• Archives of Pharmacal Research
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• v.29 no.12
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• pp.1067-1073
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• 2006

Cisplatin, a platinum coordinated complex, is a widely used antineoplastic agent for the treatment of metastatic tumors of the testis, metastatic ovarian tumors, lung cancer, advanced bladder cancer and many other solid tumors. The cytotoxic action of the drug is often thought to be associated with its ability to bind DNA to form cisplatin-DNA adducts. The development of resistance to cisplatin during treatment is common and constitutes a major obstacle to the cure of sensitive tumors. Although to understand the clinically relevant mechanisms of resistance, many studies have been aimed at clarifying the biochemical/molecular alterations of cisplatin-resistance cells, these studies did not conclusively identify the basis of cellular resistance to cisplatin. In this review, cisplatin resistance was discussed in terms of the relevant transporters, such as copper transporters (CTRs), organic cation transporters (OCTs) and multi-drug resistance related transporters (MDRs). These transporters seem to be contributed to cisplatin resistance through the reduction of drug accumulation in the cell. Better understanding the mechanism of cisplatin resistance associated with transporters will provide the useful informations for overcoming the cisplatin resistance.

• Korean Journal of Child Studies
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• v.31 no.4
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• pp.139-157
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• 2010

This study investigated the cognitive process of 5-year-old children, with a particular focus on gender, monthly age, and their tendencies towards hyperactivity through the performance of the Cognitive Assessment System (CAS; Das & Naglieri, 1997). The children with tendencies towards hyperactivity were identified based on Conners Teachers' Rating Scale (CTRS). The subjects were 75 five-year-old children in Seoul and surrounding metropolitan areas. Data were analyzed by means of descriptive statistics, an independent sample t-test, Pearson's correlation coefficient, one-way ANOVA, and by K-mean cluster analysis. Our results were as follows : (1) The CAS and CTRS' sub-factors were correlated negatively, except the positive correlation between planning factor and hyperactivity factor. (2) Girls exhibited significantly higher CAS scores in planning & sequential processing than boys. (3) The upper monthly age group (68-71 months) showed significantly higher score in terms of planning than the lower monthly age group (60-63 months). (4) The CAS scores of the children with tendencies towards hyperactivity was lower than that of normal children. (5) The CAS profile of 5-year-old children was divided into 4 groups with distinctive characteristics by means of K-mean cluster analysis.

• Journal of Biomedical Engineering Research
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• v.35 no.4
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• pp.81-86
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• 2014

One of the methods for Parkinson's disease(PD) tremor evaluation is the Clinical Tremor Rating Scale(CTRS). However, the method has some limitations that clinician ratings can vary because the scores are subjectively rated. In addition, most researches usually collected data measured on the more affected arm. In this study, we developed a portable wearable system(SNUMAP system) for measuring PD tremor. The SNUMAP system captures 3-dimensional motion using tri-accelerometer and tri-gyroscope on finger and wrist. 40 PD patients participated in resting tremor and postural tremor tasks, while wearing the system on both hands simultaneously. Estimated tremor scores from Leave-One-Out Cross Validation for regression were highly correlated to the average clinician CTRS scores for rest tremor($r^2$ = 0.87, RMSE = 0.48) and postural tremor($r^2$ = 0.82, RMSE = 0.48). Therefore, the quantitative assessment model can improve treatment of PD patients.

• The Korean Journal of Pain
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• v.34 no.3
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• pp.315-321
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• 2021

Background: Pillar pain may develop after carpal tunnel release surgery (CTRS). This prospective double-blinded randomized trial investigated the effectiveness of extracorporeal shock wave therapy (ESWT) in pillar pain relief and hand function improvement. Methods: The sample consisted of 60 patients with post-CTRS pillar pain, randomized into two groups. The ESWT group (experimental) received three sessions of ESWT, while the control group received three sessions of sham ESWT, one session per week. Participants were evaluated before treatment, and three weeks, three months, and six months after treatment. The pain was assessed using the visual analogue scale (VAS). Hand functions were assessed using the Michigan hand outcomes questionnaire (MHQ). Results: The ESWT group showed significant improvement in VAS and MHQ scores after treatment at all time points compared to the control group (P < 0.001). Before treatment, the ESWT and control groups had a VAS score of 6.8 ± 1.3 and 6.7 ± 1.0, respectively. Three weeks after treatment, they had a VAS score of 2.8 ± 1.1 and 6.1 ± 1.0, respectively. Six months after treatment, the VAS score was reduced to 1.9 ± 0.9 and 5.1 ± 1.0, respectively. The ESWT group had a MHQ score of 54.4 ± 7.7 before treatment and 73.3 ± 6.8 six months after. The control group had a MHQ score of 54.2 ± 7.1 before treatment and 57.8 ± 4.4 six months after. Conclusions: ESWT is an effective and a safe non-invasive treatment option for pain management and hand functionality in pillar pain.

• Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
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• v.6 no.6
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• pp.273-283
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• 2016

In this paper, the effect of neurofeedback training program on attention ability of ADHD children is studied. The main concept of a neurofeedback training program is a robot control with brain wave. To do this, Mindset(neurosky, ltd) was used as a brain wave measurement and lego NXT was used to a robot kit. The developed brain wave training program has a 12 chapter. Students meet a problem situation and they invent and make a problem solving robot with NXT kits. After that, they control the their own robot by their brain wave. Developed program was applied to 8 student who live in chunan area. To monitor a change of attention ability, attention behavior checklist, K-CBCL, CTRS-R, ADS were used. These checklist were recorded with before and after the program. The result shows that student attention ability is increase after the program in the most of the checklist.

