• Korean Journal of Clinical Pharmacy
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• v.28 no.1
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• pp.65-75
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• 2018

Objective: Over the last several years, immunotherapy has become one of the most promising therapeutic options for cancer. This study aims to summarize the updates on cancer immunotherapy focusing on immune checkpoint inhibitors, such as programmed cell death-1 (PD-1), programmed death-ligand 1 (PD-L1), and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) inhibitors, which have received attention as new anticancer therapeutic agents. Methods: A literature survey was carried out on PubMed to identify high-impact papers on cancer immunotherapy from 2010. The most recent data on clinical efficacy and safety have been included highlighting the response characteristics to recently approved immunotherapeutic agents. Results: In various cancers, immune checkpoints are a means for cancer cells to evade the immune system. Furthermore, CTLA-4 and PD-L1 can be overexpressed, allowing malignant cells to evade T-cells. Numerous clinical trials have been performed to seek appropriate indication of these products in various cancer types. Among them, the most conspicuous types are melanoma, non-small-cell lung cancer, and head and neck cancer. The approval of ipilimumab by Food and Drug Administration (FDA) commenced a new era of cancer immunotherapy. This was followed by the approval of nivolumab and pembrolizumab. Currently, combination therapies are being investigated for various cancer types. Conclusion: In this study, we reviewed recently reported scientific and clinical evidence for currently approved immune checkpoint inhibitors. Although these novel checkpoint inhibitors are ever evolving for cancer therapies, there exist limitations that need to be overcome, indicating the necessity for further studies aiming to improve their efficacy, toxicity, and cost.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.35 no.3
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• pp.175-186
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• 2017

In this study was to survey method of national/public land actual condition survey to utilization of UAV, in order to evaluate the economic and accuracy. we carried out the comparative evaluation of the cadastral status surveying in terms of accuracy of parcel checkpoint, economical costs. The results are summarized as follows. First, average position error of the orthoimage was 0.033m in X error, 0.023m in Y error when the RMSE average calculated 0.046m from the intersection of plane distance connections. Secondly, it was appeared the accuracy of the orthophotograph is 0.076m at the maximum RMSE of the UAV orthoimage check point and 0.042m at the minimum RMSE compared with the VRS-GNSS survey results. Thirdly, when the allowable error specified in the implementing regulation of the current cadastral survey is applied, all of the checkpoint of 0.360m tolerance corresponding to the scale of 1/1,200 is satisfied. Finally, UAV utilization method in national/public land actual condition survey is 26,497,436(KRW) cheaper than cadastral survey method for In the economic evaluation of national/public land actual condition survey. Therefore, as a result of this study shows that the method of utilizing UAV in the national/public land actual condition survey satisfies legal standards in terms of accuracy and economical aspect is a way to further reduce the local government budget.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.26 no.2
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• pp.111-116
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• 2008

The study installed non metric camera which was a 10 Mega Pixel camera in RC Helicopter. And the study controlled images hotographed in air on land, considering their overlap. The study could express DEM by abstracting TIN from the acquired images through image registration. Also, the study compared and examined accuracy between reference point and check point observed by Total Station which was a conventional type of survey. As the results, the study could get errors of $-0.194{\sim}0.224\;m$ on X axis, $-0.088{\sim}0.180\;m$ on Y axis and $-0.286{\sim}0.285\;m$ on Z axis. Expressing an error's RMSE in the checkpoint, the study could get of 0.021388 m on X axis, 0.015285 m on Y axis and 0.041872 m on Z axis. It is judged that the above photographing and analyzing technique are better than the existing Total Station to acquire more terrain elevation data.

• Journal of Convergence for Information Technology
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• v.11 no.1
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• pp.136-142
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• 2021

Open-pit mine development requires continuous management because of topographical changes and there is a risk of accidents if the current status survey is performed directly in the process of calculating the earthwork. In this study, the application of UAV photogrammetry, which can acquire spatial information without direct human access, was applied to open-pit mines development area and analyzed the accuracy, earthwork, and mountain restoration plan to determine its applicability. As a result of accuracy analysis at checkpoint using ortho image and Digital Surface Model(DSM) by UAV photogrammetry, Root Mean Square Error(RMSE) is 0.120 m in horizontal and 0.150 m in vertical coordinates. This satisfied the tolerance range of 1:1,000 digital map. As a result of the comparison of the earthwork, UAV photogrammetry yielded 11.7% more earthwork than the conventional survey method. It is because UAV photogrammetry shows more detailed topography. And result of monitoring mountain restoration showed possible to determine existence of rockfall prevention nets and vegetation. If the terrain changes are monitored by acquiring images periodically, the utility of UAV photogrammetry will be further useful to open-pit mine development.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.27 no.5
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• pp.545-553
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• 2009

Digital Elevation Models (DEM) is widely used in establishing the topographic profile in nation spatial information. Aerial Light Detection And Ranging (LiDAR) system is one of the well-known means to produce DEM. The system has fast data acquisition procedures and less weather-dependent restrictions compared to photogrammetric approaches. In this regards, LiDAR has been widely utilized and accepted in the process of nation spatial information generation due to its sufficient positional accuracy. However, the investigation of the accuracy of aerial LiDAR data over the area of forestation with various kinds of vegetations has been barely implemented in Korea. Hence, this research focuses on the investigation of the accuracy of aerial LiDAR data over the area of forestation and the evaluation of the acquired accuracy according to the characteristics of the vegetations. The study areas include land with shrubs and its adjacent forest area with mixed tree species. The spots for the investigation have been selected to be well-distributed over the whole study areas and their coordinates are surveyed by Global Positioning Systems (GPS). Then, the surveyed information and aerial LiDAR data have been compared with each other and the result accuracy has been evaluated. Conclusively, it is recommended that LiDAR data collection to be conducted after defoliation period, especially over the areas with broadleaf trees due to the possibility of significant outliers.