• Title/Summary/Keyword: Chemistry

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Synthesis and Characterization of Some Quinazoline Derivatives as Potential Antimicrobial Agents under Microwave Irradiation

  • Mehta, Sarika;Swarnkar, Neelam;Vyas, Madhuri;Vardia, Jitendra;Punjabi, Pinki B.;Ameta, Suresh C.
    • Bulletin of the Korean Chemical Society
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    • v.28 no.12
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    • pp.2338-2343
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    • 2007
  • Under the framework of green chemistry, an efficient and extremely fast procedure for the synthesis of 5a-h through four-step procedure starting from 2-arylidenetetralin-1-one 1a-d under microwave irradiation is described. A considerable increase in the reaction rate has been observed with better yield. The structures of the synthesized compounds have been characterized on the basis of their elemental analysis and spectral data. Synthesized compounds 5a-h was evaluated for their antimicrobial activity. Some of the compounds exhibited appreciable activity.

Selective Synthesis of N-(Cyclohexylmethyl)-N-alkylamines from Primary Amines and Pimelaldehyde using Tetracarbonylhydridoferrate, $HFe(CO)_4^\;-$, as a Reducing Agent

  • Sang Chul Shim;Young Gil Kwon;Chil Hoon Doh;Byung Won Woo;Jin Ook Baeg;Hong Seok Kim;Tae Jeong Kim;Dong Ho Lee;Young Woo Kwak;Jin Soon Cha;Hyung Soo Lee;Jae Kook Uhm;Young Bae Park
    • Bulletin of the Korean Chemical Society
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    • v.11 no.2
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    • pp.140-143
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    • 1990
  • Ethanolic tetra carbonylhydridoferrate solution combined with dialdehyde (no of carbon; 4,5,6) is very efficient for the selective transformation of amino group into N-heterocyclic compound. However, a large variety of both aliphatic and aromatic amines react with the ferrate-pimelaldehyde at room temperature under an atmospheric pressure of carbon monoxide to give the corresponding N-(cyclohexylmethyl)-N-alkyiamine derivatives in moderate yields instead of the corresponding N-substituted perhydroazocine derivatives.

Synchrotron Grazing Incidence X-ray Scattering and Its Applications in Polymer Nanotechnology

  • Ree, Moon-Hor;Lee, Byeong-Du;Yoon, Jin-Hwan;Heo, Kyu-Young;Jin, Kyeong-Sik;Jin, Sang-Woo;Kim, Hyun-Chul;Kim, Gha-Hee;Choi, Seung-Chul;Oh, Weon-Tae;Park, Young-Hee;Hwang, Yong-Taek;Kim, Jong-Seong
    • Proceedings of the Polymer Society of Korea Conference
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    • 2006.10a
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    • pp.120-120
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    • 2006
  • In our study grazing incidence X-ray scattering (GIXS) measurements with synchrotron radiation sources were conducted statically and in-situ for a series of nanoscale thin films prepared from nanoporous dielectrics, block copolymers, brush polymers, and molecular assemblies. All GIXS measurements were performed at the Pohang Accelerator Laboratory. The measured scattering data were analyzed in detail by using newly developed GIXS scattering theory. All GIXS results will be discussed in details with considering the materials chemistry and nanostructure formation process parameters.

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Highly Fluorescing Solid DNA-Cationic Polyelectrolyte Complexes Prepared from a Natural DNA and a Poly(fluorenevinylene-alt-phenylene) Bearing Quaternary Ammonium Pendants

  • Yu, Young-Jun;Kwon, Young-Wan;Kim, Kyu-Nam;Do, Eui-Doo;Choi, Dong-Hoon;Jin, Jung-Il;Shin, Hee-Won;Kim, Yong-Rok;Kang, Ik-Joong;Mikroyannidis, John A.
    • Macromolecular Research
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    • v.17 no.4
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    • pp.245-249
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    • 2009
  • A fluorescing, copolymer(Q)-bearing, quaternary ammonium pendant was mixed with excess natural salmon sperm DNA with a molecular weight of $1.3{\times}10^6$(2,000 base pairs) to afford highly fluorescing, complex mixtures. The fluorescence life-time of the polymer Q was greatly increased when mixed with DNA: for the mixture of Q:DNA=1:750 the fast and slow decay lifetimes increased from ca. 10 to 100 ps and from 20 ps to ca. 1 ns, respectively. The enhanced fluorescence of the mixtures was ascribed to efficient compartmentalization and reduced conformational relaxation of the polymer Q by complexation with excess DNA.

A New Cinnamyl Acid Derivative from the Roots of Willughbeia coriacea Wall.

  • Tanjung, Mulyadi;Tjahjandarie, Tjitjik Sri;Saputri, Ratih Dewi;Harsono, Andre;Aldin, Muhammad Fajar
    • Natural Product Sciences
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    • v.26 no.1
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    • pp.79-82
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    • 2020
  • A new cinnamyl acid derivative, willughbein A (1) along with pinoresinol (2), alyterinate A (3), and scopoletin (4), were isolated from the roots of Willughbeia coriacea Wall. The structure of 1 has been determined based on HRESIMS, 1D, and 2D NMR spectral data. All of the isolates were evaluated for their cytotoxicity against three human cancer cells (HeLa, T47D, MCF-7, and P-388). Compound 3 showed moderate activity against P-388 cells with an IC50 value of 3.04 ㎍/mL.