• Title/Summary/Keyword: Chemistry

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Sesbagrandiflorain F, a New 2-Arylbenzofuran from the Stem Bark of Sesbania grandiflora L.

  • Tanjung, Mulyadi;Aldin, Muhammad Fajar;Tjahjandarie, Tjitjik Srie;Rahayu, Devina Oktari;Gunawan, Alfiah Nur Irza;Saputri, Ratih Dewi
    • Natural Product Sciences
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    • v.27 no.3
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    • pp.172-175
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    • 2021
  • Sesbagrandiflorain F (1), a novel 2-arylbenzofuran, and two more 2-arylbenzofurans (2-3), were isolated from the stem bark of Sesbania grandiflora L. Based on information HRESIMS data, 1D, and 2D NMR spectra, the structure of 1 was fully assigned. Compounds 1-3 were tested for cytotoxicity in MCF-7 and HeLa cells. Compounds 1 and 3 showed moderate activity against MCF-7 cells with an IC50 value of 2.68 and 4.08 ㎍/mL, respectively. Conversely, all of the isolates were inactive towards HeLa cells.

Flavestin K, An Isoprenylated Stilbene from the Leaves of Macaranga recurvata Gage

  • Tjahjandarie, Tjitjik Srie;Tanjung, Mulyadi;Saputri, Ratih Dewi;Nadar, Puja Bintu;Aldin, Muhammad Fajar;Marliana, Eva;Permadi, Anton
    • Natural Product Sciences
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    • v.25 no.3
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    • pp.244-247
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    • 2019
  • A new isoprenylated stilbene, flavestinK (1) together with two known isoprenylated stilbenes, flavestin B (2), flavestin G (3), and two isoprenilated flavanones, 4-O-methyl-8-isoprenylnaringenin (4) and 8-isoprenyl-5,7-dihydroxyflavanone (5) were isolated from the leaves of Macaranga recurvata Gage. All of the structures have been determined based on HRESIMS, 1D and 2D NMR spectral data. All of the isolated compounds were evaluated for their cytotoxicity against three human cancer cells (HeLa, T47D and WiDr). Compound 1 showed higher activity than doxorubicin against HeLa cells with $IC_{50}$ value of $13.1{\mu}g/mL$.

Xanthones and 4-Phenylcoumarins from the Twigs of Mesua beccariana (Baill.) Kosterm

  • Mulyadi Tanjung;Tjitjik Srie Tjahjandarie;Muhammad Fajar Aldin;Shola Mardhiyyah;Ishomatul Maqfiroh;Ratih Dewi Saputri;Norizan Ahmat
    • Natural Product Sciences
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    • v.29 no.1
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    • pp.38-41
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    • 2023
  • Two xanthones and 4-phenylcoumarins were isolated from the twigs of Mesua beccariana (Baill.) Kosterm. Among them, one new xanthone, beccarianin A (1), along with 7-isoprenyl-jacareubin (2), mammea A/AA cyclo F (3), and mammea A/BA cyclo F (4). These structures were determined by spectrometric and spectroscopic methods, HRESIMS data, NMR, and UV spectra. Two xanthones (1-2) and two 4-phenylcoumarins (3-4) were evaluated for their cytotoxic effect on the HeLa cells. Compound 1 showed active activity (IC50 = 8.2 µM), and compounds 3-4 showed moderate activity (IC50 = 12.3 and 15.6 µM, respectively).