• 폴리머
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• 제34권4호
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• pp.352-356
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• 2010

2개의 종횡비에 의해 특징지어진 3차원 타원체를 사용하여 PP복합체의 충전제 형태와 함량이 열팽창률에 미 치는 영향에 대해 Lee와 Paul에 의해 제안된 이론적인 값과 실험적인 결과값이 비교분석되었다. 충전제의 형태는 구형에 황산바륨을, 섬유형에는 유리섬유를, 판상형에는 운모를 사용하였다. 실험의 결과로서 구형을 갖는 황산바륨 은 종횡비가 1의 값을 갖고 이론과 같이 열팽창률이 감소하였다. 유리섬유의 경우 함량증가에 따라 종횡비는 42, 37, 25, 20으로 감소하였으며 종단방향에선 열팽창률이 감소하였지만 수직방향에서는 증가하였다. 운모의 경우 그 함량증가에 따라 모두 종단방향과 횡단방향에서 감소하고 수직방향에서 증가하였다. 종횡비의 값은 각각, $\rho_\alpha$=13.5, $\rho_\beta$=1.8이었다.

• 대한한방부인과학회지
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• 제37권1호
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• pp.23-39
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• 2024

Objectives: Primary dysmenorrhea (PD) is defined as abdominal pain during menstruation period in the absence of an identifiable pathological lesion. Corydalis tuber (CT) is an herbal medicine that has an excellent effect in relieving pain and convulsions. The purpose of this study is to observe the effect of Corydalis tuber aqueous extracts (CTe) on primary dysmenorrhea. Methods: The rats were injected with estradiol benzoate subcutaneously for 10 days (2.5 mg/kg on the first and 10th days, and 1 mg/kg from the 2~9th day). Oxytocin 1 U/kg was treated by peritoneal injection 1 hour after the last 10th injection of estradiol benzoate. CTe 400, 200 and 100 mg/kg were administered orally, once a day for 10 days at 30 minutes after each estradiol benzoate treatment. The results of CTe were compared to those of IND 5 mg/kg orally treated rats. Results: As results of estradiol benzoate and oxytocin administration, noticeable decreases of body weights and gains, uterus weights were observed with congestion and enlargement of the uterus at gross inspections, and increases of abdominal writhing responses, uterus MDA levels, GSH contents, SOD and CAT activities. However, these oxidative stress mediated PD signs were dose-dependently decreased by 10 consecutive days of oral administration of three different doses of CTe 400, 200 and 100 mg/kg as comparable to those of IND 5 mg/kg in CTe 200 mg/kg. Conclusions: CTe had a significant improvement effect on primary dysmenorrhea in the PD rat model induced by estrogen benzoate and oxytocin.

• 마이크로전자및패키징학회지
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• 제20권3호
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• pp.37-44
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• 2013

유연 솔더가 실장된 패키지와 무연 솔더가 실장된 패키지의 온도에 따른 변형 거동은 솔더 자체의 물성치 뿐만 아니라 패키지를 구성하는 재료의 물성치에도 큰 영향을 받는다고 알려져 있다. 본 논문에서는 스트레인 게이지의 온도특성을 이용하여 미지 재료의 열팽창계수를 결정하는 방법을 정립하고, 반도체 패키지 몰딩 화합물의 열팽창계수를 실험적으로 구하였다. 탄소강과 알루미늄 시편을 기준 시편으로 사용하고 스트레인 게이지 측정을 통하여 온도에 따른 유연 솔더용 몰딩 화합물과 무연 솔더용 몰딩 화합물의 열팽창계수를 구하고, 무아레 간섭계를 이용하여 비접촉적으로 열팽창 계수를 측정하여 결과를 비교하였다. 기준 시편에 따른 두 가지 스트레인 게이지 실험 결과와 무아레 실험 결과가 잘 일치하여서 실험방법에 신뢰성이 있는 것을 보였다. 유연 솔더용 몰딩 화합물의 경우에는 열팽창계수가 온도에 관계없이 약 $15.8ppm/^{\circ}C$로 측정되었고, 무연 솔더용의 경우에는 $100^{\circ}C$이하의 온도에서 몰딩 화합물의 열팽창계수는 약 $9.9ppm/^{\circ}C$이었으나 $100^{\circ}C$이상에서는 온도가 증가함에 따라 열팽창계수가 급격하게 증가되어 $130^{\circ}C$에서는 $15.0ppm/^{\circ}C$의 값을 가졌다.

