• Journal of Ginseng Research
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• v.14 no.2
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• pp.210-212
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• 1990

• Proceedings of the Ginseng society Conference
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• 1990.06a
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• pp.68-70
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• 1990

• Journal of Ginseng Research
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• v.46 no.6
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• pp.759-770
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• 2022

Background: Aerobic cellular respiration provides chemical energy, adenosine triphosphate (ATP), to maintain multiple cellular functions. Sirtuin 1 (SIRT1) can deacetylate peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) to promote mitochondrial biosynthesis. Targeting energy metabolism is a potential strategy for the prevention and treatment of various diseases, such as cardiac and neurological disorders. Ginsenosides, one of the major bioactive constituents of Panax ginseng, have been extensively used due to their diverse beneficial effects on healthy subjects and patients with different diseases. However, the underlying molecular mechanisms of total ginsenosides (GS) on energy metabolism remain unclear. Methods: In this study, oxygen consumption rate, ATP production, mitochondrial biosynthesis, glucose metabolism, and SIRT1-PGC-1α pathways in untreated and GS-treated different cells, fly, and mouse models were investigated. Results: GS pretreatment enhanced mitochondrial respiration capacity and ATP production in aerobic respiration-dominated cardiomyocytes and neurons, and promoted tricarboxylic acid metabolism in cardiomyocytes. Moreover, GS clearly enhanced NAD⁺-dependent SIRT1 activation to increase mitochondrial biosynthesis in cardiomyocytes and neurons, which was completely abrogated by nicotinamide. Importantly, ginsenoside monomers, such as Rg1, Re, Rf, Rb1, Rc, Rh1, Rb2, and Rb3, were found to activate SIRT1 and promote energy metabolism. Conclusion: This study may provide new insights into the extensive application of ginseng for cardiac and neurological protection in healthy subjects and patients.

• Cross-Cultural Studies
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• v.23
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• pp.351-382
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• 2011

This paper aims to compare systems and questions between Chinese I in the Korea National Scholastic Aptitude Test(abbreviated by KNSAT) and Chinese with Listening in the SAT. In the beginning, we compared KNSAT and SAT, and then focused our attention on Chinese I in KNSAT and Chinese with Listening in SAT in terms of assessment purposes, sections, ranges, questions. Through the research, the following results were obtained: Firstly, compared KNSAT with SAT, it is found that Chinese I is less important in KNSAT than Chinese with Listening in SAT. Chinese I belongs to one of the second foreign languages section, and it is placed under common rule of its section. However, Chinese with Listening is similar to Chinese I in that it also belongs to one of the languages section, but it keeps under its control, so it has its own system e.g. purpose, range etc.. Next, compared Chinese I with Chinese with Listening, in the matter of purposes of them, Chinese I is less explicit and less concrete to explain it than Chinese with Listening, and in respect of sections of them, the sections of Chinese I are leaning more toward language materials contrary to Chinese with Listening leaning more toward language functions. And in terms of ranges of them, Chinese I is limited to Basic vocabulary and Examples of communicative function in curriculum of Chinese I, but Chinese with Listening has not any limit on the ranges of questions. Lastly, with regard to questions of them, Chinese I has more tendency toward assessing knowledge of Chinese, on the contrary, Chinese with Listening has more tendency toward assessing performance of it.

• Journal of the Korean Home Economics Association
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• v.43 no.3 s.205
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• pp.221-231
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• 2005

This study investigated the cross-cultural differences in temperament among Chinese, Korean-Chinese, and Korean children. Subjects were 1,046(258 Korean-Chinese, 290 Chinese, and 498 Korean) 4th graders from Yanji in China and Seoul and Ulsan in Korea. The short form of the Early Adolescent Temperament Questionnaire Scale-Revised containing 10 scales of 54 items was translated into Korean for Korean and Korean-Chinese children and into Chinese for Chinese children and was administered to children via home-room teachers. Chinese children rated themselves higher on activation control, attention, and pleasure- and perceptual-sensitivity subscales than other groups. On the contrary, Chinese-Korean children rated themselves higher on the affiliation subscale and Korean children rated themselves higher on the aggression subscale than other groups. There were larger gender differences among Chinese and Korean-Chinese than among Korean children: Gender difference was found in activation control, aggression, and attention subscales among Chinese children and in affiliation, aggression, attention and fear subscales among Korean-Chinese. There was only significant difference in pleasure sensitivity among Korean. Rapid westernization in Korea seems to be responsible for this result. Since there were significant differences of temperament between Korean and Korean-Chinese, and between Chinese and Korean-Chinese, it was interpreted that children's temperament is influenced by both their environment and genetic endowment.

