shown to explain the solution procedure.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.36 no.2
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• pp.17-24
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• 2013

This paper is to analyze the picking lead time for picking batch size in a warehouse system and to get minimum picking batch size that is the warehouse system feasible. The warehouse system consists of aisles and racks, which two racks face each other through aisle. The products are picked from the storage locations by batch size. The probability that items are picked in the each row of the rack in the aisle for order picking activity is derived. The picking lead time for picking batch size is the time passed from the first picking location to arrival at starting location in aisle picking all items included in a batch size. The picking lead time for picking batch size in an aisle is analyzed. The picking lead time for picking batch size in the whole warehouse system is obtained. The warehouse system is feasible if all items that customers order are picked from the storage locations for same period. The picking batch size that is the warehouse system feasible is obtained. The problem is analyzed, a solution procedure is developed, and a numerical example is shown to explain the problem.

• Fisheries and Aquatic Sciences
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• v.21 no.10
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• pp.33.1-33.11
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• 2018

As a process for commercial application, production of reducing sugar, antioxidant, and DNA protective compounds from shrimp-shell powder was investigated in a fed-batch biodegradation using Bacillus cereus EW5. The fed-batch biodegradation was operated in a 5-L bioreactor for 96 h according to three times pulse-feeding strategy. On the basis of the equal working volume (3 L), the fed-batch biodegradation showed a better production of the target compounds than the batch biodegradation, with higher cell density and shortened biodegradation period. The maximum values of the target compounds were 0.297 mg/mL of reducing sugar, 92.35% DPPH radical scavenging activity, 98.16% ABTS radical scavenging activity, and 1.55 reducing power at $A_{700}$, which were approximately 12.1, 3.4, 5.2, and 8.4% enhanced, respectively, compared with those obtained from the batch biodegradation. The fed-batch culture supernatant also showed the enhanced DNA damage inhibition activity than the batch culture supernatant. As a result, the fed-batch biodegradation accompanied by high cell density could produce more useful compounds, enabling an increase in the reutilization value of shrimp-shell waste.

• KSBB Journal
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• v.13 no.4
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• pp.411-417
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• 1998

The possibility of application of membrane type immobilized adsorbent to the fed-batch or perfusion culture system with anchorage-independent cells as well as batch system was investigated. The improvement in cell density and cell viability due to the combination of immobilized adsorbent with each culture system was evaluated for the investigation, and the optimum culture system employing immobilized adsorbent system was suggested based on the results. It was observed that the system with immobilized adsorbent showed better cell growth and cell viability than that without immobilized adsorbent in every operation system of batch, fed-batch, and perfusion. In case of batch system, 200% improvement of maximum cell density was observed in the system where ammonium chloride was added on purpose. And 50% improvement of maximum cell density was observed in the fed-batch system where ammonium ion accumulates significantly, while small increase in maximum cell density was observed in the perfusion system where dilution of waste byproducts exists. Especially, the fed-batch system showed the most significant improvement on cell growth because both compensation of nutrient and removal of ammonium ion occurred simultaneously in the system. Therefore a combined system of immobilized adsorbent and fed-batch operation could be suggested as an optimum system with in situ removal of ammonium ion.

• Biotechnology and Bioprocess Engineering:BBE
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• v.6 no.1
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• pp.11-17
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• 2001

To enhance the productivity and activity of nitrile hydratase in Rhodococcus rhodochrous M33, a glucose-limited fed-batch culture was performed. In a fed-batch culture where the glucose was controlled at a limited level and cobalt was supplemented during the fermentation period, the cell mass and total activity of nitrile hydratase both increased 3.3-fold compared to that in the batch fermentation. The productivity of nitrile hydratase also increased 1.9-fold compared to that in the batch fermentation. The specific activity of nitrile hydratase in the whole cell preparation when using a fed-batch culture was 120 units/mg-DCW, which was similar to that in the batch culture.

• Nuclear Engineering and Technology
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• v.51 no.4
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• pp.954-962
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• 2019

It is well known that the variance of tally is biased in a Monte Carlo calculation based on the power iteration method. Several studies have been conducted to estimate the real variance. Among them, the batch method, which was proposed by Gelbard and Prael, has been utilized actively in many Monte Carlo codes because the method is straightforward, and it is easy to implement the method in the codes. However, there is a problem when utilizing the batch method because the estimated variance varies depending on batch size. Often, the appropriate batch size is not realized before the completion of several Monte Carlo calculations. This study recognizes this shortcoming and addresses it by permitting selection of an appropriate batch size.