• Toxicological Research
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• v.23 no.1
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• pp.1-9
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• 2007

Transporters are membrane proteins that mediate the transfer of substrate across the cellular membrane. In this overview, the characteristics and the toxicological relevance were discussed for various types of transporters. For drug transporters, the overview focused on ATP-binding cassette transporters and solute carrier family 21A/22A member transporters. Except for OCTN transporters and OATP transporters, drug transporters tend to have broad substrate specificity, suggesting drug-drug interaction at the level of transport processes (e.g., interaction between methotrexate and non-steroidal anti-inflammatory agents) is likely. For metal transporters, transporters for zinc, copper and multiple metals were discussed in this overview. These metal transporters have comparatively narrow substrate specificity, except for multiple metal transporters, suggesting that inter-substrate interaction at the level of transport is less likely. In contrast, the expressions of the transporters are often regulated by their substrates, suggesting cellular adaptation mechanism exists for these transporters. The drug-drug interactions in drug transporters and the cellular adaptation mechanisms for metal transporters are likely to lead to alterations in pharmacokinetics and cellular metal homeostasis, which may be linked to the development of toxicity. Therefore, the transporter-mediated alterations may have toxicological relevance.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.31 no.11
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• pp.1124-1130
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• 2007

This paper presents a new way for fabricating sandwich plates with tetrahedral truss cores. The tetrahedral truss cores are manufactured through metal expanding and bending process and then brazed with solid face sheets. The properties of sandwich plates with the tetrahedral truss cores composed of a wrought steel SS41 under compression and shear loading have been investigated. Good agreement is observed between the measured and predicted peak strengths. Comparisons with normalized compressive strength for other cellular metals have indicated that the tetrahedral truss structures outperform aluminum open cell forms and woven core sandwich plates.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.31 no.6 s.261
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• pp.694-700
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• 2007

Recently, a new cellular metal, WBK(Wire woven Bulk Kagome) has been introduced. WBK is fabricated by assembling metal wires in six directions into a Kagome-like truss structure and by brazing it at all the crossings. Wires as the raw material are easy to handle and to attain high strength with minimum defect. And the strength and energy absorption are superior to previous cellular metals. Therefore, WBK seems to be promising once the fabrication process for mass production is developed. In this paper, an upper bound solution for the mechanical properties of the bulk WBK under compression is presented. In order to simulate uniform behavior of WBK consisted of perfectly uniform cells, a unit cell of WBK with periodic boundary conditions is analyzed by the finite element method. In comparison with experimental test results, it is found that the solution provides a good approximation of the mechanical properties of bulk WBK cellular metals except for Young's modulus. And also, the brazing joint size does not have any significant effect on the properties with an exception of an idealized thin joint.

• Corrosion Science and Technology
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• v.16 no.2
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• pp.64-68
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• 2017

The interactions between corrosion pits on stainless steel under loading conditions are studied by using a cellular automata model coupled with finite element method at a mesoscopic scale. The cellular automata model focuses on a metal/film/electrolyte system, including anodic dissolution, passivation, diffusion of hydrogen ions and salt film hydrolysis. The Chopard block algorithm is used to improve the diffusion simulation efficiency. The finite element method is used to calculate the stress concentration on the pit surface during pit growth, and the effect of local stress and strain on anodic current is obtained by using the Gutman model, which is used as the boundary conditions of the cellular automata model. The transient current characteristics of the interactions between corrosion pits under different simulation factors including the breakdown of the passive film at the pit mouth and the diffusion of hydrogen ions are analyzed. The analysis of the pit stability product shows that the simulation results are close to the experimental conclusions.

• Design & Manufacturing
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• v.17 no.3
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• pp.55-60
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• 2023

The fiber-reinforced plastics and cellular injection molding process can be used to efficiently reduce the weight of battery housing components of mild hybrid electronic vehicles(MHEV) made of metal. However, the fiber orientation of fiber-reinforced plastics and the growth of foaming cells are intertwined during the injection molding process, so it is difficult to predict the mechanical properties of products in the design process. Therefore, it is necessary to evaluate the mechanical properties of the materials prior to the efficient stiffness design of the target product. In this study, a study was conducted to evaluated the mechanical properties of fiber reinforced cellular injection-molded specimens. Two types of fiber-reinforced plastics that can be used in the target product were evaluated for changes in tensile properties of cellular injection-molded specimens depending on the foaming ratio and position from the injection gate. The PP and PA66 specimens showed a decrease of tensile modulus and strength of approximately 30% and 17% depending on the foaming ratio, respectively. Also, the tensile strength decreased approximately 26% and 17% depending on the position from the injection gate, respectively. As a result, it was confirmed that the PP specimens have a significantly mechanical property degradation compared to the PA66 specimens depending on the foaming ratio and position.