• Cross-Cultural Studies
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• v.33
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• pp.359-384
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• 2013

There is linguistic phenomenon that Korean syllable, morpheme and word are substituted with Chinese Character. These phenomenon is called Chinese Character Borrowing, the Chinese character used here is called Borrowed Chinese Character. Whereas borrowing Chinese character in Chinese is used for borrowing only sound for different word, borrowing Chinese character in Korean is used for assigning new meaning. Hence, by borrowing Chinese character in Korean, a syllable which had no meaning originally get new meaning, morpheme and word meaning has changed. At advertisement and campaign, Chinese Character Borrowing has lots of linguistical advantage such as visual immediacy, effectiveness of meaning expression. However, there are number of cases found that violate grammar rule and word constitution practice by Chinese Character Borrowing. For this reason, Chinese Character Borrowing has the problem polluting Korean along with another foreign words. Thus, this paper focus on study Chinese Character Borrowing phenomenon in Korean, and analysis its effectiveness and impact in Korean. In addition, analysis the problem of Borrowed chinese Character, and suggestion several alternative for right use of Korean is followed.

• Journal of Ginseng Research
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• v.46 no.2
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• pp.315-319
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• 2022

• Journal of Ginseng Research
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• v.44 no.3
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• pp.442-452
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• 2020

Backgroud: Sleep deprivation (SD) impairs learning and memory by inhibiting hippocampal functioning at molecular and cellular levels. Abnormal autophagy and apoptosis are closely associated with neurodegeneration in the central nervous system. This study is aimed to explore the alleviative effect and the underlying molecular mechanism of stem-leaf saponins of Panax notoginseng (SLSP) on the abnormal neuronal autophagy and apoptosis in hippocampus of mice with impaired learning and memory induced by SD. Methods: Mouse spatial learning and memory were assessed by Morris water maze test. Neuronal morphological changes were observed by Nissl staining. Autophagosome formation was examined by transmission electron microscopy, immunofluorescent staining, acridine orange staining, and transient transfection of the tf-LC3 plasmid. Apoptotic event was analyzed by flow cytometry after PI/annexin V staining. The expression or activation of autophagy and apoptosis-related proteins were detected by Western blotting assay. Results: SLSP was shown to improve the spatial learning and memory of mice after SD for 48 h, accomanied with restrained excessive autophage and apoptosis, whereas enhanced activation of phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway in hippocampal neurons. Meanwhile, it improved the aberrant autophagy and apoptosis induced by rapamycin and re-activated phosphoinositide 3-kinase/Akt/mammalian target of rapamycin signaling transduction in HT-22 cells, a hippocampal neuronal cell line. Conclusion: SLSP could alleviate cognitive impairment induced by SD, which was achieved probably through suppressing the abnormal autophagy and apoptosis of hippocampal neurons. The findings may contribute to the clinical application of SLSP in the prevention or therapy of neurological disorders associated with SD.

• Cross-Cultural Studies
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• v.21
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• pp.255-270
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• 2010

Chinese phonology is called 'juexue(絶學)' in Chinese linguistics field. For this, students of in Chinese universities as well as college students in Korea is unwilling to learn it. Chinese character phonetic is a very valuable resource in Sino-China comparative study as well as the Chinese phonology area. This study was attempt to develop the content model on education of Chinese phonology, such as Middle Chinese, Old Chinese, using close the data of Chinese character phonetic for students of Korea. In addition, I also make it known that contents of this paper is not a new discovery or analysis but recycling research of existing.

• Journal of Ginseng Research
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• v.43 no.1
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• pp.116-124
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• 2019

Background: Ginsenosides are known as the principal pharmacological active constituents in Panax medicinal plants such as Asian ginseng, American ginseng, and Notoginseng. Some ginsenosides, especially the 20(R) isomers, are found in trace amounts in natural sources and are difficult to chemically synthesize. The present study provides an approach to produce such trace ginsenosides applying biotransformation through Escherichia coli modified with relevant genes. Methods: Seven uridine diphosphate glycosyltransferase (UGT) genes originating from Panax notoginseng, Medicago sativa, and Bacillus subtilis were synthesized or cloned and constructed into pETM6, an ePathBrick vector, which were then introduced into E. coli BL21star (DE3) separately. 20(R)-Protopanaxadiol (PPD), 20(R)-protopanaxatriol (PPT), and 20(R)-type ginsenosides were used as substrates for biotransformation with recombinant E. coli modified with those UGT genes. Results: E. coli engineered with $GT95^{syn}$ selectively transfers a glucose moiety to the C20 hydroxyl of 20(R)-PPD and 20(R)-PPT to produce 20(R)-CK and 20(R)-F1, respectively. GTK1- and GTC1-modified E. coli glycosylated the C3-OH of 20(R)-PPD to form 20(R)-Rh2. Moreover, E. coli containing $p2GT95^{syn}K1$, a recreated two-step glycosylation pathway via the ePathBrich, implemented the successive glycosylation at C20-OH and C3-OH of 20(R)-PPD and yielded 20(R)-F2 in the biotransformation broth. Conclusion: This study demonstrates that rare 20(R)-ginsenosides can be produced through E. coli engineered with UTG genes.