• 한국재료학회지
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• 제24권10호
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• pp.515-519
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• 2014

The aim of this paper is to consider the effect of annealing on the coefficient of thermal expansion (CTE) of electroplated Invar Fe-Ni alloy. The CTE of the as-electroplated alloy is lower than those of alloys annealed at $400^{\circ}C$ and $800^{\circ}C$. XRD peaks become sharper as the as-electroplated alloy is annealed, which means the grain growth. The average grain sizes of as-electroplated and as-annealed alloys at $400^{\circ}C$ and $800^{\circ}C$ are 10 nm, 70 nm, and $2{\mu}m$, respectively, as determined by TEM and EBSD analyses. The CTE variation for the various grain sizes after annealing may come from the magnetostriction effect, which generates strain due to changes in the magnetization state of the alloys. The thermal expansion coefficient is considered to be affected by nano grain size in electroplated Fe-Ni Invar alloys. As grain size decreases, ferromagnetic forces might change to paramagnetic forces. The effect of lattice vibration damping of nano grain boundaries could lead to the decrease of CTE.

• BMB Reports
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• 제51권8호
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• pp.400-405
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• 2018

Chronic stress induces neuronal cell death, which can cause nervous system disorders including Parkinson's disease and Alzheimer's disease. In this study, we evaluated the neuroprotective effects of Clematis terniflora extract (CTE) against corticosterone-induced apoptosis in rat pheochromocytoma (PC12) cells, and also investigated the underlying molecular mechanisms. At concentrations of 300 and $500{\mu}g/ml$, CTE significantly decreased apoptotic cell death and mitochondrial damage induced by $200{\mu}M$ corticosterone. CTE decreased the expression levels of endoplasmic reticulum (ER) stress proteins GRP78, GADD153, and mitochondrial damage-related protein BAD, suggesting that it downregulates ER stress evoked by corticosterone. Furthermore, our results suggested that these protective effects were mediated by the upregulation of p-AKT and p-ERK1/2, which are involved in cell survival signaling. Collectively, our results indicate that CTE can lessen neural damage caused by chronic stress.

• 한국생산제조학회지
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• 제22권1호
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• pp.168-172
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• 2013

In 3D wafer-stacking technology, one of the major issues is wafer warpage. Especially, The important reason of warpage has been known due to CTE(Coefficient of Thermal Expansion) mismatch between materials. It was too hard to choose how to make the FE model for blanket structured wafer level 3D packaging, because the thickness of each layer in wafer level 3D packaging was too small (micro meter or nano meter scale) comparing with diameter of wafer (6 or 8 inches). In this study, the FE model using the shell element was selected and simulated by the ANSYS WorkBench to investigate effects of the CTE on the warpage. To verify the FE model, it was compared by experimental results.

• 한국식품조리과학회지
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• 제28권6호
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• pp.821-828
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• 2012

In an attempt to identify the neuroprotective effect of Cudrania tricuspidata (CT) leaves against ROS (reactive oxygen species)-induced oxidative stress in neuronal cells, the extracts from CT leaves were investigated using PC12 cells and N18-RE-105 cells. The methanolic and ethanolic extracts from CT were denoted as CTM (Cudrania tricuspidata Leaves methanolic extracts) and CTE (Cudrania tricuspidata Leaves ethanolic extracts), respectively. The neuroprotective effects of the extracts were measured by DCF-DA assay, MTT reduction assay, and LDH release assay. The PC12 cells exposed to $H_2O_2$-induced oxidative stress and the N18-RE-105 cells exposed to glutamate-induced oxidative stress were treated with various concentrations of CTM and CTE. The results, CTM treatments resulted in the induction of a dose-dependent protective effect in PC12 cells and N18-RE-105 cells. Interestingly, CTE also showed neuroprotective effect in PC12 cells and N18-RE-105 cells. Therefore, these results suggest that CTM and CTE could be a new potential candidate as neuroprotective agents against ROS-induced oxidative stress in neuronal cells.

