• Journal of the Korean Home Economics Association
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• v.42 no.7
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• pp.55-61
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• 2004

The Purpose or this study was to determine the optimal dyeing condition or Chelidonium majus extracts onto silk fabrics. Among the various dyeing properties, the colorfastness of fabrics dyed with Chelidonium majus extracts was investigated in different conditions such as dyeing temperature, dyeing time, dyeing pH etc. We also tried to dye fabrics using the Chelidonium majus extracts which were lyophilized. Although mordant was not used, dyed fabrics showed relatively good dyeability and the main pigment of Chelidonium majus showed yellow vividly in the appropriate dyeing conditions. At a dyeing temperature above 40$^{\circ}C$, the $\Delta$E value increased but the yellowish tint decreased. The pH value of unadjusted Chelidonium majus extracts was 6.4, at which a deep yellow was obtained. The dye equilibrium was reached 40 minutes after dyeing. The colorfastness to washing and light was poor at 1-2 and 2-3, respectively, but the dry-cleaning fastness was good at 4-5.

• Fashion & Textile Research Journal
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• v.11 no.5
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• pp.827-832
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• 2009

The purpose of this study is to scientifically proof possibility of development of natural dye which has antimicrobial activity with Chelidonium majus var. asiaticum. For that silk fabrics dyed with Chelidonium majus var. asiaticum extracts were tested for anti-microbial activity. Bacterials used for test of anti-microbial activity were Staphylococcus aureus ATCC 6538, Klebsiella pneumoniae ATCC 4352 and Trichophyton mentagrophytes IFO 5466. The results of experiment were as follows ; 1. The more the number of times of dyeing increase the more value of K/S increased. 2. Reduction of bacterium against Staphylococcus aureus ATCC 6538 of silk fabrics dyed with Chelidonium majus var. asiaticum extracts was 99.9% without reference to the number of times of dyeing. 3. Reduction of bacterium against Staphylococcus aureus ATCC 6538 of silk fabrics dyed with Chelidonium majus var. asiaticum extracts was 99.9% after irradiation of 20 hour without reference to the number of times of dyeing. 4. Reduction of bacterium against Staphylococcus aureus ATCC 6538 of silk fabrics dyed with Chelidonium majus var. asiaticum extracts was over 94.8% after dry cleaning. As above silk fabrics dyed with Chelidonium majus var. asiaticum extracts were acquired a high anti-microbial activity against Staphylococcus aureus ATCC 6538.

• Korean Journal of Veterinary Research
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• v.49 no.1
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• pp.23-34
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• 2009

This study was performed to evaluate repeated-dose oral toxicities of Chelidonium majus extract in Fischer 344/N rats. Chelidonium majus extract was administered orally to rats at dose levels of 0, 25, 74, 222, 666 and 2,000 mg/kg/day. Each group consisted of 10 rats of each gender. The Chelidonium majus extract was given once a day, 5 times a week, for 90 day repeatedly. This study was conducted in accordance with the Protocol of Korea National Toxicology Program (issued by National Institute of Toxicological Research) and The Standards of Toxicity Study for Medicinal Products (issued by Korea Food and Drug Administration). In the present study, There were no toxicologically significant changes in mortality, clinical signs, body weight gains, ophthalmoscopy, urine analysis, hematology, serum biochemistry, necropsy findings, organ weights, histopathology, estrus cycle and sperm examination of all animals treated with Chelidonium majus extract. These results suggest that the oral no observed adverse-effect level of the test item, Chelidonium majus extract, in rats is higher than 2,000 mg/kg/day in both genders. The target organs were not established.

