• Title/Summary/Keyword: Biliverdin

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Syntheses of Silica Gel Bound Hemin, Biliverdin, and Bilirubin

  • Park, Yong-Tae;David A. Lightner
    • Bulletin of the Korean Chemical Society
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    • v.6 no.2
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    • pp.112-115
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    • 1985
  • 3-Aminopropylsilated silica gel bound hemin, biliverdin, and bilirubin were synthesized by reacting 3-aminopropyl silated silica gel with hemin, biliverdin and bilirubin respectively. The aspects of binding of bilirubin to amino group of 3-aminopropylsilated silica gel were studied using the above synthetic silica immobilized hemin, biliverdin and bilirubin, and oxodipyrromethene.

Eggshell Pigmentation Study in Blue-shelled and White-shelled Ducks

  • Liu, H.C.;Hsiao, M.C.;Hu, Y.H.;Lee, S.R.;Cheng, W.T.K.
    • Asian-Australasian Journal of Animal Sciences
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    • v.23 no.2
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    • pp.162-168
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    • 2010
  • This study attempted to clarify the difference in eggshell pigmentation between blue-shelled ducks (BSD) and whiteshelled ducks (WSD). The eggshell pigmentation deposition process is discussed. Ultraviolet spectro-photometer and HPLC were used to determine the biliverdin concentration in the shell gland, uterus liquid and eggshell at 6, 12, 18, 20, 23.5 h post-oviposition. The biliverdin concentration in the eggshell and uterus fluid showed significant differences between BSD and WSD, but not in the shell gland. The heme oxygenase activity in the shell gland of both kinds of ducks remained mostly constant during the ovulatory cycle with no variation. The assay of exogenous biliverdin injection into the shell gland antrum in the WSD indicated that exogenous biliverdin could be deposited continuously into the eggshell until the source was exhausted. A layer-by-layer dissolution assay was used to examine the eggshell pigment deposition process. The biliverdin concentration in the first to sixth layers of the eggshell in the BSD was significantly higher than that in the white-shelled counterpart. The blue pigment concentration increased persistently from the 6th layer to the $1^{st}$ layer. The BSD eggshells did not accumulate a large quantity of biliverdin in the most external layer. They tended to increase the deposition layer by layer. Our results demonstrated that different BSD and WSD eggshell colors were influenced by the amount of biliverdin in the uterus fluid and not determined by the amount of biliverdin in the shell gland. This implies the existence of a mechanism that controls biliverdin transportation from the shell gland into the uterus fluid, thereby playing a key role in regulating duck eggshell color.

Electrochemical Behaviors of Biliverdin in N,N-Dimethylformamide (N,N-Dimethylformamide 용매 중에서 Biliverdin의 전기화학적 거동)

  • Zun Ung Bae;Heung Lark Lee;Tae Myeong Park
    • Journal of the Korean Chemical Society
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    • v.37 no.8
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    • pp.730-734
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    • 1993
  • The electrochemical reduction behavior or Biliverdin (BV) in N,N-dimethylformamide solvent was studied by DC polarography, cyclic voltammetry and the controlled potential coulometry. The reduced product was indentified by UV-Vis spectroscopy. In DC polarogram, two reduction waves of BV were founded. The half wave potentials of two reduction waves were -0.71 and -0.91 V vs. Ag/Ag$^+$ respectively. The current type of the 1st reduction wave was diffusion-controlled and the 2nd was diffusion current containing a little kinetic current. The 1st electrochemical reduction process was irreversible and BV reduced to Bilirubin.

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Heme Oxygenase-1 : Its Therapeutic Roles in Inflammatory Diseases

  • Pae, Hyun-Ock;Chung, Hun-Taeg
    • IMMUNE NETWORK
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    • v.9 no.1
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    • pp.12-19
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    • 2009
  • Heme oxygenase (HO)-1 is an inducible enzyme that catalyzes the first and rate-limiting step in the oxidative degradation of free heme into ferrous iron, carbon monoxide (CO), and biliverdin (BV), the latter being subsequently converted into bilirubin (BR). HO-1, once expressed during inflammation, forms high concentrations of its enzymatic by-products that can influence various biological events, and this expression is proven to be associated with the resolution of inflammation. The degradation of heme by HO-1 itself, the signaling actions of CO, the antioxidant properties of BV/BR, and the sequestration of ferrous iron by ferritin all concertedly contribute to the anti-inflammatory effects of HO-1. This review focuses on the anti-inflammatory mechanisms of HO-1 actions and its roles in inflammatory diseases.

Diagnostic Role of Bile Pigment Components in Biliary Tract Cancer

  • Keun Soo Ahn;Koo Jeong Kang;Yong Hoon Kim;Tae-Seok Kim;Kwang Bum Cho;Hye Soon Kim;Won-Ki Baek;Seong-Il Suh;Jin-Yi Han
    • Biomolecules & Therapeutics
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    • v.31 no.6
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    • pp.674-681
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    • 2023
  • Bile pigment, bilirubin, and biliverdin concentrations may change as a results of biliary tract cancer (BTC) altering the mechanisms of radical oxidation and heme breakdown. We explored whether changes in bile pigment components could help distinguish BTC from benign biliary illness by evaluating alterations in patients with BTC. We collected bile fluid from 15 patients with a common bile duct stone (CBD group) and 63 individuals with BTC (BTC group). We examined the bile fluid's bilirubin, biliverdin reductase (BVR), heme oxygenase (HO-1), and bacterial taxonomic abundance. Serum bilirubin levels had no impact on the amounts of bile HO-1, BVR, or bilirubin. In comparison to the control group, the BTC group had considerably higher amounts of HO-1, BVR, and bilirubin in the bile. The areas under the curve for the receiver operating characteristic curve analyses of the BVR and HO-1 were 0.832 (p<0.001) and 0.891 (p<0.001), respectively. Firmicutes was the most prevalent phylum in both CBD and BTC, according to a taxonomic abundance analysis, however the Firmicutes/Bacteroidetes ratio was substantially greater in the BTC group than in the CBD group. The findings of this study showed that, regardless of the existence of obstructive jaundice, biliary carcinogenesis impacts heme degradation and bile pigmentation, and that the bile pigment components HO-1, BVR, and bilirubin in bile fluid have a diagnostic significance in BTC. In tissue biopsies for the diagnosis of BTC, particularly for distinguishing BTC from benign biliary strictures, bile pigment components can be used as additional biomarkers.