• Korean Journal of Environmental Agriculture
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• v.27 no.4
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• pp.356-361
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• 2008

Chrysanthemum indicum L. (Gamgug) has been examined to study their flowering habits, yields and bioactive compounds under different planting densities and mowing dates. The planting density experiment revealed a significantly increasing stem diameter, number of flowers and branches with decreasing plant density in the $100\;cm{\times}30\;cm$ and $130\;cm{\times}30\;cm$ treatments as compared to $70\;cm{\times}30\;cm$ treatments, but not plant height, leaf and flower width. On the other hand, the mowing date experiment showed that growth characteristics of plants were similar to the control plants (not mowing) and June 20 treatment, but July 20 treatments had significantly smaller than the control. The weights (g $plant^{-1}$) of dry flowers were affected by the planting density and mowing date. The flower yield of $586\;kg\;ha^{-1}$ obtained at $100\;cm{\times}30\;cm$ density was 11% and 22% higher than that of $120\;cm{\times}30\;cm$ and $70\;cm{\times}30\;cm$ treatments, respectively. The yield of dry flowers in the control and June 20 mowing date ranged $495-508\;kg\;ha^{-1}$, which is 40-42% higher than the yield in the July 20 treatments. The amount of essential oil (g $plant^{-1}$) in medically valuable flowerheads of C. indicum L. was statistically different between mowing dates but not among planting densities. The study showed that planting density and the mowing date could increase yields of flowerheads. An optimum planting density of $100\;cm{\times}30\;cm$ and mowing date of on or before June 20 is recommended for C. indicum L.

• Korean Journal of Medicinal Crop Science
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• v.24 no.6
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• pp.479-485
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• 2016

Background: Planting vigorous cuttings that quickly develop shoots and roots is essential to the biological and economic success of producing medicinal flowers. The present study aimed to evaluate the effect of storage temperature and duration on seedling capacity in the propagation of Chrysanthemum indicum L. and to investigate the effect of rooting media on the growth of C. indicum L. after cutting. Methods and Results: Returning cuttings to supplemental cold storage ($2.0{\pm}1.0^{\circ}C$) may extend duration of cutting viability 6 weeks, returning cuttings to supplemental warm storage ($25.0{\pm}1.0^{\circ}C$) is not recommended. The treatment of the growing media experiments, which were conducted in the 2014 planting seasons, included sawdust, river sand, topsoil + sawdust, topsoil + poultry manure, sawdust + river sand, river sand + poultry manure, topsoil + river sand + poultry manure, topsoil + poultry manure + river sand + sawdust. Result indicated that the topsoil + poultry manure media performed best and supported the highest number of branches (3.47), branch length (26.39), and number of leaves (88.63). Conclusions: The results of the present study suggest that cold storage and the topsoil + poultry manure growth media was superior in supporting the early establishment of C. indicum cutting, this result will have a tremendous influence on propagation of this species.

• Korean Journal of Food Science and Technology
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• v.53 no.3
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• pp.260-266
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• 2021

This study aimed to identify the hepatoprotective effects of a fermented Chrysanthemum indicum L. water extract. The extraction yield, antioxidant activities (ABTS and DPPH), and content of luteolin and luteolin-7-glucoside were significantly higher in the fermented C. indicum L. water extract (FCI) than in the C. indicum L. water extract. Treatment with FCI (200 ㎍/mL) significantly reduced the activities of gamma(γ)-glutamyl transferase, aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase in HepG2 cells treated with 3% ethanol. Furthermore, FCI did not affect the viability of the HepG2 cells. These results suggest that FCI can be useful for the development of an effective hepatoprotective agent.

• Journal of Korean Biological Nursing Science
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• v.17 no.4
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• pp.341-347
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• 2015

Purpose: Chrysanthemum indicum (CHI) has been used for edible and medical purposes for a long time in Korea. The purpose of this study was to evaluate the anti-inflammatory effects of CHI water extract in lipopolysaccharides (LPS)-induced RAW 264.7 macrophage cells. Methods: To investigate the anti-inflammatory effects on LPS-induced RAW 264.7 macrophage cells, CHI extract as a whole plant was used in this study. RAW 264.7 cells were treated with various concentrations of CHI extract (1, 10, and $100{\mu}g/mL$). After that Nitric Oxide (NO), inducible nitric oxide synthase (iNOS), interleukin (IL)-$1{\beta}$, cyclooxygenase (COX)-2 and prostaglandin $E_2$ ($PGE_2$) expression level were measured. Results: CHI extract significantly suppressed the LPS-induced NO production and decreased the level of iNOS, IL-$1{\beta}$, COX-2 messenger ribonucleic acid (mRNA) expression and also the down regulation of $PGE_2$ expression in a dose-dependent manner. Conclusion: The present study suggested that CHI extract can be substituted for anti-inflammatory drugs and provide a safe and effective non pharmacological therapeutic approach.

