• Asian Pacific Journal of Cancer Prevention
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• v.16 no.12
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• pp.4915-4920
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• 2015

Background: : Familial adenomatous polyposis (FAP) is an autosomal dominant inherited disease mainly caused by mutations of the adenomatous polyposis coli (APC) gene with almost complete penetrance. These colorectal polyps are precancerous lesions that will inevitable develop into colorectal cancer at the median age of 40-year old if total proctocolectomy is not performed. So identification of APC germline mutations has great implications for genetic counseling and management of FAP patients. In this study, we screened APC germline mutations in Chinese FAP patients, in order to find novel mutations and the APC gene germline mutation characteristics of Chinese FAP patients. Materials and Methods: The FAP patients were diagnosed by clinical manifestations, family histories, endoscope and biopsy. Then patients peripheral blood samples were collected, afterwards, genomic DNA was extracted. The mutation analysis of the APC gene was conducted by direct polymerase chain reaction (PCR) sequencing for micromutations and multiplex ligation-dependent probe amplification (MLPA) for large duplications and/or deletions. Results: We found 6 micromutations out of 14 FAP pedigrees, while there were no large duplications and/or deletions found. These germline mutations are c.5432C>T(p. Ser1811Leu), two c.3926_3930delAAAAG (p.Glu1309AspfsX4), c.3921_3924delAAAA (p.Ile1307MetfsX13), c3184_3187delCAAA(p.Gln1061AspfsX59) and c4127_4126delAT (p.Tyr1376LysfsX9), respectively, and all deletion mutations resulted in a premature stop codon. At the same time, we found c.3921_3924delAAAA and two c.3926_3930delAAAAG are located in AAAAG short tandem repeats, c3184_3187delCAAA is located in the CAAA interrupted direct repeats, and c4127_4128 del AT is located in the 5'-CCTGAACA-3', 3'-ACAAGTCC-5 palindromes (inverted repeats) of the APC gene. Furthermore, deletion mutations are mostly located at condon 1309. Conclusions: Though there were no novel mutations found as the pathogenic gene of FAP in this study, we found nucleotide sequence containing short tandem repeats and palindromes (inverted repeats), especially the 5 bp base deletion at codon 1309, are mutations in high incidence area in APC gene,.

• Proceedings of the Korea Air Pollution Research Association Conference
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• 2001.11a
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• pp.348-349
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• 2001

휘발성유기화합물 (VOCs)은 복잡 다양한 발생원에서 배출되고 있다. 1990년에 개정된 미국 공기청정법 (US Clean Air Act Amendments, CAAA)에서는 총 189개의 화합물을 인간환경에 유해한 유해 대기 오염물질 (HAP, hazordous air pollutants)로 분류하고 있다 (MacKensie, A.R 등, 1991). 이 중 미국 EPA에서는 유해 대기오염물질로서 43개의 VOCs를 정하여, TO-14 화합물로서 일컫고 있다 (허귀석, 1999). (중략)

• Proceedings of the Korea Air Pollution Research Association Conference
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• 2003.11a
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• pp.237-238
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• 2003

대기오염물질 중 수은화합물질은 생태계와 인간에게 치명적인 독성과 생물농축의 특성 때문에 유해한 물질로 관리되어왔으며, 1990년 미국의 Clean Air Act Amendment(CAAA)의 188개의 대기오염물질대기오염물질(HAPs) 중의 하나이고, 국내에서도 25종의 특정대기유해물질 중의 하나로 관리되고 있는 물질이다. 미국 EPA의 보고서에 따르면, 수은화합물의 주요 배출원은 석탄 화력발전소를 비롯한 도시폐기물소각로, 유해폐기물소각로, 병원폐기물소각로 등의 연소설비가 미국 전체 연간 수은배출량의 약 87％를 차지하는 것으로 나타나 주요 배출시설에 대한 관리가 요구되는 것으로 나타났다(US EPA 1997,1998). (중략)

• The Transactions of the Korean Institute of Electrical Engineers A
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• v.50 no.9
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• pp.406-410
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• 2001

This paper develops an efficient evolutionary programming based algorithm for solving the environmentally constrained economic dispatch problem in thermal power system. The proposed algorithm can deal with the power balance constraints and the emission constraints which are equality and inequality constraints, respectively. Numerical results show that the proposed algorithm can provide superior solutions within reasonable time through its application to a test system.

• International Journal of Aerospace System Engineering
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• v.2 no.2
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• pp.50-53
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• 2015

It would encounter some complicated flow fields, such as transition, separation, reattachment and disturbances, in the hypersonic flight. Thus, it is difficult to theoretically analyze the hypersonic aerothermodynamics effects, so that the ground-test simulation is thought of as one of the most important methods to improve the understanding level of the hypersonic aerothermodynamics. However, the aero-heating tests could not simulate all aerodynamics and geometry parameters in the real flight due to the differences between the experimental environments supplied by the ground facilities and the flight, so that the feasible technique for the ground-test simulation of the hypersonic aerothermodynamics effects is required to be advanced. The key parameters that are especially required to simulate for aero-heating tests are analyzed and one detailed approach is suggested to perform the experimental investigation on the hypersonic aero-heating effects in the ground facilities in this paper, and the tests are performed in the FD-20 gun tunnel of CAAA (China Academy of Aerospace Aerodynamics) to give out the data which could be used to confirm the equation from the theoretical analysis.

• Journal of Korean Society for Geospatial Information Science
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• v.4 no.1 s.6
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• pp.75-82
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• 1996

As can be seen in US case with the introduction of ISTEA and CAAA, the expansion of the transportation decision-making role of local government is expected to be quite apparent in Korea, and the increased importance of decision-making in transportation issues requires increased attention to both justification and analysis of transportation initiatives. A GIS-based facility management system in a desktop computing environment has been constructed using MapInfo, ARC/INFO, and Microstation to allow such expanded role of local government's decision-making activities. In this paper, first, authors try to explain the procedures of system design; that is, the digital map production including vectorizing, data conversion, attribute data entry, and application programming development. Then, various management functions which are basically embedded in MapInfo environment, and application functions established by the use of MapBasic language has been explored Finally, the possible benefits of combining geographic information systems with traffic planning scheme has also been described with some discussion.