• Steel and Composite Structures
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• 제19권5호
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• pp.1221-1236
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• 2015

Since the coefficients of thermal expansion (CTE) between concrete and GFRP, steel and GFRP are quite different, GFRP laminates with different laminas stacking-sequence present different thermal behavior and currently there is no specification on mechanical properties of GFRP laminates, it is necessary to investigate the thermal influence on composite girder with stay-in-place (SIP) bridge deck at different levels and on different scales. This paper experimentally and theoretically investigated the CTE of GFRP at lamina's and laminate's level on micro-mechanics scales. The theoretical CTE values of laminas and laminates agreed well with test results, indicating that designers could obtain thermal properties of GFRP laminates with different lamina stacking-sequence through micro-mechanics methods. On the basis of the CTE tests and theoretical analysis, the thermal behaviors of composite girder with hybrid GFRP-concrete deck were studied numerically and theoretically on macro-mechanics scales. The theoretical results of concrete and steel components of composite girder agreed well with FE results, but the theoretical results of GFRP profiles were slightly larger than FE and tended to be conservative at a safety level.

• 대한한방부인과학회지
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• 제21권4호
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• pp.90-103
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• 2008

목적 : 본 연구는 현호색의 메탄올 추출물(Corydalis Tuber Extract:CTE)이 인간 유방암 세포인 MCF-7 세포의 자멸사에 미치는 영향을 알아보고자 하였다. 방법 : 현호색 메탄올 추출물로 인간유방암에서 유래된 MCF-7 세포를 처리하였다. CTE의 세포자멸사 유도 효과는 MTT, FACS, TUNEL, DNA laddering and immunoblot assay를 통하여 측정하였다. 결과: 본 연구에서 현호색 메탄올 추출물은 MCF-7 세포의 활성을 감소시켰다. CTE로 처리한 MCF-7 세포는 용량에 따라 세포 자멸사 과정이 증가했다. CTE에 노출하였을 때 Bcl-2와 $Bcl-_{XL}$의 발현을 억제하고, 미토콘드리아로부터 세포질로 cytochrome-c를 방출하며, caspase와 PARP의 절단을 유발하여 세포자멸사가 증가했다. 현호색 메탄올 추출물에 존재하는 성분중에서 coptisine이 세포 활성도를 효과적으로 감소시킨 것으로 사료된다. 결론: 실험결과 현호색 메탄올 추출물이 유방암의 임상 치료에 있어 가능성 있는 치료 방법이 될 수 있을 것으로 사료된다.

• Journal of Medicine and Life Science
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• 제20권3호
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• pp.107-114
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• 2023

Epidemiological control of coronavirus disease 2019 (COVID-19) is needed to estimate the infection period of confirmed cases and identify potential cases. The present study, targeting confirmed cases for which the time of COVID-19 symptom onset was disclosed, aimed to investigate the relationship between intervals (day) from symptom onset to testing the cycle threshold (CT) values of real-time reverse transcription-polymerase chain reaction. Of the COVID-19 confirmed cases, those for which the date of suspected symptom onset in the epidemiological investigation was specifically disclosed were included in this study. Interval was defined as the number of days from symptom onset (as disclosed by the patient) to specimen collection for testing. A locally weighted regression smoothing (LOWESS) curve was applied, with intervals as explanatory variables and CT values (CTR for RdRp gene and CTE for E gene) as outcome variables. After finding its non-linear relationship, a polynomial regression model was applied to estimate the 95% confidence interval values of CTR and CTE by interval. The application of LOWESS in 331 patients identified a U-shaped curve relationship between the CTR and CTE values according to the number of interval days, and both CTR and CTE satisfied the quadratic model for interval days. Active application of these results to epidemiological investigations would minimize the chance of failing to identify individuals who are in contact with COVID-19 confirmed cases, thereby reducing the potential transmission of the virus to local communities.