• Korean Journal of Human Ecology
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• v.9 no.1
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• pp.43-50
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• 2006

The main colorant of Chelidonium majus extracts is a berberine which shows relatively good dyeability onto silk fabrics in the appropriate dyeing conditions without mordant, But cotton fabrics are difficult to dye with berberine because of the low substantivity the cationic to cellulosic fibers. we treated cotton fabrics using three types of polycarboxylic acid, DL-malic acid, citric acid, 1,2,3,4-butanetetracarboxylic acid(BTCA) to increase dyeability of Chelidonium majus extracts onto cotton fabrics. As a result the cotton fabrics treated with polycarboxylic acid could be dyed with Chelidonium majus extracts and also showed yellow vividly. The dye uptake were increased with increasing the number of carboxy groups. And so dye uptake resulted the largest in the BTCA solutions which have four carboxylic groups in the molecular unit. The optimal dyeing temperature a of Chelidonium majus extracts onto polycarboxylic acid treated cotton fabrics were $60^{\circ}C$. The dye equilibrium was reached 20 minutes after dyeing. Neutral pH of dye solutions showed in higher K/S value than acidic or alkaline conditions. But the colorfastness to washing and light according to polycarboxylic acid treat was not enhance.

• 한국생물공학회:학술대회논문집
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• 2003.04a
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• pp.195-200
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• 2003

The growth of S. aureus was inhibited by combination of natural products bearing antioxidative capacity and combined two, three and four kinds of them. S. aureus was controlled by Paeonia Japonica, Galla Rhois, Geranii Herba, alone, and two mixed combinations of Paeonia japonica and Scutellaria Baicalensis George, Paeonia japonica and Theae Folium, Paeonia japonica and Chelidonium Majus L, Paeonia japonica and Geranii Herba, Paeonia japonica and Schizandrae Fructus, and three mixed combinations of Paeonia Japonica and Scutellaria Baicalensis George and Geranii Herba, Paeonia Japonica and Scutellaria Baicalensis George and Chelidonium Majus L., Paeonia Japonica and Scutellaria Baicalensis George and Theae Folium, and four mixed combinations of Scutellaria Baicalensis George and Chelidonium Majus L. and Theae Folium and Schizandrae Fructus, Paeonia Japonica and Scutellaria Baicalensis George and Chelidonium Majus L. and Schizandrae Fructus, Scutellaria Baicalensis George and Geranii Herba and Theae Folium and Schizandrae Fructus. As these combinations of natural products will activate some parts of body, they may be applied to pharmaceutical applications, functional foods, antiaging tea, also expected to control bacterial growth for fermentative beverage bearing multifunction.

• Journal of Microbiology and Biotechnology
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• v.32 no.4
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• pp.493-503
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• 2022

Forkhead transcription factor 3a (Foxo3a) is believed to be a tumor suppressor as its inactivation leads to cell transformation and tumor development. However, further investigation is required regarding the involvement of the activating transcription factor 3 (ATF3)-mediated Tat-interactive protein 60 (Tip60)/Foxo3a pathway in cancer cell apoptosis. This study demonstrated that Chelidonium majus upregulated the expression of ATF3 and Tip60 and promoted Foxo3a nuclear translocation, ultimately increasing the level of Bcl-2-associated X protein (Bax) protein. ATF3 overexpression stimulated Tip60 expression, while ATF3 inhibition by siRNA repressed Tip60 expression. Furthermore, siRNA-mediated Tip60 inhibition significantly promoted Foxo3a phosphorylation, leading to blockade of Foxo3a translocation into the nucleus. Thus, we were able to deduce that ATF3 mediates the regulation of Foxo3a by Tip60. Moreover, siRNA-mediated Foxo3a inhibition suppressed the expression of Bax and subsequent apoptosis. Taken together, our data demonstrate that Chelidonium majus induces SKOV-3 cell death by increasing ATF3 levels and its downstream proteins Tip60 and Foxo3a. This suggests a potential therapeutic role of Chelidonium majus against ovarian cancer.

• Korean Journal of Pharmacognosy
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• v.32 no.1 s.124
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• pp.10-14
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• 2001

Three alkaloids, (-)-stylopine (I), (+)-chelidonine (II), oxysanguinarine (III) and two triterpenoids, $6{\alpha}-hydroxy-A-neo-germacer-22(29)-en-30-oic\;acid$ (IV) and hop-22(29)-en-30-oic acid (V), were isolated from the methanol extract of of Chelidonium majus var. asiaticum, and their cytotoxicity were tested against five cultured human tumor cell lines.

