• Journal of Life Science
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• v.24 no.12
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• pp.1276-1283
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• 2014

Cell adhesion molecules determine the cell-cell binding and the interactions between cells and extracellular signals. Cell-cell junctional complexes, which maintain the structural integrity of tissues, consist of more than 50 proteins including multi-PDZ domain protein 1 (MUPP1). MUPP1 contains 13 postsynaptic density-95/disks large/zonula occludens-1 (PDZ) domains and serves a scaffolding function for transmembrane proteins and cytoskeletal proteins or signaling proteins, but the mechanism how MUPP1 links and stabilizes the juxtamembrane proteins has not yet been elucidated. We used the yeast two-hybrid system to identify proteins that interact with PDZ domains of MUPP1. We found an interaction between MUPP1 and cell adhesion molecule 1 (Cadm1, also known as SynCAM1, Necl-2, or TSLC1). Cadm1 bound to the second PDZ domain of MUPP1. The carboxyl (C)-terminal end of Cadm1 has a type II PDZ-association motif (-Y-F-I) which was essential for the interaction with MUPP1 in the yeast two-hybrid assay. MUPP1 also bound to the C-terminal cytoplasmic tail region of other Cadm family members (Cadm2, Cadm3, and Cadm4). In addition, these protein-protein interactions were observed in the glutathione S-transferase (GST) pull-down assay and by co-immunoprecipitation. Anti-MUPP1 antibody co-immunoprecipitated Cadm1 and Cadm4 with MUPP1 from mouse brain extracts. These results suggest that MUPP1 could mediate interaction between Cadms and cytoskeletal proteins.

• The KIPS Transactions:PartD
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• v.11D no.3
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• pp.683-690
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• 2004

MND(Ministry of National Defense) has developed .nm AF(Ministry of National Defense Architecture Framework) to guarantee interoperability among defense information systems. Users can easily and consistently develop architecture products through MND AF. There is necessity for development if CADM(Core Architecture Data Model), which facilitate exchange, integration, and comparison for architecture data, to store architecture data from architecture products and reuse them. We developed CADM from defining entities and relationships that satisfy data requirement of each architecture product from MND AF. After we developed architecture products about MIMS(Military Intelligence Management System), and inserted these architecture data to CADM repository. we verified CADM entities and relationships through query. Through CABM which provides common data model for the whole my architectures, interoperability and integration among defense information systems ran be improved, and integrated defense information resources efficiently can be managed.

• Korean Journal of Plant Resources
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• v.29 no.5
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• pp.525-531
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• 2016

Cynanchum wilfordii Radix (CWR), Arctium lappa L (ALL), and Dioscorea opposite (DO) have been known to improve blood lipid profile, blood pressure, and inflammation. To find the optimal combination ratio of CWR, ALL, and DO in terms of vascular health improvement, we compared the effects of various combinations on gene expression of Vascular cell adhesion protein 1 (VCAM-1) in human aortic smooth muscle cells (HASMC). VCAM-1 mediates endothelial leukocyte adhesion and is upregulated in atherosclerosis. Cells was stimulated by TNF-α (10 ng/㎖, 2h) and treated with various combinations for 24 h. A combination (CADM5, CWR:ALL:DO = 2:1:1) showed the strongest suppression of VCAM-1 so that CADM5 was chosen for further experiments. We performed cell viability test with CADM5 (0, 3.125, 12.5, 25, 50, and 100 ㎍/㎖) and no cytotoxicity was found. We also investigated the effect of CADM5 on protein expression of VCAM-1, ICAM-1, Nrf-2, and HO-1 using western blotting. We found that CADM5 diminished the expression of VCAM-1 and increased the expression of Nrf-2 and HO-1. Therefore, we concluded that CADM5 (CWR:ALL:DO = 2:1:1) effectively improves vascular health by regulating the expression of VCAM-1.

• The KIPS Transactions:PartD
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• v.12D no.6 s.102
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• pp.857-862
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• 2005

MND(Ministry of National Defense) has developed MND AF(Ministry of National Defense Architecture Framework) and CADM(Core Architecture Data Model to guarantee interoperability among defense information systems. But, it is very difficult to manage architecture product documented through MND AF and CADM. So, there Is necessity for development of modeling tool and repository system which can develop architecture products and manage architecture product informations in common repository In this paper, we developed architecture product management system which supports development and management of meta model and architecture product of MND AF and CADM. Through architecture product management system architect of each agency can construct architecture product in a more effective and efficient way with modeling method and a user can search and refer useful architecture product informations using query function. Also, architecture product management system provides the basis for system integration and interoperability with integration, analysis and comparison of architecture product.

