• Journal of Environmental Health Sciences
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• v.39 no.1
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• pp.1-18
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• 2013

Objectives: Although a great body of knowledge is available on the toxicity of bisphenol A (BPA), little is known about that of BPA alternatives, such as bisphenol analogues (BPs) or $Tritan^{TM}$ copolyesters. This review provides a summary of the available information on the toxicity of BPs and three components of $Tritan^{TM}$, with a special focus on endocrine disruption. Methods: We collected from the literature a battery of in vitro and in vivo assay data developed to assess endocrine disruption of four BPs (bisphenol AF, B, F, and S) and three major components of $Tritan^{TM}$ ((di-methylterephthalate (DMT), 1,4-cyclohexanedimethanol (CHDM), and 2,2,4,4-tetramethyl-1,3-cyclobutanediol (TMCD)). Results: Several alternative compounds were identified as possessing comparable or even greater endocrinedisrupting effects than BPA in in vitro and in vivo studies. Conclusions: Potential endocrine disruption of BPA alternatives requires further studies on health consequences in experimental animals and in humans following longer term exposure.

• Advances in environmental research
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• v.2 no.3
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• pp.179-202
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• 2013

Bisphenol A and other alkylphenols are widely used in plastic and other industrial consumer products. Release of these compounds into the aquatic environment during their manufacture, use and disposal has been a great scientific and public concern due to their toxicity at high concentrations and endocrine disrupting effects at low concentration on aquatic wildlife and human beings. This paper reviews the published data and researches on the environmental occurrence, distribution, health effects and analytical techniques of bisphenol A and alkylphenols. The aim is to provide an overview of the current understanding about bisphenol A and alkylphenols in the environment and the difficulties faced today in order to establish standard and systematic environmental analysis and assessment process for these endocrine disruptor compounds.

• Environmental Analysis Health and Toxicology
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• v.21 no.1 s.52
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• pp.81-86
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• 2006

Embryotoxicity tests were performed in Daphnia magna to assess aquatic ecotoxicity of bisphenol A, a well known industrial compound showing estrogen-like activity in vivo, and to examine their effectiveness in the toxicological assessment. The whole embryonic developmental period was classified into 6 stages and developmental abnormality was checked to evaluate the embryotoxicity. In the present study, bisphenol A showed the ability to interfere with embryonic development, suggesting its antiecdysteroidal activity. The rates of mortality, delayed development, deformity and immobility all showed good concentration-response relationship, demonstrating their possibility as useful toxicological indices in daphnid embryotoxicity tests that have been rarely performed so far. It seemed favorable to the test sensitivity that embryos are removed from maternal daphnids around 7 hr after deposition from the ovaries to the brood chamber. These results suggest that daphnid embryotoxicity tests can be one of useful tools available for the assessment of ecotoxicity of various chemicals in the aquatic environment.

• Environmental Analysis Health and Toxicology
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• v.18 no.3
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• pp.231-235
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• 2003

To determine whether or not bisphenol A affects the Immune system, female ICR mice were treated bisphenol A (BPA) orally at the doses of 100, 500 and 1,000 mg/kg for 30 consecutive days. Four days before enumerating Plaque -forming cells (PFCs) mice were immunized intraperitoneally with sheep red blood cells (SRBCs). The spleen cellularity and PFC/spleen were significantly reduced by 30-day exposure to BPA (1,000 mg/kg/day), but the PFC/10$\^$6/ spleen cells was slightly decreased.. When splenocytes isolated from the mice exposed to BPA for 30 days were cultured in the presence of LPS, Con A or PHA with IL-2, the lymphocyte proliferation ex vivo was not significantly suppressed by BPA. Our present results indicated that 30-day exposure of mice to BPA might have mild immunotoxic potential.

• Journal of Environmental Health Sciences
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• v.33 no.5
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• pp.392-396
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• 2007

Aquatic ecotoxicity of bisphenol A, a well-known endocrine disrupter in mammals, was studied using laboratory-reared Daphnia magna as a test organism. The static acute 48 h $EC_{50}$ of bisphenol A for daphnid neonates(<24 hold) was 12.9 mg/l and 110 h $LC_{50}$ values of bisphenol A for daphnid embryos of different ages after deposition into the brood chamber increase with ages in the range of 1.55 mg/l-8.91 mg/l. Also, 48 h $EC_{50}s$ generally increase with daphnid's ages in the range of 12.9 mg/l-19.8 mg/l. In the acute toxicity tests using mature daphnids, the lethal response and immobility all showed good concentration-response relationship with exposure concentration and exposure time, showing little difference between lethality and immobility. These results clarify that acute toxicity tests, using daphnid and its embryo, could also be useful tools easily available for the assessment of ecotoxicity of various harmful chemicals.

• Journal of Korean Society of Environmental Engineers
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• v.38 no.7
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• pp.371-376
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• 2016

In this study, the survey of bisphenol-A in indoor water service pipes rehabilitated with epoxy resin was conducted and the risk assessment was done to investigate the effect on the human health to drink tap water. Bisphenol-A in raw water was detected in a range of 50~118 ng/L in all samples, where the limit of quantification was 10 ng/L. This is caused by inflow of the sewage effluent or the tributaries of the surrounding area containing bisphenol-A. Bisphenol-A was not detected in finished water after the advanced water treatment process. It was achieved by its removal from the processes of flocculation-precipitation and oxidation of ozone and chlorine and by being changed to other by-product materials. For the indoor water service pipe, bisphenol-A was not detected in all cases which was not coated with epoxy resin. However, when epoxy resin is lined within the indoor water service pipe, bisphenol-A was identified at maximum level of 521 ng/L and was detected above the limit of quantitation at 68 percentages of all samples. The Hazard Quotient (HQ) at the maximum level (521 ng/L) of the detected bisphenol-A is 0.004, which is less than the reference value of 0.1 for the tap water intake. Therefore, it is considered that the detected levels of bisphenol-A in this study would be safe to drink tap water.

