• Journal of Acupuncture Research
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• v.29 no.2
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• pp.15-27
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• 2012

Objectives : The purpose of this study is to evaluate the effect of cotreatment with $Samgieum-gagam$, acupuncture and sweet bee venom acupuncture on post-stroke shoulder pain. Methods : The subjects in this study were 43 patients with post-stroke hemiplegic shoulder pain. These patients were randomly divided into four groups : the group treated with acupuncture, the group cotreated with acupuncture and sweet bee venom acupuncture, the group cotreated with acupuncture and $Samgieum-gagam$, the group cotreated with acupuncture, sweet bee venom acupuncture and Samgieumgagam, They were treated for 4 weeks, and the effectiveness was assessed by visual analogue scale(VAS), Fugl-Meyer motor assessment(FMMA), painless passive ROM of shoulder external rotation(PROM), Modified Ashworth sacle(MAS) and Satisfaction. Results : All groups showed significant change in VAS, FMMA and PROM. The group cotreated with acupuncture, sweet bee venom acupuncture and $Samgieum-gagam$ showed more effectiveness in VAS and FMMA than the group treated with acupuncture. There was no significant difference in MAS among groups. Conclusions : This study suggests that cotreatment with $Samgieum-gagam$, acupuncture and sweet bee venom acupuncture is more effective than acupuncture treatment only on post-stroke shoulder pain. Further study based on many other combination methods, larger population, and long term follow-up is needed to confirm this suggestion.

• The Journal of Korea CHUNA Manual Medicine
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• v.4 no.1
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• pp.29-38
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• 2003

Objectives : This report was performed to evaluate the treatment of acupuncture Therapy. Bee venom acupuncture Therapy, Herbal medication and Moxibustion In Chronic lschial bursitis. Methods : We treated 1 case of chronic Ischial Bursitis with acupuncture therapy, Bee Venom Acupuncture therapy, herbal medication and Moxibustion Results : After 8 weeks of acupuncture Therapy. Bee venom acupuncture Therapy, Herbal medication and Moxibustion. a remarkable improvenment was made for Chronic lschial bursitis. The patient couldn't feel painful swelling over the center of the buttock and down the back of the leg. Conclusion : Acupuncture Therapy, Bee venom acupuncture Therapy, Herbal medication and Moxibustion were effective In reducing the symptoms. We think that it need the further study and clinical trial for Chronic lschial bursitis.

• The Journal of Churna Manual Medicine for Spine and Nerves
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• v.1 no.1
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• pp.73-81
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• 2006

Objectives : This report was performed to evaluated the treatment of Bee venom acupuncture Therapy, acupuncture Therapy, Herbal medicaion and Moxibustion in herniation of inter-vertebral disc. Methods : We treated 1 case of herniation of inter-vertebral disc with Bee venom acupuncture Therapy, acupuncture Therapy, Herbal medicaion and Moxibustion. Results : After 12 days of Bee venom acupuncture Therapy, acupuncture Therapy, Herbal medicaion and Moxibustion, a remarkable improvement was made for herniation of inter-vertebral disc. The patient couldn't feel pain on walking. Conclusion : Bee venom acupuncture Therapy, acupuncture Therapy, Herbal medicaion and Moxibustion were effective in reducing the symptoms.

• Korean Journal of Acupuncture
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• v.37 no.2
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• pp.76-87
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• 2020

Objectives : Bee venom has been widely practiced in many countries around the world. The number of clinical trials and biochemical researches on bee venom has been constantly increasing. The objective of this study is to analyze the trend of research on bee venom using bibliometric approach, a quantitative analytical method. Methods : We searched articles about bee venom which were published from 2000 to 2019 from Web of Science Database. Original and review articles published in English were included and data were extracted in terms of publication year, country, journal, keywords, organizations, and authors. Trends in bee venom research were visualized using VOSviewer program. Results : 1,547 English articles about bee venom were identified and analyzed. South Korea is a main hub in the field of bee venom research. Research organizations in South Korea showed high link strength with domestic organizations as well as with international organizations. A keyword analysis showed the following three major types of studies: studies on components of bee venom, studies on allergy and immune response, and clinical research of bee venom therapy. Conclusions : This study provides a macroscopic overview of the research on bee venom. This bibliometric analysis has identified influential authors and organizations in the field on bee venom research and provides a useful guideline to researchers who are in search of contributory research topics.