• The KIPS Transactions:PartA
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• v.16A no.5
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• pp.369-380
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• 2009

SNMP (Simple Network Management Protocol) is a standard protocol for management of network devices, and it provides excellent features such as scalability, information management, authentication, encryption, and access control. However, SNMP has a structural weakness to fully support control functions for integrated management of digital convergence devices, and it has a limitation of message length in SNMP communication. In this paper, we present an extended SNMP scheme for integrated management of digital convergence devices with control functions. We modified the SNMP architecture by adding DDS (Device Driver Subsystem) to SNMP engine for controlling different devices and by defining CADM (Control Agent Driver Model), therefore we solved the ambiguity problem between 'set' and 'control' of SNMP. And the extended SNMP made it easy for SNMP applications to use various control functions. The extended SNMP can transport massive high-level information by adding three new SNMP commands which eliminate the limit of message length.

• Proceedings of the Korean Information Science Society Conference
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• 2003.10b
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• pp.238-240
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• 2003

현재 국방부에서는 국방정보체계간의 상호운용성을 보장하기 위해 아키텍처 산출물을 쉽고 일관성 있게 개발할 수 있는 국방 아키텍처 프레임워크를 개발하고 있다. 따라서 개발된 아키텍처 산출물을 저장하여 재사용하고 국방 전반의 아키텍처 정보의 교환, 비교, 통합을 용이하게 하는 핵심아키텍처데이터모델의 개발이 필요하다. 핵심아키텍처데이터모델은 국방 아키텍처 프레임워크에서 도출된 데이터 요구사항을 통해 엔티티를 추출하고 관계를 정의하였으며 실사례를 통해 엔티티를 검증하였다. 이를 통해 전군의 아키텍처에 대한 공통의 데이터 모델을 제공하여 국방정보체계에 대한 통합적인 정보자원관리와 상호운용 및 통합을 향상시킬 수 있다.

• The KIPS Transactions:PartD
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• v.12D no.5 s.101
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• pp.729-736
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• 2005

MND(Ministry of National Defense) has developed MND AF(Ministry of National Defense Architecture Framework) and CADM(Core Architecture Data Model) to guarantee interoperability among defense information systems. TRM(Technical Reference Model) and SP(Standard Profile) product defined in MND AF is core part of Information Technology Architecture and core element of interoperability guarantee. In this paper, we proposed a method which manages technical service and standard of TRM and SP, and developed TRM and SP management system based on the method. TRM and SP management system provides the basis for interoperability among information systems and a more efficient development and management of TRM and SP product.

• Journal of Korean Society for Atmospheric Environment
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• v.26 no.1
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• pp.34-47
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• 2010

Long-range transport of air pollutants was simulated using Comprehensive Acid Deposition Model (CADM) and Yonsei University-Sulfuric Acid Deposition Model (YU-SADM). For the simulation, weather patterns that represent the four seasons were derived through a clustering analysis with 5-years of meteorological data. The simulation result showed that in spring, influenced by strong low pressure from China, air pollutants of moved to the Korean Peninsula. In summer, humid air moved into the Korean Peninsula across the Yellow Sea while the north pacific high pressure extended, making the concentration of air pollutants lower than that in the other seasons. In autumn, air pollutants were transported by the northwest wind caused by the movement of high pressure over the Yellow Sea, while in winter air pollutants were influenced by northwest winds from continental highs. The amount of air pollutants in each season showed that high amount of pollutants were transported in winter due to the strong northwest wind. The in-flows were 3 to 8 times higher than those of the other seasons, and out-flows were about as twice as high. The amount of wet deposition in summer and autumn increased significantly compared to the amount in the other seasons due to the increase of rainfall. Source-receptor relationship analysis for sulfur showed that 70 to 91 precent of the total deposition came from the self-contribution by the Korean Peninsula. In winter, contribution from China was about 25 percent of the total deposition which was higher amount than any other season.