• Journal of Preventive Medicine and Public Health
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• v.54 no.1
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• pp.37-45
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• 2021

Objectives: Bisphenol A (BPA) is used in the electrical, mechanical, medical, and food industries. Previous studies have suggested that BPA is an endocrine disruptor. Regulation of BPA has led to increased use of bisphenol F (BPF) and bisphenol S (BPS). However, few studies have investigated the associations of BPF and BPS with thyroid dysfunction in children. Our study investigated the associations of prenatal BPA and early childhood BPA, BPF, and BPS exposure with thyroid function in 6-year-old children. Methods: Prenatal BPA concentrations were measured during the second trimester of pregnancy in an established prospective birth cohort. We measured urinary BPA, BPF, and BPS concentrations and thyroid hormone levels (thyroid-stimulating hormone, total T3, and free T4) in 6-year-old children (n=574). We examined the associations between urinary bisphenol concentrations and percentage change of thyroid hormone concentrations using multivariate linear regression. We also compared thyroid hormone levels by dividing the cohort according to BPA, BPF, and BPS concentrations. Results: The associations between prenatal BPA and total T3 levels were statistically significant in all models, except for girls when using a crude model. The associations between urinary BPA and BPS concentrations and levels of all thyroid hormones were not statistically significant. However, we observed that lower free T4 levels (-1.94%; 95% confidence interval, -3.82 to -0.03) were associated with higher urinary BPF concentrations in girls only. Conclusions: Our findings identified significant associations between prenatal BPA exposure and total T3 levels in all children and between BPF exposure and free T4 levels in girls only.

• Korean Journal of Environmental Biology
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• v.39 no.2
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• pp.160-168
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• 2021

Doublesex and mab-3 related transcription factor(dmrt) play crucial roles in sex determination and sex differentiation in vertebrates and invertebrates. Although dmrt genes have been identified in vertebrates, little is known about aquatic invertebrates. In this study, two dmrt genes, namely, Dc_dmrt93B and Dc_dmrt99B, were identified from brackish water flea, Diaphanosoma celebensis. Transcriptional changes were observed in the dmrt genes when the flea was exposed to bisphenol(BP), an endocrine disruptor. Sequence and phylogenetic analyses showed that both dmrt genes contained two conserved domains, namely, DM and DMA, closely clustered with those of Daphnia spp. Additionally, a significant increase in the Dc_dmrt99B mRNA expression level was observed upon exposure to intermediate concentrations of BP (bisphenol A>bisphenol S=bisphenol F, p<0.05), while the expression of Dc_dmrt93B mRNA was slightly modulated. These findings imply that the two dmrt genes may be involved in sex differentiation of D. celebensis. Furthermore, it was found that the ability of BP to modulate dmrt genes could affect development and reproduction. This study provides a basis for understanding the function of the dmrt genes and the molecular mode of action of BP in small crustaceans.

• Analytical Science and Technology
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• v.35 no.1
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• pp.15-23
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• 2022

Food delivery is gaining popularity due to changes in lifestyle and dietary patterns. However, packages used to delivery food may contain contaminants including heavy metals, or additives added during manufacturing process which may migrate into food during processing and transportation. In this study, a total of 58 food packages for delivery were collected and tested for migration of heavy metals (lead, cadmium and arsenic), bisphenol A and phenol into food simulants. The method was validated by evaluating linearity of calibration curve, limit of detection, limit of quantification, recovery and precision. Result of heavy metal migration showed that lead was the most frequently migrated metal and the highest concentration was detected in a polypropylene sample. Although there are no specific migration limits for bisphenol A and phenol in packaging materials tested in this study, migrations of bisphenol A and phenol were detected in some packages. This may due to contamination or additives added during manufacture of packages. Risk (%) was calculated to analyze the risk associated with the migration of heavy metals, bisphenol A and phenol, and was always below 1 %. These results showed that food packages for delivery are safe in terms of heavy metals, bisphenol A and phenol migration.

• Polymer(Korea)
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• v.25 no.4
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• pp.568-574
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• 2001

PEO-like solid polymer electrolytes based on bisphenol A ethoxylate acrylate were synthesized and their electrochemical properties and mechanical stability were studied. Low molecular weight poly(ethylene glycol) dimethyl ether (PEGDMe) was added to increase the conductivity of the electrolyte. The maximum conductivity of the resulting polymer electrolyte was found to be 1.0 ${\times}$ 10$^{-3}$ S/cm [Bisphenol A ethoxylate diacrylate ([EO]/[phenol]= 15), PEGDMe250 80 wt%, LiCF$_3SO_3$] at 30$^{\circ}$C. Tensile strength of the free standing polymer electrolyte films was measured to be in the range of 0.4 ~ 5 MPa and these polymer electrolyte films did not show a crack even in 90$^{\circ}$ and 180$^{\circ}$ bending against ${\phi}$=3 mm bar. These electrolytes showed oxidation stability up to 4.5 V vs. lithium reference electrode.