• Journal of Acupuncture Research
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• v.22 no.6
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• pp.37-50
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• 2005

Objectives : The purpose of this study was to investigate the anti-caner effect of Bee Venom and Melittin on the prostatic cancer cell(PC-3). The goal of study is to ascertain whether Bee Venom and Melittin inhibits the cell growth and cell cycle of PC-3, or the expression of relative genes and whether the regression of PC-3 cell growth is due to cell death or the expression of gene related to apoptosis. Methods : After the treatment of Pc-3 cells with Bee Venom and Melittin, we performed Fluorescence microscope, MTT assay, Western blotting, Flow cytometry, PAGE electrophoresis and Surface plasmon resonance analysis to identify the cell viability, apoptosis and gene related to apoptosis. Results : 1. Compared with Control cell, the inhibition of cell growth reduced in proportion with the dose of Bee Venom or Melittin($0{\sim}10{\mu}g/ml$) in PC-3. 2. In PC-3, Cell viabilities of Bee Venom or Melittin treatment was decreased significantly. 3. The nucli of Control cells were stained round and homogenous in DAPI staining, but those of PC-3 were stained condense and splitted. 4. In PC-3, apoptosis of Bee Venom or Melittin treatment was increased significantly. 5. Bax, Caspase-3 and P ARP of Bee Venom or Melittin treatment was increased significantly and Bcl-2 of Bee Venom or Melittin treatment was decreased significantly. Caspase-9 of Bee venom treatment was increased significantly. Conclusion : These results indicate that Bee Venom and Melittin inhibits the growth of prostate cancer cells, has anti-cancer effects by inducing apoptosis. We wish that the anti-cancer effects of Bee Venom and Melittin are used to clinical caner treatment.

• Journal of Acupuncture Research
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• v.17 no.4
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• pp.69-78
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• 2000

Objective : To research the trends of the study related to bee venom and cancer, and to establish the hereafter direction of the study on bee venom herbal acupuncture. Method : We searched in PubMed, with bee venom and cancer(in English, with abstract) Results : 1. We searched 28 Journals, 36 Papers. the frequency of Journals and Papers was as follows: Biochem Biophys Res Commun(4 Papers), FEBS Lett(3), Life Sci, Proc Natl Acad Sci USA, J Immunol(each 2), other 23 Journals(each 1). 2. The pattern of the study was as follows: Review article(3 Journals, 3 Papers), Epidemiologic study(1, 1), Experimental study(24, 32) In vivo 1, 1), In vitto(24, 31) 3. The involved components of bee venom were as follows: Melittin(20), Apamin(8), Phospholipase A2(3), Melittin & Phospholipase A2(3), Melittin& Tertiapin(1). 4. The involved cancer was as follows: leukemia(9), tumor(5), neuroblastoma(4), pituitary tumor and pheochromocytoma(each 3), lymphoma, astrocytoma, glioma and lung cancer(small cell carcinoma)(eacn 2), bladder carcinoma, pancreatic cancer, breast carcinoma, ovarian carcinoma and spuamous cell carcinoma(each 1) Conclusion : We concluded that the most frequent pattern of the study was in vitro experimental study with peptide components of bee venom and the most frequeni invovled cancer was leukemia.

• Journal of Acupuncture Research
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• v.21 no.5
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• pp.179-190
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• 2004

