• Journal of Biosystems Engineering
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• v.30 no.5 s.112
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• pp.306-311
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• 2005

In this study, a biosensor was developed to rapidly diagnose the swine sarcoptic mange (Sarcoptes scabies var. suis). The ELISA was modified to reduce the processing time for rapid diagnosis. The biosensor consists of a biological reaction part, and a measurement and control part. The biological reaction part was designed for using micro-pumps and valves for fluid transportation, and the measurement control part composed of a photodiode, a light-emitting diode fur light measurement, and a microcomputer to implement assay A polystyrene covet was used as a reaction chamber. Signal output was read as the rate of change in optical density at 645nm. Eighteen pigs diagnosed with sacroptic mange and 19 control pigs were tested. Fifteen sacbies-infested pigs showed positive results ($83.3\%$ sensitivity). Sixteen control pigs showed negative results ($84.2\%$ specificity). The system could execute a diagnosis cycle in about 45 min. The results suggest that this biosensor is useful for the rapid diagnosis of swine sacroptic mange.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.12 no.5
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• pp.930-936
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• 2008

CMOS image monitoring system for optimal measuring the activity of biosensor is developed using genetic algorithm. Most of living organism in water as water flea, fish, etc are frequently used as biological sensor for monitoring the water quality. It is very difficult to measure the activity of biosensor by image sensor because the value of measurement is varied with gathering method of biosensor images. The suggested monitoring system can optimally measures the activity of biosensor by genetic algorithm. The system is implemented with FPGA into the small hardware which is excellent in terms of the price and performance.

• Biotechnology and Bioprocess Engineering:BBE
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• v.5 no.6
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• pp.387-394
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• 2000

The relationship between Man and yeast has been a successful and enduring one. The characteristics of yeast have made it an ideal tool in scientific research and as such, it has been used extensively. In this review some of the advantages, methods and applications of yeasts in the biosensor field are outlined. In doing so, we propose a eukaryotic alternative to the current battery of bacteria-based microbial biosensors.

• 한국생물공학회:학술대회논문집
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• 2003.10a
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• pp.201-204
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• 2003

Plasma lipoproteins transporting cholesterol through blood vessels are divided into three major classes, VLDL, LDL, and HDL. The ratio of HDL cholesterol over the total can be used as an indicator for prognosis of coronary artery diseases. In this study, we have developed two analytical systems for %HDL cholesterol with different flow modes toward gravity and analyzed them for their characteristics and performances.

• Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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• 2003.09a
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• pp.475-478
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• 2003

A sol-gel fiber-optic biosensor with encapsulated pH-sensitive fluorophore and immobilized genetically modified toluene-o-xylene monooxygenase was developed to detect TCE, which is carcinogenic chlorinate organic compounds prevailing in ground water. The sensitivity was characterized for the composition of sol-gel, and manufacturing procedure.

• Proceedings of the Korean Vacuum Society Conference
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• 2011.02a
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• pp.12-12
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• 2011

Interfacing functional materials with electrical or biological systems is of prime importance in terms of expanding applicative fields and obtaining high performances of devices. Herein, I report the functionalization of graphenes through supramolecular assembly and their electrochemical applications into fuel cells, supercapacitors, and biosensor devices. The solution processable nanohybridization of graphenes by functional materials such as ionic liquids, polyelectrolytes, block copolymers, and biomaterials, described herein would pave the way to obtain high performances of flexible energy and biosensor devices as well as to overcome the existing technology barriers.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2008.05a
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• pp.898-901
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• 2008

Measuring instrument module for biosensor activity is developed using CMOS image sensor and sensor network. Most of living organism in water as water flea, fish, etc are frequently used as biological sensor for monitoring the water qualify. The activity of biosensor is changed by the quality of water. The developed measuring instrument module can easily interface to the existing instrument.

• KSBB Journal
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• v.13 no.5
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• pp.477-482
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• 1998

A biosensor with PZT piezoelectric ceramic crystal was developed for the detection of formaldehyde gas. Poled PZT piezoelectric ceramic disk was made from ZrO2, TiO2 and Nb2O5, together with the addition of PbO and polyvinyl alcohol, through various processes of mixing, calcination drying, crushing, forming, sintering, polishing, ion coating and poling. Oscillator circuit of sensor was made of operational amplifier(AD811AN). Formaldehyde dehydrogenase was immobilized onto a piezoelectic ceramic crystal, together with the cofactors, reduced glutathione and nicotinamide adenine dinucleotide. The effect of flow rate on the sensitivity was determined by varing the flow rate of carrier gas from 24.7mL/min to 111.7mL/min through detector cell. The results indicated that as the flow rate was increased, the recovery rate was increased. And a significant increase in the sensitivity was observed in enhanced flow rate of carrier gas. Frequency difference(ΔF) of immobilized PZT piezoelectic disk increased proportionally to the concentration gas and reproduced to repeated exposures of formaldehyde gas(28ppm, Δ68Hz).

• KSBB Journal
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• v.14 no.1
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• pp.1-8
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• 1999

It confirmed the facilitated diffusion of $Na^+$ of frog bladder membrane which is a tissue membrane. The mechanism was explained in $Na^+$ channel model and its referred to the $Na^+$ channel obstruction ingredient which was contained in the reference to the $Na^+$ channel obstruction ingredient and son on, e.g., seaweed, shellfish, pufferfish, phytoplankton and chinese drug. Also, it introduces the result which studied from the barrier point of the application of the tissue biosensor to the trade friction on Korea or Japan pufferfish and the marine environment in the one with high dependance. It was possible for the poison quantity of small amount pufferfish toxin (TTX), paralytic shellfish poisoning (PSP) to be measured and also to measure poison quantity in the cultivation poisonous toxin phytoplankton individual. In future, as for this tissue biosensor, it expects that it is possible to contribute widely until environment watch and also monitoring to the scene.

• BMB Reports
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• v.31 no.3
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• pp.296-302
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• 1998

A potentiometric flow injection biosensor for the analysis of anti-cholinesterases (anti-ChEs), based on inhibition of enzyme activity, was developed. The sensor system consists of a reactor with acetylcholinesterase (AChE) immobilized on controlled pore glass and a detector with an $H^{+}-selective$ PVC-based membrane electrode. The principle of the analysis is based on the fact that the degree of inhibition of AChE by an anti-ChE is dependent on the concentration of the anti-ChE in contact with AChE. The sensor system was optimized by changing systematically the operating parameters of the sensor to evaluate the effect of the changes on sensor response to ACh. The optimized biosensor was applied to the analysis of paraoxon, an organophosphorus pesticide. Treatment of the inhibited enzyme with pyridine-2-aldoxime fully restored the enzyme activity allowing repeated use of the sensor.