• Journal of Microbiology and Biotechnology
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• v.29 no.10
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• pp.1522-1542
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• 2019

To adapt to environmental changes and to maintain cellular homeostasis, microorganisms adjust the intracellular concentrations of biochemical compounds, including metal ions; these are essential for the catalytic function of many enzymes in cells, but excessive amounts of essential metals and heavy metals cause cellular damage. Metal-responsive transcriptional regulators play pivotal roles in metal uptake, pumping out, sequestration, and oxidation or reduction to a less toxic status via regulating the expression of the detoxification-related genes. The sensory and regulatory functions of the metalloregulators have made them as attractive biological parts for synthetic biology, and the exceptional sensitivity and selectivity of metalloregulators toward metal ions have been used in heavy metal biosensors to cope with prevalent heavy metal contamination. Due to their importance, substantial efforts have been made to characterize heavy metal-responsive transcriptional regulators and to develop heavy metal-sensing biosensors. In this review, we summarize the biochemical data for the two major metalloregulator families, SmtB/ArsR and MerR, to describe their metal-binding sites, specific chelating chemistry, and conformational changes. Based on our understanding of the regulatory mechanisms, previously developed metal biosensors are examined to point out their limitations, such as high background noise and a lack of well-characterized biological parts. We discuss several strategies to improve the functionality of the metal biosensors, such as reducing the background noise and amplifying the output signal. From the perspective of making heavy metal biosensors, we suggest that the characterization of novel metalloregulators and the fabrication of exquisitely designed genetic circuits will be required.

• Journal of Welding and Joining
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• v.19 no.4
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• pp.429-436
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• 2001

The effect of welding condition on the microstructures of the weld metal in A7N01 welded by $CO_2$ laser was investigated. The number of ripples was increased with decreasing power and increasing welding speed. In the bead without ripple lines, the subgrain microstructures distribution from the fusion line toward the center of the bead were in the order of cellular, dendritic and equiaxed dendrite. However, in the bead with ripple lines, cellular and dendritic were formed between the fusion boundary and the ripple line. Inaddition, those structures were also observed between the ripple line. Equiaxed dendrites were formed only at the center line region. Cellular and dendritics formed near the ripple line were larger than those formed near the fusion boundary. The cooling rates estimated by the dendrite arm spacing were in the range of 200 to 1150oC/s. Cooling rate was increased with decreasing the power and increasing the welding speed. Mg and Zn segregated at the boundaries of cellulars and dendritics, Mg was segregated more than Zn. The segregation of Mg and Zn decreased with increasing cooling rate. Hardness of the weld metal was lower than that of the base metal in all welding conditions and increased as the cooling rate increased.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.33 no.4
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• pp.353-359
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• 2009

Wire-woven Bulk Kagome (WBK) is a new truss type cellular metal fabricated by systematic assembling of helical wires in six directions. In this work, the experiments of mechanical behaviors of WBK cored sandwich panels subjected to bending load were performed and the results were compared with those by the corresponding analytic solutions. And also, finite element simulations were performed to validate the optimal design according to the analytic solutions. It is found the sandwich panel with WBK core performed excellently in terms of energy absorption and deformation stability after the peak point as well as the load capacity.

• Proceedings of the KSME Conference
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• 2008.11a
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• pp.138-143
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• 2008

Recently, a new periodic cellular metal(PCM) named as Wire wove Bulk Kagome(WBK) was introduced. Based on the shape of tetrahedra composing a WBK, WBKs are classified into two types, namely, concave and convex type. They are easily differentiated by changing the assembling sequence. The effect of geometrical parameters such as the wire diameter, strut length and number of layers on the compressive behavior of concave type WBK has already been investigated. In this work, the similar works were performed with the convex type WBKs. It was shown that the compressive strength of the convex type WBK was quite similar to that of the concave type. The compressive strengths of convex type specimens also depend on the slenderness ratio, but a little different from those of concave type specimens in the detailed behavior. And densification occurs earlier than the concave type WBK.

• Journal of Advanced Navigation Technology
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• v.20 no.6
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• pp.631-637
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• 2016

Quantum cellular automata (QCA) are one of the alternative technologies that can overcome the limits of complementary metal-oxide-semiconductor (CMOS) scaling. It consists of nano-scale cells and demands very low power consumption. Various circuits on QCA have been researched until these days, and in the middle of the researches, exclusive-OR (XOR) gates are used as error detection and recover. Typical XOR logic gates have a lack of scalable, many clock zones and crossover designs so that they are difficult to implement. In order to overcome these disadvantages, this paper proposes XOR design using majority gate reduced clock zone. The proposed design is compared and analysed to previous designs and is verified the performance.