• ETRI Journal
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• v.34 no.2
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• pp.292-295
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• 2012

Beyond the simple keyword matching methods in contextual advertising, we propose a rich contextual matching (CM) model adopting a classification method for topic targeting and a query expansion method for semantic ad matching. This letter reports on an investigation into the empirical effects of the CM model by comparing the click-through rates (CTRs) of two practical online news advertising systems. Based on the evaluation results from over 100 million impressions, we prove that the average CTR of our proposed model outperforms that of a traditional model.

• Journal of Music and Human Behavior
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• v.1 no.1
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• pp.47-71
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• 2004

Students with learning disability have difficulty with attention and academic achievement Music can be an effective tool to enhance level of participation. The purpose of this study is to examine how much can be structured to enhance the attention span and related academic skills needed to achieve educational goals. The study has implemented structured music therapy sessions for three middle school students with learning disability. They participated in 20 sessions which were 30 minutes in length for ten weeks. The implemented music therapy sessions were designed using songs, playing, and listening to music. In order to test their level of attention, Frankfurter Aufmerksamkeits-Inventar(FAIR) Attention Test is implemented and Conners' Comprehensive Teacher's Rating Scale(CTRS-10) are used on the week before and after music activities. Also videotaping is used so as to analyze how correctly they do their task and how the correctness is changed period by period and to evaluate how often for ten minutes they make an eye contact with their teacher. The conclusions of this study are as follows: Firstly, the organized music activities have a positive affection on improving the attention of three middle school students who have learning disabilities. Fair Attention Test shows that they can do their task with more accuracy than in the previous period. Secondly, three students of this study improved their attention and made an eye contact more often than before this study, which is revealed through the analysis of the pre and post test results evaluated by CTRS-10. The results of the study indicate that structured use of music in various level of activities can help students to enhance attention span and the related academic skills.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.4
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• pp.1468-1474
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• 2010

The establishment of a successful business must be preceded by comprehensive entrepreneurial preparation and research, as well as the development of a truly attractive business idea. Research to-date has tended to be based solely on factors relating to entrepreneurial activity or business performance. Research into the development and evaluation of a business idea has been insufficient. The purpose of this research is to propose a methodology for evaluating the attractiveness of a business idea objectively. This research measures the attractiveness of a business idea by the click through rate (CTR) to a website generated by specific keyword entry into internet search engines. The attractiveness of a business idea can be presented by the formula: number of relevant keyword searches x CTR on search results. As the number of searches for individual keywords is published by the search engines and it is possible to estimate CTRs for specific search results, we can objectively evaluate the attractiveness of a business idea. By analyzing keyword search data and CTRs obtained from search engines over a one month period, 1124 keywords that relate to foreign language education have been identified. A regression formula has also been derived, predicting the click through rate for search results. This research and its findings can be used to raise the success rates of new businesses; proposing objective guidelines for business idea development and evaluation. It is particularly meaningful because it introduces a new methodology to the arena.

• Journal of the Korean Home Economics Association
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• v.33 no.5
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• pp.241-253
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• 1995

The purpose of this study was to identify how th ADHD variable and family variables influence parents' perception of parental role, family functioning. Subjects were 478 preschoolers at the ages of 3-6 and their teachers and parents. The CTRS-10, the PSI, the FACESⅢ were used. The major findings were as follows ; 1) The variables which ae influential in parental strain were shown in order of the social psychological resource variables, the ADHD variable, and the social demographic variables. The sole ADHD variable's influence was high (β=.26***, increased R2=5.4%). 2) The variables which are influential in parental mastery were shown in order of the social psychological resource variables, the ADHD variable, and the social demographic variables. The sole ADHD variable's influence was high(β=.13*, increased R2=1.5%), also. 3) The variables which are influential in family cohesion and adaptability were shown in order of the social psychological resource variables, the social demographic variables. In both family cohesion and adaptability, the sole ADHD variables' influence was insignificant(β=-.08, increased R2=-0.3%, increased R3=-0.3%). Implications to knowledges as well as recommendations for future research are discussed.

• Journal of the Korean Society of School Health
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• v.23 no.2
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• pp.237-245
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• 2010

Purpose: The purpose of this thesis was to examine the effects of social skills training program onto the children with tendency of attention-deficit hyperactivity disorder. Methods: This study used nonequivalent control group pre/post-test quasi-experimental research design. The subjects were 18 children with tendency of attention- deficit hyperactivity in D City. The subjects were divided into two groups, an experimental group of 8 children and a control group of 10. The program consisted of 20 sessions of 60 minutes per session, 5 days a weeks, for 4 weeks. The research tools included Conner's Teacher Rating Scales (CTRS) and Social Skills Rating System (SSRS). The collected data were analyzed using $x^2$ test, Mann-Whitney test on the SPSS 17.0 program. Results: a) the scores for cooperation, self-assertiveness, self-control and empathy increased significantly in the experimental group, compared to the control group. b) the scores for social skills increased significantly in the experimental group, compared to the control group. Conclusion: It appears that the social skills training program is a useful nursing intervention to improve the social skills for children with tendency of attention-deficit hyperactivity.