Objectives : The purpose of this study was to investigate the effect of Bee Venom and Melittin acupuncture solution on the lipopolysaccharide and sodium nitroprusside- induced expression of cytosolic phospholipase $A_2$, tumor necrosis factor-${\alpha}$ and calcium concentration in RAW 264.7 cells, a murine macrophage cell line. Methods : The expression of cytosolic phospholipase $A_2$ and tumor necrosis factor-${\alpha}$ was determined by western blotting with corresponding antibodies, and the generation of intracellular calcium concentration was investigated by delta scan system in RAW 264.7 cells. Results : 1. Compared with control, expressions of lipopolysaccharide-induced cytosolic phospholipase $A_2$ were decreased significantly by $5{\mu}g/mL$ of bee venom and 5, $10{\mu}g/mL$ of melittin acupuncture solution and decreased by 0.5, $1{\mu}g/mL$ of bee venom. 2. Compared with control, expressions of sodium nitroprusside-induced phospholipase $A_2$ were decreased significantly by 0.5, 1, $5{\mu}g/mL$ of bee venom and by 5, $10{\mu}g/mL$ of melittin acupuncture solution. 3. Compared with control, expressions of lipopolysaccharide-induced tumor necrosis factor-${\alpha}$ were decreased significantly by $10{\mu}g/mL$ of melittin acupuncture solution and were not changed significantly by 0.5, 1, $5{\mu}g/mL$ of bee venom and $5{\mu}g/mL$ of melittin acupuncture solution. 4. Compared with control, expressions of sodium nitroprusside-induced tumor necrosis factor-${\alpha}$ were decreased significantly by 1, $5{\mu}g/mL$ of bee venom and 5, $10{\mu}g/mL$ of melittin acupuncture solution and decreased by $0.5{\mu}g/mL$ of bee venom 5. Compared with control, lipopolysaccharide-induced intracellular calcium concentrations were decreased by 0.5, 1, $5{\mu}g/mL$ of bee venom and $10{\mu}g/mL$ of melittin acupuncture solution and increased by $5{\mu}g/mL$ of melittin acupuncture solution. 6. Compared with control, sodium nitroprusside-induced intracellular calcium concentrations were decreased by 0.5, 1, $5{\mu}g/mL$ of bee venom and 5, $10{\mu}g/mL$ of melittin acupuncture solution.

• Korean Journal of Acupuncture
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• v.21 no.4
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• pp.133-143
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• 2004

Objective : The purpose of this study is to compare the effect of Bee-Venom Therapy and common acupuncture therapy for the acute ankle sprain Methods : This study has been carried out for 32 cases of ankle sprain patients who have visited Cheon-an Oriental Medical Hospital from may 1, 2004 to June 30, 2004. We have treated 16 cases of them by Bee-Venom therapy(group I) and the other 16 cases by common acupuncture therapy(group II). And we have compared those two group. Results and Conclusions : 1. There were good effect on the ankle sprain in both two groups. 2. There were no significant difference at the ROM of ankle joint in both two groups. 3. Common acupuncture therapy had more quick effect on the joint of swelling. 4. In the VAS score, Bee-Venom therapy had more quick effect on total improvement of ankle sprain.

• Journal of Acupuncture Research
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• v.19 no.6
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• pp.67-79
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• 2002

Objective : This study was designed to find out the effects of Korean bee-venom therapy on neck pain due to soft tissue damage. Methods : This study was carried out for 34 patients who had neither structral defectiveness of cervical spine nor neural injury but simple soft tissue damage among poeple who visited Hye-dang Oriental Hospital from March 4, 2002 to September 30, 2002. Group A of 17 patients was taken Korean bee-venom therapy Group B of 17 patients was taken common acupuncture therapy. Results : We have found out the good effects of Korean bee-venom therapy on the patients due to soft tissue damage. Conclusions : The Korean bee-venom therapy is useful on the patients of neck pain due to soft tissue damage.

• Journal of Haehwa Medicine
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• v.13 no.2
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• pp.267-276
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• 2004

Objective : The purpose of this study is to compare the effect of Bee-Venom Therapy and common acupuncture therapy for the lateral epicondylitis. Methods : This study has been carried out for 24 cases of ankle sprain patients who have visited Dr. An Keun Hyeong's Oriental Clinic from april 1, 2004 to august 30, 2004. We have treated 12 cases of them by Bee-Venom therapy(group I) and the other 12 cases by common acupuncture therapy(group II). And we have compared those two group. Results : 1. There were statistical significance on the pain and grip strength with bee-venom therapy group. 2. There were statistical significance on the pain and grip strength with common acupuncture therapy group. 3. Bee-venom therapy group was more statistical significance than common acupuncture therapy group on the pain. 4. There were no statistical significance between bee-venom therapy group and common acupuncture therapy group on the grip strength.