• Journal of Applied Biological Chemistry
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• v.48 no.4
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• pp.198-201
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• 2005

Two known isoquinoline alkaloids, (+)-chelidonine (1) and (-)-stylopine (2), were isolated from $CHCl_3$-soluble fraction of whole plants of Chelidonium majus L. var. asiaticum, and their structures were identified by spectroscopic methods and X-ray crystallographic analysis. Two isolates (1 and 2) were examined for their in vitro cytotoxic activities against five human cancer cell lines including DU-145 (prostate), MCF (breast), A549 (lung), HePG2 (liver), and HT-29 (colon) by sulphorhodamine B (SRB) assay.

• Journal of the Korean Society of Food Science and Nutrition
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• v.31 no.5
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• pp.931-938
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• 2002

The growth of enterobacteria, Bifidobacterium infantis KCTC 3270, was promoted by natural products bearing antioxidative capacity and mixed combinations of two, three and four kinds of them. B. infantis was expressed a good growth by Aurantii nobilis pericarpium majus L., Astragali radix, Epimedii herba, alone, and two mixed combinations of Epimedii herba and Theae folium, Epimedii herba and Crataegi fructus, Epimedii herba and Eucommiae cortex, and three mixed combinations of Theae folium, Epimedii herba and Chelidonium majus L., Theae folium, Epimedii herba and Aurantii nobilis pericarpium, Theae folium, Chelidonium majus L. and Auantii nobilis pericar pium, Theae folium, Chelidonium majus L. and Astragali radix, Theae folium, Aurantii nobilis pericarpium and puerariae radix, Epimedii herba, Chelidonium majus L. and Aurantii nobilis pericarpium, and four mixed com-binations of Theae folium, Chelidonium majus L., Astragali radix and Epimedii herba, and Theae folium, Chelidonium majus L., Astragali radix and Puerariae readix, and Theae folium, Epimedii herba, Aurantii nobilis pericarpium and Puerariae radix, and Theae folium, Chelidonium majus L., Aurantii nobilis pericarpium and Puerariae radix. The best four mixed combination ofr the growth of B. infantis was Theae folium, Chelidonium majus L. Astragali radix and Epimedii herba, which promoted 2.1 times than that of control, and its antioxidative capacity was also 5 times higher, and the ratio of elimination of hydroxyl radical was more than 80% in each dilution rate. As these combinations of natural products might activate some parts of body, they could be applied to pharmaceutical applications, functional foods, antiaging tea, also expected to promote useful bacterial growth for fermentative beverage bearing multifunction.

• Fashion & Textile Research Journal
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• v.10 no.2
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• pp.242-248
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• 2008

This study was aimed to find whether the Chelidonium majus which grows naturally in Korean soil and has a various medical ingredient is valuable as a natural dyeing material and to examine the functionality of Chelidonium majus extract. As the test result of dyeing colorfastness, colorfastness to sunlight was 1st grade for all the dyed fabrics. The colorfastness to laundry for discoloration showed from 1st to 4th grade and that for discoloration showed from 4th to 5th grade through all the dyed fabrics. Colorfastness to perspiration, rubbing, and drycleaning showed from 4th to 5th grade through all the dyed fabrics. In the result of antibiosis test, the dyed cotton fabric showed the bacteria reduction rate of 99.0% for Staphylococcus aureus and Escherichia coli evenly when washed one, three, and five times, The dyed silk fabric, when washed one, three, and five times, showed the bacteria reduction rate of 99.0% for Staphylococcus aureus, but didn't showed the significant bacteria reduction. As the test result of sun protection test, in the case of the cotton fabric which was dyed but don't use mordant, after one-time washing, S.P.F.(Sun Protection Factor) showed 20.4, the interception rate of UV-A showed 94.3%, and that of UV-B showed 95.2%. After five-time washing, S.P.F. showed 14.3, the interception rate of UV-A showed 90.0%, and that of UV-B showed 93.2%. In the case of the silk fabric which was dyed but don't use mordant, after one time washing, S.P.F. showed 30.5, the interception rate of UV-A showed 95.9%, and that of UV-B showed 96.9%, after five-time washing, S.P.F. showed 31.0, the interception rate of UV-A showed 95.6%, and that of UV-B showed 96.7%.