• Journal of Convergence for Information Technology
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• v.11 no.5
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• pp.223-231
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• 2021

The antioxidant activity of Chrysanthemum indicum L. extract (CIL) was investigated by fermenting lactic acid bacteria with the CIL from 64% and 80% ethanol extraction and measuring the total phenolic contents (TPC), flavonoid, 2,2-diphenyl-1-picrylhydrazyl (DPPH), reducing power (RP), and linoleic acid auto-oxidation inhibitory activity. CIL was confirmed to inhibit bacterial auto-oxidation. TPC was increased in strains 3109 and 3237, while flavonoid decreased in all strains. DPPH was increased in strains 3074 and 3109 fermented with 64% CIL and all the strains with 80% CIL. RP was increased and linoleic acid auto-oxidation inhibitory activity decreased in all the strains fermented with 64% or 80% CIL. Among the 4 strains, strain 3109 had the highest DPPH and RP; thus, it was most effective in increasing CIL's antioxidant efficacy through the fermentation process.

• Korean Journal of Pharmacognosy
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• v.30 no.1
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• pp.65-69
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• 1999

The flower of Chrysanthemum morifolium L. has been used as 'Kamguk' in the Korean markets instead of it from C. indicum L. In order to evaluate the quality of Chrysanthemi Flos, the method for isolation and quantitative determination of luteolin as standard compound has been developed. It is analyzed with HPLC using the solvent system of MeOH-water-acetic acid (30:70:5). The amounts of luteolin from Chrysanthemi Flos in Korean markets are in the range of $0.03{\sim}0.04%.$ The amounts of luteolin from the flowers of C. indicum and C. boreale are approximately 0.14% and 0.04%, respectively.

• Journal of the Korean Society of Food Science and Nutrition
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• v.37 no.5
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• pp.647-652
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• 2008

Quality characteristics of Chrysanthemum indicum L. flower tea were investigated with the number of pan-firing. Total nitrogen, tannin and caffeine contents of tea were increased as the number of pan-firing increased, whereas chlorophyll and total amino acid (AA) contents were decreased. TAA content was in the range of $5,226{\sim}6,561mg%$ with the number of pan-firing. The content of caffeine and chlorophyll was not changed with the number of pan-firing. As the number of pan-firing increased, total polyphenol, flavonoid content, and antioxidant activity was also increased. The highest total polyphenol and flavonoid content was 17.44 and 11.09 mg/g at 7 times pan-firing, respectively. Total antioxidant activity was the highest value of 16.45 mg AA eq/g at 7 times of pan-firing. Based on the sensory evaluation, the best overall quality of the tea was obtained with 5 times of pan-firing.

• Korean Journal of Pharmacognosy
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• v.36 no.3 s.142
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• pp.186-190
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• 2005

Searching for inhibitors of lipopolysaccharide (LPS)-induced IL-6 (Interleukin-6) production from medicinal herbs, we isolated two active compounds though bioactivity-guided fractionation from the methanol extract of Chrysanthemum indicum L.. They were determined as kikkanol F monoacetate (1) and 5-hydroxy-6,7,3',4'-tetramethoxyflavone (2) by means of spectroscopy techniques such as NMR and MS. The compound 1 and 2 inhibited LPS-induced IL-6 production in the PAW264.7 cells with $IC_{50}$ value of $47\;{\mu}g/ml$ and $27\;{\mu}g/ml$, respectively.

• Journal of the Korean Society of Food Science and Nutrition
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• v.44 no.9
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• pp.1333-1338
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• 2015

This study investigated the effects of addition of Chrysanthemum indicum L. extracts on quality characteristics of Kukhwju during fermentation. Fermented liquors without C. indicum L. were used as the control group. For experimental groups, we added 1, 2, 5, and 10% C. indicum L. extracts and brewed according to the addition method written in Yorok. The pH level during fermentation phase, alcohol concentration, level of reducing sugars, and acidity were measured in each of the experimental groups. After fermentation, we measured total contents of phenols, antioxidant effects, free sugars, organic acids, and chromaticity. During fermentation, no significant difference was observed between the C. indicum L. group and control group. Regarding total phenol contents and antioxidant effects, only the 5% and 10% C. indicum L. groups showed higher contents of phenols than the non-addition group. In general, 5% and 10% C. indicum L. addition groups were positively evaluated. In conclusion, Kukhwaju with 10% C. indicum L. extract showed the best antioxidant effects. In the present study, we obtained different characteristics and determined the optimum addition amount of C. indicum L.

• Korean Journal of Pharmacognosy
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• v.27 no.1
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• pp.15-19
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• 1996

In the course of phytochemical studies of Chrysanthermi Flos(Chrysanthemum indicum L., Compositae), two compounds were isolated by repeated column chromatography. Compound 1 is identified as adenosine on the basis of spectroscopic means and comparison with an authentic standard. Compound 2 is determined to be a new alkyl alcohol glycoside, 1-octen-3-ol $3-O-{\beta}-D-xylopyranosyl(1{\rightarrow} 6)-{\beta}-D-glucopyranoside$ on the spectroscopic evidence. Compounds 1 and 2 are reported for the first time from this plant.